Prognostic significance of molecular genetic aberrations on chromosome segment 11p15.5 in Non-small-cell lung cancer

Journal of Clinical Oncology

Volumn 20, Issue 5, 2002, Pages 1353-1360

  Bepler, Gerold ^a   Gautam, Ashish ^a   McIntyre, Lauren M ^a   Beck, Amy F ^a   Chervinsky, David S ^a   Kim, Young Chul ^a   Pitterle, Diana M ^a   Hyland, Andrew ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER MORTALITY; CANCER STAGING; CHROMOSOME 11P; CHROMOSOME ABERRATION; CONTROLLED STUDY; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; TREATMENT PLANNING;

CARCINOMA, NON-SMALL-CELL LUNG; CHROMOSOMES, HUMAN, PAIR 11; FEMALE; HUMANS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROGNOSIS; REGRESSION ANALYSIS; SURVIVAL RATE;

EID: 0036498729     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.20.5.1353     Document Type: Article

References (47)

1. Cancer statistics, 2001
2. Treatment of stage I and II disease
3. Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small cell lung cancer without overt metastases
4. 18F-fluoro-2-deoxyglucose- positron emission tomography scan in non-small-cell lung cancer: An analysis of 125 cases
5. Do molecular markers predict survival in non-small-cell lung cancer
6. Analysis of neuroendocrine markers, HER2 and CEA before and after chemotherapy in patients with stage IIIA non-small cell lung cancer: A Cancer and Leukemia Group B study
7. MCM2 is an independent predictor of survival in patients with non-small-cell lung cancer
8. Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung
9. p53 immunostaining positivity is associated with reduced survival and is imperfectly correlated with gene mutations in resected non-small cell lung cancer: A preliminary report of LCSG 871
10. K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer
11. Alterations of expression of rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance
12. Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small cell lung cancer on E4592: A laboratory ancillary study on an Eastern Cooperative Oncology Group prospective randomized trial of postoperative adjuvant therapy
13. Angiogenesis and molecular biologic sub-staging in patients with stage I non-small cell lung cancer
14. Expression of plasminogen activator inhibitors 1 and 2 in lung cancer and their role in tumor progression
15. Vascular endothelial growth factor 189 mRNA isoform expression specifically correlates with tumor angiogenesis, patient survival, and postoperative relapse in non-small-cell lung cancer
16. Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease
17. Homology-directed repair is a major double-strand break repair pathway in mammalian cells
18. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma
19. Loss of genes on the short arm of chromosome 11 in human lung carcinomas
20. Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung
21. Allelic loss on the short arm of chromosome 11 in non-small cell lung cancer
22. Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancer
23. Correlation of loss of heterozygosity at 11p with tumour progression and survival in non-small cell lung cancer
24. High-density marker analysis of 11p15.5 in non-small cell lung carcinomas reveals allelic deletion of one shared and one distinct region when compared to breast carcinomas
25. A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region
26. Transcript map and complete genomic sequence for the 310 kb region of minimal allele loss on chromosome segment 11p15.5 in non-small-cell lung cancer
27. Lung cancer and the human gene for ribonucleotide reductase subunit MI (RRM1)
28. Revisions in the international system for staging lung cancer
29. Epidemiology of tobacco use and dependence
30. Reduced survival in patients with stage-I non-small-cell lung cancer associated with DNA-replication errors
31. Prognostic markers in resected stage I and II non-small-cell lung cancer: An analysis of 260 patients with 5 year follow-up
32. p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features
33. neu expression in human lung adenocarcinomas predicts shortened survival
34. Expression of blood-group antigen A: A favorable prognostic factor in non-small-cell lung cancer
35. INK4a expression in lung adenocarcinoma
36. Smoking, gender, and survival association with allele loss for the LOH 11B lung cancer region on chromosome 11
37. Microsatellite alterations at 5q21, 11p13, and 11p15.5 do not predict survival in non-small cell lung cancer
38. Loss of heterozygosity at 3p in non-small cell lung cancer and its prognostic implication
39. Correlation of abnormal RBp16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers
40. Tumor progression and loss of heterozygosity at 5q and 18q in non-small cell lung cancer
41. The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments
42. Tumor suppressor activity of RRMI in lung cancer
43. Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer
44. Growth inhibition of a human lung adenocarcinoma cell line by genetic complementation with chromosome 11
45. Allelic loss of chromosome 18q and prognosis in colorectal cancer
46. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma