Anthocyanidins modulate the activity of human DNA topoisomerases I and II and affect cellular DNA integrity

Chemical Research in Toxicology

Volumn 18, Issue 9, 2005, Pages 1395-1404

  Habermeyer, Michael ^a   Fritz, Jessica ^b   Barthelmes, Hans U ^c   Christensen, Morten O ^c   Larsen, Morten K ^d,e   Boege, Fritz ^c   Marko, Doris ^b  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b UNIVERSITY OF KARLSRUHE   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d AARHUS UNIVERSITY   (Denmark)

^e UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANTHOCYANIDIN DERIVATIVE; ANTHOCYANIN; CELL DNA; CYANIDIN CHLORIDE; DELPHINIDIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; ETHIDIUM BROMIDE; MALVIDIN CHLORIDE; PAEONIDIN; PELARGONIDIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERCALATION COMPLEX;

ANTHOCYANINS; BISBENZIMIDE; CAMPTOTHECIN; CATALYSIS; CELL LINE; COMET ASSAY; DNA; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; ETHIDIUM; HUMANS; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS;

EID: 25444459913     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx050039n     Document Type: Article

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