메뉴 건너뛰기




Volumn 19, Issue 13, 2000, Pages 3283-3294

Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals

Author keywords

Caenorhabditis elegans; Proto oncogene; Ras pathway; Tyrosine kinase; Vulval development

Indexed keywords

ADAPTOR PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHATASE; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE; RAS PROTEIN; RNA;

EID: 0034601059     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.13.3283     Document Type: Article
Times cited : (56)

References (70)
  • 1
    • 0030795612 scopus 로고    scopus 로고
    • The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
    • Alroy, I. and Yarden, Y. (1997) The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett., 410, 83-86.
    • (1997) FEBS Lett. , vol.410 , pp. 83-86
    • Alroy, I.1    Yarden, Y.2
  • 2
    • 0025946824 scopus 로고
    • Multiple functions of let-23, a C. elegans receptor tyrosine kinase gene required for vulval induction
    • Aroian, R.V. and Sternberg, P.W. (1991) Multiple functions of let-23, a C. elegans receptor tyrosine kinase gene required for vulval induction. Genetics, 128, 251-267.
    • (1991) Genetics , vol.128 , pp. 251-267
    • Aroian, R.V.1    Sternberg, P.W.2
  • 3
    • 0025605344 scopus 로고
    • The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
    • Aroian, R.V., Koga, M., Mendel, J.E., Ohshima, Y. and Sternberg, P.W. (1990) The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature, 348, 693-699.
    • (1990) Nature , vol.348 , pp. 693-699
    • Aroian, R.V.1    Koga, M.2    Mendel, J.E.3    Ohshima, Y.4    Sternberg, P.W.5
  • 4
    • 0025226084 scopus 로고
    • The Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction
    • Beitel, G., Clark, S. and Horvitz, H.R. (1990) The Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature, 348, 503-509.
    • (1990) Nature , vol.348 , pp. 503-509
    • Beitel, G.1    Clark, S.2    Horvitz, H.R.3
  • 5
    • 0027732538 scopus 로고
    • Proteins regulating Ras and its relatives
    • Boguski, M.S. and McCormick, F. (1993) Proteins regulating Ras and its relatives. Nature, 366, 643-654.
    • (1993) Nature , vol.366 , pp. 643-654
    • Boguski, M.S.1    McCormick, F.2
  • 6
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • Brenner, S. (1974) The genetics of Caenorhabditis elegans. Genetics, 77, 71-94.
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 7
    • 0027153103 scopus 로고
    • ras through the formation of a complex of receptor, GRB2 adaptor protein and Sos nucleotide exchange factor
    • ras through the formation of a complex of receptor, GRB2 adaptor protein and Sos nucleotide exchange factor. Cell, 73, 611-620.
    • (1993) Cell , vol.73 , pp. 611-620
    • Buday, L.1    Downward, J.2
  • 8
    • 0028857006 scopus 로고
    • Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos
    • Buday, L., Warne, P.H. and Downward, J. (1995) Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos. Oncogene, 11, 1327-1331.
    • (1995) Oncogene , vol.11 , pp. 1327-1331
    • Buday, L.1    Warne, P.H.2    Downward, J.3
  • 9
    • 0027937835 scopus 로고
    • The lin-3/let-23 pathway mediates inductive signaling during male spicule development in Caenorhabditis elegans
    • Chamberlin, H.M. and Sternberg, P.W. (1994) The lin-3/let-23 pathway mediates inductive signaling during male spicule development in Caenorhabditis elegans. Development, 120, 2713-2721.
    • (1994) Development , vol.120 , pp. 2713-2721
    • Chamberlin, H.M.1    Sternberg, P.W.2
  • 10
    • 0033545660 scopus 로고    scopus 로고
    • Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia
    • Chang, C., Newman, A.P. and Sternberg, P.W. (1999) Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia. Curr. Biol., 9, 237-246.
    • (1999) Curr. Biol. , vol.9 , pp. 237-246
    • Chang, C.1    Newman, A.P.2    Sternberg, P.W.3
  • 12
    • 0031081274 scopus 로고    scopus 로고
    • Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites
    • Chen, E.B., Branda, C.S. and Stern, M.J. (1997) Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites. Dev. Biol., 182, 88-100.
    • (1997) Dev. Biol. , vol.182 , pp. 88-100
    • Chen, E.B.1    Branda, C.S.2    Stern, M.J.3
  • 13
    • 0032438571 scopus 로고    scopus 로고
    • Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation
    • Cheng, A.M. et al. (1998) Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell, 95, 793-803.
    • (1998) Cell , vol.95 , pp. 793-803
    • Cheng, A.M.1
  • 14
    • 0029021421 scopus 로고
    • Three genes of the MAP kinase cascade, mek-2, mpk-l/sur-l and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans
    • Church, D., Guan, K.-L. and Lambie, E.J. (1995) Three genes of the MAP kinase cascade, mek-2, mpk-l/sur-l and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans. Development, 121, 2525-2535.
    • (1995) Development , vol.121 , pp. 2525-2535
    • Church, D.1    Guan, K.-L.2    Lambie, E.J.3
  • 15
    • 0032548839 scopus 로고    scopus 로고
    • Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor kinase activation in C. elegans
    • Clandinin, T.R., DeModena, J.A. and Sternberg, P.W. (1998) Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor kinase activation in C. elegans. Cell, 92, 523-533.
    • (1998) Cell , vol.92 , pp. 523-533
    • Clandinin, T.R.1    DeModena, J.A.2    Sternberg, P.W.3
  • 16
    • 0026608178 scopus 로고
    • C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
    • Clark, S.G., Stern, M.J. and Horvitz, H.R. (1992a) C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature, 356, 340-344.
    • (1992) Nature , vol.356 , pp. 340-344
    • Clark, S.G.1    Stern, M.J.2    Horvitz, H.R.3
  • 18
    • 0027935308 scopus 로고
    • The C. elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins
    • Clark, S.G., Lu, X. and Horvitz, H.R. (1994) The C. elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins. Genetics, 137, 987-997.
    • (1994) Genetics , vol.137 , pp. 987-997
    • Clark, S.G.1    Lu, X.2    Horvitz, H.R.3
  • 19
    • 0022065262 scopus 로고
    • Identification and characterization of 22 genes that affect the vulval cell lineages of Caenorhabditis elegans
    • Ferguson, E. and Horvitz, H.R. (1985) Identification and characterization of 22 genes that affect the vulval cell lineages of Caenorhabditis elegans. Genetics, 110, 17-72.
    • (1985) Genetics , vol.110 , pp. 17-72
    • Ferguson, E.1    Horvitz, H.R.2
  • 20
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. and Mello, C.C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391, 806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 21
    • 0032238298 scopus 로고    scopus 로고
    • Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
    • Gu, H.H., Pratt, J.C., Burakoff, S.J. and Neel, B.G. (1998) Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol. Cell, 2, 729-740.
    • (1998) Mol. Cell , vol.2 , pp. 729-740
    • Gu, H.H.1    Pratt, J.C.2    Burakoff, S.J.3    Neel, B.G.4
  • 22
    • 0031830508 scopus 로고    scopus 로고
    • Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction
    • Gu, T., Satoshi, O. and Han, M. (1998) Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. Mol. Cell. Biol., 18, 4556-4564.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4556-4564
    • Gu, T.1    Satoshi, O.2    Han, M.3
  • 23
    • 0032519587 scopus 로고    scopus 로고
    • The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development
    • Gutch, M.J., Flint, A.J., Keller, J., Tonks, N.K. and Hengartner, M.O. (1998) The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Genes Dev., 12, 571-585.
    • (1998) Genes Dev. , vol.12 , pp. 571-585
    • Gutch, M.J.1    Flint, A.J.2    Keller, J.3    Tonks, N.K.4    Hengartner, M.O.5
  • 24
    • 0030774790 scopus 로고    scopus 로고
    • Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase
    • Hajnal, A., Whitfield, C.W. and Kim, S.K. (1997) Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase. Genes Dev., 11, 2715-2728.
    • (1997) Genes Dev. , vol.11 , pp. 2715-2728
    • Hajnal, A.1    Whitfield, C.W.2    Kim, S.K.3
  • 25
    • 0025633434 scopus 로고
    • let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein
    • Han, M. and Sternberg, P.W. (1990) let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein. Cell, 63, 921-931.
    • (1990) Cell , vol.63 , pp. 921-931
    • Han, M.1    Sternberg, P.W.2
  • 26
    • 0025721855 scopus 로고
    • Analysis of dominant negative mutations of the Caenorhabditis elegans let-60 ras gene
    • Han, M. and Sternberg, P.W. (1991) Analysis of dominant negative mutations of the Caenorhabditis elegans let-60 ras gene. Genes Dev., 5, 2188-2198.
    • (1991) Genes Dev. , vol.5 , pp. 2188-2198
    • Han, M.1    Sternberg, P.W.2
  • 27
    • 0027263251 scopus 로고
    • C. elegans lin-45 raf gene participates in let-60 ras stimulated vulval differentiation
    • Han, M., Golden, A., Man, Y. and Sternberg, P.W. (1993) C. elegans lin-45 raf gene participates in let-60 ras stimulated vulval differentiation. Nature, 363, 133-140.
    • (1993) Nature , vol.363 , pp. 133-140
    • Han, M.1    Golden, A.2    Man, Y.3    Sternberg, P.W.4
  • 28
    • 0025332245 scopus 로고
    • The unc-5, unc-6 and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans
    • Hedgecock, E.M., Culotti, J.G. and Hall, D.H. (1990) The unc-5, unc-6 and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron, 4, 61-85.
    • (1990) Neuron , vol.4 , pp. 61-85
    • Hedgecock, E.M.1    Culotti, J.G.2    Hall, D.H.3
  • 29
    • 0028838012 scopus 로고
    • Dimerization of cell surface receptors in signal transduction
    • Heldin, C.-H. (1995) Dimerization of cell surface receptors in signal transduction. Cell, 80, 213-223.
    • (1995) Cell , vol.80 , pp. 213-223
    • Heldin, C.-H.1
  • 30
    • 0030003293 scopus 로고    scopus 로고
    • Daughter of Sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during Sevenless signaling
    • Herbst, R., Carroll, P.M., Allard, J.D., Schilling, J., Raabe, T. and Simon, M.A. (1996) Daughter of Sevenless is a substrate of the phosphotyrosine phosphatase corkscrew and functions during Sevenless signaling. Cell, 85, 899-909.
    • (1996) Cell , vol.85 , pp. 899-909
    • Herbst, R.1    Carroll, P.M.2    Allard, J.D.3    Schilling, J.4    Raabe, T.5    Simon, M.A.6
  • 31
    • 0026763373 scopus 로고
    • The lin-3 gene encodes an inductive signal for vulval development in C. elegans
    • Hill, R.J. and Sternberg, P.W. (1992) The lin-3 gene encodes an inductive signal for vulval development in C. elegans. Nature, 358, 470-476.
    • (1992) Nature , vol.358 , pp. 470-476
    • Hill, R.J.1    Sternberg, P.W.2
  • 32
    • 0033634782 scopus 로고    scopus 로고
    • ARK-1 inhibits EGFR signaling in C. elegans
    • in press
    • Hopper, N.A., Lee, J. and Sternberg, P.W. (2000) ARK-1 inhibits EGFR signaling in C. elegans. Mol. Cell, in press.
    • (2000) Mol. Cell
    • Hopper, N.A.1    Lee, J.2    Sternberg, P.W.3
  • 33
    • 0026423579 scopus 로고
    • Multiple intercellular signalling systems control the development of the C. elegans vulva
    • Horvitz, H.R. and Sternberg, P.W. (1991) Multiple intercellular signalling systems control the development of the C. elegans vulva. Nature, 351, 535-541.
    • (1991) Nature , vol.351 , pp. 535-541
    • Horvitz, H.R.1    Sternberg, P.W.2
  • 34
    • 0030014704 scopus 로고    scopus 로고
    • Sos1 rapidly associates with Grb2 and is hypophosphorylated when complexed with the EGF receptor after EGF stimulation
    • Hu, Y. and Bowtell, D.D. (1996) Sos1 rapidly associates with Grb2 and is hypophosphorylated when complexed with the EGF receptor after EGF stimulation. Oncogene, 12, 1865-1872.
    • (1996) Oncogene , vol.12 , pp. 1865-1872
    • Hu, Y.1    Bowtell, D.D.2
  • 35
    • 0028340308 scopus 로고
    • The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development
    • Huang, L.S., Tzou, P. and Sternberg, P.W. (1994) The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol. Biol. Cell, 5, 395-412.
    • (1994) Mol. Biol. Cell , vol.5 , pp. 395-412
    • Huang, L.S.1    Tzou, P.2    Sternberg, P.W.3
  • 36
    • 0031868411 scopus 로고    scopus 로고
    • Interactions of EGF, Wnt and HOM-C genes specify P12 neuroectoblast fate in C. elegans
    • Jiang, L. and Sternberg, P.W. (1998) Interactions of EGF, Wnt and HOM-C genes specify P12 neuroectoblast fate in C. elegans. Development, 125, 2337-2347.
    • (1998) Development , vol.125 , pp. 2337-2347
    • Jiang, L.1    Sternberg, P.W.2
  • 37
    • 0033536637 scopus 로고    scopus 로고
    • The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
    • Joazeiro, C.A., Wing, S.S., Huang, H., Leverson, J.D., Hunter, T. and Liu, Y.C. (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science, 286, 309-312.
    • (1999) Science , vol.286 , pp. 309-312
    • Joazeiro, C.A.1    Wing, S.S.2    Huang, H.3    Leverson, J.D.4    Hunter, T.5    Liu, Y.C.6
  • 38
    • 0026005522 scopus 로고
    • Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans
    • Johnsen, R.C. and Baillie, D.L. (1991) Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans. Genetics, 129, 735-752.
    • (1991) Genetics , vol.129 , pp. 735-752
    • Johnsen, R.C.1    Baillie, D.L.2
  • 39
    • 0028920694 scopus 로고
    • Sli-1, a negative regulator of let-23-mediated signaling in C. elegans
    • Jongeward, G.D., Clandinin, T.R. and Sternberg, P.W. (1995) sli-1, a negative regulator of let-23-mediated signaling in C. elegans. Genetics, 139, 1553-1566.
    • (1995) Genetics , vol.139 , pp. 1553-1566
    • Jongeward, G.D.1    Clandinin, T.R.2    Sternberg, P.W.3
  • 40
    • 0028596158 scopus 로고
    • An alternative to SH2 domains for binding tyrasine-phosphorylated proteins
    • Kavanaugh, W.M. and Williams, L.T. (1994) An alternative to SH2 domains for binding tyrasine-phosphorylated proteins. Science, 266, 1862-1865.
    • (1994) Science , vol.266 , pp. 1862-1865
    • Kavanaugh, W.M.1    Williams, L.T.2
  • 41
    • 0029067403 scopus 로고
    • PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine
    • Kavanaugh, W.M., Turck, C.W. and Williams, L.T. (1995) PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine. Science, 268, 1177-1179.
    • (1995) Science , vol.268 , pp. 1177-1179
    • Kavanaugh, W.M.1    Turck, C.W.2    Williams, L.T.3
  • 42
    • 0032523935 scopus 로고    scopus 로고
    • Clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans
    • Kokel, M., Borland, C.Z., DeLong, L., Horvitz, H.R. and Stern, M.J. (1998) clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev., 12, 1425-1437.
    • (1998) Genes Dev. , vol.12 , pp. 1425-1437
    • Kokel, M.1    Borland, C.Z.2    DeLong, L.3    Horvitz, H.R.4    Stern, M.J.5
  • 43
    • 0028947528 scopus 로고
    • The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK
    • Kornfeld, K., Guan, K.-L. and Horvitz, H.R. (1995) The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes Dev., 9, 756-768.
    • (1995) Genes Dev. , vol.9 , pp. 756-768
    • Kornfeld, K.1    Guan, K.-L.2    Horvitz, H.R.3
  • 44
    • 0028107517 scopus 로고
    • A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans
    • Lackner, M.R., Kornfeld, K., Miller, L.M., Horvitz, H.R. and Kim, S.K. (1994) A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Genes Dev., 8, 160-173.
    • (1994) Genes Dev. , vol.8 , pp. 160-173
    • Lackner, M.R.1    Kornfeld, K.2    Miller, L.M.3    Horvitz, H.R.4    Kim, S.K.5
  • 45
    • 0028104202 scopus 로고
    • Regulation of signal transduction and signal diversity by receptor oligomerization
    • Lemmon, M.A. and Schlessinger, J. (1994) Regulation of signal transduction and signal diversity by receptor oligomerization. Trends Biochem. Sci., 19, 459-463.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 459-463
    • Lemmon, M.A.1    Schlessinger, J.2
  • 46
    • 0030978136 scopus 로고    scopus 로고
    • Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor
    • Meisner, H., Daga, A., Buxton, J., Fernandez, B., Chawla, A., Banerjee, U. and Czech, M.P. (1997) Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor. Mol. Cell. Biol., 17, 2217-2225.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2217-2225
    • Meisner, H.1    Daga, A.2    Buxton, J.3    Fernandez, B.4    Chawla, A.5    Banerjee, U.6    Czech, M.P.7
  • 47
    • 0029796897 scopus 로고    scopus 로고
    • Coordinated morphogenesis of epithelia during development of the Caenorhabditis elegans uterine-vulval connection
    • Newman, A.P. and Sternberg, P.W. (1996) Coordinated morphogenesis of epithelia during development of the Caenorhabditis elegans uterine-vulval connection. Proc. Natl Acad. Sci. USA, 93, 9329-9333.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 9329-9333
    • Newman, A.P.1    Sternberg, P.W.2
  • 48
    • 0032559211 scopus 로고    scopus 로고
    • Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos
    • Nimnual, A.S., Yatsula, B.A. and Bar-Sagi, D. (1998) Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science, 279, 560-563.
    • (1998) Science , vol.279 , pp. 560-563
    • Nimnual, A.S.1    Yatsula, B.A.2    Bar-Sagi, D.3
  • 49
    • 0027570012 scopus 로고
    • The assembly of signalling complexes by receptor tyrosine kinases
    • Panayotou, G. and Waterfield, M.D. (1993) The assembly of signalling complexes by receptor tyrosine kinases. Bioessays. 15, 171-177.
    • (1993) Bioessays. , vol.15 , pp. 171-177
    • Panayotou, G.1    Waterfield, M.D.2
  • 50
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • Pawson, T. (1995) Protein modules and signalling networks. Nature, 373, 573-580.
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 51
    • 0033032591 scopus 로고    scopus 로고
    • Signaling networks-do all roads lead to the same genes?
    • Pawson, T. and Saxton, T.M. (1999) Signaling networks-do all roads lead to the same genes? Cell, 97, 675-678.
    • (1999) Cell , vol.97 , pp. 675-678
    • Pawson, T.1    Saxton, T.M.2
  • 52
    • 0026777369 scopus 로고
    • A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
    • Pelicci, G. et al. (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell, 70, 93-104.
    • (1992) Cell , vol.70 , pp. 93-104
    • Pelicci, G.1
  • 53
    • 0029984739 scopus 로고    scopus 로고
    • DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between Sevenless and Ras1 in Drosophila
    • Raabe, T., Riesgo-Escovar, J., Liu, X., Bausenwein, B.S., Deak, P., Maröy, P. and Hafen, E. (1996) DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between Sevenless and Ras1 in Drosophila. Cell, 85, 911-920.
    • (1996) Cell , vol.85 , pp. 911-920
    • Raabe, T.1    Riesgo-Escovar, J.2    Liu, X.3    Bausenwein, B.S.4    Deak, P.5    Maröy, P.6    Hafen, E.7
  • 54
    • 0026793456 scopus 로고
    • Growth factor signaling by receptor tyrosine kinases
    • Schlessinger, J. and Ullrich, A. (1992) Growth factor signaling by receptor tyrosine kinases. Neuron, 9, 383-391.
    • (1992) Neuron , vol.9 , pp. 383-391
    • Schlessinger, J.1    Ullrich, A.2
  • 56
    • 0032499688 scopus 로고    scopus 로고
    • Soc-2 encodes a leucine-ricn repeat protein implicated in fibroblast growth factor receptor signaling
    • Selfors, L.M., Schultzman, J.L., Borland, C.Z. and Stern, M.J. (1998) soc-2 encodes a leucine-ricn repeat protein implicated in fibroblast growth factor receptor signaling. Proc. Natl Acad Sci. USA, 95, 6903-6908.
    • (1998) Proc. Natl Acad Sci. USA , vol.95 , pp. 6903-6908
    • Selfors, L.M.1    Schultzman, J.L.2    Borland, C.Z.3    Stern, M.J.4
  • 57
    • 0027213431 scopus 로고
    • Isolation and characterization of mutations causing abnormal eversion of the vulva in Caenorhabditis elegans
    • Seydoux, G., Savage, C. and Greenwald, I. (1993) Isolation and characterization of mutations causing abnormal eversion of the vulva in Caenorhabditis elegans. Dev. Biol., 157, 423-436.
    • (1993) Dev. Biol. , vol.157 , pp. 423-436
    • Seydoux, G.1    Savage, C.2    Greenwald, I.3
  • 58
    • 0033555703 scopus 로고    scopus 로고
    • RNAi and double-strand RNA
    • Sharp, P.A. (1999) RNAi and double-strand RNA. Genes Dev., 13, 139-141.
    • (1999) Genes Dev. , vol.13 , pp. 139-141
    • Sharp, P.A.1
  • 59
    • 0027403027 scopus 로고
    • SH2 domains recognize specific phosphopeptide sequences
    • Songyang, Z. et al. (1993) SH2 domains recognize specific phosphopeptide sequences. Cell, 72, 767-778.
    • (1993) Cell , vol.72 , pp. 767-778
    • Songyang, Z.1
  • 60
    • 0028351583 scopus 로고
    • Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes. GRB-2, HCP, SHC, Syk and Vav
    • Songyang, Z. et al. (1994) Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes. GRB-2, HCP, SHC, Syk and Vav. Mol. Cell. Biol., 14, 2777-2785.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2777-2785
    • Songyang, Z.1
  • 61
    • 0025992127 scopus 로고
    • A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants
    • Stern, M.J. and Horvitz, H.R. (1991) A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants. Development, 113, 797-803.
    • (1991) Development , vol.113 , pp. 797-803
    • Stern, M.J.1    Horvitz, H.R.2
  • 62
    • 0022500775 scopus 로고
    • Pattern formation during vulval development in Caenorhabditis elegans
    • Sternberg, P.W. and Horvitz, H.R. (1986) Pattern formation during vulval development in Caenorhabditis elegans. Cell, 44, 761-772.
    • (1986) Cell , vol.44 , pp. 761-772
    • Sternberg, P.W.1    Horvitz, H.R.2
  • 63
  • 64
    • 0019311310 scopus 로고
    • Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans
    • Sulston, J.E. and White, J.G. (1980) Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans. Dev. Biol., 78, 577-597.
    • (1980) Dev. Biol. , vol.78 , pp. 577-597
    • Sulston, J.E.1    White, J.G.2
  • 65
    • 0029559183 scopus 로고
    • The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in ras-mediated signal transduction
    • Sundaram, M. and Han, M. (1995) The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in ras-mediated signal transduction. Cell, 83, 889-901.
    • (1995) Cell , vol.83 , pp. 889-901
    • Sundaram, M.1    Han, M.2
  • 66
    • 10144220631 scopus 로고    scopus 로고
    • A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans
    • Sundaram, M., Yochem, J. and Han, M. (1996) A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans. Development, 122, 2823-2833.
    • (1996) Development , vol.122 , pp. 2823-2833
    • Sundaram, M.1    Yochem, J.2    Han, M.3
  • 67
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich, A. and Schlessinger, J. (1990) Signal transduction by receptors with tyrosine kinase activity. Cell, 61, 203-212.
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 68
    • 0028180320 scopus 로고
    • Suppression of activated Let-60 Ras protein defines a role of C. elegans Sur-1 MAP kinase in vulval differentiation
    • Wu, Y. and Han, M. (1994) Suppression of activated Let-60 Ras protein defines a role of C. elegans Sur-1 MAP kinase in vulval differentiation. Genes Dev., 8, 147-159.
    • (1994) Genes Dev. , vol.8 , pp. 147-159
    • Wu, Y.1    Han, M.2
  • 69
    • 0028943025 scopus 로고
    • MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events
    • Wu, Y., Han, M. and Guan, K.-L. (1995) MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes Dev., 9, 724-755.
    • (1995) Genes Dev. , vol.9 , pp. 724-755
    • Wu, Y.1    Han, M.2    Guan, K.-L.3
  • 70
    • 0029124883 scopus 로고
    • Similarity of sli-1, a regulator of vulval development in Caenorhabditis elegans, to the mammalian proto-oncogene. c-cbl
    • Yoon, C.H., Lee, J., Jongeward, G.D. and Sternberg, P.W. (1995) Similarity of sli-1, a regulator of vulval development in Caenorhabditis elegans, to the mammalian proto-oncogene. c-cbl. Science, 269, 1102-1105.
    • (1995) Science , vol.269 , pp. 1102-1105
    • Yoon, C.H.1    Lee, J.2    Jongeward, G.D.3    Sternberg, P.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.