메뉴 건너뛰기




Volumn 8, Issue 1, 2011, Pages

Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: Relevance to neural disorders

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 GUANIDINOBUTYRIC ACID; AMINO ACID TRANSPORTER; ARGININE; ASPARTIC ACID; CREATINE; CREATINE PHOSPHATE; CREATINE TRANSPORTER; CREATININE; DEXTRO ASPARTIC ACID; GLUTAMIC ACID; GLYCINE; GLYCINE AMIDINOTRANSFERASE; GUANIDINE DERIVATIVE; GUANIDINOACETATE METHYLTRANSFERASE; GUANIDINOACETIC ACID; GUANIDINOPROPIONIC ACID; GUANIDINOSUCCINIC ACID; METHYLGUANIDINE; ORGANIC CATION TRANSPORTER; S ADENOSYLMETHIONINE; SERINE; TAURINE; TAURINE TRANSPORTER; UNCLASSIFIED DRUG;

EID: 79959944962     PISSN: None     EISSN: 20458118     Source Type: Journal    
DOI: 10.1186/2045-8118-8-13     Document Type: Review
Times cited : (65)

References (87)
  • 1
    • 0037304972 scopus 로고    scopus 로고
    • A role for guanidino compounds in the brain
    • 10.1023/A:1022491419813, 12701810
    • Hiramatsu M. A role for guanidino compounds in the brain. Mol Cell Biochem 2003, 244:57-62. 10.1023/A:1022491419813, 12701810.
    • (2003) Mol Cell Biochem , vol.244 , pp. 57-62
    • Hiramatsu, M.1
  • 2
    • 0022636387 scopus 로고
    • Comparative study of guanidino compounds in serum and brain of mouse, rat, rabbit, and man
    • 10.1111/j.1471-4159.1986.tb13030.x, 3950603
    • Marescau B, De Deyn P, Wiechert P, Van Gorp L, Lowenthal A. Comparative study of guanidino compounds in serum and brain of mouse, rat, rabbit, and man. J Neurochem 1986, 46:717-720. 10.1111/j.1471-4159.1986.tb13030.x, 3950603.
    • (1986) J Neurochem , vol.46 , pp. 717-720
    • Marescau, B.1    De Deyn, P.2    Wiechert, P.3    Van Gorp, L.4    Lowenthal, A.5
  • 3
    • 0026723952 scopus 로고
    • Guanidino compounds in serum, urine, liver, kidney, and brain of man and some ureotelic animals
    • 10.1016/0026-0495(92)90213-T, 1588833
    • Marescau B, Deshmukh DR, Kockx M, Possemiers I, Qureshi IA, Wiechert P, De Deyn PP. Guanidino compounds in serum, urine, liver, kidney, and brain of man and some ureotelic animals. Metabolism 1992, 41:526-532. 10.1016/0026-0495(92)90213-T, 1588833.
    • (1992) Metabolism , vol.41 , pp. 526-532
    • Marescau, B.1    Deshmukh, D.R.2    Kockx, M.3    Possemiers, I.4    Qureshi, I.A.5    Wiechert, P.6    De Deyn, P.P.7
  • 4
    • 0033935979 scopus 로고    scopus 로고
    • Creatine and creatinine metabolism
    • Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 2000, 80:1107-1213.
    • (2000) Physiol Rev , vol.80 , pp. 1107-1213
    • Wyss, M.1    Kaddurah-Daouk, R.2
  • 5
    • 4644290559 scopus 로고    scopus 로고
    • A new in vitro model for blood-cerebrospinal fluid barrier transport studies: an immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat
    • 10.1016/j.addr.2004.07.013, 15381338
    • Hosoya K, Hori S, Ohtsuki S, Terasaki T. A new in vitro model for blood-cerebrospinal fluid barrier transport studies: an immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat. Adv Drug Deliv Rev 2004, 56:1875-1885. 10.1016/j.addr.2004.07.013, 15381338.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1875-1885
    • Hosoya, K.1    Hori, S.2    Ohtsuki, S.3    Terasaki, T.4
  • 6
    • 34547632714 scopus 로고    scopus 로고
    • Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development
    • 10.1007/s11095-007-9374-5, 17619998
    • Ohtsuki S, Terasaki T. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm Res 2007, 24:1745-1758. 10.1007/s11095-007-9374-5, 17619998.
    • (2007) Pharm Res , vol.24 , pp. 1745-1758
    • Ohtsuki, S.1    Terasaki, T.2
  • 7
    • 43849095420 scopus 로고    scopus 로고
    • Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology
    • full_text, 18652076
    • Stockler S, Schutz PW, Salomons GS. Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology. Subcell Biochem 2007, 46:149-166. full_text, 18652076.
    • (2007) Subcell Biochem , vol.46 , pp. 149-166
    • Stockler, S.1    Schutz, P.W.2    Salomons, G.S.3
  • 8
    • 3242725272 scopus 로고    scopus 로고
    • Creatine and guanidinoacetate: diagnostic markers for inborn errors in creatine biosynthesis and transport
    • 10.1016/j.ymgme.2004.05.001, 15234334
    • Almeida LS, Verhoeven NM, Roos B, Valongo C, Cardoso ML, Vilarinho L, Salomons GS, Jakobs C. Creatine and guanidinoacetate: diagnostic markers for inborn errors in creatine biosynthesis and transport. Mol Genet Metab 2004, 82:214-219. 10.1016/j.ymgme.2004.05.001, 15234334.
    • (2004) Mol Genet Metab , vol.82 , pp. 214-219
    • Almeida, L.S.1    Verhoeven, N.M.2    Roos, B.3    Valongo, C.4    Cardoso, M.L.5    Vilarinho, L.6    Salomons, G.S.7    Jakobs, C.8
  • 9
    • 0034077740 scopus 로고    scopus 로고
    • Reversible brain creatine deficiency in two sisters with normal blood creatine level
    • 10.1002/1531-8249(200004)47:4<511::AID-ANA15>3.0.CO;2-N, 10762163
    • Bianchi MC, Tosetti M, Fornai F, Alessandri MG, Cipriani P, De Vito G, Canapicchi R. Reversible brain creatine deficiency in two sisters with normal blood creatine level. Ann Neurol 2000, 47:511-513. 10.1002/1531-8249(200004)47:4<511::AID-ANA15>3.0.CO;2-N, 10762163.
    • (2000) Ann Neurol , vol.47 , pp. 511-513
    • Bianchi, M.C.1    Tosetti, M.2    Fornai, F.3    Alessandri, M.G.4    Cipriani, P.5    De Vito, G.6    Canapicchi, R.7
  • 12
    • 0034987448 scopus 로고    scopus 로고
    • X-linked creatine-transporter gene (SLC6A8) defect: a new creatine-deficiency syndrome
    • 10.1086/320595, 1226136, 11326334
    • Salomons GS, van Dooren SJ, Verhoeven NM, Cecil KM, Ball WS, Degrauw TJ, Jakobs C. X-linked creatine-transporter gene (SLC6A8) defect: a new creatine-deficiency syndrome. Am J Hum Genet 2001, 68:1497-1500. 10.1086/320595, 1226136, 11326334.
    • (2001) Am J Hum Genet , vol.68 , pp. 1497-1500
    • Salomons, G.S.1    van Dooren, S.J.2    Verhoeven, N.M.3    Cecil, K.M.4    Ball, W.S.5    Degrauw, T.J.6    Jakobs, C.7
  • 13
    • 0035008935 scopus 로고    scopus 로고
    • Clinical pharmacology of the dietary supplement creatine monohydrate
    • Persky AM, Brazeau GA. Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol Rev 2001, 53:161-176.
    • (2001) Pharmacol Rev , vol.53 , pp. 161-176
    • Persky, A.M.1    Brazeau, G.A.2
  • 14
    • 0032852064 scopus 로고    scopus 로고
    • Increase of total creatine in human brain after oral supplementation of creatine-monohydrate
    • Dechent P, Pouwels PJ, Wilken B, Hanefeld F, Frahm J. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol 1999, 277:R698-704.
    • (1999) Am J Physiol , vol.277
    • Dechent, P.1    Pouwels, P.J.2    Wilken, B.3    Hanefeld, F.4    Frahm, J.5
  • 15
    • 0030596907 scopus 로고    scopus 로고
    • Creatine replacement therapy in guanidinoacetate methyltransferase deficiency, a novel inborn error of metabolism
    • 10.1016/S0140-6736(96)04116-5, 8813986
    • Stockler S, Hanefeld F, Frahm J. Creatine replacement therapy in guanidinoacetate methyltransferase deficiency, a novel inborn error of metabolism. Lancet 1996, 348:789-790. 10.1016/S0140-6736(96)04116-5, 8813986.
    • (1996) Lancet , vol.348 , pp. 789-790
    • Stockler, S.1    Hanefeld, F.2    Frahm, J.3
  • 17
    • 0035098030 scopus 로고    scopus 로고
    • Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect?
    • 10.1002/ana.79, 11261517
    • Cecil KM, Salomons GS, Ball WS, Wong B, Chuck G, Verhoeven NM, Jakobs C, DeGrauw TJ. Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect?. Ann Neurol 2001, 49:401-404. 10.1002/ana.79, 11261517.
    • (2001) Ann Neurol , vol.49 , pp. 401-404
    • Cecil, K.M.1    Salomons, G.S.2    Ball, W.S.3    Wong, B.4    Chuck, G.5    Verhoeven, N.M.6    Jakobs, C.7    DeGrauw, T.J.8
  • 19
    • 0023898536 scopus 로고
    • Measurement during convulsions of guanidino compound levels in cerebrospinal fluid collected with a catheter inserted into the cisterna magna of rabbits
    • 10.1016/0006-8993(88)90111-4, 3416191
    • Hiramatsu M, Edamatsu R, Fujikawa N, Shirasu A, Yamamoto M, Suzuki S, Mori A. Measurement during convulsions of guanidino compound levels in cerebrospinal fluid collected with a catheter inserted into the cisterna magna of rabbits. Brain Res 1988, 455:38-42. 10.1016/0006-8993(88)90111-4, 3416191.
    • (1988) Brain Res , vol.455 , pp. 38-42
    • Hiramatsu, M.1    Edamatsu, R.2    Fujikawa, N.3    Shirasu, A.4    Yamamoto, M.5    Suzuki, S.6    Mori, A.7
  • 20
    • 78651314432 scopus 로고    scopus 로고
    • Lipophilicity and transporter influence on blood-retinal barrier permeability: a comparison with blood-brain barrier permeability
    • 10.1007/s11095-010-0272-x, 20859661
    • Hosoya K, Yamamoto A, Akanuma S, Tachikawa M. Lipophilicity and transporter influence on blood-retinal barrier permeability: a comparison with blood-brain barrier permeability. Pharm Res 2010, 27:2715-2724. 10.1007/s11095-010-0272-x, 20859661.
    • (2010) Pharm Res , vol.27 , pp. 2715-2724
    • Hosoya, K.1    Yamamoto, A.2    Akanuma, S.3    Tachikawa, M.4
  • 21
    • 0036843535 scopus 로고    scopus 로고
    • The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain
    • 10.1097/00004647-200211000-00006, 12439290
    • Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T. The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. J Cereb Blood Flow Metab 2002, 22:1327-1335. 10.1097/00004647-200211000-00006, 12439290.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 1327-1335
    • Ohtsuki, S.1    Tachikawa, M.2    Takanaga, H.3    Shimizu, H.4    Watanabe, M.5    Hosoya, K.6    Terasaki, T.7
  • 22
    • 43149115227 scopus 로고    scopus 로고
    • A novel relationship between creatine transport at the blood-brain and blood-retinal barriers, creatine biosynthesis, and its use for brain and retinal energy homeostasis
    • full_text, 18652073
    • Tachikawa M, Hosoya K, Ohtsuki S, Terasaki T. A novel relationship between creatine transport at the blood-brain and blood-retinal barriers, creatine biosynthesis, and its use for brain and retinal energy homeostasis. Subcell Biochem 2007, 46:83-98. full_text, 18652073.
    • (2007) Subcell Biochem , vol.46 , pp. 83-98
    • Tachikawa, M.1    Hosoya, K.2    Ohtsuki, S.3    Terasaki, T.4
  • 23
    • 0030426820 scopus 로고    scopus 로고
    • Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier
    • Kakee A, Terasaki T, Sugiyama Y. Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier. J Pharmacol Exp Ther 1996, 277:1550-1559.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1550-1559
    • Kakee, A.1    Terasaki, T.2    Sugiyama, Y.3
  • 24
    • 0034108608 scopus 로고    scopus 로고
    • In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier
    • 10.1211/0022357001773968, 10757415
    • Kitazawa T, Hosoya K, Takahashi T, Sugiyama Y, Terasaki T. In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier. J Pharm Pharmacol 2000, 52:281-288. 10.1211/0022357001773968, 10757415.
    • (2000) J Pharm Pharmacol , vol.52 , pp. 281-288
    • Kitazawa, T.1    Hosoya, K.2    Takahashi, T.3    Sugiyama, Y.4    Terasaki, T.5
  • 25
    • 1042283687 scopus 로고    scopus 로고
    • Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive simian virus 40 large T-antigen gene
    • 10.1208/ps020328, 2761138, 11741243
    • Hosoya K, Tetsuka K, Nagase K, Tomi M, Saeki S, Ohtsuki S, Takanaga H, Yanai N, Obinata M, Kikuchi A, et al. Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive simian virus 40 large T-antigen gene. AAPS PharmSci 2000, 2:E27. 10.1208/ps020328, 2761138, 11741243.
    • (2000) AAPS PharmSci , vol.2
    • Hosoya, K.1    Tetsuka, K.2    Nagase, K.3    Tomi, M.4    Saeki, S.5    Ohtsuki, S.6    Takanaga, H.7    Yanai, N.8    Obinata, M.9    Kikuchi, A.10
  • 26
    • 0034452792 scopus 로고    scopus 로고
    • MRna expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting
    • 10.3109/10611860008997912, 11328662
    • Hosoya K, Takashima T, Tetsuka K, Nagura T, Ohtsuki S, Takanaga H, Ueda M, Yanai N, Obinata M, Terasaki T. mRna expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting. J Drug Target 2000, 8:357-370. 10.3109/10611860008997912, 11328662.
    • (2000) J Drug Target , vol.8 , pp. 357-370
    • Hosoya, K.1    Takashima, T.2    Tetsuka, K.3    Nagura, T.4    Ohtsuki, S.5    Takanaga, H.6    Ueda, M.7    Yanai, N.8    Obinata, M.9    Terasaki, T.10
  • 27
    • 0035046185 scopus 로고    scopus 로고
    • Characterization of the amino acid transport of new immortalized choroid plexus epithelial cell lines: a novel in vitro system for investigating transport functions at the blood-cerebrospinal fluid barrier
    • 10.1023/A:1011014424212, 11336348
    • Kitazawa T, Hosoya K, Watanabe M, Takashima T, Ohtsuki S, Takanaga H, Ueda M, Yanai N, Obinata M, Terasaki T. Characterization of the amino acid transport of new immortalized choroid plexus epithelial cell lines: a novel in vitro system for investigating transport functions at the blood-cerebrospinal fluid barrier. Pharm Res 2001, 18:16-22. 10.1023/A:1011014424212, 11336348.
    • (2001) Pharm Res , vol.18 , pp. 16-22
    • Kitazawa, T.1    Hosoya, K.2    Watanabe, M.3    Takashima, T.4    Ohtsuki, S.5    Takanaga, H.6    Ueda, M.7    Yanai, N.8    Obinata, M.9    Terasaki, T.10
  • 28
    • 0141923651 scopus 로고    scopus 로고
    • New approaches to in vitro models of blood-brain barrier drug transport
    • 10.1016/S1359-6446(03)02858-7, 14554158
    • Terasaki T, Ohtsuki S, Hori S, Takanaga H, Nakashima E, Hosoya K. New approaches to in vitro models of blood-brain barrier drug transport. Drug Discov Today 2003, 8:944-954. 10.1016/S1359-6446(03)02858-7, 14554158.
    • (2003) Drug Discov Today , vol.8 , pp. 944-954
    • Terasaki, T.1    Ohtsuki, S.2    Hori, S.3    Takanaga, H.4    Nakashima, E.5    Hosoya, K.6
  • 30
    • 0027263315 scopus 로고
    • Identification of the cationic amino acid transporter (System y+) of the rat blood-brain barrier
    • 10.1111/j.1471-4159.1993.tb13428.x, 8473910
    • Stoll J, Wadhwani KC, Smith QR. Identification of the cationic amino acid transporter (System y+) of the rat blood-brain barrier. J Neurochem 1993, 60:1956-1959. 10.1111/j.1471-4159.1993.tb13428.x, 8473910.
    • (1993) J Neurochem , vol.60 , pp. 1956-1959
    • Stoll, J.1    Wadhwani, K.C.2    Smith, Q.R.3
  • 31
    • 0037307003 scopus 로고    scopus 로고
    • Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation
    • 10.1023/A:1022479017087, 12701804
    • Aoyagi K. Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation. Mol Cell Biochem 2003, 244:11-15. 10.1023/A:1022479017087, 12701804.
    • (2003) Mol Cell Biochem , vol.244 , pp. 11-15
    • Aoyagi, K.1
  • 33
    • 0020620292 scopus 로고
    • Blood-brain barrier permeability to dipeptides and their constituent amino acids
    • 10.1016/0006-8993(83)91365-3, 6883121
    • Zlokovic BV, Begley DJ, Chain DG. Blood-brain barrier permeability to dipeptides and their constituent amino acids. Brain Res 1983, 271:65-71. 10.1016/0006-8993(83)91365-3, 6883121.
    • (1983) Brain Res , vol.271 , pp. 65-71
    • Zlokovic, B.V.1    Begley, D.J.2    Chain, D.G.3
  • 34
    • 0037593543 scopus 로고    scopus 로고
    • Novel neuroglial and glioglial relationships mediated by L-serine metabolism
    • 10.1679/aohc.66.109, 12846552
    • Furuya S, Watanabe M. Novel neuroglial and glioglial relationships mediated by L-serine metabolism. Arch Histol Cytol 2003, 66:109-121. 10.1679/aohc.66.109, 12846552.
    • (2003) Arch Histol Cytol , vol.66 , pp. 109-121
    • Furuya, S.1    Watanabe, M.2
  • 35
    • 78650664020 scopus 로고    scopus 로고
    • Brain-specific Phgdh Deletion Reveals a Pivotal Role for L-Serine Biosynthesis in Controlling the Level of D-Serine, an N-methyl-D-aspartate Receptor Co-agonist, in Adult Brain
    • 10.1074/jbc.M110.187443, 20966073
    • Yang JH, Wada A, Yoshida K, Miyoshi Y, Sayano T, Esaki K, Kinoshita MO, Tomonaga S, Azuma N, Watanabe M, et al. Brain-specific Phgdh Deletion Reveals a Pivotal Role for L-Serine Biosynthesis in Controlling the Level of D-Serine, an N-methyl-D-aspartate Receptor Co-agonist, in Adult Brain. J Biol Chem 2010, 285:41380-41390. 10.1074/jbc.M110.187443, 20966073.
    • (2010) J Biol Chem , vol.285 , pp. 41380-41390
    • Yang, J.H.1    Wada, A.2    Yoshida, K.3    Miyoshi, Y.4    Sayano, T.5    Esaki, K.6    Kinoshita, M.O.7    Tomonaga, S.8    Azuma, N.9    Watanabe, M.10
  • 36
    • 0032818545 scopus 로고    scopus 로고
    • Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method
    • 10.1046/j.1471-4159.1999.0731206.x, 10461913
    • Hosoya K, Sugawara M, Asaba H, Terasaki T. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem 1999, 73:1206-1211. 10.1046/j.1471-4159.1999.0731206.x, 10461913.
    • (1999) J Neurochem , vol.73 , pp. 1206-1211
    • Hosoya, K.1    Sugawara, M.2    Asaba, H.3    Terasaki, T.4
  • 37
    • 0034795873 scopus 로고    scopus 로고
    • Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier
    • 10.1046/j.1471-4159.2001.00540.x, 11595763
    • Kakee A, Takanaga H, Terasaki T, Naito M, Tsuruo T, Sugiyama Y. Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier. J Neurochem 2001, 79:110-118. 10.1046/j.1471-4159.2001.00540.x, 11595763.
    • (2001) J Neurochem , vol.79 , pp. 110-118
    • Kakee, A.1    Takanaga, H.2    Terasaki, T.3    Naito, M.4    Tsuruo, T.5    Sugiyama, Y.6
  • 38
    • 4444354347 scopus 로고    scopus 로고
    • The brain-to-blood efflux transport of taurine and changes in the blood-brain barrier transport system by tumor necrosis factor-alpha
    • 10.1016/j.brainres.2004.07.033, 15364029
    • Lee NY, Kang YS. The brain-to-blood efflux transport of taurine and changes in the blood-brain barrier transport system by tumor necrosis factor-alpha. Brain Res 2004, 1023:141-147. 10.1016/j.brainres.2004.07.033, 15364029.
    • (2004) Brain Res , vol.1023 , pp. 141-147
    • Lee, N.Y.1    Kang, Y.S.2
  • 39
    • 0036262643 scopus 로고    scopus 로고
    • ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline
    • 10.1124/mol.61.6.1289, 12021389
    • Takanaga H, Tokuda N, Ohtsuki S, Hosoya K, Terasaki T. ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline. Mol Pharmacol 2002, 61:1289-1296. 10.1124/mol.61.6.1289, 12021389.
    • (2002) Mol Pharmacol , vol.61 , pp. 1289-1296
    • Takanaga, H.1    Tokuda, N.2    Ohtsuki, S.3    Hosoya, K.4    Terasaki, T.5
  • 40
    • 0030858918 scopus 로고    scopus 로고
    • Family of neutral and acidic amino acid transporters: molecular biology, physiology and medical implications
    • 10.1016/S0955-0674(97)80035-X, 9261059
    • Kanai Y. Family of neutral and acidic amino acid transporters: molecular biology, physiology and medical implications. Curr Opin Cell Biol 1997, 9:565-572. 10.1016/S0955-0674(97)80035-X, 9261059.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 565-572
    • Kanai, Y.1
  • 41
    • 0039967156 scopus 로고    scopus 로고
    • Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal
    • O'Kane RL, Martinez-Lopez I, DeJoseph MR, Vina JR, Hawkins RA. Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal. J Biol Chem 1999, 274:31891-31895.
    • (1999) J Biol Chem , vol.274 , pp. 31891-31895
    • O'Kane, R.L.1    Martinez-Lopez, I.2    DeJoseph, M.R.3    Vina, J.R.4    Hawkins, R.A.5
  • 42
    • 0029884574 scopus 로고    scopus 로고
    • Glutamate is transported across the rat blood-brain barrier by a sodium-independent system
    • 10.1016/0304-3940(96)12635-5, 8762179
    • Benrabh H, Lefauconnier JM. Glutamate is transported across the rat blood-brain barrier by a sodium-independent system. Neurosci Lett 1996, 210:9-12. 10.1016/0304-3940(96)12635-5, 8762179.
    • (1996) Neurosci Lett , vol.210 , pp. 9-12
    • Benrabh, H.1    Lefauconnier, J.M.2
  • 43
    • 0031958583 scopus 로고    scopus 로고
    • Glutamine transport by the blood-brain barrier: a possible mechanism for nitrogen removal
    • Lee WJ, Hawkins RA, Vina JR, Peterson DR. Glutamine transport by the blood-brain barrier: a possible mechanism for nitrogen removal. Am J Physiol 1998, 274:C1101-1107.
    • (1998) Am J Physiol , vol.274
    • Lee, W.J.1    Hawkins, R.A.2    Vina, J.R.3    Peterson, D.R.4
  • 44
    • 0344393085 scopus 로고    scopus 로고
    • The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier
    • 10.1046/j.1471-4159.2003.02063.x, 14622120
    • Tetsuka K, Takanaga H, Ohtsuki S, Hosoya K, Terasaki T. The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier. J Neurochem 2003, 87:891-901. 10.1046/j.1471-4159.2003.02063.x, 14622120.
    • (2003) J Neurochem , vol.87 , pp. 891-901
    • Tetsuka, K.1    Takanaga, H.2    Ohtsuki, S.3    Hosoya, K.4    Terasaki, T.5
  • 45
    • 0034784396 scopus 로고    scopus 로고
    • GAT2/BGT-1 as a system responsible for the transport of gamma-aminobutyric acid at the mouse blood-brain barrier
    • 10.1097/00004647-200110000-00012, 11598501
    • Takanaga H, Ohtsuki S, Hosoya K, Terasaki T. GAT2/BGT-1 as a system responsible for the transport of gamma-aminobutyric acid at the mouse blood-brain barrier. J Cereb Blood Flow Metab 2001, 21:1232-1239. 10.1097/00004647-200110000-00012, 11598501.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 1232-1239
    • Takanaga, H.1    Ohtsuki, S.2    Hosoya, K.3    Terasaki, T.4
  • 47
    • 1242295211 scopus 로고    scopus 로고
    • Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6
    • 10.1007/s00424-003-1064-5, 12719981
    • Chen NH, Reith ME, Quick MW. Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflugers Arch 2004, 447:519-531. 10.1007/s00424-003-1064-5, 12719981.
    • (2004) Pflugers Arch , vol.447 , pp. 519-531
    • Chen, N.H.1    Reith, M.E.2    Quick, M.W.3
  • 48
    • 0029805748 scopus 로고    scopus 로고
    • Expression of the rat brain creatine transporter in situ and in transfected HeLa cells
    • 10.1159/000111450, 8940628
    • Saltarelli MD, Bauman AL, Moore KR, Bradley CC, Blakely RD. Expression of the rat brain creatine transporter in situ and in transfected HeLa cells. Dev Neurosci 1996, 18:524-534. 10.1159/000111450, 8940628.
    • (1996) Dev Neurosci , vol.18 , pp. 524-534
    • Saltarelli, M.D.1    Bauman, A.L.2    Moore, K.R.3    Bradley, C.C.4    Blakely, R.D.5
  • 49
    • 0028264171 scopus 로고
    • The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues
    • 10.1006/bbrc.1994.1093, 8297374
    • Schloss P, Mayser W, Betz H. The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues. Biochem Biophys Res Commun 1994, 198:637-645. 10.1006/bbrc.1994.1093, 8297374.
    • (1994) Biochem Biophys Res Commun , vol.198 , pp. 637-645
    • Schloss, P.1    Mayser, W.2    Betz, H.3
  • 50
    • 53149101457 scopus 로고    scopus 로고
    • Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant
    • 10.1111/j.1471-4159.2008.05652.x, 18761709
    • Tachikawa M, Fujinawa J, Takahashi M, Kasai Y, Fukaya M, Sakai K, Yamazaki M, Tomi M, Watanabe M, Sakimura K, et al. Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant. J Neurochem 2008, 107:768-778. 10.1111/j.1471-4159.2008.05652.x, 18761709.
    • (2008) J Neurochem , vol.107 , pp. 768-778
    • Tachikawa, M.1    Fujinawa, J.2    Takahashi, M.3    Kasai, Y.4    Fukaya, M.5    Sakai, K.6    Yamazaki, M.7    Tomi, M.8    Watanabe, M.9    Sakimura, K.10
  • 51
    • 53149142766 scopus 로고    scopus 로고
    • The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process
    • 10.1111/j.1471-4159.2008.05641.x, 18752646
    • Tachikawa M, Kasai Y, Takahashi M, Fujinawa J, Kitaichi K, Terasaki T, Hosoya K. The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process. J Neurochem 2008, 107:432-442. 10.1111/j.1471-4159.2008.05641.x, 18752646.
    • (2008) J Neurochem , vol.107 , pp. 432-442
    • Tachikawa, M.1    Kasai, Y.2    Takahashi, M.3    Fujinawa, J.4    Kitaichi, K.5    Terasaki, T.6    Hosoya, K.7
  • 52
    • 22744453219 scopus 로고    scopus 로고
    • Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3
    • 10.1016/j.bbrc.2005.06.164, 16036218
    • Shojaiefard M, Christie DL, Lang F. Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3. Biochem Biophys Res Commun 2005, 334:742-746. 10.1016/j.bbrc.2005.06.164, 16036218.
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 742-746
    • Shojaiefard, M.1    Christie, D.L.2    Lang, F.3
  • 53
    • 34447526785 scopus 로고    scopus 로고
    • Selective amino acid substitutions convert the creatine transporter to a gamma-aminobutyric acid transporter
    • 10.1074/jbc.M611705200, 17400549
    • Dodd JR, Christie DL. Selective amino acid substitutions convert the creatine transporter to a gamma-aminobutyric acid transporter. J Biol Chem 2007, 282:15528-15533. 10.1074/jbc.M611705200, 17400549.
    • (2007) J Biol Chem , vol.282 , pp. 15528-15533
    • Dodd, J.R.1    Christie, D.L.2
  • 54
    • 2642559478 scopus 로고    scopus 로고
    • Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters
    • 10.1111/j.1471-4159.2004.02410.x, 15147512
    • Dominy J, Thinschmidt JS, Peris J, Dawson R, Papke RL. Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters. J Neurochem 2004, 89:1195-1205. 10.1111/j.1471-4159.2004.02410.x, 15147512.
    • (2004) J Neurochem , vol.89 , pp. 1195-1205
    • Dominy, J.1    Thinschmidt, J.S.2    Peris, J.3    Dawson, R.4    Papke, R.L.5
  • 55
    • 0027391644 scopus 로고
    • Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected]
    • Liu QR, Lopez-Corcuera B, Mandiyan S, Nelson H, Nelson N. Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected]. J Biol Chem 1993, 268:2106-2112.
    • (1993) J Biol Chem , vol.268 , pp. 2106-2112
    • Liu, Q.R.1    Lopez-Corcuera, B.2    Mandiyan, S.3    Nelson, H.4    Nelson, N.5
  • 56
    • 70349329705 scopus 로고    scopus 로고
    • The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters
    • 10.1111/j.1471-4159.2009.06332.x, 19682207
    • Tachikawa M, Kasai Y, Yokoyama R, Fujinawa J, Ganapathy V, Terasaki T, Hosoya K. The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters. J Neurochem 2009, 111:499-509. 10.1111/j.1471-4159.2009.06332.x, 19682207.
    • (2009) J Neurochem , vol.111 , pp. 499-509
    • Tachikawa, M.1    Kasai, Y.2    Yokoyama, R.3    Fujinawa, J.4    Ganapathy, V.5    Terasaki, T.6    Hosoya, K.7
  • 57
    • 52049118519 scopus 로고    scopus 로고
    • Function of taurine transporter (Slc6a6/TauT) as a GABA transporting protein and its relevance to GABA transport in rat retinal capillary endothelial cells
    • 10.1016/j.bbamem.2008.04.012, 18501699
    • Tomi M, Tajima A, Tachikawa M, Hosoya K. Function of taurine transporter (Slc6a6/TauT) as a GABA transporting protein and its relevance to GABA transport in rat retinal capillary endothelial cells. Biochim Biophys Acta 2008, 1778:2138-2142. 10.1016/j.bbamem.2008.04.012, 18501699.
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 2138-2142
    • Tomi, M.1    Tajima, A.2    Tachikawa, M.3    Hosoya, K.4
  • 58
    • 3042726691 scopus 로고    scopus 로고
    • Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney
    • 10.1023/B:PHAM.0000029286.45788.ad, 15212162
    • Urakami Y, Kimura N, Okuda M, Inui K. Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney. Pharm Res 2004, 21:976-981. 10.1023/B:PHAM.0000029286.45788.ad, 15212162.
    • (2004) Pharm Res , vol.21 , pp. 976-981
    • Urakami, Y.1    Kimura, N.2    Okuda, M.3    Inui, K.4
  • 59
    • 62549101989 scopus 로고    scopus 로고
    • Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2
    • 10.1016/j.bcp.2009.01.010, 19426682
    • Kimura N, Masuda S, Katsura T, Inui K. Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2. Biochem Pharmacol 2009, 77:1429-1436. 10.1016/j.bcp.2009.01.010, 19426682.
    • (2009) Biochem Pharmacol , vol.77 , pp. 1429-1436
    • Kimura, N.1    Masuda, S.2    Katsura, T.3    Inui, K.4
  • 60
    • 0023159133 scopus 로고
    • Quantitative assessment of the permeability of the rat blood-retinal barrier to small water-soluble non-electrolytes
    • 1192091, 3119820
    • Lightman SL, Palestine AG, Rapoport SI, Rechthand E. Quantitative assessment of the permeability of the rat blood-retinal barrier to small water-soluble non-electrolytes. J Physiol 1987, 389:483-490. 1192091, 3119820.
    • (1987) J Physiol , vol.389 , pp. 483-490
    • Lightman, S.L.1    Palestine, A.G.2    Rapoport, S.I.3    Rechthand, E.4
  • 62
    • 0027537622 scopus 로고
    • A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression
    • Guimbal C, Kilimann MW. A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression. J Biol Chem 1993, 268:8418-8421.
    • (1993) J Biol Chem , vol.268 , pp. 8418-8421
    • Guimbal, C.1    Kilimann, M.W.2
  • 63
    • 33845302602 scopus 로고    scopus 로고
    • Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro
    • 10.1016/j.neuint.2006.07.005, 16956696
    • Belanger M, Asashima T, Ohtsuki S, Yamaguchi H, Ito S, Terasaki T. Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro. Neurochem Int 2007, 50:95-101. 10.1016/j.neuint.2006.07.005, 16956696.
    • (2007) Neurochem Int , vol.50 , pp. 95-101
    • Belanger, M.1    Asashima, T.2    Ohtsuki, S.3    Yamaguchi, H.4    Ito, S.5    Terasaki, T.6
  • 64
    • 3142683647 scopus 로고    scopus 로고
    • Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis
    • 10.1111/j.1460-9568.2004.03478.x, 15245487
    • Tachikawa M, Fukaya M, Terasaki T, Ohtsuki S, Watanabe M. Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis. Eur J Neurosci 2004, 20:144-160. 10.1111/j.1460-9568.2004.03478.x, 15245487.
    • (2004) Eur J Neurosci , vol.20 , pp. 144-160
    • Tachikawa, M.1    Fukaya, M.2    Terasaki, T.3    Ohtsuki, S.4    Watanabe, M.5
  • 65
    • 0035977693 scopus 로고    scopus 로고
    • Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization study
    • 10.1016/S0169-328X(00)00269-2, 11165387
    • Braissant O, Henry H, Loup M, Eilers B, Bachmann C. Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization study. Brain Res Mol Brain Res 2001, 86:193-201. 10.1016/S0169-328X(00)00269-2, 11165387.
    • (2001) Brain Res Mol Brain Res , vol.86 , pp. 193-201
    • Braissant, O.1    Henry, H.2    Loup, M.3    Eilers, B.4    Bachmann, C.5
  • 66
    • 0033573708 scopus 로고    scopus 로고
    • Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: dose-effect relationship
    • 10.1016/S0006-8993(98)01131-7, 9878706
    • Balestrino M, Rebaudo R, Lunardi G. Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: dose-effect relationship. Brain Res 1999, 816:124-130. 10.1016/S0006-8993(98)01131-7, 9878706.
    • (1999) Brain Res , vol.816 , pp. 124-130
    • Balestrino, M.1    Rebaudo, R.2    Lunardi, G.3
  • 67
    • 0034006323 scopus 로고    scopus 로고
    • Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons
    • 10.1046/j.1471-4159.2000.0741968.x, 10800940
    • Brewer GJ, Wallimann TW. Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons. J Neurochem 2000, 74:1968-1978. 10.1046/j.1471-4159.2000.0741968.x, 10800940.
    • (2000) J Neurochem , vol.74 , pp. 1968-1978
    • Brewer, G.J.1    Wallimann, T.W.2
  • 71
    • 2442475483 scopus 로고    scopus 로고
    • Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency
    • 10.1093/hmg/ddh112, 15028668
    • Schmidt A, Marescau B, Boehm EA, Renema WK, Peco R, Das A, Steinfeld R, Chan S, Wallis J, Davidoff M, et al. Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency. Hum Mol Genet 2004, 13:905-921. 10.1093/hmg/ddh112, 15028668.
    • (2004) Hum Mol Genet , vol.13 , pp. 905-921
    • Schmidt, A.1    Marescau, B.2    Boehm, E.A.3    Renema, W.K.4    Peco, R.5    Das, A.6    Steinfeld, R.7    Chan, S.8    Wallis, J.9    Davidoff, M.10
  • 72
  • 73
    • 0036966277 scopus 로고    scopus 로고
    • Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism
    • 10.1006/nbdi.2002.0547, 12505422
    • Neu A, Neuhoff H, Trube G, Fehr S, Ullrich K, Roeper J, Isbrandt D. Activation of GABA(A) receptors by guanidinoacetate: a novel pathophysiological mechanism. Neurobiol Dis 2002, 11:298-307. 10.1006/nbdi.2002.0547, 12505422.
    • (2002) Neurobiol Dis , vol.11 , pp. 298-307
    • Neu, A.1    Neuhoff, H.2    Trube, G.3    Fehr, S.4    Ullrich, K.5    Roeper, J.6    Isbrandt, D.7
  • 74
    • 0029972641 scopus 로고    scopus 로고
    • Choroid plexus taurine transport
    • 10.1016/0006-8993(95)01294-X, 8739618
    • Keep RF, Xiang J. Choroid plexus taurine transport. Brain Res 1996, 715:17-24. 10.1016/0006-8993(95)01294-X, 8739618.
    • (1996) Brain Res , vol.715 , pp. 17-24
    • Keep, R.F.1    Xiang, J.2
  • 76
    • 43149113670 scopus 로고    scopus 로고
    • AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: A review
    • Braissant O, Henry H. AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: A review. J Inherit Metab Dis 2008, 31:230-239.
    • (2008) J Inherit Metab Dis , vol.31 , pp. 230-239
    • Braissant, O.1    Henry, H.2
  • 77
    • 34249297046 scopus 로고    scopus 로고
    • Successful treatment of a guanidinoacetate methyltransferase deficient patient: findings with relevance to treatment strategy and pathophysiology
    • 10.1016/j.ymgme.2007.03.006, 17466557
    • Verbruggen KT, Sijens PE, Schulze A, Lunsing RJ, Jakobs C, Salomons GS, van Spronsen FJ. Successful treatment of a guanidinoacetate methyltransferase deficient patient: findings with relevance to treatment strategy and pathophysiology. Mol Genet Metab 2007, 91:294-296. 10.1016/j.ymgme.2007.03.006, 17466557.
    • (2007) Mol Genet Metab , vol.91 , pp. 294-296
    • Verbruggen, K.T.1    Sijens, P.E.2    Schulze, A.3    Lunsing, R.J.4    Jakobs, C.5    Salomons, G.S.6    van Spronsen, F.J.7
  • 82
    • 69249155619 scopus 로고    scopus 로고
    • Guanidino compounds as uremic (neuro)toxins
    • 10.1111/j.1525-139X.2009.00577.x, 19708978
    • De Deyn PP, Vanholder R, Eloot S, Glorieux G. Guanidino compounds as uremic (neuro)toxins. Semin Dial 2009, 22:340-345. 10.1111/j.1525-139X.2009.00577.x, 19708978.
    • (2009) Semin Dial , vol.22 , pp. 340-345
    • De Deyn, P.P.1    Vanholder, R.2    Eloot, S.3    Glorieux, G.4
  • 83
    • 0023276514 scopus 로고
    • Guanidino compounds in serum and cerebrospinal fluid of non-dialyzed patients with renal insufficiency
    • 10.1016/0009-8981(87)90088-X, 3665089
    • De Deyn PP, Marescau B, Cuykens JJ, Van Gorp L, Lowenthal A, De Potter WP. Guanidino compounds in serum and cerebrospinal fluid of non-dialyzed patients with renal insufficiency. Clin Chim Acta 1987, 167:81-88. 10.1016/0009-8981(87)90088-X, 3665089.
    • (1987) Clin Chim Acta , vol.167 , pp. 81-88
    • De Deyn, P.P.1    Marescau, B.2    Cuykens, J.J.3    Van Gorp, L.4    Lowenthal, A.5    De Potter, W.P.6
  • 84
    • 0029164714 scopus 로고
    • Guanidino compound levels in brain regions of non-dialyzed uremic patients
    • 10.1016/0197-0186(95)00041-6, 8520461
    • De Deyn PP, Marescau B, D'Hooge R, Possemiers I, Nagler J, Mahler C. Guanidino compound levels in brain regions of non-dialyzed uremic patients. Neurochem Int 1995, 27:227-237. 10.1016/0197-0186(95)00041-6, 8520461.
    • (1995) Neurochem Int , vol.27 , pp. 227-237
    • De Deyn, P.P.1    Marescau, B.2    D'Hooge, R.3    Possemiers, I.4    Nagler, J.5    Mahler, C.6
  • 86
    • 0019173725 scopus 로고
    • Creatine and creatinine transport in old and young human red blood cells
    • 10.1016/0005-2736(80)90426-5, 7397170
    • Ku CP, Passow H. Creatine and creatinine transport in old and young human red blood cells. Biochim Biophys Acta 1980, 600:212-227. 10.1016/0005-2736(80)90426-5, 7397170.
    • (1980) Biochim Biophys Acta , vol.600 , pp. 212-227
    • Ku, C.P.1    Passow, H.2
  • 87
    • 36348987970 scopus 로고    scopus 로고
    • The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats
    • 10.1016/j.brainres.2007.09.072, 17988657
    • Nakayama H, Kitaichi K, Ito Y, Hashimoto K, Takagi K, Yokoi T, Ozaki N, Yamamoto T, Hasegawa T. The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats. Brain Res 2007, 1184:260-269. 10.1016/j.brainres.2007.09.072, 17988657.
    • (2007) Brain Res , vol.1184 , pp. 260-269
    • Nakayama, H.1    Kitaichi, K.2    Ito, Y.3    Hashimoto, K.4    Takagi, K.5    Yokoi, T.6    Ozaki, N.7    Yamamoto, T.8    Hasegawa, T.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.