ANTINEOPLASTIC ACTIVITY;
CANCER CELL;
CANCER THERAPY;
CELL PROLIFERATION;
CLINICAL TRIAL;
CYTOTOXICITY;
HUMAN;
HYPOXIA;
NOTE;
PRIORITY JOURNAL;
PROGNOSIS;
PROTEIN DEGRADATION;
PROTEIN SYNTHESIS;
SIGNAL TRANSDUCTION;
TUMOR GROWTH;
Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway
Tan C, de Noronha RG, Roecker AJ, et al. Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. Cancer Res 2005;65:605-612
Schedule-dependent inhibition of hypoxia-inducible factor-1á protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts
DOI 10.1158/0008-5472.CAN-04-2116
Rapisarda A, Zalek J, Hollingshead M, et al. Schedule-dependent inhibition of hypoxia-inducible factor-1á protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts. Cancer Res 2004;64:6845-6848 (Pubitemid 39330988)
A novel mode of action of YC-1 in HIF inhibition: Stimulation of FIH-dependent p300 dissociation from HIF-1á
PubMed doi:10.1158/1535-7163.MCT-08-0074
Li SH, Shin DH, Chun YS, Lee MK, Kim MS, Park JW. A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1á. Mol Cancer Ther 2008;7:3729-3738 PubMed doi:10.1158/1535-7163. MCT-08-0074.
Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1á
PubMed doi:10.1158/1535-7163.MCT-07-0463
Koh MY, Spivak-Kroizman T, Venturini S, et al. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1á. Mol Cancer Ther 2008;7:90-100. PubMed doi:10.1158/1535-7163. MCT-07-0463.
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1á and vascular endothelial growth factor formation
Welsh SJ, Williams RR, Birmingham A, Newman DJ, Kirkpatrick DL, Powis G. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1á and vascular endothelial growth factor formation. Mol Cancer Ther 2003;2:235-243
Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival
Barnhart BC, Lam JC, Young RM, Houghton PJ, Keith B, Simon MC. Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival. Cancer Biol Ther 2008;7:1441-1449