Phase I study of a new radiosensitizer containing hydrogen peroxide and sodium hyaluronate for topical tumor injection: A new enzyme-targeting radiosensitization treatment, Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II)

International Journal of Oncology

Volumn 34, Issue 3, 2009, Pages 609-618

  Ogawa, Yasuhiro ^a   Kubota, Kei ^a   Ue, Hironobu ^a   Kataoka, Yuko ^a   Tadokoro, Michiko ^a   Miyatake, Kana ^a   Tsuzuki, Kazuhiro ^a   Yamanishi, Tomoaki ^a   Itoh, Satoshi ^a   Hitomi, Jiro ^a   Hamada, Norihiko ^a   Kariya, Shinji ^a   Fukumoto, Mitsutaka ^a   Nishioka, Akihito ^a   Inomata, Taisuke ^b  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Breast cancer; Breast conservation treatment; Hydrogen peroxide; Intratumoral injection; Radiosensitizer; Sodium hyaluronate

Indexed keywords

HYALURONIC ACID PLUS HYDROGEN PEROXIDE; OXYDOL; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CLINICAL TRIAL; DERMATITIS; DRUG EFFICACY; DRUG TOLERABILITY; ENZYME TARGETING RADIOSENSITIZATION; FEMALE; FIBROSARCOMA; HUMAN; INJECTION SITE PAIN; LYMPH NODE METASTASIS; MALE; MALIGNANT FIBROUS HISTIOCYTOMA; MALIGNANT NEURILEMOMA; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RADIOSENSITIZATION; SOLID TUMOR; TREATMENT RESPONSE;

AGED; AGED, 80 AND OVER; COMBINED MODALITY THERAPY; FEMALE; HUMANS; HYALURONIC ACID; HYDROGEN PEROXIDE; INJECTIONS, INTRALESIONAL; MALE; MIDDLE AGED; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; RADIOTHERAPY, HIGH-ENERGY;

EID: 64549134284     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000186     Document Type: Article

References (41)

1. Ogawa Y, Takahashi T, Kobayashi T, et al: Mechanism of apoptotic resistance of human osteosarcoma cell line, HS-Os-1, against irradiation. Int J Mol Med 12: 453-458, 2003.
2. Ogawa Y, Takahashi T, Kobayashi T, et al: Apoptotic-resistance of the human osteosarcoma cell line HS-Os-1 to irradiation is converted to apoptotic-susceptibility by hydrogen peroxide: a potent role of hydrogen peroxide as a new radiosensitizer. Int J Mol Med 12: 845-850, 2003.
3. Ogawa Y, Takahashi T, Kobayashi T, et al: Immunocytochemical characteristics of human osteosarcoma cell line HSOs-1: Possible implication in apoptotic resistance against irradiation. Int J Mol Med 14: 397-403, 2004.
4. Ogawa Y, Ue H, Tsuzuki K, et al: New radiosensitization treatment (KORTUC I) using hydrogen peroxide solution-soaked gauze bolus for unresectable and superficially exposed neoplasms. Oncol Rep 19: 1389-1394, 2008.
5. Ogawa Y, Kubota K, Ue H, et al: Development and clinical application of a new radiosensitizer containing hydrogen peroxide and hyaluronic acid sodium for topical tumor injection - a new enzyme-targeting radiosensitization treatment, KORTUC II (Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II). Strahlenther Onkol 183 (Sondernr.2): 100-101, 2007.
6. Ogawa Y, Nishioka A, Inomata T, et al: Conservation treatment intensified with an anti-estrogen agent and CAF chemotherapy for stage I and II breast cancer. Oncol Rep 7: 479-484, 2000.
7. Ogawa Y, Nishioka A, Inomata T, et al: Conservation treatment intensified with tamoxifen and CAF chemotherapy without axillary dissection for early breast cancer patients with clinically-negative axillary nodes. Oncol Rep 6: 801-805, 1999.
8. Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 92: 205-216, 2000.
9. Hall EJ (ed): The oxygen effect and reoxygenation. In: Radiobiology for the Radiologist. 5th edition. J.B. Lippincott Co., Philadelphia, PA, pp91-111, 2000.
10. Ogawa Y, Nishioka A, Hamada N, et al: Immunohistochemical study of c-fos-positive lymphocytes infiltrated into human squamous cell carcinomas of the head and neck radiation therapy and its clinical significance. Clin Cancer Res 3: 2301-2307, 1997.
11. Ogawa Y, Nishioka A, Hamada N, et al: Expression of Fas (CD95/ APO-1) antigen induced by radiation therapy for diffuse B-cell lymphoma: immunohistochemical study. Clin Cancer Res 3: 2211-2216, 1997.
12. Kamada T, Tsujii H, Tsuji H, et al: Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas. J Clin Oncol 20: 4466-4471, 2002.
13. Ogawa Y, Nishioka A, Inomata T, et al: Radiation kills human peripheral T cells by a Fas-independent mechanism. Int J Mol Med 2: 403-408, 1998.
14. Ogawa Y, Nishioka A, Kobayashi T, et al: Mitochondrial cytochrome c release in radiation-induced apoptosis of human peripheral T cells. Int J Mol Med 1: 263-268, 1998.
15. Ogawa Y, Nishioka A, Kobayashi T, et al: Radiation-induced apoptosis of human peripheral T cells: analyses with c DNA expression arrays and mitochondrial membrane potential assay. Int J Mol Med 7: 603-607, 2001.
16. Ogawa Y, Kobayashi T, Nishioka A, et al: Radiation-induced oxidative DNA damage, 8-oxoguanine, in human peripheral T cells. Int J Mol Med 11: 27-32, 2003.
17. Ogawa Y, Kobayashi T, Nishioka A, et al: Radiation-induced reactive oxygen species (ROS) formation in human peripheral T cells. Int J Mol Med 11: 149-152, 2003.
18. Ogawa Y, Kobayashi T, Nishioka A, et al: Reactive oxygen species-producing site in radiation-induced apoptosis of human peripheral T cells: involvement of lysosomal membrane destabilization. Int J Mol Med 13: 69-73, 2004.
19. Lawrence TS, Blackstock AW and McGinn C: The mechanism of action of radiosensitization of conventional chemotherapeutic agents. Semin Radiat Oncol 13: 13-21, 2003.
20. Bohm L, Roos, WP and Serafin AM: Inhibition of DNA repair by pentoxifylline and related methylxanthine derivatives. Toxicology 193: 153-160, 2003.
21. Milas L: Cyclooxygenase-2 (COX-2) enzyme inhibitors as potential enhancers of tumor radioresponse. Semin Radiat Oncol 11: 290-299, 2001.
22. Choy H and Milas L: Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: a rational advance? J Natl Cancer Inst 95: 1440-1452, 2003.
23. Overgaad J: Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors. Oncol Res 6: 509-518, 1994.
24. Gerlach NL, Barkhuysen R, Kaanders JH, et al: The effect of hyperbaric oxygen therapy on quality of life in oral and oropharyngeal cancer patients treated with radiotherapy. Int J Oral Maxiilofac Surg 37: 255-259, 2008.
25. Overgaad J: Hypoxic radiosensitization: adored and ignored. J Clin Oncol 25: 4066-4074, 2007.
26. Williamson RA: An experimental study of the use of hyperbaric oxygen to reduce the side effects of radiation treatment for malignant disease. Int J Oral Maxillofac Surg 36: 533-540, 2007.
27. Wagner BA, Britigan BE, Reszka KJ, et al: Hydrogen peroxide-induced apoptosis of HL-60 human leukemia cells is mediated by the oxidants hypochlorous acid and chloramines. Arch Biochem Biophys 401: 223-234, 2002.
28. Li JM, Zhou H, Cai Q and Xiao GX: Role of mitochondrial dysfunction in hydrogen peroxide-induced apoptosis of intestinal epithelial cells. World J Gastroenterol 9: 562-567, 2003.
29. 2. Free Radic Biol Med 33: 691-702, 2002.
30. 2 induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell line. J Cell Physiol 193: 180-186, 2002.
31. Neil S, Desikan R and Hancock J: Hydrogen peroxide signaling. Curr Opin Plant Biol 5: 389-395, 2002.
32. Maxwell DP, Nickels R and McIntosh L: Evidence of mitochondrial involvement in the transduction of signals required for the induction of genes associated with pathogen attack and senescence. Plant J 29: 269-279, 2002.
33. Kovtun Y, Chiu W-L, Tena G and Sheen J: Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants. Proc Natl Acad Sci USA 97: 2940-2945, 2000.
34. 2 and NO: redox signals in disease resistance. Trends Plant Sci 3: 330-334, 1998.
35. Chasin WD, Gross CC, Wang CC and Miller D: Hydrogen peroxide and irradiation of tumors. Arch Otolaryngol 85: 151-155, 1967.
36. Bianchini G, Salgarello G, Mennini T and Lorini G: Intra-arterial infusion of hydrogen peroxide in radiotherapy of malignant tumors. Radiol Med (Torino) 55: 207-225, 1969.
37. Whittle RJ: Technique and results of radiotherapy aided by arterial infusion of hydrogen peroxide. Nunt Radiol 34: 191-205, 1968.
38. Mallams JT, Balla GA and Finney JW: Regional intra-arterial hydrogen peroxide infusion and irradiation in the treatment of head and neck malignancies: a progress report. Trans Am Acad Ophthalmol Otolaryngol 67: 546-553, 1963.
39. Lichtenbaum R, De Souza AA and Jafar JJ: Intratumoral hydrogen peroxide injection during meningioma resection. Neurosurgery 59 (ONS Suppl. 4): 470-473, 2006.
40. Karatosun V, Unver B, Ozden A, et al: Intra-articular hyaluronic acid compared to exercise therapy in osteoarthritis of the ankle. A prospective randomized trial with long-term follow-up. Clin Exp Rheumatol 26: 288-294, 2008.
41. Brandt FS, Cazzaniga A: Hyaluronic acid gel fillers in the management of facial aging. Clin Interv Aging 3: 153-159, 2008.