A phase I single-dose trial of gadolinium texaphyrin (Gd-Tex), a tumor selective radiation sensitizer detectable by magnetic resonance imaging

Clinical Cancer Research

Volumn 5, Issue 4, 1999, Pages 739-745

  Rosenthal, David I ^a   Nurenberg, Pamela ^b   Becerra, Carlos R ^b   Frenkel, Eugene P ^b   Carbone, David P ^c   Lum, Bert L ^d   Miller, Richard ^e   Engel, Julie ^e   Young, Stuart ^e   Miles, Dale ^e   Renschler, Markus F ^e  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d STANFORD UNIVERSITY   (United States)

^e PHARMACYCLICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RADIOSENSITIZING AGENT;

ACUTE KIDNEY TUBULE NECROSIS; ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; FEMALE; HEMOLYTIC ANEMIA; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LIVER TOXICITY; LUNG CANCER; MALE; NAUSEA; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RADIOSENSITIZATION; SKIN DISCOLORATION; UTERINE CERVIX CANCER; VOMITING;

ADULT; AGED; ANTINEOPLASTIC AGENTS; COMBINED MODALITY THERAPY; DIGESTIVE SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ERUPTIONS; FEMALE; HEMATOPOIESIS; HUMANS; KIDNEY; LIVER; MAGNETIC RESONANCE IMAGING; MALE; METALLOPORPHYRINS; MIDDLE AGED; NEOPLASMS; RADIATION-SENSITIZING AGENTS; TISSUE DISTRIBUTION;

EID: 0032907689     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

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6. Young, S. W., Qing, F., Harriman, A., Sessler, J. L., Mody, T. D., Hemmi, G. W., Hao, Y., and Miller, R. A. Gadolinium (III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI. Proc. Natl. Acad. Sci. USA, 93: 6610-6615, 1996.
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