Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 1, 2008, Pages 361-364

  Marchand, Christophe ^a   Beutler, John A ^b   Wamiru, Antony ^b,c   Budihas, Scott ^b   Möllmann, Ute ^d   Heinisch, Lothar ^d   Mellors, John W ^e   Le Grice, Stuart F ^b   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

^d HANS KNÖLL INSTITUTE   (Germany)

^e UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE; INTEGRASE INHIBITOR; LACTONE DERIVATIVE; MADURAHYDROXYLACTONE DERIVATIVE; RIBONUCLEASE H; RIBONUCLEASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMOLUMINESCENCE; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SOIL MICROFLORA; VIRUS INHIBITION;

ANTI-HIV AGENTS; ENZYME INHIBITORS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; LACTONES; RIBONUCLEASE H; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 37849020692     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00883-07     Document Type: Article

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