Linear analogues of human β-defensin 3: Concepts for design of antimicrobial peptides with reduced cytotoxicity to mammalian cells

ChemBioChem

Volumn 9, Issue 6, 2008, Pages 964-973

  Liu, Shouping ^a   Zhou, Lei ^a,b   Li, Jing ^a,b   Suresh, Anita ^c   Verma, Chandra ^c   Foo, Yong Hwee ^a   Yap, Eric P H ^d   Tan, Donald T H ^a,b,e   Beuerman, Roger W ^a,b  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c BIOINFORMATICS INSTITUTE   (Singapore)

^d Defence Medical and Environmental Research Institute   (Singapore)

^e SINGAPORE NATIONAL EYE CENTRE   (Singapore)

Author keywords

Antibiotics; Cytotoxicity; Epithelial cells; Human beta defensin 3 (hBD3); Molecular modeling

Indexed keywords

BETA DEFENSIN 3; BETA DEFENSIN 3 DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA DEFENSIN; BETA-DEFENSIN 3; CYSTEINE;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; DISULFIDE BOND; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; EPITHELIUM CELL; ERYTHROCYTE; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; MAMMAL CELL; MASS SPECTROMETRY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CONJUNCTIVA; CYTOLOGY; DRUG EFFECT; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MOLECULAR GENETICS; RABBIT;

MAMMALIA; ORYCTOLAGUS CUNICULUS;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; BETA-DEFENSINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; CONJUNCTIVA; CYSTEINE; DRUG DESIGN; EPITHELIAL CELLS; ERYTHROCYTES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; INHIBITORY CONCENTRATION 50; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; RABBITS;

EID: 44049109194     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700560     Document Type: Article

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