A synthetic congener modeled on a microbicidal domain of thrombin-induced platelet microbicidal protein 1 recapitulates staphylocidal mechanisms of the native molecule

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 11, 2006, Pages 3786-3792

  Xiong, Yan Q ^a,b   Bayer, Arnold S ^a,b   Elazegui, Lisa ^a,c   Yeaman, Michael R ^a,b  

^a LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LOMA LINDA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOVOBIOCIN; POLYPEPTIDE ANTIBIOTIC AGENT; RIFAMPICIN; RP 1; TETRACYCLINE; THROMBIN INDUCED PLATELET MICROBICIDAL PROTEIN 1; UNCLASSIFIED DRUG; VALINOMYCIN;

ALPHA HELIX; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE DEPOLARIZATION; CELL PERMEABILIZATION; CORRELATION ANALYSIS; CULTURE MEDIUM; DNA SYNTHESIS INHIBITION; DRUG EFFECT; DRUG EFFICACY; GROWTH INHIBITION; HOST RESISTANCE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS; RNA SYNTHESIS; STAPHYLOCOCCUS AUREUS; THROMBOCYTE ACTIVATION;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL PROTEINS; BETA-THROMBOGLOBULIN; CELL MEMBRANE PERMEABILITY; DNA, BACTERIAL; MEMBRANE POTENTIALS; MICROBIAL SENSITIVITY TESTS; MUTANT CHIMERIC PROTEINS; NOVOBIOCIN; RNA, BACTERIAL; STAPHYLOCOCCUS AUREUS;

EID: 33750578182     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00038-06     Document Type: Article

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