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Volumn 17, Issue 7, 2008, Pages 1085-1096

Apaziquone for non-muscle invasive bladder cancer: A critical review

Author keywords

Apaziquone; Bladder cancer; Non muscle invasive; Pharmacokinetics; Therapy

Indexed keywords

ANTINEOPLASTIC AGENT; APAZIQUONE; BCG VACCINE; BICARBONATE; CISPLATIN; DOXORUBICIN; EPIRUBICIN; GEMCITABINE; HYDRALAZINE; MANNITOL; MITOMYCIN C; THIOTEPA;

EID: 48249155730     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.17.7.1085     Document Type: Review
Times cited : (13)

References (73)
  • 2
    • 30044441045 scopus 로고    scopus 로고
    • Bladder cancer: Epidemiology, staging and grading, and diagnosis
    • Kirkali Z, Chan T, Manoharan M, et al. Bladder cancer: epidemiology, staging and grading, and diagnosis. Urology 2005;66:4-34
    • (2005) Urology , vol.66 , pp. 4-34
    • Kirkali, Z.1    Chan, T.2    Manoharan, M.3
  • 3
    • 32944465832 scopus 로고    scopus 로고
    • Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: A combined analysis of 2596 patients from seven EORTC trials
    • Sylvester RJ, van der Meijden AP, Oosterlinck W, et al. Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol 2006;49:466-77
    • (2006) Eur Urol , vol.49 , pp. 466-477
    • Sylvester, R.J.1    van der Meijden, A.P.2    Oosterlinck, W.3
  • 4
  • 5
    • 2442581163 scopus 로고    scopus 로고
    • A single immediate postoperative instillation of chemotherapy decreases the risk of recurrence in patients with stage Ta T1 bladder cancer: A meta-analysis of published results of randomized clinical trials
    • Sylvester RJ, Oosterlinck W, van der Meijden AP. A single immediate postoperative instillation of chemotherapy decreases the risk of recurrence in patients with stage Ta T1 bladder cancer: a meta-analysis of published results of randomized clinical trials. J Urol 2004;171:2186-90
    • (2004) J Urol , vol.171 , pp. 2186-2190
    • Sylvester, R.J.1    Oosterlinck, W.2    van der Meijden, A.P.3
  • 6
    • 0036668380 scopus 로고    scopus 로고
    • Factors explaining recurrence in patients undergoing chemoimmunotherapy regimens for frequently recurring superficial bladder carcinoma
    • Kaasinen E, Rintala E, Hellstrom P, et al. Factors explaining recurrence in patients undergoing chemoimmunotherapy regimens for frequently recurring superficial bladder carcinoma. Eur Urol 2002;42:167-74
    • (2002) Eur Urol , vol.42 , pp. 167-174
    • Kaasinen, E.1    Rintala, E.2    Hellstrom, P.3
  • 7
  • 8
    • 0032874440 scopus 로고    scopus 로고
    • The value of a second transurethral resection in evaluating patients with bladder tumors
    • Herr HW. The value of a second transurethral resection in evaluating patients with bladder tumors. J Urol 1999;162:74-6
    • (1999) J Urol , vol.162 , pp. 74-76
    • Herr, H.W.1
  • 9
    • 0034946057 scopus 로고    scopus 로고
    • Clinical under staging of high risk nonmuscle invasive urothelial carcinoma treated with radical cystectomy
    • Dutta SC, Smith JA Jr, Shappell SB, et al. Clinical under staging of high risk nonmuscle invasive urothelial carcinoma treated with radical cystectomy. J Urol 2001;166:490-3
    • (2001) J Urol , vol.166 , pp. 490-493
    • Dutta, S.C.1    Smith Jr, J.A.2    Shappell, S.B.3
  • 10
    • 0036837453 scopus 로고    scopus 로고
    • Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: A meta-analysis of the published results of randomized clinical trials
    • Sylvester RJ, van der Meijden AP, Lamm DL. Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a meta-analysis of the published results of randomized clinical trials. J Urol 2002;168:1964-70
    • (2002) J Urol , vol.168 , pp. 1964-1970
    • Sylvester, R.J.1    van der Meijden, A.P.2    Lamm, D.L.3
  • 11
    • 33645763275 scopus 로고    scopus 로고
    • Management of BCG failures in superficial bladder cancer: A review
    • Witjes JA. Management of BCG failures in superficial bladder cancer: a review. Eur Urol 2006;49:790-7
    • (2006) Eur Urol , vol.49 , pp. 790-797
    • Witjes, J.A.1
  • 12
    • 0030002747 scopus 로고    scopus 로고
    • A combined analysis of EORTC and MRC randomized clinical trials for the prophylactic treatment of stage TaT1 bladder cancer
    • Pawinski A, Sylvester R, Kurth KH, et al. A combined analysis of EORTC and MRC randomized clinical trials for the prophylactic treatment of stage TaT1 bladder cancer. J Urol 1996;156:1934-40
    • (1996) J Urol , vol.156 , pp. 1934-1940
    • Pawinski, A.1    Sylvester, R.2    Kurth, K.H.3
  • 13
    • 39549083897 scopus 로고    scopus 로고
    • The schedule and duration of intravesical chemotherapy in patients with non muscle invasive bladder cancer: A systematic review of the published results of randomized clinical trials
    • Sylvester RJ, Oosterlinck W, Witjes JA. The schedule and duration of intravesical chemotherapy in patients with non muscle invasive bladder cancer: a systematic review of the published results of randomized clinical trials. Eur Urol 2008;53:709-19
    • (2008) Eur Urol , vol.53 , pp. 709-719
    • Sylvester, R.J.1    Oosterlinck, W.2    Witjes, J.A.3
  • 14
    • 34347219416 scopus 로고    scopus 로고
    • Epidemiology of urinary bladder cancer: From tumour development to patient's death
    • Murta-Nascimento C, Schmitz-Dräger BJ, Zeegers MP, et al. Epidemiology of urinary bladder cancer: from tumour development to patient's death. World J Urol 2007;25:285-95
    • (2007) World J Urol , vol.25 , pp. 285-295
    • Murta-Nascimento, C.1    Schmitz-Dräger, B.J.2    Zeegers, M.P.3
  • 15
    • 48249101360 scopus 로고    scopus 로고
    • IARC. GLOBOCAN 2002. Available from: http://www-dep.iarc-fr [Accessed 6 December 2007]
    • IARC. GLOBOCAN 2002. Available from: http://www-dep.iarc-fr [Accessed 6 December 2007]
  • 16
    • 0346100499 scopus 로고    scopus 로고
    • The health economics of bladder cancer: A comprehensive review of the published literature
    • Botteman M, Pashos C, Redaelli A, et al. The health economics of bladder cancer: a comprehensive review of the published literature. Pharmacoeconomics 2003;21:1315-30
    • (2003) Pharmacoeconomics , vol.21 , pp. 1315-1330
    • Botteman, M.1    Pashos, C.2    Redaelli, A.3
  • 17
    • 33748925553 scopus 로고    scopus 로고
    • Clinical model of lifetime cost of treating bladder cancer and associated complications
    • Avritscher E, Cooksley CD, Grossman HB, et al. Clinical model of lifetime cost of treating bladder cancer and associated complications. Urology 2006;68:549-53
    • (2006) Urology , vol.68 , pp. 549-553
    • Avritscher, E.1    Cooksley, C.D.2    Grossman, H.B.3
  • 18
    • 41149134455 scopus 로고    scopus 로고
    • Comparison of three schedules of intravesical epirubicin in patients with non-muscle invasive bladder cancer
    • Hendricksen K, Witjes WPJ, Idema JG, et al. Comparison of three schedules of intravesical epirubicin in patients with non-muscle invasive bladder cancer. Eur Urol 2008;53(5):984-91
    • (2008) Eur Urol , vol.53 , Issue.5 , pp. 984-991
    • Hendricksen, K.1    Witjes, W.P.J.2    Idema, J.G.3
  • 19
    • 0742302619 scopus 로고    scopus 로고
    • Intravesical gemcitabine: A phase 1 and pharmacokinetic study
    • Witjes JA, van der Heijden AG, Vriesema JL, et al. Intravesical gemcitabine: a phase 1 and pharmacokinetic study. Eur Urol 2004;45:182-6
    • (2004) Eur Urol , vol.45 , pp. 182-186
    • Witjes, J.A.1    van der Heijden, A.G.2    Vriesema, J.L.3
  • 20
    • 0037441977 scopus 로고    scopus 로고
    • Intravesical gemcitabine therapy for superficial transitional cell carcinoma of the bladder: A phase I and pharmacokinetic study
    • Laufer M, Ramalingam S, Schoenberg MP, et al. Intravesical gemcitabine therapy for superficial transitional cell carcinoma of the bladder: a phase I and pharmacokinetic study. J Clin Oncol 2003;21:697-703
    • (2003) J Clin Oncol , vol.21 , pp. 697-703
    • Laufer, M.1    Ramalingam, S.2    Schoenberg, M.P.3
  • 21
    • 4043085510 scopus 로고    scopus 로고
    • Phase II study to investigate the ablative efficacy of intravesical administration of gemcitabine in intermediate-risk superficial bladder cancer (SBC)
    • Gontero P, Casetta G, Maso G, et al. Phase II study to investigate the ablative efficacy of intravesical administration of gemcitabine in intermediate-risk superficial bladder cancer (SBC). Eur Urol 2004;46:339-43
    • (2004) Eur Urol , vol.46 , pp. 339-343
    • Gontero, P.1    Casetta, G.2    Maso, G.3
  • 22
    • 0036682430 scopus 로고    scopus 로고
    • Phase I trial of intravesical gemcitabine in bacillus Calmette-Guerin-refractory transitional-cell carcinoma of the bladder
    • Dalbagni G, Russo P, Sheinfeld J, et al. Phase I trial of intravesical gemcitabine in bacillus Calmette-Guerin-refractory transitional-cell carcinoma of the bladder. J Clin Oncol 2002;20:3193-8
    • (2002) J Clin Oncol , vol.20 , pp. 3193-3198
    • Dalbagni, G.1    Russo, P.2    Sheinfeld, J.3
  • 23
    • 33745527134 scopus 로고    scopus 로고
    • Phase II trial of intravesical gemcitabine in bacille Calmette-Guerin-refractory transitional cell carcinoma of the bladder
    • Dalbagni G, Russo P, Bochner B, et al. Phase II trial of intravesical gemcitabine in bacille Calmette-Guerin-refractory transitional cell carcinoma of the bladder. J Clin Oncol 2006;24:2729-34
    • (2006) J Clin Oncol , vol.24 , pp. 2729-2734
    • Dalbagni, G.1    Russo, P.2    Bochner, B.3
  • 24
    • 3142616896 scopus 로고    scopus 로고
    • Phase I pharmacokinetic study of a single intravesical instillation of gemcitabine administered immediately after transurethral resection plus multiple random biopsies in patients with superficial bladder cancer
    • Palou J, Carcas A, Segarra J, et al. Phase I pharmacokinetic study of a single intravesical instillation of gemcitabine administered immediately after transurethral resection plus multiple random biopsies in patients with superficial bladder cancer. J Urol 2004;172:485-8
    • (2004) J Urol , vol.172 , pp. 485-488
    • Palou, J.1    Carcas, A.2    Segarra, J.3
  • 25
    • 24144443874 scopus 로고    scopus 로고
    • Randomized phase II marker lesion study evaluating effect of scheduling on response to intravesical gemcitabine in recurrent Stage Ta urothelial cell carcinoma of the bladder
    • Gardmark T, Carringer M, Beckman E, Malmstrom PU. Randomized phase II marker lesion study evaluating effect of scheduling on response to intravesical gemcitabine in recurrent Stage Ta urothelial cell carcinoma of the bladder. Urology 2005;66:527-30
    • (2005) Urology , vol.66 , pp. 527-530
    • Gardmark, T.1    Carringer, M.2    Beckman, E.3    Malmstrom, P.U.4
  • 26
    • 26644473451 scopus 로고    scopus 로고
    • Intravesical gemcitabine therapy for superficial transitional cell carcinoma: Results of a phase II prospective multicenter study
    • Bartoletti R, Cai T, Gacci M, et al. Intravesical gemcitabine therapy for superficial transitional cell carcinoma: results of a phase II prospective multicenter study. Urology 2005;66:726-31
    • (2005) Urology , vol.66 , pp. 726-731
    • Bartoletti, R.1    Cai, T.2    Gacci, M.3
  • 27
    • 0029939907 scopus 로고    scopus 로고
    • Neoadjuvant combined microwave induced local hyperthermia and topical chemotherapy versus chemotherapy alone for superficial bladder cancer
    • Colombo R, Da Pozzo LF, Lev A, et al. Neoadjuvant combined microwave induced local hyperthermia and topical chemotherapy versus chemotherapy alone for superficial bladder cancer. J Urol 1996;155:1227-32
    • (1996) J Urol , vol.155 , pp. 1227-1232
    • Colombo, R.1    Da Pozzo, L.F.2    Lev, A.3
  • 28
    • 0642368614 scopus 로고    scopus 로고
    • Multicentric study comparing intravesical chemotherapy alone and with local microwave hyperthermia for prophylaxis of recurrence of superficial transitional cell carcinoma
    • Colombo R, Da Pozzo LF, Salonia A, et al. Multicentric study comparing intravesical chemotherapy alone and with local microwave hyperthermia for prophylaxis of recurrence of superficial transitional cell carcinoma. J Clin Oncol 2003;21:4270-6
    • (2003) J Clin Oncol , vol.21 , pp. 4270-4276
    • Colombo, R.1    Da Pozzo, L.F.2    Salonia, A.3
  • 29
    • 2942683157 scopus 로고    scopus 로고
    • Combined local bladder hyperthermia and intravesical chemotherapy for the treatment of high-grade superficial bladder cancer
    • Gofrit ON, Shapiro A, Pode D, et al. Combined local bladder hyperthermia and intravesical chemotherapy for the treatment of high-grade superficial bladder cancer. Urology 2004;63:466-71
    • (2004) Urology , vol.63 , pp. 466-471
    • Gofrit, O.N.1    Shapiro, A.2    Pode, D.3
  • 30
    • 2942538278 scopus 로고    scopus 로고
    • Preliminary European results of local microwave hyperthermia and chemotherapy treatment in intermediate or high risk superficial transitional cell carcinoma of the bladder
    • van der Heijden AG, Kiemeney LA, Gofrit ON, et al. Preliminary European results of local microwave hyperthermia and chemotherapy treatment in intermediate or high risk superficial transitional cell carcinoma of the bladder. Eur Urol 2004;46:65-71
    • (2004) Eur Urol , vol.46 , pp. 65-71
    • van der Heijden, A.G.1    Kiemeney, L.A.2    Gofrit, O.N.3
  • 31
    • 0032030507 scopus 로고    scopus 로고
    • Intravesical electromotive administration of drugs for treatment of superficial bladder cancer: A comparative phase II study
    • Brausi M, Campo B, Pizzocaro G, et al. Intravesical electromotive administration of drugs for treatment of superficial bladder cancer: a comparative phase II study. Urology 1998;51:506-9
    • (1998) Urology , vol.51 , pp. 506-509
    • Brausi, M.1    Campo, B.2    Pizzocaro, G.3
  • 32
    • 0035135911 scopus 로고    scopus 로고
    • Thermo-chemotherapy and electromotive drug administration of mitomycin C in superficial bladder cancer eradication. a pilot study on marker lesion
    • Colombo R, Brausi M, Da Pozzo L, et al. Thermo-chemotherapy and electromotive drug administration of mitomycin C in superficial bladder cancer eradication. a pilot study on marker lesion. Eur Urol 2001;39:95-100
    • (2001) Eur Urol , vol.39 , pp. 95-100
    • Colombo, R.1    Brausi, M.2    Da Pozzo, L.3
  • 33
    • 0043240101 scopus 로고    scopus 로고
    • Intravesical electromotive mitomycin C versus passive transport mitomycin C for high risk superficial bladder cancer: A prospective randomized study
    • Di Stasi SM, Giannantoni A, Stephen RL, et al. Intravesical electromotive mitomycin C versus passive transport mitomycin C for high risk superficial bladder cancer: a prospective randomized study. J Urol 2003;170:777-82
    • (2003) J Urol , vol.170 , pp. 777-782
    • Di Stasi, S.M.1    Giannantoni, A.2    Stephen, R.L.3
  • 34
    • 29744470225 scopus 로고    scopus 로고
    • Sequential BCG and electromotive mitomycin versus BCG alone for high-risk superficial bladder cancer: A randomised controlled trial
    • Di Stasi SM, Giannantoni A, Giurioli A, et al. Sequential BCG and electromotive mitomycin versus BCG alone for high-risk superficial bladder cancer: a randomised controlled trial. Lancet Oncol 2006;7:43-51
    • (2006) Lancet Oncol , vol.7 , pp. 43-51
    • Di Stasi, S.M.1    Giannantoni, A.2    Giurioli, A.3
  • 35
    • 0023104247 scopus 로고
    • Mitomycin analogs I. Indoloquinones as (potential) bisalkylating agents
    • Oostveen EA, Speckamp WN. Mitomycin analogs I. Indoloquinones as (potential) bisalkylating agents. Tetrahedron 1987;43:255-62
    • (1987) Tetrahedron , vol.43 , pp. 255-262
    • Oostveen, E.A.1    Speckamp, W.N.2
  • 36
    • 0027450014 scopus 로고
    • apaziquone, a novel bioreductive alkylating indoloquinone with preferential solid tumor activity and lack of bone marrow toxicity in preclinical models
    • Hendriks HR, Pizao PE, Berger DP, et al. apaziquone, a novel bioreductive alkylating indoloquinone with preferential solid tumor activity and lack of bone marrow toxicity in preclinical models. Eur J Cancer 1993;29A:897-906
    • (1993) Eur J Cancer , vol.29 A , pp. 897-906
    • Hendriks, H.R.1    Pizao, P.E.2    Berger, D.P.3
  • 37
    • 0033981669 scopus 로고    scopus 로고
    • Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6- methyl-1,4-benzoquinone), in mice
    • Loadman PM, Phillips RM, Lim LE, et al. Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6- methyl-1,4-benzoquinone), in mice. Biochem Pharmacol 2000;59:831-7
    • (2000) Biochem Pharmacol , vol.59 , pp. 831-837
    • Loadman, P.M.1    Phillips, R.M.2    Lim, L.E.3
  • 38
    • 0035914266 scopus 로고    scopus 로고
    • Choudry GA, Stewart PA, Double JA, et al. A novel strategy for NQO1 (NAD(P) H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of apaziquone. Br J Cancer 2001;85:1137-46
    • Choudry GA, Stewart PA, Double JA, et al. A novel strategy for NQO1 (NAD(P) H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of apaziquone. Br J Cancer 2001;85:1137-46
  • 39
    • 0242298213 scopus 로고    scopus 로고
    • GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: Relationship with vascularity and proliferation as predictors of outcome of ARCON
    • Hoskin PJ, Sibtain A, Daley FM, et al. GLUT1 and CAIX as intrinsic markers of hypoxia in bladder cancer: relationship with vascularity and proliferation as predictors of outcome of ARCON. Br J Cancer 2003;89:1290-7
    • (2003) Br J Cancer , vol.89 , pp. 1290-1297
    • Hoskin, P.J.1    Sibtain, A.2    Daley, F.M.3
  • 40
    • 0031672124 scopus 로고    scopus 로고
    • Enzymology of mitomycin C metabolic activation in tumor tissue
    • Cummings J, Spanswick VJ, Tomasz M, et al. Enzymology of mitomycin C metabolic activation in tumor tissue. Biochem Pharmacol 1998;56:405-14
    • (1998) Biochem Pharmacol , vol.56 , pp. 405-414
    • Cummings, J.1    Spanswick, V.J.2    Tomasz, M.3
  • 41
    • 0029943044 scopus 로고    scopus 로고
    • Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone apaziquone
    • Smitskamp-Wilms E, Hendriks HR, Peters GJ. Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone apaziquone. Gen Pharmacol 1996;27:421-9
    • (1996) Gen Pharmacol , vol.27 , pp. 421-429
    • Smitskamp-Wilms, E.1    Hendriks, H.R.2    Peters, G.J.3
  • 42
    • 0026686324 scopus 로고    scopus 로고
    • Walton MI, Bibby MC, Double JA, et al. DT-diaphorase activity correlates with sensitivity to the indoloquinone apaziquone in mouse and human colon carcinomas. Eur J Cancer 1992;28A.1597-600
    • Walton MI, Bibby MC, Double JA, et al. DT-diaphorase activity correlates with sensitivity to the indoloquinone apaziquone in mouse and human colon carcinomas. Eur J Cancer 1992;28A.1597-600
  • 43
    • 0028063368 scopus 로고
    • DT-Diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone apaziquone
    • Plumb JA, Gerritsen M, Workman P. DT-Diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone apaziquone. Br J Cancer 1994;70:1136-43
    • (1994) Br J Cancer , vol.70 , pp. 1136-1143
    • Plumb, J.A.1    Gerritsen, M.2    Workman, P.3
  • 44
    • 0026462426 scopus 로고
    • Keynote address: Bioreductive mechanisms
    • Workman P. Keynote address: bioreductive mechanisms. Int J Rad Oncol Biol Phys 1992;22:631-7
    • (1992) Int J Rad Oncol Biol Phys , vol.22 , pp. 631-637
    • Workman, P.1
  • 45
    • 0035882749 scopus 로고    scopus 로고
    • Involvement of NADPH: Cytochrome P450 reductase in the activation of indoloquinone apaziquone to free radical and DNA damaging species
    • Bailey SM, Lewis AD, Patterson LH, et al. Involvement of NADPH: cytochrome P450 reductase in the activation of indoloquinone apaziquone to free radical and DNA damaging species. Biochem Pharmacol 2001;62:461-8
    • (2001) Biochem Pharmacol , vol.62 , pp. 461-468
    • Bailey, S.M.1    Lewis, A.D.2    Patterson, L.H.3
  • 46
    • 0031930369 scopus 로고    scopus 로고
    • 5-Substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2[1H-indole-4,7-dione]prop-2-en-1- ol (apaziquone, NSC 382459) and their regioisomers as hypoxia-selective agents: Structure-cytotoxicity in vitro
    • Jaffar M, Naylor MA, Lockyer SD, et al. 5-Substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2[1H-indole-4,7-dione]prop-2-en-1- ol (apaziquone, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro. Anticancer Drug Des 1998;13:105-23
    • (1998) Anticancer Drug Des , vol.13 , pp. 105-123
    • Jaffar, M.1    Naylor, M.A.2    Lockyer, S.D.3
  • 47
    • 0033533801 scopus 로고    scopus 로고
    • Bioreductive activation of a series of indolequinones by human DT-diaphorase: Structure-activity relationships
    • Phillips RM, Naylor MA, Jaffar M, et al. Bioreductive activation of a series of indolequinones by human DT-diaphorase: Structure-activity relationships. J Med Chem 1999;42:4071-80
    • (1999) J Med Chem , vol.42 , pp. 4071-4080
    • Phillips, R.M.1    Naylor, M.A.2    Jaffar, M.3
  • 48
    • 0030710552 scopus 로고    scopus 로고
    • Involvement of DT-diaphorase in the DNA cross-linking and sequence selectivity of the indoloquinone bioreductive antitumor agent apaziquone
    • Bailey SM, Wyatt M, Friedlos F, et al. Involvement of DT-diaphorase in the DNA cross-linking and sequence selectivity of the indoloquinone bioreductive antitumor agent apaziquone. Br J Cancer 1997;76:1596-603
    • (1997) Br J Cancer , vol.76 , pp. 1596-1603
    • Bailey, S.M.1    Wyatt, M.2    Friedlos, F.3
  • 49
    • 0028987032 scopus 로고
    • Indoloquinone apaziquone: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase
    • Maliepaard M, Wolfs A, Groot SE, et al. Indoloquinone apaziquone: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase. Br J Cancer 1995;71:836-9
    • (1995) Br J Cancer , vol.71 , pp. 836-839
    • Maliepaard, M.1    Wolfs, A.2    Groot, S.E.3
  • 50
    • 0025893246 scopus 로고    scopus 로고
    • Walton MI, Smith PJ, Workman P. The role of NAD(P)H: quinone reductase (EC1.6.99.2,DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent apaziquone. Cancer Commun 1991;3:199-206
    • Walton MI, Smith PJ, Workman P. The role of NAD(P)H: quinone reductase (EC1.6.99.2,DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent apaziquone. Cancer Commun 1991;3:199-206
  • 51
    • 0025688249 scopus 로고
    • Metabolism of mitomycin C by DT-diaphorase: Role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells
    • Siegel D, Gibson NW, Preusch PC, et al. Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells. Cancer Res 1990;50:7483-9
    • (1990) Cancer Res , vol.50 , pp. 7483-7489
    • Siegel, D.1    Gibson, N.W.2    Preusch, P.C.3
  • 52
    • 0024313837 scopus 로고
    • DT-diaphorase: Questionable role in Mitomycin resistance, but a target for novel bioreductive drugs?
    • Workman P, Walton MI, Powis G, et al. DT-diaphorase: questionable role in Mitomycin resistance, but a target for novel bioreductive drugs? Br J Cancer 1989;60:800-2
    • (1989) Br J Cancer , vol.60 , pp. 800-802
    • Workman, P.1    Walton, M.I.2    Powis, G.3
  • 53
    • 0023682539 scopus 로고
    • Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H: (quinone-acceptor) oxidoreductase
    • Schlager JJ, Powis G. Mitomycin C is not metabolized by but is an inhibitor of human kidney NAD(P)H: (quinone-acceptor) oxidoreductase. Cancer Chemother Pharmacol 1988;22:126-30
    • (1988) Cancer Chemother Pharmacol , vol.22 , pp. 126-130
    • Schlager, J.J.1    Powis, G.2
  • 54
    • 0026602870 scopus 로고
    • Structurc-activity relationships for DT-Diaphorase reduction of hypoxic cell directed agents: Indoloquinones and diaziridinyl benzoquinones
    • Bailey SM, Suggert N, Walton MI, et al. Structurc-activity relationships for DT-Diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones. Int J Rad Oncol Biol Phys 1992;22:649-53
    • (1992) Int J Rad Oncol Biol Phys , vol.22 , pp. 649-653
    • Bailey, S.M.1    Suggert, N.2    Walton, M.I.3
  • 55
    • 0011974552 scopus 로고
    • Bioreductive activation of indoloquinone apaziquone: Involvement of DT-diaphorase and DNA cross-linking
    • Bailey SM, Friedlos F, Knox RJ, et al. Bioreductive activation of indoloquinone apaziquone: involvement of DT-diaphorase and DNA cross-linking. Ann Oncol 1992;3(Suppl 1):185
    • (1992) Ann Oncol , vol.3 , Issue.SUPPL. 1 , pp. 185
    • Bailey, S.M.1    Friedlos, F.2    Knox, R.J.3
  • 56
    • 0026724635 scopus 로고
    • The sensitivity of human tumor cells to quinone bioreductive drugs: What role for DT-diaphorase?
    • Robertson N, Stratford IJ, Houlbrook S, et al. The sensitivity of human tumor cells to quinone bioreductive drugs: What role for DT-diaphorase? Biochem Pharmacol 1992;44:409-12
    • (1992) Biochem Pharmacol , vol.44 , pp. 409-412
    • Robertson, N.1    Stratford, I.J.2    Houlbrook, S.3
  • 57
    • 0029917028 scopus 로고    scopus 로고
    • Reductase enzyme expression across the National Cancer Institute tumor cell line panel - correlation with sensitivity to mitomycin C and apaziquone
    • Fitzsimmons SA, Workman P, Grever M, et al. Reductase enzyme expression across the National Cancer Institute tumor cell line panel - correlation with sensitivity to mitomycin C and apaziquone. J Natl Cancer Inst 1996;88:259-69
    • (1996) J Natl Cancer Inst , vol.88 , pp. 259-269
    • Fitzsimmons, S.A.1    Workman, P.2    Grever, M.3
  • 58
    • 0026575978 scopus 로고
    • In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity
    • Phillips RM, Hulbert PB, Bibby MC, et al. In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity. Br J Cancer 1992;65:359-64
    • (1992) Br J Cancer , vol.65 , pp. 359-364
    • Phillips, R.M.1    Hulbert, P.B.2    Bibby, M.C.3
  • 59
    • 0028282993 scopus 로고
    • Relative importance of DT-diaphorase and hypoxia in the bioactivation of apaziquone by human lung tumor cell lines
    • Plumb JA, Gerritsen M, Milroy R, et al. Relative importance of DT-diaphorase and hypoxia in the bioactivation of apaziquone by human lung tumor cell lines. Int J Radiat Oncol Biol Phys 1994;29:295-9
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 295-299
    • Plumb, J.A.1    Gerritsen, M.2    Milroy, R.3
  • 60
    • 6844243752 scopus 로고
    • The assessment of bioreductive drug toxicity in vitro and in experimental tumors in vivo
    • Adams GE, Breccia A, Fieldan EM, Wardman P, editors, New York: Plenum Press;
    • Stratford IJ, Adams GE, Bremner JCM, et al. The assessment of bioreductive drug toxicity in vitro and in experimental tumors in vivo. In: Adams GE, Breccia A, Fieldan EM, Wardman P, editors, Selective activation of drugs by redox processes. New York: Plenum Press; 1990. p. 203-12
    • (1990) Selective activation of drugs by redox processes , pp. 203-212
    • Stratford, I.J.1    Adams, G.E.2    Bremner, J.C.M.3
  • 61
    • 0026552497 scopus 로고
    • Bioreductive drugs as post-irradiation sensitizers: Comparison of dual function agents with SR 4233 and the mitomycin C analogue apaziquone
    • Adams GE, Stratford IJ, Edwards HS, et al. Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue apaziquone. Int J Rad Oncol Biol Phys 1992;22:717-20
    • (1992) Int J Rad Oncol Biol Phys , vol.22 , pp. 717-720
    • Adams, G.E.1    Stratford, I.J.2    Edwards, H.S.3
  • 62
    • 0027190529 scopus 로고    scopus 로고
    • Bibby MC, Sleigh NP, Loadman PM, et al. Potentiation of apaziquone anti-tumor activity by hydralazine. Eur J Cancer 1993;29A.1033-5
    • Bibby MC, Sleigh NP, Loadman PM, et al. Potentiation of apaziquone anti-tumor activity by hydralazine. Eur J Cancer 1993;29A.1033-5
  • 63
    • 84884670257 scopus 로고    scopus 로고
    • Available from:, accessed 29 February 2008
    • Developmental Therapeutics Program, NCI. Available from: http://dtp.nci.nih.gov/dtpstandard/servlet/MeanGraphSummary?searchtype= NSC&chemnameboolean=and&outputformat=htmL&searchlist= 26980%2C+382459 [accessed 29 February 2008]
    • Developmental Therapeutics Program, NCI
  • 64
    • 0026519089 scopus 로고
    • Pharmacokinetics, distribution, and metabolism of the novel bioreductive alkylating indoloquinone apaziquone in rodents
    • Workman P, Binger M, Kooistra KL. Pharmacokinetics, distribution, and metabolism of the novel bioreductive alkylating indoloquinone apaziquone in rodents. Int J Radiat Oncol Biol Phys 1992;22:713-6
    • (1992) Int J Radiat Oncol Biol Phys , vol.22 , pp. 713-716
    • Workman, P.1    Binger, M.2    Kooistra, K.L.3
  • 65
    • 48249110408 scopus 로고    scopus 로고
    • Spectrum Pharmaceuticals, pers. Commun
    • Spectrum Pharmaceuticals, pers. Commun.
  • 66
    • 0028657069 scopus 로고
    • Clinical studies with apaziquone, a new indoloquinone bioreductive alkylating cytotoxic agent. EORTC Early Clinical Trials Group
    • Verweij J, Aamdal S, Schellens J, et al. Clinical studies with apaziquone, a new indoloquinone bioreductive alkylating cytotoxic agent. EORTC Early Clinical Trials Group. Oncol Res 1994;6:519-23
    • (1994) Oncol Res , vol.6 , pp. 519-523
    • Verweij, J.1    Aamdal, S.2    Schellens, J.3
  • 67
    • 33750536273 scopus 로고    scopus 로고
    • Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry
    • Vainchtein LD, Rosing H, Mirejovsky D, et al. Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry. J Mass Spectrom 2006;41:1268-76
    • (2006) J Mass Spectrom , vol.41 , pp. 1268-1276
    • Vainchtein, L.D.1    Rosing, H.2    Mirejovsky, D.3
  • 68
    • 33748094636 scopus 로고    scopus 로고
    • Phase I/II pilot study of intravesical apaziquone (apaziquone) for superficial bladder cancer
    • Puri R, Palit V, Loadmian PM, Flannigan M, et al. Phase I/II pilot study of intravesical apaziquone (apaziquone) for superficial bladder cancer. J Urol 2006;176:1344-8
    • (2006) J Urol , vol.176 , pp. 1344-1348
    • Puri, R.1    Palit, V.2    Loadmian, P.M.3    Flannigan, M.4
  • 69
    • 0028338822 scopus 로고
    • Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug apaziquone
    • Schellens JHM, Planting AST, van Acker BAC, et al. Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug apaziquone. J Natl Cancer Inst 1994;86:906-12
    • (1994) J Natl Cancer Inst , vol.86 , pp. 906-912
    • Schellens, J.H.M.1    Planting, A.S.T.2    van Acker, B.A.C.3
  • 70
    • 15044358944 scopus 로고    scopus 로고
    • Effect of hyperthermia on the cytotoxicity of 4 chemotherapeutic agents currently used for the treatment of transitional cell carcinoma of the bladder: An in vitro study
    • van der Heijden AG, Verhaegh G, Jansen CF, et al. Effect of hyperthermia on the cytotoxicity of 4 chemotherapeutic agents currently used for the treatment of transitional cell carcinoma of the bladder: an in vitro study. J Urol 2005;173:1375-80
    • (2005) J Urol , vol.173 , pp. 1375-1380
    • van der Heijden, A.G.1    Verhaegh, G.2    Jansen, C.F.3
  • 71
    • 33748109210 scopus 로고    scopus 로고
    • Phase II marker lesion study with intravesical instillation of apaziquone for superficial bladder cancer: Toxicity and marker response
    • van der Heijden AG, Moonen PM, Cornel EB, et al. Phase II marker lesion study with intravesical instillation of apaziquone for superficial bladder cancer: toxicity and marker response. J Urol 2006;176:1349-53
    • (2006) J Urol , vol.176 , pp. 1349-1353
    • van der Heijden, A.G.1    Moonen, P.M.2    Cornel, E.B.3
  • 72
    • 0030217846 scopus 로고    scopus 로고
    • McLeod HL, Graham MA, Aamdal S, et al. Phase I pharmacokinetics and limited sampling strategies for the bioreductive alkylating drug apaziquone. EORTC Early Clinical Trials Group. Eur J Cancer 1996;32A.1518-22
    • McLeod HL, Graham MA, Aamdal S, et al. Phase I pharmacokinetics and limited sampling strategies for the bioreductive alkylating drug apaziquone. EORTC Early Clinical Trials Group. Eur J Cancer 1996;32A.1518-22
  • 73
    • 0035173676 scopus 로고    scopus 로고
    • Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: Cytochrome p450 oxidoreductase in bladder tissues and tumors
    • Li D, Gan Y, Wientjes MG, et al. Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors. J Urol 2001;166:2500-5
    • (2001) J Urol , vol.166 , pp. 2500-2505
    • Li, D.1    Gan, Y.2    Wientjes, M.G.3


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