Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4- (alkylamino)-5-nitroquinoline bioreductive drugs

Journal of Medicinal Chemistry

Volumn 40, Issue 9, 1997, Pages 1381-1390

  Siim, Bronwyn G ^a   Atwell, Graham J ^a   Anderson, Robert F ^a   Wardman, Peter ^b   Pullen, Susan M ^a   Wilson, William R ^a   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(2,3 DIHYDROXYPROPYL)AMINO] 5 NITROQUINOLINE; 4 [(2,3 DIHYDROXYPROPYL)AMINO] 8 METHOXY 5 NITROQUINOLINE; 4 [(2,3 DIHYDROXYPROPYL)AMINO] 8 METHYL 5 NITROQUINOLINE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CYTOPATHOGENIC EFFECT; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG UPTAKE; ELECTRON TRANSPORT; HYPOXIC CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL HYPOXIA; CELL LINE; DRUG SCREENING ASSAYS, ANTITUMOR; KINETICS; LYSOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; NITROQUINOLINES; OXIDATION-REDUCTION; OXYGEN;

EID: 0030900482     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9607865     Document Type: Article

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