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Volumn 4, Issue 4, 2011, Pages 189-198

Six degrees of separation: The oxygen effect in the development of radiosensitizers

Author keywords

[No Author keywords available]

Indexed keywords

APAZIQUONE; BANOXANTRONE; CARBOGEN; CARBOPLATIN; CD47 ANTIGEN; CISPLATIN; CYTOTOXIN; EFAPROXIRAL; ERYTHROPOIETIN; GADOLINIUM TEXAPHYRIN; HYALURONIC ACID; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INHIBITOR OF APOPTOSIS PROTEIN; MITOMYCIN; NICOTINAMIDE; NITRIC OXIDE; NITROIMIDAZOLE DERIVATIVE; OXALIPLATIN; OXYGEN; PLATINUM COMPLEX; PORFIROMYCIN; RADIOSENSITIZING AGENT; SURVIVIN; THROMBOSPONDIN 1; TIRAPAZAMINE; TRANSITION ELEMENT; UNINDEXED DRUG; VASCULOTROPIN; X LINKED INHIBITOR OF APOPTOSIS;

EID: 79960313911     PISSN: None     EISSN: 19365233     Source Type: Journal    
DOI: 10.1593/tlo.11166     Document Type: Review
Times cited : (69)

References (126)
  • 1
    • 33746748089 scopus 로고    scopus 로고
    • The role of hypoxia inducible factor-1 in cell metabolism-a possible target in cancer therapy
    • Bel Aiba RS, Dimova EY, Görlach A, and Kietzmann T (2006). The role of hypoxia inducible factor-1 in cell metabolism-a possible target in cancer therapy. Expert Opin Ther Targets 10, 583-599.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 583-599
    • Bel Aiba, R.S.1    Dimova, E.Y.2    Görlach, A.3    Kietzmann, T.4
  • 3
    • 24344488419 scopus 로고    scopus 로고
    • The HIF pathway in cancer
    • Maxwell PH (2005). The HIF pathway in cancer. Semin Cell Dev Biol 16, 523-530.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 523-530
    • Maxwell, P.H.1
  • 4
    • 0034842881 scopus 로고    scopus 로고
    • Hypoxia and oxidative stress. Tumour hypoxia-therapeutic considerations
    • Williams KJ, Cowen RL, and Stratford IJ (2001). Hypoxia and oxidative stress. Tumour hypoxia-therapeutic considerations. Breast Cancer Res 3, 328-331.
    • (2001) Breast Cancer Res , vol.3 , pp. 328-331
    • Williams, K.J.1    Cowen, R.L.2    Stratford, I.J.3
  • 5
    • 0025807618 scopus 로고
    • Oxygenation of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements
    • Vaupel P, Schlenger K, Knoop C, and Höckel M (1991). Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements. Cancer Res 51, 3316-3322.
    • (1991) Cancer Res , vol.51 , pp. 3316-3322
    • Vaupel, P.1    Schlenger, K.2    Knoop, C.3    Höckel, M.4
  • 6
    • 0344972991 scopus 로고    scopus 로고
    • New insights into factors influencing the clinically relevant oxygen enhancement ratio
    • Daşu A and Denekamp J (1998). New insights into factors influencing the clinically relevant oxygen enhancement ratio. Radiother Oncol 46, 269-277.
    • (1998) Radiother Oncol , vol.46 , pp. 269-277
    • Daşu, A.1    Denekamp, J.2
  • 7
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH and Gray LH (1955). The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9, 539-549.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 9
    • 62649092475 scopus 로고    scopus 로고
    • Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: Mature results of a phase II nonrandomized study
    • Hoskin P, Rojas A, and Saunders M(2009). Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: mature results of a phase II nonrandomized study. Int J Radiat Oncol Biol Phys 73, 1425-1431.
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , pp. 1425-1431
    • Hoskin, P.1    Rojas, A.2    Saunders, M.3
  • 10
    • 0036898268 scopus 로고    scopus 로고
    • ARCON: A novel biologybased approach in radiotherapy
    • Kaanders JH, Bussink J, and van der Kogel AJ (2002). ARCON: a novel biologybased approach in radiotherapy. Lancet Oncol 3, 728-737.
    • (2002) Lancet Oncol , vol.3 , pp. 728-737
    • Kaanders, J.H.1    Bussink, J.2    van der Kogel, A.J.3
  • 12
    • 77953916219 scopus 로고    scopus 로고
    • Erythropoietin in cancer patients: Pros and cons
    • Dicato M and Plawny L (2010). Erythropoietin in cancer patients: pros and cons. Curr Opin Oncol 22, 307-311.
    • (2010) Curr Opin Oncol , vol.22 , pp. 307-311
    • Dicato, M.1    Plawny, L.2
  • 13
    • 77749236113 scopus 로고    scopus 로고
    • Results of the phase III ENRICH (RT-016) study of efaproxiral administered concurrent with Whole Brain Radiation Therapy (WBRT) in women with brain metastases from breast cancer
    • Suh JH, Stea B, Tankel K, Marsiglia H, Belkacemi Y, Gomez H, Falcone- Lizaraso S, May J, and Saunders M (2008). Results of the phase III ENRICH (RT-016) study of efaproxiral administered concurrent with Whole Brain Radiation Therapy (WBRT) in women with brain metastases from breast cancer. Int J Radiat Oncol Biol Phys 72, S50-S51.
    • (2008) Int J Radiat Oncol Biol Phys , vol.72
    • Suh, J.H.1    Stea, B.2    Tankel, K.3    Marsiglia, H.4    Belkacemi, Y.5    Gomez, H.6    Falcone-lizaraso, S.7    May, J.8    Saunders, M.9
  • 15
    • 33750350963 scopus 로고    scopus 로고
    • Suppression of hypoxia-induced HIF-1alpha and of angiogenesis in endothelial cells by myo-inositol trispyrophosphate-treated erythrocytes
    • Kieda C, Greferath R, Crola da Silva C, Fylaktakidou KC, Lehn JM, and Nicolau C (2006). Suppression of hypoxia-induced HIF-1alpha and of angiogenesis in endothelial cells by myo-inositol trispyrophosphate-treated erythrocytes. Proc Natl Acad Sci USA 103, 15576-15581.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15576-15581
    • Kieda, C.1    Greferath, R.2    Crola da Silva, C.3    Fylaktakidou, K.C.4    Lehn, J.M.5    Nicolau, C.6
  • 16
    • 48849106799 scopus 로고    scopus 로고
    • New radiosensitization treatment (KORTUC I) using hydrogen peroxide solution-soaked gauze bolus for unresectable and superficially exposed neoplasms
    • Ogawa Y, Ue H, Tsuzuki K, Tadokoro M, Miyatake K, Sasaki T, Yokota N, Hamada N, Kariya S, Hitomi J, et al. (2008). New radiosensitization treatment (KORTUC I) using hydrogen peroxide solution-soaked gauze bolus for unresectable and superficially exposed neoplasms. Oncol Rep 19, 1389-1394.
    • (2008) Oncol Rep , vol.19 , pp. 1389-1394
    • Ogawa, Y.1    Ue, H.2    Tsuzuki, K.3    Tadokoro, M.4    Miyatake, K.5    Sasaki, T.6    Yokota, N.7    Hamada, N.8    Kariya, S.9    Hitomi, J.10
  • 17
    • 78149311437 scopus 로고    scopus 로고
    • Non-surgical care for locally advanced breast cancer: Radiologically assessed therapeutic outcome of a new enzyme-targeting radiosensitization treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II) with systemic chemotherapy
    • Miyatake K, Kubota K, Ogawa Y, Hamada N, Murata Y, and Nishioka A (2010). Non-surgical care for locally advanced breast cancer: radiologically assessed therapeutic outcome of a new enzyme-targeting radiosensitization treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II) with systemic chemotherapy. Oncol Rep 24, 1161-1168.
    • (2010) Oncol Rep , vol.24 , pp. 1161-1168
    • Miyatake, K.1    Kubota, K.2    Ogawa, Y.3    Hamada, N.4    Murata, Y.5    Nishioka, A.6
  • 18
    • 64549134284 scopus 로고    scopus 로고
    • Phase I study of a new radiosensitizer containing hydrogen peroxide and sodium hyaluronate for topical tumor injection: A new enzyme-targeting radio sensitization treatment
    • Kochi Oxydol- Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II)
    • Ogawa Y, Kubota K, Ue H, Kataoka Y, Tadokoro M, Miyatake K, Tsuzuki K, Yamanishi T, Itoh S, Hitomi J, et al. (2009). Phase I study of a new radiosensitizer containing hydrogen peroxide and sodium hyaluronate for topical tumor injection: a new enzyme-targeting radio sensitization treatment, Kochi Oxydol- Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II). Int J Oncol 34, 609-618.
    • (2009) Int J Oncol , vol.34 , pp. 609-618
    • Ogawa, Y.1    Kubota, K.2    Ue, H.3    Kataoka, Y.4    Tadokoro, M.5    Miyatake, K.6    Tsuzuki, K.7    Yamanishi, T.8    Itoh, S.9    Hitomi, J.10
  • 19
    • 0016587704 scopus 로고
    • Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582
    • Brown JM (1975). Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582. Radiat Res 64, 633-647.
    • (1975) Radiat Res , vol.64 , pp. 633-647
    • Brown, J.M.1
  • 20
    • 0017388874 scopus 로고
    • Clinical testing of the radiosensitizer Ro 07-0582: Experience with multiple doses
    • Dische S, Saunders MI, Lee ME, Adams GE, and Flockhart IR (1977). Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses. Br J Cancer 35, 567-579.
    • (1977) Br J Cancer , vol.35 , pp. 567-579
    • Dische, S.1    Saunders, M.I.2    Lee, M.E.3    Adams, G.E.4    Flockhart, I.R.5
  • 21
    • 0021236301 scopus 로고
    • Clinical trials of radiosensitizers: What should we expect?
    • Brown JM (1984). Clinical trials of radiosensitizers: what should we expect? Int J Radiat Oncol Biol Phys 10, 425-429.
    • (1984) Int J Radiat Oncol Biol Phys , vol.10 , pp. 425-429
    • Brown, J.M.1
  • 22
    • 30544446570 scopus 로고    scopus 로고
    • Radiation sensitization with redox modulators: A promising approach
    • Rosenberg A and Knox S (2006). Radiation sensitization with redox modulators: a promising approach. Int J Radiat Oncol Biol Phys 64, 343-354.
    • (2006) Int J Radiat Oncol Biol Phys , vol.64 , pp. 343-354
    • Rosenberg, A.1    Knox, S.2
  • 23
    • 0023274989 scopus 로고
    • Generation of nitro radical anions of some 5- nitrofurans, 2- and 5-nitroimidazoles by norepinephrine, dopamine, and serotonin. A possible mechanism for neurotoxicity caused by nitroheterocyclic drugs
    • Rao DN and Mason RP (1987). Generation of nitro radical anions of some 5- nitrofurans, 2- and 5-nitroimidazoles by norepinephrine, dopamine, and serotonin. A possible mechanism for neurotoxicity caused by nitroheterocyclic drugs. J Biol Chem 262, 11731-11736.
    • (1987) J Biol Chem , vol.262 , pp. 11731-11736
    • Rao, D.N.1    Mason, R.P.2
  • 25
    • 0029017052 scopus 로고
    • Reversible magnetic resonance imaging findings in metronidazole-induced encephalopathy
    • Ahmed A, Loes DJ, and Bressler EL (1995). Reversible magnetic resonance imaging findings in metronidazole-induced encephalopathy. Neurology 45, 588-589.
    • (1995) Neurology , vol.45 , pp. 588-589
    • Ahmed, A.1    Loes, D.J.2    Bressler, E.L.3
  • 26
    • 33846224376 scopus 로고    scopus 로고
    • AK-2123 (Sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: Results of an IAEA multicentre randomized trial
    • Dobrowsky W, Huigol NG, Jayatilake RS, Kizilbash NI, Okkan S, Kagiya VT, and Tatsuzaki H (2007). AK-2123 (Sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: results of an IAEA multicentre randomized trial. Radiother Oncol 82, 24-29.
    • (2007) Radiother Oncol , vol.82 , pp. 24-29
    • Dobrowsky, W.1    Huigol, N.G.2    Jayatilake, R.S.3    Kizilbash, N.I.4    Okkan, S.5    Kagiya, V.T.6    Tatsuzaki, H.7
  • 27
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown JM and Wilson WR (2004). Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 4, 437-447.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 28
    • 0031001406 scopus 로고    scopus 로고
    • Palladium or platinum exacerbates hydroxyl radical mediated DNA damage
    • Liu TZ, Lin TF, Chiu DT, Tsai KJ, and Stern A (1997). Palladium or platinum exacerbates hydroxyl radical mediated DNA damage. Free Radic Biol Med 23, 155-161.
    • (1997) Free Radic Biol Med , vol.23 , pp. 155-161
    • Liu, T.Z.1    Lin, T.F.2    Chiu, D.T.3    Tsai, K.J.4    Stern, A.5
  • 29
    • 78349311299 scopus 로고    scopus 로고
    • Proteomic analysis of lanthanum citrate-induced apoptosis in human cervical carcinoma SiHa cells
    • Shen L, Lan Z, Sun X, Shi L, Liu Q, and Ni J (2010). Proteomic analysis of lanthanum citrate-induced apoptosis in human cervical carcinoma SiHa cells. Biometals 23, 1179-1189.
    • (2010) Biometals , vol.23 , pp. 1179-1189
    • Shen, L.1    Lan, Z.2    Sun, X.3    Shi, L.4    Liu, Q.5    Ni, J.6
  • 30
  • 32
    • 0033983719 scopus 로고    scopus 로고
    • Texaphyrins: New drugs with diverse clinical applications in radiation and photodynamic therapy
    • Sessler JL and Miller RA (2000). Texaphyrins: new drugs with diverse clinical applications in radiation and photodynamic therapy. BiochemPharmacol 59, 733-739.
    • (2000) BiochemPharmacol , vol.59 , pp. 733-739
    • Sessler, J.L.1    Miller, R.A.2
  • 33
    • 1042281012 scopus 로고    scopus 로고
    • Motexafin gadolinium: Gadolinium(III) texaphyrin, gadolinium texaphyrin
    • Adis International, Limited, Gd-Tex, GdT2B2, PCI 0120
    • Adis International, Limited (2004). Motexafin gadolinium: gadolinium(III) texaphyrin, gadolinium texaphyrin, Gd-Tex, GdT2B2, PCI 0120. Drugs RD 5, 52-57.
    • (2004) Drugs RD , vol.5 , pp. 52-57
  • 37
    • 0037676125 scopus 로고    scopus 로고
    • Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases
    • Mehta MP, Rodrigus P, Terhaard CH, Rao A, Suh J, Roa W, Souhami L, Bezjak A, Leibenhaut M, Komaki R, et al. (2003). Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases. J Clin Oncol 21, 2529-2536.
    • (2003) J Clin Oncol , vol.21 , pp. 2529-2536
    • Mehta, M.P.1    Rodrigus, P.2    Terhaard, C.H.3    Rao, A.4    Suh, J.5    Roa, W.6    Souhami, L.7    Bezjak, A.8    Leibenhaut, M.9    Komaki, R.10
  • 38
    • 0015451983 scopus 로고
    • Potential bioreductive alkylating agents. 1. Benzoquinone derivatives
    • Lin AJ, Cosby LA, Shansky CW, and Sartorelli AC (1972). Potential bioreductive alkylating agents. 1. Benzoquinone derivatives. J Med Chem 15, 1247-1252.
    • (1972) J Med Chem , vol.15 , pp. 1247-1252
    • Lin, A.J.1    Cosby, L.A.2    Shansky, C.W.3    Sartorelli, A.C.4
  • 39
    • 0025291491 scopus 로고
    • Mitomycin antibiotic reductive potential and related pharmacological activities
    • Pan SS and Gonzalez H (1990). Mitomycin antibiotic reductive potential and related pharmacological activities. Mol Pharmacol 37, 966-970.
    • (1990) Mol Pharmacol , vol.37 , pp. 966-970
    • Pan, S.S.1    Gonzalez, H.2
  • 40
    • 53549100988 scopus 로고    scopus 로고
    • Differential enzymatic reductions governing the differential hypoxia-selective cytotoxicities of phenazine 5,10-dioxides
    • Lavaggi ML, Cabrera M, González M, and Cerecetto H (2008). Differential enzymatic reductions governing the differential hypoxia-selective cytotoxicities of phenazine 5,10-dioxides. Chem Res Toxicol 21, 1900-1906.
    • (2008) Chem Res Toxicol , vol.21 , pp. 1900-1906
    • Lavaggi, M.L.1    Cabrera, M.2    González, M.3    Cerecetto, H.4
  • 41
    • 0029917028 scopus 로고    scopus 로고
    • Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: Correlation with sensitivity to mitomycin C and EO9
    • Fitzsimmons SA, Workman P, Grever M, Paull K, Camalier R, and Lewis AD (1996). Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. J Natl Cancer Inst 88, 259-269.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 259-269
    • Fitzsimmons, S.A.1    Workman, P.2    Grever, M.3    Paull, K.4    Camalier, R.5    Lewis, A.D.6
  • 42
    • 13944258034 scopus 로고    scopus 로고
    • Extravascular transport of drugs in tumor tissue: Effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures
    • Pruijn FB, Sturman JR, Liyanage HD, Hicks KO, Hay MP, and Wilson WR (2005). Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures. J Med Chem 48, 1079-1087.
    • (2005) J Med Chem , vol.48 , pp. 1079-1087
    • Pruijn, F.B.1    Sturman, J.R.2    Liyanage, H.D.3    Hicks, K.O.4    Hay, M.P.5    Wilson, W.R.6
  • 43
    • 0030900482 scopus 로고    scopus 로고
    • Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs
    • Siim BG, Atwell GJ, Anderson RF, Wardman P, Pullen SM, Wilson WR, and Denny WA (1997). Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs. J Med Chem 40, 1381-1390.
    • (1997) J Med Chem , vol.40 , pp. 1381-1390
    • Siim, B.G.1    Atwell, G.J.2    Anderson, R.F.3    Wardman, P.4    Pullen, S.M.5    Wilson, W.R.6    Denny, W.A.7
  • 44
    • 42149091693 scopus 로고    scopus 로고
    • Hypoxic tumor cell radiosensitization: Role of the iNOS/NO pathway
    • De RidderM, Van EschG, Engels B, Verovski V, and Storme G(2008).Hypoxic tumor cell radiosensitization: role of the iNOS/NO pathway. Bull Cancer 95, 282-291.
    • (2008) Bull Cancer , vol.95 , pp. 282-291
    • De, R.1    Van, E.2    Engels, B.3    Verovski, V.4    Storme, G.5
  • 45
    • 0017397793 scopus 로고
    • Bioactivation as a model for drug design bioreductive alkylation
    • Moore HW (1977). Bioactivation as a model for drug design bioreductive alkylation. Science 197, 527-532.
    • (1977) Science , vol.197 , pp. 527-532
    • Moore, H.W.1
  • 46
    • 0002548343 scopus 로고
    • Mitomycins and porfiromycin: Chemical mechanism of activation and cross-linking of dna
    • Iyer VN and Szybalski W (1964). Mitomycins and porfiromycin: chemical mechanism of activation and cross-linking of dna. Science 145, 55-58.
    • (1964) Science , vol.145 , pp. 55-58
    • Iyer, V.N.1    Szybalski, W.2
  • 47
    • 0021971997 scopus 로고
    • Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro
    • Keyes SR, Rockwell S, and Sartorelli AC (1985). Porfiromycin as a bioreductive alkylating agent with selective toxicity to hypoxic EMT6 tumor cells in vivo and in vitro. Cancer Res 45, 3642-3645.
    • (1985) Cancer Res , vol.45 , pp. 3642-3645
    • Keyes, S.R.1    Rockwell, S.2    Sartorelli, A.C.3
  • 49
    • 0023798415 scopus 로고
    • Preclinical studies of porfiromycin as an adjunct to radiotherapy
    • Rockwell S, Keyes SR, and Sartorelli AC (1988). Preclinical studies of porfiromycin as an adjunct to radiotherapy. Radiat Res 116, 100-113.
    • (1988) Radiat Res , vol.116 , pp. 100-113
    • Rockwell, S.1    Keyes, S.R.2    Sartorelli, A.C.3
  • 52
    • 48249155730 scopus 로고    scopus 로고
    • Apaziquone for non-muscle invasive bladder cancer: A critical review
    • Witjes JA and Kolli PS (2008). Apaziquone for non-muscle invasive bladder cancer: a critical review. Expert Opin Investig Drugs 17, 1085-1096.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1085-1096
    • Witjes, J.A.1    Kolli, P.S.2
  • 53
    • 0028645493 scopus 로고
    • Enzyme-directed biore ductive drug development revisited: A commentary on recent progress and future prospects with emphasis on quinine anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase
    • Workman P (1994). Enzyme-directed biore ductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinine anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase. Oncol Res 6, 461-475.
    • (1994) Oncol Res , vol.6 , pp. 461-475
    • Workman, P.1
  • 54
    • 0026503552 scopus 로고
    • The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins
    • Walton MI, Sugget N, andWorkman P (1992). The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins. Int J Radiat Oncol Biol Phys 22, 643-647.
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 643-647
    • Walton, M.I.1    Sugget, N.2    Andworkman, P.3
  • 55
    • 0026686324 scopus 로고
    • DT diaphorase activity correlates with sensitivity to the indo loquinone EO9 in mouse and human colon carcinomas
    • Walton MI, Bibby MC, Double JA, Plumb JA, and Workman P (1992). DT diaphorase activity correlates with sensitivity to the indo loquinone EO9 in mouse and human colon carcinomas. Eur J Cancer 28A, 1597-1600.
    • (1992) Eur J Cancer , vol.28 A , pp. 1597-1600
    • Walton, M.I.1    Bibby, M.C.2    Double, J.A.3    Plumb, J.A.4    Workman, P.5
  • 57
    • 65049084348 scopus 로고    scopus 로고
    • Response of multiple recurrent TaT1 bladder cancer to intravesical apaziquone (EO9): Comparative analysis of tumor recurrence rates
    • Jain A, Phillips RM, Scally AJ, Lenaz G, Beer M, and Puri R (2009). Response of multiple recurrent TaT1 bladder cancer to intravesical apaziquone (EO9): comparative analysis of tumor recurrence rates. Urology 73, 1083-1086.
    • (2009) Urology , vol.73 , pp. 1083-1086
    • Jain, A.1    Phillips, R.M.2    Scally, A.J.3    Lenaz, G.4    Beer, M.5    Puri, R.6
  • 59
    • 85019304039 scopus 로고    scopus 로고
    • Spectrum Pharma, June 19, 2011
    • Spectrum Pharma. Available at http://www.spectrumpharma.com/eoquin.html Accessed June 19, 2011.
  • 60
  • 61
    • 0027288316 scopus 로고
    • SR 4233 (tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours
    • Brown JM (1993). SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. Br J Cancer 67, 1163-1170.
    • (1993) Br J Cancer , vol.67 , pp. 1163-1170
    • Brown, J.M.1
  • 62
    • 0025972731 scopus 로고
    • Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation
    • Brown JM and Lemmon MJ (1991). Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation. Int J Radiat Oncol Biol Phys 20, 457-461.
    • (1991) Int J Radiat Oncol Biol Phys , vol.20 , pp. 457-461
    • Brown, J.M.1    Lemmon, M.J.2
  • 63
    • 67649380881 scopus 로고    scopus 로고
    • Tirapazamine: A novel agent targeting hypoxic tumor cells
    • Reddy SB and Williamson SK (2009). Tirapazamine: a novel agent targeting hypoxic tumor cells. Expert Opin Investig Drugs 18, 77-87.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 77-87
    • Reddy, S.B.1    Williamson, S.K.2
  • 66
    • 77958060317 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors
    • Hicks KO, Siim BG, Jaiswal JK, Pruijn FB, Fraser AM, Patel R, Hogg A, Liyanage HD, Dorie MJ, Brown JM, et al. (2010). Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors. Clin Cancer Res 16, 4946-4957.
    • (2010) Clin Cancer Res , vol.16 , pp. 4946-4957
    • Hicks, K.O.1    Siim, B.G.2    Jaiswal, J.K.3    Pruijn, F.B.4    Fraser, A.M.5    Patel, R.6    Hogg, A.7    Liyanage, H.D.8    Dorie, M.J.9    Brown, J.M.10
  • 67
    • 33747443851 scopus 로고    scopus 로고
    • Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxiatargeted anticancer drugs
    • Hicks KO, Pruijn FB, Secomb TW, Hay MP, Hsu R, Brown JM, Denny WA, Dewhirst MW, and Wilson WR (2006). Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxiatargeted anticancer drugs. J Natl Cancer Inst 98, 1118-1128.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1118-1128
    • Hicks, K.O.1    Pruijn, F.B.2    Secomb, T.W.3    Hay, M.P.4    Hsu, R.5    Brown, J.M.6    Denny, W.A.7    Dewhirst, M.W.8    Wilson, W.R.9
  • 68
    • 50249160554 scopus 로고    scopus 로고
    • Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase
    • Nishida CR and Ortiz de Montellano PR (2008). Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase. J Med Chem 51, 5118-5120.
    • (2008) J Med Chem , vol.51 , pp. 5118-5120
    • Nishida, C.R.1    de Ortiz, M.P.R.2
  • 69
    • 0034543132 scopus 로고    scopus 로고
    • AQ4N: A new approach to hypoxiaactivated cancer chemotherapy
    • Patterson LH and McKeown SR (2000). AQ4N: a new approach to hypoxiaactivated cancer chemotherapy. Br J Cancer 83, 1589-1593.
    • (2000) Br J Cancer , vol.83 , pp. 1589-1593
    • Patterson, L.H.1    McKeown, S.R.2
  • 70
    • 0034029002 scopus 로고    scopus 로고
    • Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent
    • Patterson LH, McKeown SR, Ruparelia K, Double JA, Bibby MC, Cole S, and Stratford IJ (2000). Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent. Br J Cancer 82, 1984-1990.
    • (2000) Br J Cancer , vol.82 , pp. 1984-1990
    • Patterson, L.H.1    McKeown, S.R.2    Ruparelia, K.3    Double, J.A.4    Bibby, M.C.5    Cole, S.6    Stratford, I.J.7
  • 71
    • 0030022191 scopus 로고    scopus 로고
    • DNA damage following combination of radiation with the bioreductive drug AQ4N: Possible selective toxicity to oxic and hypoxic tumour cells
    • Hejmadi MV, McKeown SR, Friery OP, McIntyre IA, Patterson LH, and Hirst DG (1996). DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells. Br J Cancer 73, 499-505.
    • (1996) Br J Cancer , vol.73 , pp. 499-505
    • Hejmadi, M.V.1    McKeown, S.R.2    Friery, O.P.3    McIntyre, I.A.4    Patterson, L.H.5    Hirst, D.G.6
  • 73
    • 0029054994 scopus 로고
    • AQ4N: An alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in viv
    • McKeown SR, Hejmadi MV, McIntyre IA, McAleer JJ, and Patterson LH (1995). AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo. Br J Cancer 72, 76-81.
    • (1995) Br J Cance , vol.72 , pp. 76-78
    • McKeow, S.1    Hejmad, M.2    McIntyr, I.3    McAlee, J.4    Patterso, L.5
  • 77
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    • Wang GL and Semenza GL (1993). General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 90, 4304-4308.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4304-4308
    • Wang, G.L.1    Semenza, G.L.2
  • 78
    • 33645786505 scopus 로고    scopus 로고
    • Development of novel therapeutic strategies that target HIF-1
    • Semenza GL (2006). Development of novel therapeutic strategies that target HIF-1. Expert Opin Ther Targets 10, 267-280.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 267-280
    • Semenza, G.L.1
  • 79
    • 70349673606 scopus 로고    scopus 로고
    • Inhibiting the hypoxia response for cancer therapy: The new kid on the block
    • Koh MY, Spivak-Kroizman TR, and Powis G (2009). Inhibiting the hypoxia response for cancer therapy: the new kid on the block. Clin Cancer Res 15, 5945-5946.
    • (2009) Clin Cancer Res , vol.15 , pp. 5945-5946
    • Koh, M.Y.1    Spivak-Kroizman, T.R.2    Powis, G.3
  • 80
    • 72849115544 scopus 로고    scopus 로고
    • Development of HIF-1 inhibitors for cancer therapy
    • Onnis B, Rapisarda A, and Melillo G (2009). Development of HIF-1 inhibitors for cancer therapy. J Cell Mol Med 13, 2780-2786.
    • (2009) J Cell Mol Med , vol.13 , pp. 2780-2786
    • Onnis, B.1    Rapisarda, A.2    Melillo, G.3
  • 81
    • 53449096820 scopus 로고    scopus 로고
    • PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells
    • Palayoor ST, Mitchell JB, Cerna D, Degraff W, John-Aryankalayil M, and Coleman CN (2008). PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer 123, 2430-2437.
    • (2008) Int J Cancer , vol.123 , pp. 2430-2437
    • Palayoor, S.T.1    Mitchell, J.B.2    Cerna, D.3    Degraff, W.4    John-Aryankalayil, M.5    Coleman, C.N.6
  • 87
    • 0036088471 scopus 로고    scopus 로고
    • IAP proteins: Blocking the road to death'sdoor
    • Salvesen GS and Duckett CS (2002). IAP proteins: blocking the road to death'sdoor. Nat Rev Mol Cell Biol 3, 401-410.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 401-410
    • Salvesen, G.S.1    Duckett, C.S.2
  • 88
    • 33646049360 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen, survivin, and CD34 expressions in pancreatic cancer and their correlation with hypoxia-inducible factor 1alpha
    • Wei H, Wang C, and Chen L (2006). Proliferating cell nuclear antigen, survivin, and CD34 expressions in pancreatic cancer and their correlation with hypoxia-inducible factor 1alpha. Pancreas 32, 159-163.
    • (2006) Pancreas , vol.32 , pp. 159-163
    • Wei, H.1    Wang, C.2    Chen, L.3
  • 89
    • 0032403126 scopus 로고    scopus 로고
    • IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs
    • Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, and Reed JC (1998). IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res 58, 5315-5320.
    • (1998) Cancer Res , vol.58 , pp. 5315-5320
    • Tamm, I.1    Wang, Y.2    Sausville, E.3    Scudiero, D.A.4    Vigna, N.5    Oltersdorf, T.6    Reed, J.C.7
  • 90
    • 4844231863 scopus 로고    scopus 로고
    • XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
    • Cao C, Mu Y, Hallahan DE, and Lu B (2004). XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer. Oncogene 23, 7047-7052.
    • (2004) Oncogene , vol.23 , pp. 7047-7052
    • Cao, C.1    Mu, Y.2    Hallahan, D.E.3    Lu, B.4
  • 91
    • 0037478904 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lungcancer cells in vitro and in vivo
    • Hu Y, Cherton-Horvat G, Dragowska V, Baird S, Korneluk RG, Durkin JP, Mayer LD, and LaCasse EC (2003). Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lungcancer cells in vitro and in vivo. Clin Cancer Res 9, 2826-2836.
    • (2003) Clin Cancer Res , vol.9 , pp. 2826-2836
    • Hu, Y.1    Cherton-Horvat, G.2    Dragowska, V.3    Baird, S.4    Korneluk, R.G.5    Durkin, J.P.6    Mayer, L.D.7    Lacasse, E.C.8
  • 92
    • 0342657718 scopus 로고    scopus 로고
    • A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy
    • Olie RA, Simões-Wüst AP, Baumann B, Leech SH, Fabbro D, Stahel RA, and Zangemeister-Wittke U (2000). A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res 60, 2805-2809.
    • (2000) Cancer Res , vol.60 , pp. 2805-2809
    • Olie, R.A.1    Simões-Wüst, A.P.2    Baumann, B.3    Leech, S.H.4    Fabbro, D.5    Stahel, R.A.6    Zangemeister-Wittke, U.7
  • 94
    • 85019302528 scopus 로고    scopus 로고
    • Survivin vaccine therapy for patients with malignant gliomas, Clinicaltrialsfeeds.org/clinical-trials/show/NCT01250470 Accessed June 19, 2011
    • Survivin vaccine therapy for patients with malignant gliomas. Available at: Clinicaltrialsfeeds.org/clinical-trials/show/NCT01250470.Accessed June 19, 2011.
  • 97
    • 77955551373 scopus 로고    scopus 로고
    • Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302
    • Li S, Zhang J, Li J, Chen D, Matteucci M, Curd J, and Duan JX (2010). Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302. Biol Trace Elem Res 136, 294-301.
    • (2010) Biol Trace Elem Res , vol.136 , pp. 294-301
    • Li, S.1    Zhang, J.2    Li, J.3    Chen, D.4    Matteucci, M.5    Curd, J.6    Duan, J.X.7
  • 98
    • 67649347492 scopus 로고    scopus 로고
    • Radiosensitising agents for the radiotherapy of cancer: Advances in traditional and hypoxia targeted radiosensitisers
    • Bischoff P, Altmeyer A, and Dumont F (2009). Radiosensitising agents for the radiotherapy of cancer: advances in traditional and hypoxia targeted radiosensitisers. Expert Opin Ther Pat 19, 643-662.
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 643-662
    • Bischoff, P.1    Altmeyer, A.2    Dumont, F.3
  • 100
    • 34548513083 scopus 로고    scopus 로고
    • Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: Comparison of the dinitrobenzamide mustard PR-104A and tirapazamine
    • Hicks KO, Myint H, Patterson AV, Pruijn FB, Siim BG, Patel K, and Wilson WR(2007). Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine. Int J Radiat Oncol Biol Phys 69, 560-571.
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , pp. 560-571
    • Hicks, K.O.1    Myint, H.2    Patterson, A.V.3    Pruijn, F.B.4    Siim, B.G.5    Patel, K.6    Wilson, W.R.7
  • 101
    • 75749084473 scopus 로고    scopus 로고
    • A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors
    • Jameson MB, Rischin D, Pegram M, Gutheil J, Patterson AV, Denny WA, and Wilson WR (2010). A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors. Cancer Chemother Pharmacol 65, 791-801.
    • (2010) Cancer Chemother Pharmacol , vol.65 , pp. 791-801
    • Jameson, M.B.1    Rischin, D.2    Pegram, M.3    Gutheil, J.4    Patterson, A.V.5    Denny, W.A.6    Wilson, W.R.7
  • 102
    • 85019296070 scopus 로고    scopus 로고
    • Proacta Updates PR1-4 Phase II Program,Accessed June 19, 2011
    • Proacta Updates PR1-4 Phase II Program, Vol. 2010. Available at: http://www.proacta.com/news/pr_feb0110.htm. Accessed June 19, 2011.
  • 105
    • 0038103656 scopus 로고    scopus 로고
    • Nitric oxide and S-nitrosylation: Excitotoxic and cell signaling mechanism
    • Nelson EJ, Connolly J, and McArthur P (2003). Nitric oxide and S-nitrosylation: excitotoxic and cell signaling mechanism. Biol Cell 95, 3-8.
    • (2003) Biol Cell , vol.95 , pp. 3-8
    • Nelson, E.J.1    Connolly, J.2    McArthur, P.3
  • 107
    • 0024388901 scopus 로고
    • Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor
    • Tayeh MA and Marletta MA (1989). Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. J Biol Chem 264, 19654-19658.
    • (1989) J Biol Chem , vol.264 , pp. 19654-19658
    • Tayeh, M.A.1    Marletta, M.A.2
  • 108
    • 0042665423 scopus 로고    scopus 로고
    • Nitric oxide: NO apoptosis or turning it ON?
    • Brüne B (2003). Nitric oxide: NO apoptosis or turning it ON? Cell Death Differ 10, 864-869.
    • (2003) Cell Death Differ , vol.10 , pp. 864-869
    • Brüne, B.1
  • 109
    • 79251609206 scopus 로고    scopus 로고
    • Dual role of NO donors in the reversal of tumor cell resistance and EMT: Downregulation of the NF-κB/Snail/YY1/RKIPcircuitry
    • Bonavida B and Baritaki S (2011). Dual role of NO donors in the reversal of tumor cell resistance and EMT: downregulation of the NF-κB/Snail/YY1/RKIPcircuitry. Nitric Oxide 24, 1-7.
    • (2011) Nitric Oxide , vol.24 , pp. 1-7
    • Bonavida, B.1    Baritaki, S.2
  • 110
    • 0030811240 scopus 로고    scopus 로고
    • Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma
    • Shan SQ, Rosner GL, Braun RD, Hahn J, Pearce C, and Dewhirst MW (1997). Effects of diethylamine/nitric oxide on blood perfusion and oxygenation in the R3230Ac mammary carcinoma. Br J Cancer 76, 429-437.
    • (1997) Br J Cancer , vol.76 , pp. 429-437
    • Shan, S.Q.1    Rosner, G.L.2    Braun, R.D.3    Hahn, J.4    Pearce, C.5    Dewhirst, M.W.6
  • 112
    • 47049088507 scopus 로고    scopus 로고
    • Novel therapeutic applications of nitric oxide donors in cancer: Roles in chemo- and mmunosensitization to apoptosis and inhibition of metastases
    • Bonavida B, Baritaki S, Huerta-Yepez S, Vega MI, Chatterjee D, and Yeung K (2008). Novel therapeutic applications of nitric oxide donors in cancer: roles in chemo- and mmunosensitization to apoptosis and inhibition of metastases. Nitric Oxide 19, 152-157.
    • (2008) Nitric Oxide , vol.19 , pp. 152-157
    • Bonavida, B.1    Baritaki, S.2    Huerta-Yepez, S.3    Vega, M.I.4    Chatterjee, D.5    Yeung, K.6
  • 113
    • 67749086634 scopus 로고    scopus 로고
    • Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate
    • Gao X, Saha D, Kapur P, Anthony T, Livingston EH, and Huerta S (2009). Radiosensitization of HT-29 cells and xenografts by the nitric oxide donor DETANONOate. J Surg Oncol 100, 149-158.
    • (2009) J Surg Oncol , vol.100 , pp. 149-158
    • Gao, X.1    Saha, D.2    Kapur, P.3    Anthony, T.4    Livingston, E.H.5    Huerta, S.6
  • 114
    • 0034267721 scopus 로고    scopus 로고
    • Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: Monitoring by EPR and MRI
    • Jordan BF, Misson P, Demeure R, Baudelet C, Beghein N, and Gallez B (2000). Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI. Int J Radiat Oncol Biol Phys 48, 565-570.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 565-570
    • Jordan, B.F.1    Misson, P.2    Demeure, R.3    Baudelet, C.4    Beghein, N.5    Gallez, B.6
  • 115
    • 0027769525 scopus 로고
    • 5-Nitroimidazoles
    • II: Unexpected reactivity, of ronidazole and dimetridazole with thiols
    • Girard M, Clairmont F, Maneckjee A, Mousseau N, Dawson B, and Whitehouse L (1993). 5-Nitroimidazoles. II: Unexpected reactivity of ronidazole and dimetridazole with thiols. Can J Chem 71, 1349-1352.
    • (1993) Can J Chem , vol.71 , pp. 1349
    • Girard, M.1    Clairmont, F.2    Maneckjee, A.3    Mousseau, N.4    Dawson, B.5    Whitehouse, L.6
  • 118
    • 70349466391 scopus 로고    scopus 로고
    • Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer
    • Siemens DR, Heaton JP, Adams MA, Kawakami J, and Graham CH (2009). Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer. Urology 74, 878-883.
    • (2009) Urology , vol.74 , pp. 878-883
    • Siemens, D.R.1    Heaton, J.P.2    Adams, M.A.3    Kawakami, J.4    Graham, C.H.5
  • 119
    • 60749091126 scopus 로고    scopus 로고
    • Regulation of nitric oxide signalling by thrombospondin 1: Implications for antiangiogenic therapies
    • Isenberg JS, Martin-Manso G, Maxhimer JB, and Roberts DD (2009). Regulation of nitric oxide signalling by thrombospondin 1: implications for antiangiogenic therapies. Nat Rev Cancer 9, 182-194.
    • (2009) Nat Rev Cancer , vol.9 , pp. 182-194
    • Isenberg, J.S.1    Martin-Manso, G.2    Maxhimer, J.B.3    Roberts, D.D.4
  • 121
    • 77957013504 scopus 로고    scopus 로고
    • Inhibitors of angiogenesis: New hopes for oncologists, new challenges for anesthesiologists
    • Libert N, Tourtier JP, Védrine L, and Chargari C (2010). Inhibitors of angiogenesis: new hopes for oncologists, new challenges for anesthesiologists. Anesthesiology 113, 704-712.
    • (2010) Anesthesiology , vol.113 , pp. 704-712
    • Libert, N.1    Tourtier, J.P.2    Védrine, L.3    Chargari, C.4
  • 126
    • 34748860952 scopus 로고    scopus 로고
    • Hypoxic radiosensitization: Adored and ignored
    • Overgaard J (2007). Hypoxic radiosensitization: adored and ignored. J Clin Oncol 25, 4066-4074.
    • (2007) J Clin Oncol , vol.25 , pp. 4066-4074
    • Overgaard, J.1


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