TGF-β1-induced connective tissue growth factor (CCN2) expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling

Nephron - Experimental Nephrology

Volumn 100, Issue 4, 2005, Pages

  Phanish, Mysore K ^a   Wahab, Nadia A ^b   Hendry, Bruce M ^c   Dockrell, Mark E C ^a  

^a ST HELIER HOSPITAL   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

CCN2; Connective tissue growth factor; Fibrosis; Proximal tubule epithelial cells; Ras MEK ERK; Signalling; Smads; Transforming growth factor

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAS PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; IMMEDIATE EARLY PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; SIGNAL PEPTIDE; SMAD PROTEIN; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE ACTIVITY; GENE OVEREXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; FIBROSIS; KIDNEY; KIDNEY TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY;

EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROSIS; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; KIDNEY NEOPLASMS; KIDNEY TUBULES, PROXIMAL; MAP KINASE SIGNALING SYSTEM; RAS PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR CELLS, CULTURED;

EID: 21344470149     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000085445     Document Type: Article

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