Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling

Clinical Cancer Research

Volumn 13, Issue 7, 2007, Pages 2199-2206

  Frederiksen, Lisa J ^a   Sullivan, Richard ^a   Maxwell, Lori R ^a   Macdonald Goodfellow, Shannyn K ^a   Adams, Michael A ^a   Bennett, Brian M ^a   Siemens, D Robert ^a   Graham, Charles H ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 8 BROMO CYCLIC GMP; BREAST CANCER RESISTANCE PROTEIN; CYCLIC GMP; DOXORUBICIN; GLYCEROL 1,2 DINITRATE; GLYCEROL 1,3 DINITRATE; GLYCERYL TRINITRATE; ISOSORBIDE DINITRATE; KT 5823; MULTIDRUG RESISTANCE PROTEIN 1; N(G) METHYLARGININE; NITRIC OXIDE; PACLITAXEL; PLACEBO; RESERPINE; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CHEMOSENSITIZATION; CLONOGENIC ASSAY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INHIBITION; DRUG POTENTIATION; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; CYCLIC GMP; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; ISOSORBIDE DINITRATE; MALE; MICE; NEOPLASMS, EXPERIMENTAL; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROGLYCERIN; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 34247511420     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-1807     Document Type: Article

References (41)

1. Ogiso Y, Tomida A, Lei S, Omura S, Tsuruo T. Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs. Cancer Res 2000;60:2429-34.
2. Shen J, Hughes C, Chao C, et al. Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells. Proc Natl Acad Sci U S A 1987;84:3278-82.
3. Vaupel PW, Frinak S, Bicher HI. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma. Cancer Res 1981;41:2008-13.
4. Vaupel PW. The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia. Klin Padiatr 1997;209:243-9.
5. Teicher BA. Hypoxia and drug resistance. Cancer Metastasis Rev 1994;13:139-68.
6. Shannon AM, Bouchier-Hayes DJ, Condron CM, Toomey D. Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev 2003;29:297-307.
7. Hockel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001;93:266-76.
8. Brown LM, Cowen RL, Debray C, et al. Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1. Mol Pharmacol 2006;69:411-8.
9. Matthews NE, Adams MA, Maxwell LR, Gofton TE, Graham CH. Nitric oxide-mediated regulation of chemosensitivity in cancer cells. J Natl Cancer Inst 2001;93:1879-85.
10. Frederiksen LJ, Siemens DR, Heaton JP, Maxwell LR, Adams MA, Graham CH. Hypoxia induced resistance to doxorubicin in prostate cancer cells is inhibited by low concentrations of glyceryl trinitrate. J Urol 2003;170:1003-7.
11. Muir CP, Adams MA, Graham CH. Nitric oxide attenuates resistance to doxorubicin in three-dimensional aggregates of human breast carcinoma cells. Breast Cancer Res Treat 2006;96:169-76.
12. Nathan C, Xie QW. Regulation of biosynthesis of nitric oxide. J Biol Chem 1994;269:13725-8.
13. Whorton AR, Simonds DB, Piantadosi CA. Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells. Am J Physiol 1997;272:L1161-6.
14. McCormick CC, Li WP, Calero M. Oxygen tension limits nitric oxide synthesis by activated macrophages. Biochem J 2000;350:709-16.
15. Palmer LA, Semenza GL, Stoler MH, Johns RA. Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am J Physiol 1998;274:L212-9.
16. Shaul PW, North AJ, Brannon TS, et al. Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung. Am J Respir Cell Mol Biol 1995;13:167-74.
17. Hanafy KA, Krumenacker JS, Murad F. NO, nitrotyrosine, and cyclic GMP in signal transduction. Med Sci Monit 2001;7:801-19.
18. Wartenberg M, Schallenberg M, Hescheler J, Sauer H. Reactive oxygen species-mediated regulation of eNOS and iNOS expression in multicellular prostate tumor spheroids. Int J Cancer 2003;104:274-82.
19. McDonald BJ, Bennett BM. Cytochrome P-450 mediated biotransformation of organic nitrates. Can J Physiol Pharmacol 1990;68:1552-7.
20. Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM. Targeting multidrug resistance in cancer. Nat Rev Drug Discov 2006;5:219-34.
21. Qian XD, Beck WT. Binding of an optically pure photoaffinity analogue of verapamil, LU-49888, to P-glycoprotein from multidrug-resistant human leukemic cell lines. Cancer Res 1990;50:1132-7.
22. Wierdl M, Wall A, Morton CL, et al. Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance. Mol Pharmacol 2003;64:279-88.
23. Postovit LM, Adams MA, Lash GE, Heaton JP, Graham CH. Oxygen-mediated regulation of tumour cell invasiveness: involvement of a nitric oxide signalling pathway. J Biol Chem 2002;277:35730-7.
24. Louis CA, Reichner JS, Henry WL, Jr., et al. Distinct arginase isoforms expressed in primary and transformed macrophages: regulation by oxygen tension. Am J Physiol 1998;274:R775-82.
25. Algara-Suarez P, Espinosa-Tanguma R. 8Br-cGMP mediates relaxation of tracheal smooth muscle through PKA. Biochem Biophys Res Commun 2004;314:597-601.
26. Haase A, Bicker G. Nitric oxide and cyclic nucleotides are regulators of neuronal migration in an insect embryo. Development 2003;130:3977-87.
27. Bell EN, Tse MY, Frederiksen LJ, et al. Atrial natriuretic peptide (ANP) attenuates hypoxia-induced chemoresistance in prostate cancer cells. J Urol 2007;177:751-6.
28. Simpson D, Plosker GL. Paclitaxel: as adjuvant or neoadjuvant therapy in early breast cancer. Drugs 2004;64:1839-47.
29. Crown J, O'Leary M, Ooi WS. Docetaxel and paclitaxel in the treatment of breast cancer: a review of clinical experience. Oncologist 2004;9 Suppl 2:24-32.
30. Jassem J. Gemcitabine and anthracyclines in breast cancer. Semin Oncol 2003;30:11-4.
31. Decatris MP, Sundar S, O'byrne KJ. Platinum-based chemotherapy in metastatic breast cancer: current status. CancerTreat Rev 2004;30:53-81.
32. Olson KB, Pienta KJ. Recent advances in chemotherapy for advanced prostate cancer. Curr Urol Rep 2000;1:48-56.
33. Petrylak DP, Tangen CM, Hussain MH, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004;351:1513-20.
34. Tannock IF, de Wit R, Berry WR, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004;351:1502-12.
35. Osnes JB. Some pharmacological properties of organic nitrates. Scand J Clin Lab Invest Suppl 1984;173:19-25.
36. van Brussel JP, van Steenbrugge GJ, Romijn JC, Schroder FH, Mickisch GH. Chemosensitivity of prostate cancer cell lines and expression of multidrug resistance-related proteins. Eur J Cancer 1999;35:664-71.
37. de la TM, Hao XY, Larsson R, et al. Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases. Anticancer Res 1993;13:1425-30.
38. David-Beabes GL, Overman MJ, Petrofski JA, Campbell PA, De Marzo AM, Nelson WG. Doxorubicin-resistant variants of human prostate cancer cell lines DU 145, PC-3, PPC-1, and TSU-PR1: characterization of biochemical determinants of antineoplastic drug sensitivity. Int J Oncol 2000;17:1077-86.
39. Pipili-Synetos E, Papageorgiou A, Sakkoula E, et al. Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate. Br J Pharmacol 1995;116:1829-34.
40. Postovit LM, Adams MA, Lash GE, Heaton JP, Graham CH. Nitric oxide-mediated regulation of hypoxia-induced B16F10 melanoma metastasis. Int J Cancer 2004;108:47-53.
41. Agvald P, Adding LC, Artlich A, Persson MG, Gustafsson LE. Mechanisms of nitric oxide generation from nitroglycerin and endogenous sources during hypoxia in vivo. Br J Pharmacol 2002;135:373-82.