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Volumn 59, Issue 13, 2011, Pages 6966-6973

Anthocyanin-rich blackberry extract suppresses the DNA-damaging properties of topoisomerase i and II poisons in colon carcinoma cells

Author keywords

camptothecin; cyanidin; DNA damage; doxorubicin; topoisomerase

Indexed keywords

CAMPTOTHECINS; CYANIDIN; DNA DAMAGE; DOXORUBICIN; TOPOISOMERASES;

EID: 79960035234     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf200379c     Document Type: Article
Times cited : (34)

References (46)
  • 1
    • 27644546239 scopus 로고    scopus 로고
    • Anthocyans from fruits and vegetables - Does bright colour signal cancer chemopreventive activity?
    • DOI 10.1016/j.ejca.2005.06.009
    • Cooke, D.; Steward, W. P.; Gescher, A. J.; Marczylo, T. Anthocyans from fruits and vegetables-Does bright colour signal cancer chemopreventive activity? Eur. J. Cancer 2005, 41, 1931-40 (Pubitemid 41557679)
    • (2005) European Journal of Cancer , vol.41 , Issue.13 , pp. 1931-1940
    • Cooke, D.1    Steward, W.P.2    Gescher, A.J.3    Marczylo, T.4
  • 2
    • 0033915810 scopus 로고    scopus 로고
    • Plant polyphenols in cancer and heart disease: Implications as nutritional antioxidants
    • Duthie, G. G.; Duthie, S. J.; Kyle, J. A. M. Plant polyphenols in cancer and heart disease: Implications as nutritional antioxidants Nutr. Res. Rev. 2000, 13, 79-106 (Pubitemid 30495755)
    • (2000) Nutrition Research Reviews , vol.13 , Issue.1 , pp. 79-106
    • Duthie, G.G.1    Duthie, S.J.2    Kyle, J.A.M.3
  • 3
    • 0027291905 scopus 로고
    • Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands
    • Hertog, M. G.; Hollman, P. C.; Katan, M. B.; Kromhout, D. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands Nutr. Cancer 1993, 20, 21-29 (Pubitemid 23225364)
    • (1993) Nutrition and Cancer , vol.20 , Issue.1 , pp. 21-29
    • Hertog, M.G.L.1    Hollman, P.C.H.2    Katan, M.B.3    Kromhout, D.4
  • 4
    • 33749241899 scopus 로고    scopus 로고
    • Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities
    • DOI 10.1080/10715760600758522, PII NP0262105217K647, Polyphenols and Health
    • Prior, R. L.; Wu, X. Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities Free Radic. Res. 2006, 40, 1014-28 (Pubitemid 44480542)
    • (2006) Free Radical Research , vol.40 , Issue.10 , pp. 1014-1028
    • Prior, R.L.1    Wu, X.2
  • 5
    • 33748849064 scopus 로고    scopus 로고
    • Min mouse model of intestinal carcinogenesis - Relationship with tissue anthocyanin levels
    • DOI 10.1002/ijc.22090
    • Cooke, D.; Schwarz, M.; Boocock, D.; Winterhalter, P.; Steward, W. P.; Gescher, A. J.; Marczylo, T. H. Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis-Relationship with tissue anthocyanin levels Int. J. Cancer 2006, 119, 2213-20 (Pubitemid 44423683)
    • (2006) International Journal of Cancer , vol.119 , Issue.9 , pp. 2213-2220
    • Cooke, D.1    Schwarz, M.2    Boocock, D.3    Winterhalter, P.4    Steward, W.P.5    Gescher, A.J.6    Marczylo, T.H.7
  • 6
    • 0346668337 scopus 로고    scopus 로고
    • Min mice and reduce proliferation of human colon cancer cells
    • DOI 10.1016/S0304-3940(02)00583-9
    • Kang, S. Y.; Seeram, N. P.; Nair, M. G.; Bourquin, L. D. Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells Cancer Lett. 2003, 194, 13-9 (Pubitemid 36428880)
    • (2003) Cancer Letters , vol.194 , Issue.1 , pp. 13-19
    • Kang, S.-Y.1    Seeram, N.P.2    Nair, M.G.3    Bourquin, L.D.4
  • 7
    • 33645902167 scopus 로고    scopus 로고
    • Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo
    • Chen, P. N.; Chu, S. C.; Chiou, H. L.; Chiang, C. L.; Yang, S. F.; Hsieh, Y. S. Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo Nutr. Cancer 2005, 53, 232-243
    • (2005) Nutr. Cancer , vol.53 , pp. 232-243
    • Chen, P.N.1    Chu, S.C.2    Chiou, H.L.3    Chiang, C.L.4    Yang, S.F.5    Hsieh, Y.S.6
  • 8
    • 33745197329 scopus 로고    scopus 로고
    • Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity
    • Ding, M.; Feng, R.; Wang, S. Y.; Bowman, L.; Lu, Y.; Qian, Y.; Castranova, V.; Jiang, B. H.; Shi, X. Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity J. Biol. Chem. 2006, 281, 17359-68
    • (2006) J. Biol. Chem. , vol.281 , pp. 17359-68
    • Ding, M.1    Feng, R.2    Wang, S.Y.3    Bowman, L.4    Lu, Y.5    Qian, Y.6    Castranova, V.7    Jiang, B.H.8    Shi, X.9
  • 10
    • 50549092185 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetables
    • Afaq, F.; Zaman, N.; Khan, N.; Syed, D. N.; Sarfaraz, S.; Zaid, M. A.; Mukhtar, H. Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetables Int. J. Cancer 2008, 123, 1508-15
    • (2008) Int. J. Cancer , vol.123 , pp. 1508-15
    • Afaq, F.1    Zaman, N.2    Khan, N.3    Syed, D.N.4    Sarfaraz, S.5    Zaid, M.A.6    Mukhtar, H.7
  • 11
    • 53249119839 scopus 로고    scopus 로고
    • Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation
    • Fridrich, D.; Teller, N.; Esselen, M.; Pahlke, G.; Marko, D. Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation Mol. Nutr. Food Res. 2008, 52, 815-22
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 815-22
    • Fridrich, D.1    Teller, N.2    Esselen, M.3    Pahlke, G.4    Marko, D.5
  • 13
    • 54249083134 scopus 로고    scopus 로고
    • A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: Involvement of nuclear factor-kappaB signaling
    • Hafeez, B. B.; Siddiqui, I. A.; Asim, M.; Malik, A.; Afaq, F.; Adhami, V. M.; Saleem, M.; Din, M.; Mukhtar, H. A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: Involvement of nuclear factor-kappaB signaling Cancer Res. 2008, 68, 8564-72
    • (2008) Cancer Res. , vol.68 , pp. 8564-72
    • Hafeez, B.B.1    Siddiqui, I.A.2    Asim, M.3    Malik, A.4    Afaq, F.5    Adhami, V.M.6    Saleem, M.7    Din, M.8    Mukhtar, H.9
  • 14
    • 33846131249 scopus 로고    scopus 로고
    • Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro
    • DOI 10.1021/jf061750g
    • Seeram, N. P.; Adams, L. S.; Zhang, Y.; Lee, R.; Sand, D.; Scheuller, H. S.; Heber, D. Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro J. Agric. Food Chem. 2006, 54, 9329-39 (Pubitemid 46086089)
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , Issue.25 , pp. 9329-9339
    • Seeram, N.P.1    Adams, L.S.2    Zhang, Y.3    Lee, R.4    Sand, D.5    Scheuller, H.S.6    Heber, D.7
  • 15
    • 33645765580 scopus 로고    scopus 로고
    • Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols
    • Jo, J. Y.; Gonzalez de Mejia, E.; Lila, M. A. Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols J. Agric. Food Chem. 2006, 54, 2083-7
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 2083-7
    • Jo, J.Y.1    Gonzalez De Mejia, E.2    Lila, M.A.3
  • 17
    • 65949104278 scopus 로고    scopus 로고
    • Delphinidin modulates the DNA-damaging properties of topoisomerase II poisons
    • Esselen, M.; Fritz, J.; Hutter, M.; Marko, D. Delphinidin modulates the DNA-damaging properties of topoisomerase II poisons Chem. Res. Toxicol. 2009, 22, 554-564
    • (2009) Chem. Res. Toxicol. , vol.22 , pp. 554-564
    • Esselen, M.1    Fritz, J.2    Hutter, M.3    Marko, D.4
  • 18
    • 33646240144 scopus 로고    scopus 로고
    • Studies on apple and blueberry fruit constituents: Do the polyphenols reach the colon after ingestion?
    • Kahle, K.; Kraus, M.; Scheppach, W.; Ackermann, M.; Ridder, F.; Richling, E. Studies on apple and blueberry fruit constituents: Do the polyphenols reach the colon after ingestion? Mol. Nutr. Food Res. 2006, 50, 418-423
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 418-423
    • Kahle, K.1    Kraus, M.2    Scheppach, W.3    Ackermann, M.4    Ridder, F.5    Richling, E.6
  • 19
    • 33746878757 scopus 로고    scopus 로고
    • Absorption of anthocyanins from blueberry extracts by Caco-2 human intestinal cell monolayers
    • DOI 10.1021/jf0531959
    • Yi, W.; Akoh, C. C.; Fischer, J.; Krewer, G. Absorption of anthocyanins from blueberry extracts by caco-2 human intestinal cell monolayers J. Agric. Food Chem. 2006, 54, 5651-8 (Pubitemid 44195753)
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , Issue.15 , pp. 5651-5658
    • Yi, W.1    Akoh, C.C.2    Fischer, J.3    Krewer, G.4
  • 20
    • 34948835711 scopus 로고    scopus 로고
    • Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid
    • DOI 10.1002/mnfr.200700004
    • Kern, M.; Fridrich, D.; Reichert, J.; Skrbek, S.; Nussher, A.; Hofem, S.; Vatter, S.; Pahlke, G.; Rüfer, C. E.; Marko, D. Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid Mol. Nutr. Food Res. 2007, 51, 1163-72 (Pubitemid 47522810)
    • (2007) Molecular Nutrition and Food Research , vol.51 , Issue.9 , pp. 1163-1172
    • Kern, M.1    Fridrich, D.2    Reichert, J.3    Skrbek, S.4    Nussher, A.5    Hofem, S.6    Vatter, S.7    Pahlke, G.8    Rufer, C.9    Marke, D.10
  • 21
    • 32344444354 scopus 로고    scopus 로고
    • Stability and biotransformation of various dietary anthocyanins in vitro
    • DOI 10.1007/s00394-005-0557-8
    • Fleschhut, J.; Kratzer, F.; Rechkemmer, G.; Kulling, S. E. Stability and biotransformation of various dietary anthocyanins in vitro Eur. J. Nutr. 2006, 45, 7-18 (Pubitemid 43221279)
    • (2006) European Journal of Nutrition , vol.45 , Issue.1 , pp. 7-18
    • Fleschhut, J.1    Kratzer, F.2    Rechkemmer, G.3    Kulling, S.E.4
  • 22
    • 0034779121 scopus 로고    scopus 로고
    • Degradation products of cyanidin glycosides from tart cherries and their bioactivities
    • DOI 10.1021/jf0107508
    • Seeram, N. P.; Bourquin, L. D.; Nair, M. G. Degradation products of cyanidin glucosides from tart cherries and their bioactivities J. Agric. Food Chem. 2001, 49, 4924-9 (Pubitemid 32988741)
    • (2001) Journal of Agricultural and Food Chemistry , vol.49 , Issue.10 , pp. 4924-4929
    • Seeram, N.P.1    Bourquin, L.D.2    Nair, M.G.3
  • 23
    • 22844442338 scopus 로고    scopus 로고
    • Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora
    • DOI 10.1016/j.bmc.2005.05.003, PII S0968089605003986
    • Keppler, K.; umpf, H. U. Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora Bioorg. Med. Chem. 2005, 13, 5195-205 (Pubitemid 41039980)
    • (2005) Bioorganic and Medicinal Chemistry , vol.13 , Issue.17 , pp. 5195-5205
    • Keppler, K.1    Humpf, H.-U.2
  • 24
    • 67349116818 scopus 로고    scopus 로고
    • Phenolic acids in black raspberry and in the gastrointestinal tract of pigs following ingestion of black raspberry
    • Wu, X.; Pittman, H. E.; Hager, T.; Hager, A.; Howard, L.; Prior, R. L. Phenolic acids in black raspberry and in the gastrointestinal tract of pigs following ingestion of black raspberry Mol. Nutr. Food Res. 2009, 53 (Suppl 1) S76-S84
    • (2009) Mol. Nutr. Food Res. , vol.53 , Issue.SUPPL. 1
    • Wu, X.1    Pittman, H.E.2    Hager, T.3    Hager, A.4    Howard, L.5    Prior, R.L.6
  • 26
    • 0036589809 scopus 로고    scopus 로고
    • Hydrogen peroxide generation in Caco-2 cell culture medium by addition of phenolic compounds: Effect of ascorbic acid
    • DOI 10.1080/10715760290025979
    • Roques, S. C.; Landrault, N.; Teissȩdre, P. L.; Laurent, C.; Besançon, P.; Rouane, J. M.; Caporiccio, B. Hydrogen peroxide generation in caco-2 cell culture medium by addition of phenolic compounds: Effect of ascorbic acid Free Radic. Res. 2002, 36, 593-9 (Pubitemid 36285031)
    • (2002) Free Radical Research , vol.36 , Issue.5 , pp. 593-599
    • Roques, S.C.1    Landrault, N.2    Teissedre, P.-L.3    Laurent, C.4    Besancon, P.5    Rouanet, J.-M.6    Caporiccio, B.7
  • 27
    • 0034709554 scopus 로고    scopus 로고
    • Artifacts in cell culture: Rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media
    • DOI 10.1006/bbrc.2000.2895
    • Long, L. H.; Clement, M. V.; Halliwell, B. Artifacts in cell culture: Rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media Biochem. Biophys. Res. Commun. 2000, 273, 50-3 (Pubitemid 30426861)
    • (2000) Biochemical and Biophysical Research Communications , vol.273 , Issue.1 , pp. 50-53
    • Long, L.H.1    Clement, M.V.2    Halliwell, B.3
  • 28
    • 0142125716 scopus 로고    scopus 로고
    • Factors affecting the ascorbate- and phenolic-dependent generation of hydrogen peroxide in Dulbecco's Modified Eagles Medium
    • DOI 10.1080/10715760310001607041
    • Wee, L. M.; Long, L. H.; Whiteman, M.; Halliwell, B. Factors affecting the ascorbate-and phenolic-dependent generation of hydrogen peroxide in Dulbeccos modified Eagle's medium Free Radic. Res. 2003, 37, 1123-30 (Pubitemid 37265335)
    • (2003) Free Radical Research , vol.37 , Issue.10 , pp. 1123-1130
    • Wee, L.M.1    Long, L.H.2    Whiteman, M.3    Halliwell, B.4
  • 32
    • 67149133494 scopus 로고    scopus 로고
    • Three-year comparison of the polyphenol content and the antioxidant capacity in organically and conventionally produced apples (Malus domestica Bork., cultivar Golden Delicious)
    • Stracke, B. A.; Rüfer, C. E.; Weibel, F. P.; Bub, A.; Watzl, B. Three-year comparison of the polyphenol content and the antioxidant capacity in organically and conventionally produced apples (Malus domestica Bork., cultivar Golden Delicious) J. Agric. Food Chem. 2009, 57, 4598-605
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 4598-605
    • Stracke, B.A.1    Rüfer, C.E.2    Weibel, F.P.3    Bub, A.4    Watzl, B.5
  • 33
    • 77955926305 scopus 로고    scopus 로고
    • No effect of the farming system (organic/conventional) on the bioavailability of polyphenols from apples (Malus domestica Bork., cultivar Golden Delicious) in healthy men-A comparative study
    • Stracke, B. A.; Rüfer, C. E.; Bub, A.; Seifert, S.; Weibel, F. P.; Kunz, C.; Watzl, B. No effect of the farming system (organic/conventional) on the bioavailability of polyphenols from apples (Malus domestica Bork., cultivar Golden Delicious) in healthy men-A comparative study Eur. J. Nutr. 2010, 4, 301-10
    • (2010) Eur. J. Nutr. , vol.4 , pp. 301-10
    • Stracke, B.A.1    Rüfer, C.E.2    Bub, A.3    Seifert, S.4    Weibel, F.P.5    Kunz, C.6    Watzl, B.7
  • 35
    • 0032460862 scopus 로고    scopus 로고
    • Measuring oxidative damage to DNA; HPLC and the comet assay compared
    • Gedik, C. M.; Wood, S. G.; Collins, A. R. Measuring oxidative damage to DNA; HPLC and the comet assay compared Free Radic Res. 1998, 29, 609-15 (Pubitemid 29112731)
    • (1998) Free Radical Research , vol.29 , Issue.6 , pp. 609-615
    • Gedik, C.M.1    Wood, S.G.2    Collins, A.R.3
  • 36
    • 9944249485 scopus 로고    scopus 로고
    • The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation
    • DOI 10.1002/mnfr.200400034
    • Marko, D.; Puppel, N.; Tjaden, Z.; Jakobs, S.; Pahlke, G. The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation Mol. Nutr. Food Res. 2004, 48, 318-25 (Pubitemid 39592264)
    • (2004) Molecular Nutrition and Food Research , vol.48 , Issue.4 , pp. 318-325
    • Marko, D.1    Puppel, N.2    Tjaden, Z.3    Jakobs, S.4    Pahlke, G.5
  • 37
    • 0037229268 scopus 로고    scopus 로고
    • Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins
    • Katsube, N.; Iwashita, K.; Tsushida, T.; Yamaki, K.; Kobori, M. Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins J. Agric. Food Chem. 2003, 51, 68-75
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 68-75
    • Katsube, N.1    Iwashita, K.2    Tsushida, T.3    Yamaki, K.4    Kobori, M.5
  • 38
    • 9344256065 scopus 로고    scopus 로고
    • Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels
    • Olsson, M. E.; Gustavsson, K. E.; Andersson, S.; Nilsson, A.; Duan, R. D. Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels J. Agric. Food Chem. 2004, 52, 7264-71
    • (2004) J. Agric. Food Chem. , vol.52 , pp. 7264-71
    • Olsson, M.E.1    Gustavsson, K.E.2    Andersson, S.3    Nilsson, A.4    Duan, R.D.5
  • 39
    • 67649202443 scopus 로고    scopus 로고
    • Anthocyanin stability and recovery: Implications for the analysis of clinical and experimental samples
    • Woodward, G.; Kroon, P.; Cassidy, A.; Kay, C. Anthocyanin stability and recovery: Implications for the analysis of clinical and experimental samples J. Agric. Food Chem. 2009, 57, 5271-5278
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 5271-5278
    • Woodward, G.1    Kroon, P.2    Cassidy, A.3    Kay, C.4
  • 40
    • 43149124005 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases
    • DOI 10.1021/tx700434v
    • Bandele, O. J.; Osheroff, N. (-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases Chem. Res. Toxicol. 2008, 21, 936-43 (Pubitemid 351644572)
    • (2008) Chemical Research in Toxicology , vol.21 , Issue.4 , pp. 936-943
    • Bandele, O.J.1    Osheroff, N.2
  • 41
    • 43849086499 scopus 로고    scopus 로고
    • The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines
    • Schmidt, F.; Knobbe, C. B.; Frank, B.; Wolburg, H.; Weller, M. The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines Oncol. Rep. 2008, 19, 1061-6 (Pubitemid 351802681)
    • (2008) Oncology Reports , vol.19 , Issue.4 , pp. 1061-1066
    • Schmidt, F.1    Knobbe, C.B.2    Frank, B.3    Wolburg, H.4    Weller, M.5
  • 42
    • 79957806456 scopus 로고    scopus 로고
    • Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human cancer cells
    • Esselen, M.; Fritz, J.; Hutter, M.; Teller, N.; Marczylo, T. H.; Gescher, A. J.; Marko, D. Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human cancer cells. Mol. Nutr. Food Res. 2011, 55 (Suppl 1), S143-53.
    • (2011) Mol. Nutr. Food Res. , vol.55 , Issue.SUPPL. 1 , pp. 143-53
    • Esselen, M.1    Fritz, J.2    Hutter, M.3    Teller, N.4    Marczylo, T.H.5    Gescher, A.J.6    Marko, D.7
  • 43
    • 34250897841 scopus 로고    scopus 로고
    • The epidermal growth factor receptor and human topoisomerases represent potential cellular targets of oligomeric procyanidins
    • DOI 10.1002/mnfr.200600186
    • Fridrich, D.; Kern, M.; Fritz, J.; Pahlke, G.; Köhler, N.; Winterhalter, P.; Marko, D. The epidermal growth factor receptor and human topoisomerases represent potential cellular targets of oligomeric procyanidins Mol. Nutr. Food Res. 2007, 51, 192-200 (Pubitemid 47083250)
    • (2007) Molecular Nutrition and Food Research , vol.51 , Issue.2 , pp. 192-200
    • Fridrich, D.1    Kern, M.2    Fritz, J.3    Pahlke, G.4    Kohler, N.5    Winterhalter, P.6    Marko, D.7
  • 44
    • 41849137615 scopus 로고    scopus 로고
    • Influence of alternative liquid chromatography techniques on the chemical complexity and bioactivity of isolated proanthocyanidin mixtures
    • DOI 10.1021/jf073001k
    • Alwerdt, J. L.; Seigler, D. S.; Gonzalez de Mejia, E.; Yousef, G. G.; Lila, M. A. Influence of alternative liquid chromatography techniques on the chemical complexity and bioactivity of isolated proanthocyanidin mixtures J. Agric. Food Chem. 2008, 56, 1896-906 (Pubitemid 351497844)
    • (2008) Journal of Agricultural and Food Chemistry , vol.56 , Issue.6 , pp. 1896-1906
    • Alwerdt, J.L.1    Seigler, D.S.2    De Mejia, E.G.3    Yousef, G.G.4    Lila, M.A.5
  • 45
    • 33646240144 scopus 로고    scopus 로고
    • Studies on apple and blueberry fruit constituents: Do the polyphenols reach the colon after ingestion?
    • Kahle, K.; Kraus, M.; Scheppach, W.; Ackermann, M.; Ridder, F.; Richling, E. Studies on apple and blueberry fruit constituents: Do the polyphenols reach the colon after ingestion? Mol. Nutr. Food Res. 2006, 50, 418-423
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 418-423
    • Kahle, K.1    Kraus, M.2    Scheppach, W.3    Ackermann, M.4    Ridder, F.5    Richling, E.6
  • 46
    • 77952923632 scopus 로고    scopus 로고
    • Phenolic content and antioxidant activity of raspberry and blackberry cultivars
    • Sariburun, E.; Sahin, S.; Demir, C.; Türkben, C.; Uylaşer, V. Phenolic content and antioxidant activity of raspberry and blackberry cultivars J. Food Sci. 2010, 75, 328-335
    • (2010) J. Food Sci. , vol.75 , pp. 328-335
    • Sariburun, E.1    Sahin, S.2    Demir, C.3    Türkben, C.4    Uylaşer, V.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.