메뉴 건너뛰기




Volumn 24, Issue 7, 2011, Pages 932-943

Genetic and epigenetic changes in lung carcinoma and their clinical implications

Author keywords

epigenomic alterations; genomic alterations; lung cancer; molecular testing; tumor markers

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; MICRORNA; PROTEIN KINASE LKB1; PROTEIN P53;

EID: 79959945851     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2011.46     Document Type: Review
Times cited : (61)

References (158)
  • 3
    • 34848837026 scopus 로고    scopus 로고
    • Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    • DOI 10.1378/chest.07-1347
    • Alberg AJ, Ford JG, Samet JM, American College of Chest P. Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 2007;132:29S-55S. (Pubitemid 47502798)
    • (2007) Chest , vol.132 , Issue.3 SUPPL.
    • Alberg, A.J.1    Ford, J.G.2    Samet, J.M.3
  • 12
    • 26444596500 scopus 로고    scopus 로고
    • Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: Association with smoking, TP53, and survival
    • DOI 10.1016/j.cancergencyto.2005.04.001, PII S0165460805002049
    • Marsit CJ, Wiencke JK, Nelson HH, et al. Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: association with smoking, TP53, and survival. Cancer Genet Cytogenet 2005;162: 115-121. (Pubitemid 41423467)
    • (2005) Cancer Genetics and Cytogenetics , vol.162 , Issue.2 , pp. 115-121
    • Marsit, C.J.1    Wiencke, J.K.2    Nelson, H.H.3    Kim, D.-H.4    Hinds, P.W.5    Aldape, K.6    Kelsey, K.T.7
  • 13
    • 16444374716 scopus 로고    scopus 로고
    • Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer
    • DOI 10.1158/0008-5472.CAN-04-3297
    • Pan H, Califano J, Ponte JF, et al. Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer. Cancer Res 2005;65:1664-1669. (Pubitemid 40478590)
    • (2005) Cancer Research , vol.65 , Issue.5 , pp. 1664-1669
    • Pan, H.1    Califano, J.2    Ponte, J.F.3    Russo, A.L.4    Cheng, K.-H.5    Thiagalingam, A.6    Nemani, P.7    Sidransky, D.8    Thiagalingam, S.9
  • 14
    • 0032080899 scopus 로고    scopus 로고
    • Chromosome 3p14 alterations in lung cancer: Evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos
    • Nelson HH, Wiencke JK, Gunn L, et al. Chromosome 3p14 alterations in lung cancer: evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos. Cancer Res 1998;58:1804-1807. (Pubitemid 28217450)
    • (1998) Cancer Research , vol.58 , Issue.9 , pp. 1804-1807
    • Nelson, H.H.1    Wiencke, J.K.2    Gunn, L.3    Wain, J.C.4    Christiani, D.C.5    Kelsey, K.T.6
  • 16
    • 33644697320 scopus 로고    scopus 로고
    • Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokers
    • Grepmeier U, Dietmaier W, Merk J, et al. Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokers. Int J Oncol 2005;27:481-488.
    • (2005) Int J Oncol , vol.27 , pp. 481-488
    • Grepmeier, U.1    Dietmaier, W.2    Merk, J.3
  • 17
    • 58149376465 scopus 로고    scopus 로고
    • The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development
    • Sharp TV, Al-Attar A, Foxler DE, et al. The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development. Proc Natl Acad Sci USA 2008;105:19932-19937.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19932-19937
    • Sharp, T.V.1    Al-Attar, A.2    Foxler, D.E.3
  • 18
    • 58149134374 scopus 로고    scopus 로고
    • 3p22.1 and 10q22.3 deletions detected by fluorescence in situ hybridization (FISH): A potential new tool for early detection of non-small cell lung cancer (NSCLC)
    • Yendamuri S, Vaporciyan AA, Zaidi T, et al. 3p22.1 and 10q22.3 deletions detected by fluorescence in situ hybridization (FISH): a potential new tool for early detection of non-small cell lung cancer (NSCLC). J Thorac Oncol 2008;3:979-984.
    • (2008) J Thorac Oncol , vol.3 , pp. 979-984
    • Yendamuri, S.1    Vaporciyan, A.A.2    Zaidi, T.3
  • 19
    • 63449140725 scopus 로고    scopus 로고
    • Genomic profiles associated with early micrometastasis in lung cancer: Relevance of 4q deletion
    • Wrage M, Ruosaari S, Eijk PP, et al. Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletion. Clin Cancer Res 2009;15:1566-1574.
    • (2009) Clin Cancer Res , vol.15 , pp. 1566-1574
    • Wrage, M.1    Ruosaari, S.2    Eijk, P.P.3
  • 21
    • 25444439612 scopus 로고    scopus 로고
    • Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer
    • Tseng RC, Chang JW, Hsien FJ, et al. Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancer. Int J Cancer 2005;117:241-247.
    • (2005) Int J Cancer , vol.117 , pp. 241-247
    • Tseng, R.C.1    Chang, J.W.2    Hsien, F.J.3
  • 22
    • 33947502512 scopus 로고    scopus 로고
    • Lung cancer in never smokers: A review
    • DOI 10.1200/JCO.2006.06.8015
    • Subramanian J, Govindan R. Lung cancer in never smokers: a review. J Clin Oncol 2007;25:561-570. (Pubitemid 350002964)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.5 , pp. 561-570
    • Subramanian, J.1    Govindan, R.2
  • 23
    • 0031758362 scopus 로고    scopus 로고
    • A specific spectrum of p53 mutations in lung cancer from smokers: Review of mutations compiled in the IARC p53 database
    • Hernandez-Boussard TM, Hainaut P. A specific spectrum of P53 mutations in lung cancer from smokers: review of mutations compiled in the IARC P53 database. Environ Health Perspect 1998;106: 385-391. (Pubitemid 28524103)
    • (1998) Environmental Health Perspectives , vol.106 , Issue.7 , pp. 385-391
    • Hernandez-Boussard, T.M.1    Hainaut, P.2
  • 24
    • 0029990683 scopus 로고    scopus 로고
    • The role of individual susceptibility in cancer burden related to environmental exposure
    • Bartsch H, Hietanen E. The role of individual susceptibility in cancer burden related to environmental exposure. Environ Health Perspect 1996; 104(Suppl 3):569-577. (Pubitemid 26196406)
    • (1996) Environmental Health Perspectives , vol.104 , Issue.SUPPL. 3 , pp. 569-577
    • Bartsch, H.1    Hietanen, E.2
  • 26
    • 0142027533 scopus 로고    scopus 로고
    • P53 gene mutations in non-small cell lung cancer detected by polymerase chain reaction single-strand conformation polymorphism analysis
    • Zhao Y, Wu D, Xiang X, et al. P53 gene mutations in non-small cell lung cancer detected by polymerase chain reaction single-strand conformation polymorphism analysis. Chin Med Sci J 1999;14: 134-137.
    • (1999) Chin Med Sci J , vol.14 , pp. 134-137
    • Zhao, Y.1    Wu, D.2    Xiang, X.3
  • 27
    • 0034124449 scopus 로고    scopus 로고
    • Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer
    • Ahrendt SA, Chow JT, Yang SC, et al. alcohol consumption and cigarette smoking increase the frequency of P53 mutations in non-small cell lung cancer. Cancer Res 2000;60:3155-3159. (Pubitemid 30407910)
    • (2000) Cancer Research , vol.60 , Issue.12 , pp. 3155-3159
    • Ahrendt, S.A.1    Chow, J.T.2    Yang, S.C.3    Wu, L.4    Zhang, M.-J.5    Jen, J.6    Sidransky, D.7
  • 33
    • 67649185268 scopus 로고    scopus 로고
    • Potential increase in the prognostic value of P53 mutation by Pro72 allele in stage i non-small-cell lung cancer
    • Chien WP,Wong RH,Wu TC, et al. Potential increase in the prognostic value of P53 mutation by Pro72 allele in stage I non-small-cell lung cancer. Ann Surg Oncol 2009;16:1918-1924.
    • (2009) Ann Surg Oncol , vol.16 , pp. 1918-1924
    • Chien, W.P.1    Wong, R.H.2    Wu, T.C.3
  • 34
    • 61549091557 scopus 로고    scopus 로고
    • Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma
    • Kosaka T, Yatabe Y, Onozato R, et al. Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma. J Thorac Oncol 2009;4:22-29.
    • (2009) J Thorac Oncol , vol.4 , pp. 22-29
    • Kosaka, T.1    Yatabe, Y.2    Onozato, R.3
  • 35
    • 61549108028 scopus 로고    scopus 로고
    • Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, P53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC)
    • Lim EH, Zhang SL, Li JL, et al. Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, P53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC). J Thorac Oncol 2009;4: 12-21.
    • (2009) J Thorac Oncol , vol.4 , pp. 12-21
    • Lim, E.H.1    Zhang, S.L.2    Li, J.L.3
  • 37
    • 48849105881 scopus 로고    scopus 로고
    • FHIT and P53 status and response to platinum-based treatment in advanced non-small cell lung cancer
    • Cortinovis DL, Andriani F, Livio A, et al. FHIT and P53 status and response to platinum-based treatment in advanced non-small cell lung cancer. Curr Cancer Drug Targets 2008;8:342-348.
    • (2008) Curr Cancer Drug Targets , vol.8 , pp. 342-348
    • Cortinovis, D.L.1    Andriani, F.2    Livio, A.3
  • 39
    • 33947498978 scopus 로고    scopus 로고
    • Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer
    • DOI 10.1200/JCO.2006.07.3585
    • Sequist LV, Bell DW, Lynch TJ, et al. Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol 2007;25:587-595. (Pubitemid 350002967)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.5 , pp. 587-595
    • Sequist, L.V.1    Bell, D.W.2    Lynch, T.J.3    Haber, D.A.4
  • 41
    • 28444478439 scopus 로고    scopus 로고
    • Oncogenic transformation by inhibitor-sensitive and-resistant EGFR mutants
    • Greulich H, Chen TH, Feng W, et al. Oncogenic transformation by inhibitor-sensitive and-resistant EGFR mutants. PLoS Med 2005;2:E313.
    • (2005) PLoS Med , vol.2
    • Greulich, H.1    Chen, T.H.2    Feng, W.3
  • 43
    • 33744814638 scopus 로고    scopus 로고
    • Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors
    • DOI 10.1101/gad.1417406
    • Politi K, Zakowski MF, Fan PD, et al. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to downregulation of the receptors. Genes Dev 2006;20: 1496-1510. (Pubitemid 43830656)
    • (2006) Genes and Development , vol.20 , Issue.11 , pp. 1496-1510
    • Politi, K.1    Zakowski, M.F.2    Fan, P.-D.3    Schonfeld, E.A.4    Pao, W.5    Varmus, H.E.6
  • 44
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in national cancer institute of Canada clinical trials group study BR21
    • Zhu CQ, Da Cunha Santos G, Ding K, et al. Role of KRAS and EGFR as biomarkers of response to erlotinib in national cancer institute of Canada clinical trials group study BR21. J Clin Oncol 2008;26:4268-4275.
    • (2008) J Clin Oncol , vol.26 , pp. 4268-4275
    • Zhu, C.Q.1    Da Cunha Santos, G.2    Ding, K.3
  • 45
    • 22044454824 scopus 로고    scopus 로고
    • EGFR mutation conferring primary resistance to gefitinib in nonsmall-cell lung cancer
    • Shih JY, Gow CH, Yang PC. EGFR mutation conferring primary resistance to gefitinib in nonsmall-cell lung cancer. N Engl J Med 2005;353: 207-208.
    • (2005) N Engl J Med , vol.353 , pp. 207-208
    • Shih, J.Y.1    Gow, C.H.2    Yang, P.C.3
  • 46
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:E73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 49
    • 70349464846 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway
    • Nguyen KS, Kobayashi S, Costa DB. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin Lung Cancer 2009;10: 281-289.
    • (2009) Clin Lung Cancer , vol.10 , pp. 281-289
    • Nguyen, K.S.1    Kobayashi, S.2    Costa, D.B.3
  • 51
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 2007;104:20932-20937.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3
  • 52
    • 34250165729 scopus 로고    scopus 로고
    • Downstream intracellular effectors of epidermal growth factor receptor as targets for anticancer therapy
    • DOI 10.1517/14728222.11.6.771
    • Milano A, De Rosa V, Iaffaioli RV, et al. Downstream intracellular effectors of epidermal growth factor receptor as targets for anticancer therapy. Expert Opin Ther Targets 2007;11:771-782. (Pubitemid 46901396)
    • (2007) Expert Opinion on Therapeutic Targets , vol.11 , Issue.6 , pp. 771-782
    • Milano, A.1    De Rosa, V.2    Iaffaioli, R.V.3    Caponigro, F.4
  • 54
    • 33646716077 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors
    • Ji H, Zhao X, Yuza Y, et al. Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci USA 2006;103: 7817-7822.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7817-7822
    • Ji, H.1    Zhao, X.2    Yuza, Y.3
  • 55
    • 0025708183 scopus 로고
    • P185neu expression in human lung adenocarcinomas predicts shortened survival
    • Kern JA, Schwartz DA, Nordberg JE, et al. P185neu expression in human lung adenocarcinomas predicts shortened survival. Cancer Res 1990;50: 5184-5187.
    • (1990) Cancer Res , vol.50 , pp. 5184-5187
    • Kern, J.A.1    Schwartz, D.A.2    Nordberg, J.E.3
  • 56
    • 0026549424 scopus 로고
    • Overexpression of the C-Erbb-2/Neu-encoded P185 protein in primary lung cancer
    • Shi D, He G, Cao S, et al. Overexpression of the C-Erbb-2/Neu-encoded P185 protein in primary lung cancer. Mol Carcinog 1992;5:213-218.
    • (1992) Mol Carcinog , vol.5 , pp. 213-218
    • Shi, D.1    He, G.2    Cao, S.3
  • 58
    • 4944232647 scopus 로고    scopus 로고
    • Lung cancer: Intragenic ERBB2 kinase mutations in tumours
    • Stephens P, Hunter C, Bignell G, et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 2004;431:525-526.
    • (2004) Nature , vol.431 , pp. 525-526
    • Stephens, P.1    Hunter, C.2    Bignell, G.3
  • 60
    • 33745727112 scopus 로고    scopus 로고
    • HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
    • Wang SE, Narasanna A, Perez-Torres M, et al. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell 2006;10:25-38.
    • (2006) Cancer Cell , vol.10 , pp. 25-38
    • Wang, S.E.1    Narasanna, A.2    Perez-Torres, M.3
  • 61
    • 0032898582 scopus 로고    scopus 로고
    • Expression of P185erbb-2, P160erbb-3, P180erbb-4, and heregulin alpha in human normal bronchial epithelial and lung cancer cell lines
    • Al Moustafa AE, Alaoui-Jamali M, Paterson J, et al. Expression Of P185erbb-2, P160erbb-3, P180erbb-4, and heregulin alpha in human normal bronchial epithelial and lung cancer cell lines. Anticancer Res 1999;19:481-486.
    • (1999) Anticancer Res , vol.19 , pp. 481-486
    • Al Moustafa, A.E.1    Alaoui-Jamali, M.2    Paterson, J.3
  • 63
    • 33745206339 scopus 로고    scopus 로고
    • Erbb4 increases the proliferation potential of human lung cancer cells and its blockage can be used as a target for anti-cancer therapy
    • Starr A, Greif J, Vexler A, et al. Erbb4 increases the proliferation potential of human lung cancer cells and its blockage can be used as a target for anti-cancer therapy. Int J Cancer 2006;119: 269-274.
    • (2006) Int J Cancer , vol.119 , pp. 269-274
    • Starr, A.1    Greif, J.2    Vexler, A.3
  • 64
    • 33644515295 scopus 로고    scopus 로고
    • Somatic mutations of the ERBB4 kinase domain in human cancers
    • Soung YH, Lee JW, Kim SY, et al. Somatic mutations of the ERBB4 kinase domain in human cancers. Int J Cancer 2006;118:1426-1429.
    • (2006) Int J Cancer , vol.118 , pp. 1426-1429
    • Soung, Y.H.1    Lee, J.W.2    Kim, S.Y.3
  • 65
    • 33751573874 scopus 로고    scopus 로고
    • ERBB3 kinase domain mutations are rare in lung, breast and colon carcinomas
    • Jeong EG, Soung YH, Lee JW, et al. ERBB3 kinase domain mutations are rare in lung, breast and colon carcinomas. Int J Cancer 2006;119:2986-2987.
    • (2006) Int J Cancer , vol.119 , pp. 2986-2987
    • Jeong, E.G.1    Soung, Y.H.2    Lee, J.W.3
  • 68
    • 16644401351 scopus 로고    scopus 로고
    • Risk for K-Ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms
    • Noda N, Matsuzoe D, Konno T, et al. Risk for K-Ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms. Oncol Rep 2004;12:773-779.
    • (2004) Oncol Rep , vol.12 , pp. 773-779
    • Noda, N.1    Matsuzoe, D.2    Konno, T.3
  • 70
    • 21244500107 scopus 로고    scopus 로고
    • Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas
    • Soung YH, Lee JW, Kim SY, et al. Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas. Virchows Arch 2005;446:483-488.
    • (2005) Virchows Arch , vol.446 , pp. 483-488
    • Soung, Y.H.1    Lee, J.W.2    Kim, S.Y.3
  • 72
    • 0025851146 scopus 로고
    • Relationship between K-Ras oncogene activation and smoking in adenocarcinoma of the human lung
    • Slebos RJ, Hruban RH, Dalesio O, et al. Relationship between K-Ras oncogene activation and smoking in adenocarcinoma of the human lung. J Natl Cancer Inst 1991;83:1024-1027.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 1024-1027
    • Slebos, R.J.1    Hruban, R.H.2    Dalesio, O.3
  • 73
    • 0027166695 scopus 로고
    • K-ras oncogene activation in lung adenocarcinomas from former smokers: Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung
    • Westra WH, Slebos RJ, Offerhaus GJ, et al. K-Ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that k-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung. Cancer 1993;72: 432-438. (Pubitemid 23193449)
    • (1993) Cancer , vol.72 , Issue.2 , pp. 432-438
    • Westra, W.H.1    Slebos, R.J.C.2    Offerhaus, G.J.A.3    Goodman, S.N.4    Evers, S.G.5    Kensler, T.W.6    Askin, F.B.7    Rodenhuis, S.8    Hruban, R.H.9
  • 75
    • 33646345615 scopus 로고    scopus 로고
    • Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer
    • DOI 10.1002/cncr.21853
    • Suzuki M, Shigematsu H, Iizasa T, et al. Exclusive mutation in epidermal growth factor receptor gene, HER-2, And KRAS, and synchronous methylation of nonsmall cell lung cancer. Cancer 2006;106: 2200-2207. (Pubitemid 43673242)
    • (2006) Cancer , vol.106 , Issue.10 , pp. 2200-2207
    • Suzuki, M.1    Shigematsu, H.2    Iizasa, T.3    Hiroshima, K.4    Nakatani, Y.5    Minna, J.D.6    Gazdar, A.F.7    Fujisawa, T.8
  • 77
    • 0026356298 scopus 로고
    • Selective targeting of P53 gene mutational hotspots in human cancers by etiologically defined carcinogens
    • Puisieux A, Lim S, Groopman J, et al. Selective targeting of P53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res 1991;51:6185-6189.
    • (1991) Cancer Res , vol.51 , pp. 6185-6189
    • Puisieux, A.1    Lim, S.2    Groopman, J.3
  • 78
    • 53249145767 scopus 로고    scopus 로고
    • Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
    • Riely GJ, Kris MG, Rosenbaum D, et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res 2008;14:5731-5734.
    • (2008) Clin Cancer Res , vol.14 , pp. 5731-5734
    • Riely, G.J.1    Kris, M.G.2    Rosenbaum, D.3
  • 79
    • 0024376173 scopus 로고
    • Ras Oncogenes in human cancer: A review
    • Bos JL. Ras oncogenes in human cancer: a review. Cancer Res 1989;49:4682-4689. (Pubitemid 19213607)
    • (1989) Cancer Research , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 81
    • 56749176442 scopus 로고    scopus 로고
    • LKB1; Linking cell structure and tumor suppression
    • Hezel AF, Bardeesy N. LKB1; linking cell structure and tumor suppression. Oncogene 2008;27: 6908-6919.
    • (2008) Oncogene , vol.27 , pp. 6908-6919
    • Hezel, A.F.1    Bardeesy, N.2
  • 83
    • 2542590883 scopus 로고    scopus 로고
    • Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene
    • DOI 10.1038/sj.onc.1207502
    • Carretero J, Medina PP, Pio R, et al. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 2004;23:4037-4040. (Pubitemid 38747933)
    • (2004) Oncogene , vol.23 , Issue.22 , pp. 4037-4040
    • Carretero, J.1    Medina, P.P.2    Pio, R.3    Montuenga, L.M.4    Sanchez-Cespedes, M.5
  • 86
    • 34748845413 scopus 로고    scopus 로고
    • Prevalence and specificity of LKB1 genetic alterations in lung cancers
    • Matsumoto S, Iwakawa R, Takahashi K, et al. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 2007;26: 5911-5918.
    • (2007) Oncogene , vol.26 , pp. 5911-5918
    • Matsumoto, S.1    Iwakawa, R.2    Takahashi, K.3
  • 88
    • 48549098388 scopus 로고    scopus 로고
    • Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
    • Choi YL, Takeuchi K, Soda M, et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res 2008;68:4971-4976.
    • (2008) Cancer Res , vol.68 , pp. 4971-4976
    • Choi, Y.L.1    Takeuchi, K.2    Soda, M.3
  • 89
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • McDermott U, Iafrate AJ, Gray NS, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res 2008;68:3389-3395.
    • (2008) Cancer Res , vol.68 , pp. 3389-3395
    • McDermott, U.1    Iafrate, A.J.2    Gray, N.S.3
  • 91
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 2009;27:4247-4253.
    • (2009) J Clin Oncol , vol.27 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 92
    • 47649105190 scopus 로고    scopus 로고
    • EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas
    • Shinmura K, Kageyama S, Tao H, et al. EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, Or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. Lung Cancer 2008;61:163-169.
    • (2008) Lung Cancer , vol.61 , pp. 163-169
    • Shinmura, K.1    Kageyama, S.2    Tao, H.3
  • 93
    • 69349083935 scopus 로고    scopus 로고
    • Unique clinicopathologic features characterize ALKrearranged lung adenocarcinoma in the western population
    • Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicopathologic features characterize ALKrearranged lung adenocarcinoma in the western population. Clin Cancer Res 2009;15:5216-5223.
    • (2009) Clin Cancer Res , vol.15 , pp. 5216-5223
    • Rodig, S.J.1    Mino-Kenudson, M.2    Dacic, S.3
  • 94
    • 77149130499 scopus 로고    scopus 로고
    • Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene
    • Takahashi T, Sonobe M, Kobayashi M, et al. Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene. Ann Surg Oncol 2010;17:889-897.
    • (2010) Ann Surg Oncol , vol.17 , pp. 889-897
    • Takahashi, T.1    Sonobe, M.2    Kobayashi, M.3
  • 95
    • 59649127007 scopus 로고    scopus 로고
    • EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues
    • Martelli MP, Sozzi G, Hernandez L, et al. EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues. Am J Pathol 2009; 174:661-670.
    • (2009) Am J Pathol , vol.174 , pp. 661-670
    • Martelli, M.P.1    Sozzi, G.2    Hernandez, L.3
  • 96
    • 37549060017 scopus 로고    scopus 로고
    • EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers
    • Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol 2008;3: 13-17.
    • (2008) J Thorac Oncol , vol.3 , pp. 13-17
    • Inamura, K.1    Takeuchi, K.2    Togashi, Y.3
  • 99
    • 33646427172 scopus 로고    scopus 로고
    • Aberrant promoter methylation of P16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients
    • Liu Y, Lan Q, Siegfried JM, et al. Aberrant promoter methylation of P16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. Neoplasia 2006;8:46-51.
    • (2006) Neoplasia , vol.8 , pp. 46-51
    • Liu, Y.1    Lan, Q.2    Siegfried, J.M.3
  • 100
    • 58249098396 scopus 로고    scopus 로고
    • Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors
    • Vaissiere T, Hung RJ, Zaridze D, et al. Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors. Cancer Res 2009;69:243-252.
    • (2009) Cancer Res , vol.69 , pp. 243-252
    • Vaissiere, T.1    Hung, R.J.2    Zaridze, D.3
  • 101
    • 77449124527 scopus 로고    scopus 로고
    • PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage i and II nonsmall cell lung cancer patients
    • Buckingham L, Penfield Faber L, Kim A, et al. PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patients. Int J Cancer 2010;126:1630-1639.
    • (2010) Int J Cancer , vol.126 , pp. 1630-1639
    • Buckingham, L.1    Penfield Faber, L.2    Kim, A.3
  • 102
    • 34548277011 scopus 로고    scopus 로고
    • Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers
    • Kaira K, Sunaga N, Tomizawa Y, et al. Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers. Int J Oncol 2007;31:169-173.
    • (2007) Int J Oncol , vol.31 , pp. 169-173
    • Kaira, K.1    Sunaga, N.2    Tomizawa, Y.3
  • 103
    • 67650164499 scopus 로고    scopus 로고
    • Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers
    • Tessema M, Yu YY, Stidley CA, et al. Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers. Carcinogenesis 2009;30:1132-1138.
    • (2009) Carcinogenesis , vol.30 , pp. 1132-1138
    • Tessema, M.1    Yu, Y.Y.2    Stidley, C.A.3
  • 104
    • 70349774795 scopus 로고    scopus 로고
    • RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not P16ink4a, DAPK1, PTEN and MT1G genes were frequently methylated in the stage i non-small cell lung cancer in China
    • Lin Q, Geng J, Ma K, et al. RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not P16ink4a, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. J Cancer Res Clin Oncol 2009;135:1675-1684.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 1675-1684
    • Lin, Q.1    Geng, J.2    Ma, K.3
  • 108
    • 70449592216 scopus 로고    scopus 로고
    • Promoter hypermethylation of the P16 and Wif-1 genes as an independent prognostic marker in Stage IA non-small cell lung cancers
    • Yoshino M, Suzuki M, Tian L, et al. Promoter hypermethylation of the P16 and Wif-1 genes as an independent prognostic marker in Stage IA non-small cell lung cancers. Int J Oncol 2009;35:1201-1209.
    • (2009) Int J Oncol , vol.35 , pp. 1201-1209
    • Yoshino, M.1    Suzuki, M.2    Tian, L.3
  • 109
    • 51049091703 scopus 로고    scopus 로고
    • Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis
    • Suzuki M, Mohamed S, Nakajima T, et al. Aberrant methylation of CXCL12 in non-small cell lung cancer is associated with an unfavorable prognosis. Int J Oncol 2008;33:113-119.
    • (2008) Int J Oncol , vol.33 , pp. 113-119
    • Suzuki, M.1    Mohamed, S.2    Nakajima, T.3
  • 110
    • 48249117114 scopus 로고    scopus 로고
    • DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma
    • Seng TJ, Currey N, Cooper WA, et al. DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma. Br J Cancer 2008;99:375-382.
    • (2008) Br J Cancer , vol.99 , pp. 375-382
    • Seng, T.J.1    Currey, N.2    Cooper, W.A.3
  • 111
    • 34548513807 scopus 로고    scopus 로고
    • Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers
    • DOI 10.1016/j.lungcan.2007.05.011, PII S0169500207003157
    • Yanagawa N, Tamura G, Oizumi H, et al. Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. Lung Cancer 2007;58:131-138. (Pubitemid 47379969)
    • (2007) Lung Cancer , vol.58 , Issue.1 , pp. 131-138
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3    Kanauchi, N.4    Endoh, M.5    Sadahiro, M.6    Motoyama, T.7
  • 114
    • 33644824212 scopus 로고    scopus 로고
    • 14-3-3sigma methylation in pretreatment serum circulating DNA of cisplatin-plus-gemcitabine-treated advanced non-small-cell lung cancer patients predicts survival: The Spanish lung cancer group
    • Ramirez JL, Rosell R, Taron M, et al. 14-3-3sigma methylation in pretreatment serum circulating DNA of cisplatin-plus-gemcitabine-treated advanced non-small-cell lung cancer patients predicts survival: the Spanish lung cancer group. J Clin Oncol 2005;23:9105-9112.
    • (2005) J Clin Oncol , vol.23 , pp. 9105-9112
    • Ramirez, J.L.1    Rosell, R.2    Taron, M.3
  • 115
    • 34247265566 scopus 로고    scopus 로고
    • Identification of epigenetic aberrant promoter methylation of RASSF1A in serum DNA and its clinicopathological significance in lung cancer
    • DOI 10.1016/j.lungcan.2006.12.007, PII S0169500206006520
    • Wang Y, Yu Z, Wang T, et al. Identification of epigenetic aberrant promoter methylation of RASSF1A in serum DNA and its clinicopathological significance in lung cancer. Lung Cancer 2007;56: 289-294. (Pubitemid 46613917)
    • (2007) Lung Cancer , vol.56 , Issue.2 , pp. 289-294
    • Wang, Y.1    Yu, Z.2    Wang, T.3    Zhang, J.4    Hong, L.5    Chen, L.6
  • 116
    • 33645967485 scopus 로고    scopus 로고
    • Methylation of RAS association domain family protein 1A as a biomarker of lung cancer
    • Grote HJ, Schmiemann V, Geddert H, et al. Methylation of RAS association domain family protein 1A as a biomarker of lung cancer. Cancer 2006;108:129-134.
    • (2006) Cancer , vol.108 , pp. 129-134
    • Grote, H.J.1    Schmiemann, V.2    Geddert, H.3
  • 119
    • 33645521023 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort
    • Belinsky SA, Liechty KC, Gentry FD, et al. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res 2006;66:3338-3344.
    • (2006) Cancer Res , vol.66 , pp. 3338-3344
    • Belinsky, S.A.1    Liechty, K.C.2    Gentry, F.D.3
  • 120
    • 33846111256 scopus 로고    scopus 로고
    • Alteration of DNA methyltransferases contributes to 50cpg methylation and poor prognosis in lung cancer
    • Lin RK, Hsu HS, Chang JW, et al. Alteration of DNA methyltransferases contributes to 50cpg methylation and poor prognosis in lung cancer. Lung Cancer 2007;55:205-213.
    • (2007) Lung Cancer , vol.55 , pp. 205-213
    • Lin, R.K.1    Hsu, H.S.2    Chang, J.W.3
  • 121
    • 76649112380 scopus 로고    scopus 로고
    • The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients
    • Lin RK, Hsieh YS, Lin P, et al. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J Clin Invest 2010;120:521-532.
    • (2010) J Clin Invest , vol.120 , pp. 521-532
    • Lin, R.K.1    Hsieh, Y.S.2    Lin, P.3
  • 122
    • 43649106748 scopus 로고    scopus 로고
    • Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer
    • DOI 10.1038/sj.bjc.6604343, PII 6604343
    • Xing J, Stewart DJ, Gu J, et al. Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. Br J Cancer 2008;98:1716-1722. (Pubitemid 351684678)
    • (2008) British Journal of Cancer , vol.98 , Issue.10 , pp. 1716-1722
    • Xing, J.1    Stewart, D.J.2    Gu, J.3    Lu, C.4    Spitz, M.R.5    Wu, X.6
  • 123
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • DOI 10.1038/nrg2005, PII NRG2005
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 2007;8:286-298. (Pubitemid 46439286)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.4 , pp. 286-298
    • Esteller, M.1
  • 125
    • 65649142216 scopus 로고    scopus 로고
    • Global levels of histone modifications predict prognosis in different cancers
    • Seligson DB, Horvath S, Mcbrian MA, et al. Global levels of histone modifications predict prognosis in different cancers. Am J Pathol 2009;174:1619-1628.
    • (2009) Am J Pathol , vol.174 , pp. 1619-1628
    • Seligson, D.B.1    Horvath, S.2    McBrian, M.A.3
  • 127
    • 61849144810 scopus 로고    scopus 로고
    • HDAC family: What are the cancer relevant targets?
    • Witt O, Deubzer HE, Milde T, et al. HDAC family: what are the cancer relevant targets? Cancer Lett 2009;277:8-21.
    • (2009) Cancer Lett , vol.277 , pp. 8-21
    • Witt, O.1    Deubzer, H.E.2    Milde, T.3
  • 129
    • 22044434278 scopus 로고    scopus 로고
    • Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma
    • DOI 10.1016/j.lungcan.2005.02.006, PII S0169500205001078
    • Bartling B, Hofmann HS, Boettger T, et al. Comparative application of antibody and gene array for expression profiling in human squamous cell lung carcinoma. Lung Cancer 2005;49:145-154. (Pubitemid 40966741)
    • (2005) Lung Cancer , vol.49 , Issue.2 , pp. 145-154
    • Bartling, B.1    Hofmann, H.-S.2    Boettger, T.3    Hansen, G.4    Burdach, S.5    Silber, R.-E.6    Simm, A.7
  • 130
    • 4544322261 scopus 로고    scopus 로고
    • Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients
    • DOI 10.1002/ijc.20395
    • Osada H, Tatematsu Y, Saito H, et al. Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients. Int J Cancer 2004;112:26-32. (Pubitemid 39249488)
    • (2004) International Journal of Cancer , vol.112 , Issue.1 , pp. 26-32
    • Osada, H.1    Tatematsu, Y.2    Saito, H.3    Yatabe, Y.4    Mitsudomi, T.5    Takahashi, T.6
  • 131
    • 15044343269 scopus 로고    scopus 로고
    • Suppression of phosphatidylinositol 3-kinase/Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor, FK228, in lung adenocarcinoma cells
    • Kodani M, Igishi T, Matsumoto S, et al. Suppression of phosphatidylinositol 3-kinase/Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor, FK228, in lung adenocarcinoma cells. Oncol Rep 2005;13:477-483.
    • (2005) Oncol Rep , vol.13 , pp. 477-483
    • Kodani, M.1    Igishi, T.2    Matsumoto, S.3
  • 132
    • 34347261742 scopus 로고    scopus 로고
    • Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells
    • Yu XD, Wang SY, Chen GA, et al. Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells. Cancer J 2007;13:105-113.
    • (2007) Cancer J , vol.13 , pp. 105-113
    • Yu, X.D.1    Wang, S.Y.2    Chen, G.A.3
  • 133
    • 33644688961 scopus 로고    scopus 로고
    • Induction of apoptosis by Trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of Cyclooxygenase-2 activity in human non-small cell lung cancer cells
    • Choi YH. Induction of apoptosis by Trichostatin A, a histone deacetylase inhibitor, is associated with inhibition of Cyclooxygenase-2 activity in human non-small cell lung cancer cells. Int J Oncol 2005;27:473-479.
    • (2005) Int J Oncol , vol.27 , pp. 473-479
    • Choi, Y.H.1
  • 135
    • 30544445468 scopus 로고    scopus 로고
    • Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
    • DOI 10.1038/sj.onc.1209049, PII 1209049
    • Ota H, Tokunaga E, Chang K, et al. Sirt1 inhibitor, sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 2006;25:176-185. (Pubitemid 43083679)
    • (2006) Oncogene , vol.25 , Issue.2 , pp. 176-185
    • Ota, H.1    Tokunaga, E.2    Chang, K.3    Hikasa, M.4    Iijima, K.5    Eto, M.6    Kozaki, K.7    Akishita, M.8    Ouchi, Y.9    Kaneki, M.10
  • 136
    • 0038819943 scopus 로고    scopus 로고
    • Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-κB through the Akt pathway
    • DOI 10.1074/jbc.M211695200
    • Mayo MW, Denlinger CE, Broad RM, et al. Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway. J Biol Chem 2003;278:18980-18989. (Pubitemid 36799282)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.21 , pp. 18980-18989
    • Mayo, M.W.1    Denlinger, C.E.2    Broad, R.M.3    Yeung, F.4    Reilly, E.T.5    Shi, Y.6    Jones, D.R.7
  • 137
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • DOI 10.1038/nrc1997, PII NRC1997
    • Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-866. (Pubitemid 44629897)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 138
    • 66049084202 scopus 로고    scopus 로고
    • Mir-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo
    • Liu B, Peng XC, Zheng XL, et al. Mir-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer 2009;66:169-175.
    • (2009) Lung Cancer , vol.66 , pp. 169-175
    • Liu, B.1    Peng, X.C.2    Zheng, X.L.3
  • 139
    • 77951154173 scopus 로고    scopus 로고
    • MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors
    • Liu X, Sempere LF, Ouyang H, et al. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest 2010;120:1298-1309.
    • (2010) J Clin Invest , vol.120 , pp. 1298-1309
    • Liu, X.1    Sempere, L.F.2    Ouyang, H.3
  • 140
    • 77950799838 scopus 로고    scopus 로고
    • MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis
    • Cha ST, Chen PS, Johansson G, et al. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res 2010;70: 2675-2685.
    • (2010) Cancer Res , vol.70 , pp. 2675-2685
    • Cha, S.T.1    Chen, P.S.2    Johansson, G.3
  • 141
    • 70350326303 scopus 로고    scopus 로고
    • Let-7a elevates P21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells
    • He X, Duan C, Chen J, et al. Let-7a elevates P21(WAF1) levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells. FEBS Lett 2009;583:3501-3507.
    • (2009) FEBS Lett , vol.583 , pp. 3501-3507
    • He, X.1    Duan, C.2    Chen, J.3
  • 142
    • 69549101926 scopus 로고    scopus 로고
    • MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer
    • Crawford M, Batte K, Yu L, et al. MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. Biochem Biophys Res Commun 2009;388:483-489.
    • (2009) Biochem Biophys Res Commun , vol.388 , pp. 483-489
    • Crawford, M.1    Batte, K.2    Yu, L.3
  • 143
    • 67650422613 scopus 로고    scopus 로고
    • Mir-15a and Mir-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer
    • Bandi N, Zbinden S, Gugger M, et al. Mir-15a and Mir-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res 2009;69:5553-5559.
    • (2009) Cancer Res , vol.69 , pp. 5553-5559
    • Bandi, N.1    Zbinden, S.2    Gugger, M.3
  • 144
    • 53949115677 scopus 로고    scopus 로고
    • MicroRNA-183 regulates ezrin expression in lung cancer cells
    • Wang G, Mao W, Zheng S. MicroRNA-183 regulates ezrin expression in lung cancer cells. FEBS Lett 2008;582:3663-3668.
    • (2008) FEBS Lett , vol.582 , pp. 3663-3668
    • Wang, G.1    Mao, W.2    Zheng, S.3
  • 145
    • 48949115082 scopus 로고    scopus 로고
    • MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines
    • Crawford M, Brawner E, Batte K, et al. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun 2008;373: 607-612.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 607-612
    • Crawford, M.1    Brawner, E.2    Batte, K.3
  • 146
    • 73949116135 scopus 로고    scopus 로고
    • Mir-126 inhibits nonsmall cell lung cancer cells proliferation by targeting EGFL7
    • Sun Y, Bai Y, Zhang F, et al. Mir-126 inhibits nonsmall cell lung cancer cells proliferation by targeting EGFL7. Biochem Biophys Res Commun 2010;391: 1483-1489.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1483-1489
    • Sun, Y.1    Bai, Y.2    Zhang, F.3
  • 147
    • 74549118209 scopus 로고    scopus 로고
    • Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach
    • Bishop JA, Benjamin H, Cholakh H, et al. Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach. Clin Cancer Res 2010;16:610-619.
    • (2010) Clin Cancer Res , vol.16 , pp. 610-619
    • Bishop, J.A.1    Benjamin, H.2    Cholakh, H.3
  • 148
    • 65349166324 scopus 로고    scopus 로고
    • Diagnostic assay based on Hsa-Mir-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma
    • Lebanony D, Benjamin H, Gilad S, et al. Diagnostic assay based on Hsa-Mir-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. J Clin Oncol 2009;27:2030-2037.
    • (2009) J Clin Oncol , vol.27 , pp. 2030-2037
    • Lebanony, D.1    Benjamin, H.2    Gilad, S.3
  • 149
    • 54049115558 scopus 로고    scopus 로고
    • Prognostic value of mature microRNA-21 and micro-RNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR
    • Markou A, Tsaroucha EG, Kaklamanis L, et al. Prognostic value of mature microRNA-21 and micro-RNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR. Clin Chem 2008;54:1696-1704.
    • (2008) Clin Chem , vol.54 , pp. 1696-1704
    • Markou, A.1    Tsaroucha, E.G.2    Kaklamanis, L.3
  • 150
    • 72449187466 scopus 로고    scopus 로고
    • Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer
    • Xie Y, Todd NW, Liu Z, et al. Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer. Lung Cancer 2010;67:170-176.
    • (2010) Lung Cancer , vol.67 , pp. 170-176
    • Xie, Y.1    Todd, N.W.2    Liu, Z.3
  • 152
    • 70849087385 scopus 로고    scopus 로고
    • Mir-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer
    • Gallardo E, Navarro A, Vinolas N, et al. Mir-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. Carcinogenesis 2009;30: 1903-1909.
    • (2009) Carcinogenesis , vol.30 , pp. 1903-1909
    • Gallardo, E.1    Navarro, A.2    Vinolas, N.3
  • 153
    • 67651002796 scopus 로고    scopus 로고
    • MicroRNA classifiers for predicting prognosis of squamous cell lung cancer
    • Raponi M, Dossey L, Jatkoe T, et al. MicroRNA classifiers for predicting prognosis of squamous cell lung cancer. Cancer Res 2009;69:5776-5783.
    • (2009) Cancer Res , vol.69 , pp. 5776-5783
    • Raponi, M.1    Dossey, L.2    Jatkoe, T.3
  • 155
    • 37349096992 scopus 로고    scopus 로고
    • MicroRNA signature predicts survival and relapse in lung cancer
    • Yu SL, Chen HY, Chang GC, et al. MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell 2008;13:48-57.
    • (2008) Cancer Cell , vol.13 , pp. 48-57
    • Yu, S.L.1    Chen, H.Y.2    Chang, G.C.3
  • 156
    • 77950498821 scopus 로고    scopus 로고
    • Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer
    • Hu Z, Chen X, Zhao Y, et al. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol 2010;28: 1721-1726.
    • (2010) J Clin Oncol , vol.28 , pp. 1721-1726
    • Hu, Z.1    Chen, X.2    Zhao, Y.3
  • 158
    • 77349125581 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition in lung cancer: The evolving role of individualized therapy
    • Gazdar AF. Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy. Cancer Metastasis Rev 2010;29:37-48.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 37-48
    • Gazdar, A.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.