Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 18, 2006, Pages 7036-7041

  Hashimoto, Shigeru ^a   Hirose, Mayumi ^a,b   Hashimoto, Ari ^a   Morishige, Masaki ^a,d   Yamada, Atsuko ^a   Hosaka, Harumi ^b   Akagi, Ken Ichi ^b   Ogawa, Eiji ^a,e   Oneyama, Chitose ^a   Agatsuma, Tsutomu ^f   Okada, Masato ^c   Kobayashi, Hidenori ^d   Wada, Hiromi ^e   Nakano, Hirofumi ^f   Ikegami, Takahisa ^b   Nakagawa, Atsushi ^b   Sabe, Hisataka ^a  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d OITA UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

^f KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Cell permeable peptide; Molecular target; NMR; Small molecule inhibitor; X ray structure

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; CORTACTIN; GUANOSINE TRIPHOSPHATE; PAXILLIN; PEPTIDE; PROLINE; PROTEIN; PROTEIN AMAP1; PROTEIN INHIBITOR; PROTEIN SH3; SERYLLYSYLLYSYLARGINYLPROLYLPROLYLPROLYLPROLYLPROLYLPROLYLGLYCYLHISTIDYLLYS YLARGINYLTHREONINE; SERYLSERYLTHREONYLLYSYLSERYLLYSYLLYSYLARGINYLPROLYLPROLYLPROLYLPROLYLPROLYL PROLYLGLYCYLHISTIDYLLYSYLARGINYLTHREONYLLYSYLSERYLASPARTYLGLYCYLARGINYLLYSYLLYSY LARGINYLARGINYLGLUTAMINYLARGINYLARGINYLARGININE; UCS15A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER INVASION; CELL MEMBRANE PERMEABILITY; COMPLEX FORMATION; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; HUMAN; LUNG CARCINOMA; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTEIN TARGETING; STOICHIOMETRY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BENZALDEHYDES; BREAST NEOPLASMS; CELL LINE, TUMOR; CORTACTIN; FEMALE; GENE PRODUCTS, TAT; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MULTIPROTEIN COMPLEXES; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PEPTIDES; PROLINE; PROTEIN BINDING; PROTEIN CONFORMATION; SRC HOMOLOGY DOMAINS;

EID: 33646476831     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509166103     Document Type: Article

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