The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines

Oncology Reports

Volumn 19, Issue 4, 2008, Pages 1061-1066

  Schmidt, Friederike ^a   Knobbe, Christiane B ^a   Frank, Brigitte ^a   Wolburg, Hartwig ^b   Weller, Michael ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Apoptosis; Differentiation; Genistein; Glioma; Isoflavones

Indexed keywords

CASPASE 8 INHIBITOR; CASPASE INHIBITOR; CISPLATIN; CYTARABINE; CYTOKINE RESPONSE MODIFIER A; DNA TOPOISOMERASE (ATP HYDROLYSING); FAS LIGAND; GENISTEIN; GYRASE INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME; KETONE DERIVATIVE; LACTATE DEHYDROGENASE; LOMUSTINE; MUTANT PROTEIN; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; TENIPOSIDE; THYMIDINE DERIVATIVE; TOPOTECAN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ENZYME INHIBITOR;

APOPTOSIS; ARTICLE; ASTROCYTE; CANCER CELL; CANCER INHIBITION; CARCINOMA CELL; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRUCTURE; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; ELECTRON MICROSCOPY; ENZYME INHIBITION; ENZYME RELEASE; ENZYME SUBSTRATE; GLIOMA CELL; HUMAN; HUMAN CELL; MITOCHONDRION SWELLING; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; WILD TYPE; CELL DIVISION; CELL SURVIVAL; DRUG ANTAGONISM; GLIOMA; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; G2 PHASE; GENISTEIN; GLIOMA; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 43849086499     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: 10.3892/or.19.4.1061     Document Type: Article

References (23)

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