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Volumn 2, Issue 3, 2011, Pages 298-305

Mammalian son of sevenless guanine nucleotide exchange factors: Old concepts and new perspectives

Author keywords

Ras; Ras GEF; RTK; Signaling; Sos

Indexed keywords

MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; RAF INHIBITOR; SOS PROTEIN; SOS2 PROTEIN; UCS 15A; UNCLASSIFIED DRUG;

EID: 79960066478     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601911408078     Document Type: Review
Times cited : (61)

References (103)
  • 1
    • 0036302247 scopus 로고    scopus 로고
    • Ras genes and human cancer: Different implications and different roles
    • Rojas JM, Santos E. Ras genes and human cancer: different implications and different roles. Curr Genomics. 2002;3:295-311.
    • (2002) Curr Genomics , vol.3 , pp. 295-311
    • Rojas, J.M.1    Santos, E.2
  • 2
    • 0030464444 scopus 로고    scopus 로고
    • How Ras-related proteins talk to their effectors
    • Wittinghofer A, Nassar N. How Ras-related proteins talk to their effectors. Trends Biochem Sci. 1996;21:488-91.
    • (1996) Trends Biochem Sci , vol.21 , pp. 488-491
    • Wittinghofer, A.1    Nassar, N.2
  • 3
    • 0030738592 scopus 로고    scopus 로고
    • The interaction of Ras with GTPase-activating proteins
    • Wittinghofer A, Scheffzek K, Ahmadian MR. The interaction of Ras with GTPase-activating proteins. FEBS Lett. 1997;410:63-7.
    • (1997) FEBS Lett , vol.410 , pp. 63-67
    • Wittinghofer, A.1    Scheffzek, K.2    Ahmadian, M.R.3
  • 4
    • 0029955128 scopus 로고    scopus 로고
    • Control of ras activation
    • Downward J. Control of ras activation. Cancer Surv. 1996;27:87-100.
    • (1996) Cancer Surv , vol.27 , pp. 87-100
    • Downward, J.1
  • 6
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski M, McCormick F. Proteins regulating Ras and its relatives. Nature. 1993;366:643-54.
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.1    McCormick, F.2
  • 7
    • 0029865523 scopus 로고    scopus 로고
    • Expression of alternative forms of Ras exchange factors GRF and SOS1 in different human tissues and cell lines
    • Guerrero C, Rojas JM, Chedid M, et al. Expression of alternative forms of Ras exchange factors GRF and SOS1 in different human tissues and cell lines. Oncogene. 1996;12:1097-107.
    • (1996) Oncogene , vol.12 , pp. 1097-1107
    • Guerrero, C.1    Rojas, J.M.2    Chedid, M.3
  • 8
    • 0027279176 scopus 로고
    • How receptor tyrosine kinases activate Ras
    • Schlessinger J. How receptor tyrosine kinases activate Ras. Trends Biochem Sci. 1993;18:273-6.
    • (1993) Trends Biochem Sci , vol.18 , pp. 273-276
    • Schlessinger, J.1
  • 10
    • 0026523616 scopus 로고
    • Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator
    • Martegani E, Vanoni M, Zippel R, et al. Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator. EMBO J. 1992;11:2151-7.
    • (1992) EMBO J , vol.11 , pp. 2151-2157
    • Martegani, E.1    Vanoni, M.2    Zippel, R.3
  • 11
    • 0031581209 scopus 로고    scopus 로고
    • A role for the Ras signalling pathway in synaptic transmission and long-term memory
    • Brambilla R, Gnesutta N, Minichiello L, et al. A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature. 1997;390:281-6.
    • (1997) Nature , vol.390 , pp. 281-286
    • Brambilla, R.1    Gnesutta, N.2    Minichiello, L.3
  • 12
    • 0027220836 scopus 로고
    • Localization of the cellular expression pattern of cdc25NEF and ras in the juvenile rat brain
    • Wei W, Schreiber SS, Baudry M, Tocco G, Broek D. Localization of the cellular expression pattern of cdc25NEF and ras in the juvenile rat brain. Brain Res Mol Brain Res. 1993;19:339-44.
    • (1993) Brain Res Mol Brain Res , vol.19 , pp. 339-344
    • Wei, W.1    Schreiber, S.S.2    Baudry, M.3    Tocco, G.4    Broek, D.5
  • 13
    • 0032524389 scopus 로고    scopus 로고
    • RasGRP, a Ras guanyl nucleotidereleasing protein with calcium- and diacylglycerol- binding motifs
    • Ebinu JO, Bottorff DA, Chan EY, Stang SL, Dunn RJ, Stone JC. RasGRP, a Ras guanyl nucleotidereleasing protein with calcium- and diacylglycerol- binding motifs. Science. 1998;280:1082-6.
    • (1998) Science , vol.280 , pp. 1082-1086
    • Ebinu, J.O.1    Bottorff, D.A.2    Chan, E.Y.3    Stang, S.L.4    Dunn, R.J.5    Stone, J.C.6
  • 16
    • 0025997867 scopus 로고
    • Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
    • Simon MA, Bowtell DD, Dodson GS, Laverty TR, Rubin GM. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell. 1991;67:701-16.
    • (1991) Cell , vol.67 , pp. 701-716
    • Simon, M.A.1    Bowtell, D.D.2    Dodson, G.S.3    Laverty, T.R.4    Rubin, G.M.5
  • 17
    • 0034601059 scopus 로고    scopus 로고
    • Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals
    • Chang C, Hopper NA, Sternberg PW. Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals. EMBO J. 2000;19:3283-94.
    • (2000) EMBO J , vol.19 , pp. 3283-3294
    • Chang, C.1    Hopper, N.A.2    Sternberg, P.W.3
  • 18
    • 0026627960 scopus 로고
    • Identification of murine homologues of the Drosophila son of sevenless gene: Potential activators of ras
    • Bowtell D, Fu P, Simon M, Senior P. Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A. 1992;89:6511-5.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 6511-6515
    • Bowtell, D.1    Fu, P.2    Simon, M.3    Senior, P.4
  • 19
    • 0027304731 scopus 로고
    • Human Sos1: A guanine nucleotide exchange factor for Ras that binds to GRB2
    • Chardin P, Camonis JH, Gale NW, et al. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science. 1993;260:1338-43.
    • (1993) Science , vol.260 , pp. 1338-1343
    • Chardin, P.1    Camonis, J.H.2    Gale, N.W.3
  • 20
    • 0027980179 scopus 로고
    • Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome
    • Chardin P, Mattei MG. Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome. Cytogenet Cell Genet. 1994;66:68-9.
    • (1994) Cytogenet Cell Genet , vol.66 , pp. 68-69
    • Chardin, P.1    Mattei, M.G.2
  • 21
    • 0029944222 scopus 로고    scopus 로고
    • A 15 amino acid stretch close to the Grb2-binding domain defines two differentially expressed hSos1 isoforms with markedly different Grb2 binding affinity and biological activity
    • Rojas JM, Coque JJR, Guerrero C, et al. A 15 amino acid stretch close to the Grb2-binding domain defines two differentially expressed hSos1 isoforms with markedly different Grb2 binding affinity and biological activity. Oncogene. 1996;12:2291-300.
    • (1996) Oncogene , vol.12 , pp. 2291-2300
    • Rojas, J.M.1    Coque, J.J.R.2    Guerrero, C.3
  • 22
    • 0033522139 scopus 로고    scopus 로고
    • Isoform- specific insertion near the Grb2-binding domain modulates the intrinsic guanine nucleotide exchange activity of hSos1
    • Rojas JM, Subleski M, Coque JJ, et al. Isoform- specific insertion near the Grb2-binding domain modulates the intrinsic guanine nucleotide exchange activity of hSos1. Oncogene. 1999;18:1651-61.
    • (1999) Oncogene , vol.18 , pp. 1651-1661
    • Rojas, J.M.1    Subleski, M.2    Coque, J.J.3
  • 23
    • 0030666849 scopus 로고    scopus 로고
    • The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: MSos2 contains ubiquitination signals absent in mSos1
    • Nielsen KH, Papageorge AG, Vass WC, Willumsen BM, Lowy DR. The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1. Mol Cell Biol. 1997;17:7132-8.
    • (1997) Mol Cell Biol , vol.17 , pp. 7132-7138
    • Nielsen, K.H.1    Papageorge, A.G.2    Vass, W.C.3    Willumsen, B.M.4    Lowy, D.R.5
  • 24
    • 0034651705 scopus 로고    scopus 로고
    • The Sos1 and Sos2 Ras-specific exchange factors: Differences in placental expression and signaling properties
    • Qian X, Esteban L, Vass WC, et al. The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. EMBO J. 2000;19:642-54.
    • (2000) EMBO J , vol.19 , pp. 642-654
    • Qian, X.1    Esteban, L.2    Vass, W.C.3
  • 25
    • 0025966709 scopus 로고
    • Genetic dissection of a neurodevelopmental pathway: Son of Sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases
    • Rogge RD, Karlovich CA, Banerjee U. Genetic dissection of a neurodevelopmental pathway: Son of Sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases. Cell. 1991;64:39-48.
    • (1991) Cell , vol.64 , pp. 39-48
    • Rogge, R.D.1    Karlovich, C.A.2    Banerjee, U.3
  • 26
    • 0009722399 scopus 로고    scopus 로고
    • Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development
    • Esteban LM, Fernandez-Medarde A, Lopez E, et al. Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development. Mol Cell Biol. 2000;20:6410-3.
    • (2000) Mol Cell Biol , vol.20 , pp. 6410-6413
    • Esteban, L.M.1    Fernandez-Medarde, A.2    Lopez, E.3
  • 27
    • 0031043507 scopus 로고    scopus 로고
    • Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development
    • Wang DZ, Hammond VE, Abud HE, Bertoncello I, McAvoy JW, Bowtell DD. Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development. Genes Dev. 1997;11:309-20.
    • (1997) Genes Dev , vol.11 , pp. 309-320
    • Wang, D.Z.1    Hammond, V.E.2    Abud, H.E.3    Bertoncello, I.4    McAvoy, J.W.5    Bowtell, D.D.6
  • 30
    • 0029031112 scopus 로고
    • The Grb2 binding domain of mSos1 is not required for downstream signal transduction
    • Wang W, Fisher E, Jia Q, et al. The Grb2 binding domain of mSos1 is not required for downstream signal transduction. Nature Gen. 1995;10:294-300.
    • (1995) Nature Gen , vol.10 , pp. 294-300
    • Wang, W.1    Fisher, E.2    Jia, Q.3
  • 31
    • 0029003471 scopus 로고
    • In vivo functional analysis of the Ras exchange factor son of sevenless
    • Karlovich CA, Bonfini L, McCollam L, et al. In vivo functional analysis of the Ras exchange factor son of sevenless. Science. 1995;268:576-9.
    • (1995) Science , vol.268 , pp. 576-579
    • Karlovich, C.A.1    Bonfini, L.2    McCollam, L.3
  • 32
    • 0029849810 scopus 로고    scopus 로고
    • p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus
    • Byrne JL, Paterson HF, Marshall CJ. P21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus. Oncogene. 1996;13:2055-65.
    • (1996) Oncogene , vol.13 , pp. 2055-2065
    • Byrne, J.L.1    Paterson, H.F.2    Marshall, C.J.3
  • 33
    • 0030729024 scopus 로고    scopus 로고
    • The solution structure of the pleckstrin homology domain of human SOS1: A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains
    • Zheng J, Chen RH, Corblan-Garcia S, Cahill SM, Bar-Sagi D, Cowburn D. The solution structure of the pleckstrin homology domain of human SOS1: a possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. J Biol Chem. 1997;272:30340-4.
    • (1997) J Biol Chem , vol.272 , pp. 30340-30344
    • Zheng, J.1    Chen, R.H.2    Corblan-Garcia, S.3    Cahill, S.M.4    Bar-Sagi, D.5    Cowburn, D.6
  • 34
    • 0031580202 scopus 로고    scopus 로고
    • The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1)
    • Koshiba S, Kigawa T, Kim JH, Shirouzu M, Bowtell D, Yokoyama S. The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1). J Mol Biol. 1997;269:579-91.
    • (1997) J Mol Biol , vol.269 , pp. 579-591
    • Koshiba, S.1    Kigawa, T.2    Kim, J.H.3    Shirouzu, M.4    Bowtell, D.5    Yokoyama, S.6
  • 35
    • 0030820924 scopus 로고    scopus 로고
    • A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains
    • Rameh LE, Arvidsson A, Carraway KL 3rd, et al. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem. 1997;272:22059-66.
    • (1997) J Biol Chem , vol.272 , pp. 22059-22066
    • Rameh, L.E.1    Arvidsson, A.2    Carraway 3rd, K.L.3
  • 36
    • 0031929680 scopus 로고    scopus 로고
    • N terminus of Sos1 Ras exchange factor: Critical roles for the Dbl and pleckstrin homology domains
    • Qian X, Vass WC, Papageorge AG, Anborgh PH, Lowy DR. N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains. Mol Cell Biol. 1998;18:771-8.
    • (1998) Mol Cell Biol , vol.18 , pp. 771-778
    • Qian, X.1    Vass, W.C.2    Papageorge, A.G.3    Anborgh, P.H.4    Lowy, D.R.5
  • 38
    • 0036371326 scopus 로고    scopus 로고
    • Autoinhibition of Sos by intramolecular interactions
    • Hall BE, Yang SS, Bar-Sagi D. Autoinhibition of Sos by intramolecular interactions. Front Biosci. 2002;7:288-94.
    • (2002) Front Biosci , vol.7 , pp. 288-294
    • Hall, B.E.1    Yang, S.S.2    Bar-Sagi, D.3
  • 39
    • 0344885558 scopus 로고    scopus 로고
    • Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide. exchange factor SOS
    • Margarit SM, Sondermann H, Hall BE, et al. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell. 2003;112:685-95.
    • (2003) Cell , vol.112 , pp. 685-695
    • Margarit, S.M.1    Sondermann, H.2    Hall, B.E.3
  • 40
    • 0037113966 scopus 로고    scopus 로고
    • HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain
    • Jorge R, Zarich N, Oliva JL, et al. HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain. J Biol Chem. 2002;277:44171-9.
    • (2002) J Biol Chem , vol.277 , pp. 44171-44179
    • Jorge, R.1    Zarich, N.2    Oliva, J.L.3
  • 41
    • 0345528059 scopus 로고    scopus 로고
    • Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless
    • Sondermann H, Soisson SM, Bar-Sagi D, Kuriyan J. Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless. Structure (Camb). 2003;11:1583-93.
    • (2003) Structure (Camb) , vol.11 , pp. 1583-1593
    • Sondermann, H.1    Soisson, S.M.2    Bar-Sagi, D.3    Kuriyan, J.4
  • 43
    • 0027312272 scopus 로고
    • Guanine-nucleotide- releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
    • Li N, Batzer A, Daly R, et al. Guanine-nucleotide- releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 1993;363:85-8.
    • (1993) Nature , vol.363 , pp. 85-88
    • Li, N.1    Batzer, A.2    Daly, R.3
  • 44
    • 0027294981 scopus 로고
    • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
    • Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature. 1993;363:83-5.
    • (1993) Nature , vol.363 , pp. 83-85
    • Rozakis-Adcock, M.1    Fernley, R.2    Wade, J.3    Pawson, T.4    Bowtell, D.5
  • 45
    • 0028410481 scopus 로고
    • Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition
    • Lim WA, Richards FM. Critical residues in an SH3 domain from Sem-5 suggest a mechanism for proline-rich peptide recognition. Nat Struct Biol. 1994;1:221-5.
    • (1994) Nat Struct Biol , vol.1 , pp. 221-225
    • Lim, W.A.1    Richards, F.M.2
  • 46
    • 0027962645 scopus 로고
    • Two binding orientations for peptides to the Src SH3 domain: Development of a general model for SH3-ligand interactions
    • Feng S, Chen JK, Yu H, Simon JA, Schreiber SL. Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science. 1994;266:1241-7.
    • (1994) Science , vol.266 , pp. 1241-1247
    • Feng, S.1    Chen, J.K.2    Yu, H.3    Simon, J.A.4    Schreiber, S.L.5
  • 47
  • 49
    • 0032905306 scopus 로고    scopus 로고
    • A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity
    • Cussac D, Vidal M, Leprince C, et al. A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity. FASEB J. 1999;13:31-8.
    • (1999) FASEB J , vol.13 , pp. 31-38
    • Cussac, D.1    Vidal, M.2    Leprince, C.3
  • 50
    • 0029110042 scopus 로고
    • Grb2 SH3 binding to peptides from Sos: Evaluation of a general model for SH3-ligand interactions
    • Simon JA, Schreiber SL. Grb2 SH3 binding to peptides from Sos: evaluation of a general model for SH3-ligand interactions. Chem Biol. 1995;2:53-60.
    • (1995) Chem Biol , vol.2 , pp. 53-60
    • Simon, J.A.1    Schreiber, S.L.2
  • 51
    • 0032541641 scopus 로고    scopus 로고
    • From Src homology domains to other signaling modules: Proposal of the protein recognition code
    • Sudol M. From Src homology domains to other signaling modules: proposal of the protein recognition code. Oncogene. 1998;17:1469-74.
    • (1998) Oncogene , vol.17 , pp. 1469-1474
    • Sudol, M.1
  • 52
    • 0034735893 scopus 로고    scopus 로고
    • The isoform-specific stretch of hSos1 defines a new Grb2-binding domain
    • Zarich N, Oliva JL, Jorge R, Santos E, Rojas JM. The isoform-specific stretch of hSos1 defines a new Grb2-binding domain. Oncogene. 2000;19:5872-83.
    • (2000) Oncogene , vol.19 , pp. 5872-5883
    • Zarich, N.1    Oliva, J.L.2    Jorge, R.3    Santos, E.4    Rojas, J.M.5
  • 53
    • 0032554774 scopus 로고    scopus 로고
    • Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1)
    • Kim JH, Shirouzu M, Kataoka T, Bowtell D, Yokoyama S. Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless 1 (mSos1). Oncogene. 1998;16:2597-607.
    • (1998) Oncogene , vol.16 , pp. 2597-2607
    • Kim, J.H.1    Shirouzu, M.2    Kataoka, T.3    Bowtell, D.4    Yokoyama, S.5
  • 54
    • 0036201303 scopus 로고    scopus 로고
    • A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1
    • Hart TC, Zhang Y, Gorry MC, et al. A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. Am J Hum Genet. 2002;70:943-54.
    • (2002) Am J Hum Genet , vol.70 , pp. 943-954
    • Hart, T.C.1    Zhang, Y.2    Gorry, M.C.3
  • 55
    • 0030767442 scopus 로고    scopus 로고
    • EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2
    • Douville E, Downward J. EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2. Oncogene. 1997;15:373-83.
    • (1997) Oncogene , vol.15 , pp. 373-383
    • Douville, E.1    Downward, J.2
  • 56
    • 33746631240 scopus 로고    scopus 로고
    • Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1
    • Zarich N, Oliva JL, Martinez N, et al. Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1. Mol Biol Cell. 2006;17:3591-7.
    • (2006) Mol Biol Cell , vol.17 , pp. 3591-3597
    • Zarich, N.1    Oliva, J.L.2    Martinez, N.3
  • 58
    • 0027212082 scopus 로고
    • How receptors turn Ras on
    • McCormick F. How receptors turn Ras on. Nature. 1993;363:15-6.
    • (1993) Nature , vol.363 , pp. 15-16
    • McCormick, F.1
  • 59
    • 0027422247 scopus 로고
    • The pathway to signal achievement
    • Egan S, Weinberg R. The pathway to signal achievement. Nature. 1993;365:781-3.
    • (1993) Nature , vol.365 , pp. 781-783
    • Egan, S.1    Weinberg, R.2
  • 60
    • 34447568476 scopus 로고    scopus 로고
    • Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
    • Zhao C, Du G, Skowronek K, Frohman MA, Bar-Sagi D. Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat Cell Biol. 2007;9:706-12.
    • (2007) Nat Cell Biol , vol.9 , pp. 706-712
    • Zhao, C.1    Du, G.2    Skowronek, K.3    Frohman, M.A.4    Bar-Sagi, D.5
  • 61
    • 77649264378 scopus 로고    scopus 로고
    • Allosteric gating of Son of Sevenless activity by the histone domain
    • Yadav KK, Bar-Sagi D. Allosteric gating of Son of Sevenless activity by the histone domain. Proc Natl Acad Sci U S A. 2010;107:3436-40.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3436-3440
    • Yadav, K.K.1    Bar-Sagi, D.2
  • 62
    • 0035920116 scopus 로고    scopus 로고
    • Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange
    • Hall BE, Yang SS, Boriack-Sjodin PA, Kuriyan J, Bar-Sagi D. Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange. J Biol Chem. 2001;276:27629-37.
    • (2001) J Biol Chem , vol.276 , pp. 27629-27637
    • Hall, B.E.1    Yang, S.S.2    Boriack-Sjodin, P.A.3    Kuriyan, J.4    Bar-Sagi, D.5
  • 63
    • 0037016758 scopus 로고    scopus 로고
    • The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase
    • Jaumot M, Yan J, Clyde-Smith J, Sluimer J, Hancock JF. The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase. J Biol Chem. 2002;277:272-8.
    • (2002) J Biol Chem , vol.277 , pp. 272-278
    • Jaumot, M.1    Yan, J.2    Clyde-Smith, J.3    Sluimer, J.4    Hancock, J.F.5
  • 64
    • 0842304220 scopus 로고    scopus 로고
    • Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors
    • Arozarena I, Matallanas D, Berciano MT, et al. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Mol Cell Biol. 2004;24:1516-30.
    • (2004) Mol Cell Biol , vol.24 , pp. 1516-1530
    • Arozarena, I.1    Matallanas, D.2    Berciano, M.T.3
  • 65
    • 0032559211 scopus 로고    scopus 로고
    • Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
    • Nimnual AS, Yatsula BA, Bar-Sagi D. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science. 1998;279:560-3.
    • (1998) Science , vol.279 , pp. 560-563
    • Nimnual, A.S.1    Yatsula, B.A.2    Bar-Sagi, D.3
  • 66
    • 0033575885 scopus 로고    scopus 로고
    • EPS8 and E3B1 transduce signals from Ras to Rac
    • Scita G, Nordstrom J, Carbone R, et al. EPS8 and E3B1 transduce signals from Ras to Rac. Nature. 1999;401:290-3.
    • (1999) Nature , vol.401 , pp. 290-293
    • Scita, G.1    Nordstrom, J.2    Carbone, R.3
  • 67
    • 33746601546 scopus 로고    scopus 로고
    • An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actinpolymerizing machine
    • Scita G, Tenca P, Areces LB, et al. An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actinpolymerizing machine. J Cell Biol. 2001;27:27.
    • (2001) J Cell Biol , vol.27 , pp. 27
    • Scita, G.1    Tenca, P.2    Areces, L.B.3
  • 68
    • 78649830989 scopus 로고    scopus 로고
    • Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation
    • Chen PC, Wakimoto H, Conner D, et al. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation. J Clin Invest. 2010;120:4353-65.
    • (2010) J Clin Invest , vol.120 , pp. 4353-4365
    • Chen, P.C.1    Wakimoto, H.2    Conner, D.3
  • 69
    • 0037033797 scopus 로고    scopus 로고
    • Mechanisms through which Sos-1 coordinates the activation of Ras and Rac
    • Innocenti M, Tenca P, Frittoli E, et al. Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. J Cell Biol. 2002;156:125-36.
    • (2002) J Cell Biol , vol.156 , pp. 125-136
    • Innocenti, M.1    Tenca, P.2    Frittoli, E.3
  • 70
    • 0027938510 scopus 로고
    • Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase
    • Cherniack A, Klarlund J, Czech M. Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase. J Biol Chem. 1994;269:4717-20.
    • (1994) J Biol Chem , vol.269 , pp. 4717-4720
    • Cherniack, A.1    Klarlund, J.2    Czech, M.3
  • 71
    • 0037057295 scopus 로고    scopus 로고
    • Light chain 3 associates with a Sos1 guanine nucleotide exchange factor: Its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling
    • Furuta S, Miura K, Copeland T, Shang WH, Oshima A, Kamata T. Light chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling. Oncogene. 2002;21:7060-6.
    • (2002) Oncogene , vol.21 , pp. 7060-7066
    • Furuta, S.1    Miura, K.2    Copeland, T.3    Shang, W.H.4    Oshima, A.5    Kamata, T.6
  • 72
    • 38549168319 scopus 로고    scopus 로고
    • SOS1 mutations are rare in human malignancies: Implications for Noonan Syndrome patients
    • Swanson KD, Winter JM, Reis M, et al. SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients. Genes Chromosomes Cancer. 2008;47:253-9.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 253-259
    • Swanson, K.D.1    Winter, J.M.2    Reis, M.3
  • 73
    • 70449410985 scopus 로고    scopus 로고
    • Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African- American men
    • Timofeeva OA, Zhang X, Ressom HW, et al. Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African- American men. Int J Oncol. 2009;35:751-60.
    • (2009) Int J Oncol , vol.35 , pp. 751-760
    • Timofeeva, O.A.1    Zhang, X.2    Ressom, H.W.3
  • 74
    • 78649952069 scopus 로고    scopus 로고
    • Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis
    • Chen H, Wu X, Pan ZK, Huang S. Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis. Cancer Res. 2010;70:9979-90.
    • (2010) Cancer Res , vol.70 , pp. 9979-9990
    • Chen, H.1    Wu, X.2    Pan, Z.K.3    Huang, S.4
  • 75
    • 0014337521 scopus 로고
    • Hypertelorism with Turner phenotype: A new syndrome with associated congenital heart disease
    • Noonan JA. Hypertelorism with Turner phenotype: a new syndrome with associated congenital heart disease. Am J Dis Child. 1968;116:373-80.
    • (1968) Am J Dis Child , vol.116 , pp. 373-380
    • Noonan, J.A.1
  • 76
    • 77955574059 scopus 로고    scopus 로고
    • Noonan syndrome: Clinical aspects and molecular pathogenesis
    • Tartaglia M, Zampino G, Gelb BD. Noonan syndrome: clinical aspects and molecular pathogenesis. Mol Syndromol. 2010;1:2-26.
    • (2010) Mol Syndromol , vol.1 , pp. 2-26
    • Tartaglia, M.1    Zampino, G.2    Gelb, B.D.3
  • 77
    • 34547530823 scopus 로고    scopus 로고
    • Gainof- function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
    • Pandit B, Sarkozy A, Pennacchio LA, et al. Gainof- function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat Genet. 2007;39:1007-12.
    • (2007) Nat Genet , vol.39 , pp. 1007-1012
    • Pandit, B.1    Sarkozy, A.2    Pennacchio, L.A.3
  • 78
    • 34547539552 scopus 로고    scopus 로고
    • Germline gain-of-function mutations in RAF1 cause Noonan syndrome
    • Razzaque MA, Nishizawa T, Komoike Y, et al. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nat Genet. 2007;39:1013-7.
    • (2007) Nat Genet , vol.39 , pp. 1013-1017
    • Razzaque, M.A.1    Nishizawa, T.2    Komoike, Y.3
  • 79
    • 33644622238 scopus 로고    scopus 로고
    • Germline KRAS mutations cause Noonan syndrome
    • Schubbert S, Zenker M, Rowe SL, et al. Germline KRAS mutations cause Noonan syndrome. Nat Genet. 2006;38:331-6.
    • (2006) Nat Genet , vol.38 , pp. 331-336
    • Schubbert, S.1    Zenker, M.2    Rowe, S.L.3
  • 80
    • 69349105766 scopus 로고    scopus 로고
    • Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonanlike syndrome with loose anagen hair
    • Cordeddu V, di Schiavi E, Pennacchio LA, et al. Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonanlike syndrome with loose anagen hair. Nat Genet. 2009;41:1022-6.
    • (2009) Nat Genet , vol.41 , pp. 1022-1026
    • Cordeddu, V.1    di Schiavi, E.2    Pennacchio, L.A.3
  • 81
    • 33845900943 scopus 로고    scopus 로고
    • Germline gain-of-function mutations in SOS1 cause Noonan syndrome
    • Roberts AE, Araki T, Swanson KD, et al. Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Nat Genet. 2007;39:70-4.
    • (2007) Nat Genet , vol.39 , pp. 70-74
    • Roberts, A.E.1    Araki, T.2    Swanson, K.D.3
  • 82
    • 35348871857 scopus 로고    scopus 로고
    • SOS1 is the second most common Noonan gene but plays no major role in cardio-facio-cutaneous syndrome
    • Zenker M, Horn D, Wieczorek D, et al. SOS1 is the second most common Noonan gene but plays no major role in cardio-facio-cutaneous syndrome. J Med Genet. 2007;44:651-6.
    • (2007) J Med Genet , vol.44 , pp. 651-656
    • Zenker, M.1    Horn, D.2    Wieczorek, D.3
  • 83
    • 73849142941 scopus 로고    scopus 로고
    • Malignant diseases in Noonan syndrome and related disorders
    • Hasle H. Malignant diseases in Noonan syndrome and related disorders. Horm Res. 2009;72 Suppl 2:8-14.
    • (2009) Horm Res , vol.72 , Issue.SUPPL. 2 , pp. 8-14
    • Hasle, H.1
  • 88
    • 0025821019 scopus 로고
    • Noonan-like/ multiple giant cell lesion syndrome
    • Cohen MM Jr., Gorlin RJ. Noonan-like/ multiple giant cell lesion syndrome. Am J Med Genet. 1991;40:159-66.
    • (1991) Am J Med Genet , vol.40 , pp. 159-166
    • Cohen Jr., M.M.1    Gorlin, R.J.2
  • 89
    • 62849124342 scopus 로고    scopus 로고
    • Multiple giant cell lesions in patients with Noonan syndrome and cardio-faciocutaneous syndrome
    • Neumann TE, Allanson J, Kavamura I, et al. Multiple giant cell lesions in patients with Noonan syndrome and cardio-faciocutaneous syndrome. Eur J Hum Genet. 2009; 17:420-5.
    • (2009) Eur J Hum Genet , vol.17 , pp. 420-425
    • Neumann, T.E.1    Allanson, J.2    Kavamura, I.3
  • 90
    • 34547126021 scopus 로고    scopus 로고
    • Germ line gain of function with SOS1 mutation in hereditary gingival fibromatosis
    • Jang SI, Lee EJ, Hart PS, Ramaswami M, Pallos D, Hart TC. Germ line gain of function with SOS1 mutation in hereditary gingival fibromatosis. J Biol Chem. 2007;282:20245-55.
    • (2007) J Biol Chem , vol.282 , pp. 20245-20255
    • Jang, S.I.1    Lee, E.J.2    Hart, P.S.3    Ramaswami, M.4    Pallos, D.5    Hart, T.C.6
  • 91
    • 0034697962 scopus 로고    scopus 로고
    • The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development
    • Sibilia M, Fleischmann A, Behrens A, et al. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell. 2000;102:211-20.
    • (2000) Cell , vol.102 , pp. 211-220
    • Sibilia, M.1    Fleischmann, A.2    Behrens, A.3
  • 92
    • 0035912062 scopus 로고    scopus 로고
    • UCS15A, a non-kinase inhibitor of Src signal transduction
    • Sharma SV, Oneyama C, Yamashita Y, et al. UCS15A, a non-kinase inhibitor of Src signal transduction. Oncogene. 2001;20:2068-79.
    • (2001) Oncogene , vol.20 , pp. 2068-2079
    • Sharma, S.V.1    Oneyama, C.2    Yamashita, Y.3
  • 93
    • 0037150229 scopus 로고    scopus 로고
    • UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug
    • Oneyama C, Nakano H, Sharma SV. UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug. Oncogene. 2002;21:2037-50.
    • (2002) Oncogene , vol.21 , pp. 2037-2050
    • Oneyama, C.1    Nakano, H.2    Sharma, S.V.3
  • 94
    • 0038183834 scopus 로고    scopus 로고
    • Synthetic inhibitors of proline-rich ligand-mediated protein-protein interaction: Potent analogs of UCS15A
    • Oneyama C, Agatsuma T, Kanda Y, et al. Synthetic inhibitors of proline-rich ligand-mediated protein-protein interaction: potent analogs of UCS15A. Chem Biol. 2003;10:443-51.
    • (2003) Chem Biol , vol.10 , pp. 443-451
    • Oneyama, C.1    Agatsuma, T.2    Kanda, Y.3
  • 95
    • 33646476831 scopus 로고    scopus 로고
    • Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
    • Hashimoto S, Hirose M, Hashimoto A, et al. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2006;103:7036-41.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7036-7041
    • Hashimoto, S.1    Hirose, M.2    Hashimoto, A.3
  • 96
    • 0344987879 scopus 로고    scopus 로고
    • The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras
    • Oliva JL, Perez-Sala D, Castrillo A, et al. The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. Proc Natl Acad Sci U S A. 2003;100:4772-7.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4772-4777
    • Oliva, J.L.1    Perez-Sala, D.2    Castrillo, A.3
  • 97
    • 34249893910 scopus 로고    scopus 로고
    • Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selective
    • Renedo M, Gayarre J, Garcia-Dominguez CA, et al. Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selective. Biochemistry. 2007;46:6607-16.
    • (2007) Biochemistry , vol.46 , pp. 6607-6616
    • Renedo, M.1    Gayarre, J.2    Garcia-Dominguez, C.A.3
  • 98
    • 0031054520 scopus 로고    scopus 로고
    • A molecular redox switch on p21(ras): Structural basis for the nitric oxide-p21(ras) interaction
    • Lander HM, Hajjar DP, Hempstead BL, et al. A molecular redox switch on p21(ras): structural basis for the nitric oxide-p21(ras) interaction. J Biol Chem. 1997;272:4323-6.
    • (1997) J Biol Chem , vol.272 , pp. 4323-4326
    • Lander, H.M.1    Hajjar, D.P.2    Hempstead, B.L.3
  • 99
    • 0031000742 scopus 로고    scopus 로고
    • Structural and functional analysis of a mutant Ras protein that is insensitive to nitric oxide activation
    • Mott HR, Carpenter JW, Campbell SL. Structural and functional analysis of a mutant Ras protein that is insensitive to nitric oxide activation. Biochemistry. 1997;36:3640-4.
    • (1997) Biochemistry , vol.36 , pp. 3640-3644
    • Mott, H.R.1    Carpenter, J.W.2    Campbell, S.L.3
  • 101
    • 4644362561 scopus 로고    scopus 로고
    • Dioxin revisited: Developments since the 1997 IARC classification of dioxin as a human carcinogen
    • Steenland K, Bertazzi P, Baccarelli A, Kogevinas M. Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen. Environ Health Perspect. 2004;112:1265-8.
    • (2004) Environ Health Perspect , vol.112 , pp. 1265-1268
    • Steenland, K.1    Bertazzi, P.2    Baccarelli, A.3    Kogevinas, M.4
  • 102
    • 34447511096 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein
    • Barouki R, Coumoul X, Fernandez-Salguero PM. The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein. FEBS Lett. 2007;581:3608-15.
    • (2007) FEBS Lett , vol.581 , pp. 3608-3615
    • Barouki, R.1    Coumoul, X.2    Fernandez-Salguero, P.M.3
  • 103
    • 78650170612 scopus 로고    scopus 로고
    • Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation
    • Pierre S, Bats AS, Chevallier A, et al. Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation. Biochem Pharmacol. 2011;81:304-13.
    • (2011) Biochem Pharmacol , vol.81 , pp. 304-313
    • Pierre, S.1    Bats, A.S.2    Chevallier, A.3


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