AK-2123 (Sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: Results of an IAEA multicentre randomised trial

Radiotherapy and Oncology

Volumn 82, Issue 1, 2007, Pages 24-29

  Dobrowsky, Werner ^a   Huigol, Nagraj G ^b   Jayatilake, Ranapala S ^c   Kizilbash, Noor I Alam ^d   Okkan, Sait ^e   Kagiya, V Tsutomu ^f   Tatsuzaki, Hideo ^g  

^a NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

^b DR BALABHAI NANAVATI HOSPITAL   (India)

^c Oncology and Radiotherapy Institute ^*  (Sri Lanka)

^d PAKISTAN ATOMIC ENERGY COMMISSION   (Pakistan)

^e ISTANBUL UNIVERSITY   (Turkey)

^f HEALTH RESEARCH FOUNDATION   (Japan)

^g INTERNATIONAL ATOMIC ENERGY AGENCY   (Austria)

Author keywords

Cervical cancer; Hypoxic radiosensitizer; Radiotherapy

Indexed keywords

SANAZOL; SENAZOLE; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; ARTICLE; BLADDER DISEASE; BLOOD TOXICITY; BRACHYTHERAPY; CANCER CONTROL; CANCER GRADING; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EVALUATION; EXTERNAL BEAM RADIOTHERAPY; FEMALE; GASTROINTESTINAL TOXICITY; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NEUROLOGIC DISEASE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIOSENSITIZATION; RANDOMIZED CONTROLLED TRIAL; STANDARD; TREATMENT DURATION; UTERINE CERVIX CANCER;

ADULT; AGED; BRACHYTHERAPY; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROSPECTIVE STUDIES; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY; SURVIVAL ANALYSIS; TREATMENT OUTCOME; TRIAZOLES; UTERINE CERVICAL NEOPLASMS;

EID: 33846224376     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2006.11.007     Document Type: Article

References (24)

1. Balmukhanov S.B., Beisebaev A.A., Aitkolovo Z.I., et al. Intratumoral and parametrial infusion of metronidazole in the radiotherapy of uterine cervix cancer: preliminary report. Int J Radiat Oncol Biol Phys 16 (1989) 1061-1063
2. Borowsky M.E., Elliott K.S., Pezzullo J.C., et al. A retrospective review of 15 years of radical radiotherapy with or without concurrent cisplatin and/or 5-fluorouracil for the treatment of locally advanced cervical cancer. Bull Cancer 92 (2005) 19-24
3. Bush R.S. The significance of anemia in clinical radiation therapy. Int J Radiat Oncol Biol Phys 12 (1986) 2047-2050
4. Chan P., Milosevic M., Fyles A., et al. A phase III randomized study of misonidazole plus radiation vs. radiation alone for cervix cancer. Radiother Oncol 70 (2004) 295-299
5. Dische S., Adams G.E., Ash D.V., et al. The Medical Research Council trial of misonidazole in carcinoma of the utervix. Br J Radiol 57 (1984) 491-499
6. Dische S., Machin D., and Chassagne D. A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: an interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix. Radiother Oncol 26 (1993) 93-103
7. Gacia-Angulo A.H., and Kagiya V.T. Intratumoral and parametrial infusion of a 3-nitrotriazole (AK-2123) in the radiotherapy of the uterine cervix cancer: stage II-III-preliminary positive result. Int J Radiat Oncol Biol Phys 22 (1992) 589-591
8. Green J.A., Kirwan J.M., Tierney J.F., et al. Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet 358 (2001) 781-786
9. Grigsby P.W., Winter K., Wasserman T.H., et al. Irradiation with or without misonidazole for patients with stages IIIB and IVA carcinoma of the cervix: final results from of RTOG 80-05. Int J Radiat Oncol Biol Phys 44 (1999) 513-517
10. Höckel M., Schlenger K., Aral B., et al. Association between tumour hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56 (1996) 4509-4515
11. Huan L.C., and Hua B.Y. Clinical pharmacokinetic study and sensitive effect of AK-2123. Int J Radiat Oncol Biol Phys 29 (1994) 607-610
12. Huilgol N.G., Chatterjee N., and Mehta A.R. An overview of the initial experience with AK-2123 as a hypoxic cell sensitizer with radiation in the treatment of advanced head and neck cancers. Int J Radiat Oncol Biol Phys 34 (1996) 1121-1124
13. Kagiya V.T. AK-2123 Chemical modifier of cancer treatment, part I. Int. Coordinated Research Program. Jpn Radiosensitization Res Ass Kyoto Japan (1993)
14. Keys H.M., Bundy B.N., Stehman F.B., et al. Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma. NEJM 340 (1999) 1154-1161
15. Morris M., Eifel P.J., Lu J., et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer. NEJM 340 (1999) 1137-1143
16. Okkan S., Atkovar G., Sahinler I., et al. A randomised study of ornidazole as a radiosensitiser in carcinoma of the cervix: long-term results. Br J Cancer 74 (1996) S282-S286
17. Overgaard J., Bentzen S.M., Kolstad P., et al. Misonidazole combined with radiotherapy in the treatment of carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 16 (1989) 1069-1072
18. Pearcey R.G., Brudage P., Drovin J., et al. A clinical trial comparing concurrent cisplatin and radiotherapy versus radiotherapy alone for locally advanced squamous cell carcinoma of the cervix. Carried out by the National Cancer Institute of Canada Clinical Trials Group. Proc Am Soc Clin Oncol 19 (2000) 378
19. Pearcey R., Brundage M., Drouin P., et al. Phase III trial comparing radical radiotherapy with and without cisplatin chemotherapy in patients with advanced squamous cell cancer of the cervix. J Clin Oncol 20 (2002) 966-972
20. Rose P.G., Bundy B.N., Watkins E.B., et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. NEJM 340 (1999) 1144-1152
21. Rose P.G. Chemoradiotherapy for cervical cancer. Eur J Cancer 38 (2002) 270-278
22. Serkies K., and Jassem J. Concurrent weekly cisplatin and radiotherapy in routine management of cervical cancer: a report on patient compliance and acute toxicity. Int J Radiat Oncol Biol Phys 60 (2004) 814-821
23. Shibamoto Y., Sakano K., Kimura R., et al. Radiosensitization in vitro and in vivo by 3-nitrotriazoles. Int J Radiat Oncol Biol Phys 12 (1986) 1063-1066
24. Watson E.R., Halnan K.E., Dische S., et al. Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix. Br J Radiol 51 (1978) 879-887