Endogenous synthesis and transport of creatine in the rat brain: An in situ hybridization study

Molecular Brain Research

Volumn 86, Issue 1-2, 2001, Pages 193-201

  Braissant, Olivier ^a   Henry, Hugues ^a   Loup, Marc ^a   Eilers, Barbara ^a   Bachmann, Claude ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Brain; Creatine; Creatine transporter; In situ hybridization; L Arginine:glycine amidinotransferase; S Adenosyl L methionine:N guanidinoacetate methyltransferase

Indexed keywords

ARGININE; CARRIER PROTEIN; CREATINE; CREATINE TRANSPORTER 1; GLYCINE AMIDINOTRANSFERASE; MESSENGER RNA; METHIONINE DERIVATIVE; S ADENOSYL L METHIONINE N GUANIDINOACETATE METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIOSYNTHESIS; BLOOD BRAIN BARRIER; BRAIN TISSUE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GLIA CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE DISTRIBUTION;

AMIDINOTRANSFERASES; ANIMALS; BRAIN; BRAIN CHEMISTRY; CARRIER PROTEINS; CREATINE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GUANIDINOACETATE N-METHYLTRANSFERASE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MEMBRANE TRANSPORT PROTEINS; METHYLTRANSFERASES; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 0035977693     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00269-2     Document Type: Article

References (41)

1. L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: An in situ hybridization study
2. A simplified in situ hybridization protocol using non-radioactively labelled probes to detect abundant and rare mRNAs on tissue sections
3. Guanidinoacetate methyltransferase activity in tissues and cultured cells
4. DISEC-TRISEC: Di- and trinucleotide-sticky-end cloning of PCR-amplified DNA
5. Metabolism of glycine in primary astroglial cells: Synthesis of creatine, serine, and glutathione
6. Guanidinoacetate methyltransferase deficiency: New clinical features
7. A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression
8. Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine
9. In situ hybridization analysis of CHOT1, a creatine transporter, in the rat central nervous system
10. Creatine kinase isoenzymes in chicken cerebellum: Specific localization of brain-type creatine kinase in Bergmann glial cells and muscle-type creatine kinase in Purkinje neurons
11. Brain creatine phosphate and creatine kinase in mice fed an analogue of creatine
12. Aggregating neural cell culture
13. The amino acid sequences of human and pig L-arginine:glycine amidinotransferase
14. Cloning and sequence analysis of human guanidinoacetate N-methyltransferase cDNA
15. Identification of a testis-expressed creatine transporter gene at 16p11.2 and confirmation of the X-linked locus to Xq28
16. The human guanidinoacetate methyltransferase (GAMT) gene maps to a syntenic region on 19p13.3, homologous to band C of mouse chromosome 10, but GAMT is not mutated in jittery mice
17. 'Hot spots' of creatine kinase localization in brain: Cerebellum, hippocampus and choroid plexus
18. Creatine synthesis and transport systems in the male rat reproductive tract
19. Primary structure and functional expression of a choline transporter expressed in the rat nervous system
20. Creatine transport in cultured cells of rat and mouse brain
21. Cloning, pharmacological characterization, and genomic localization of the human creatine transporter
22. Molecular cloning, sequence analysis, and expression in Escherichia coli of the cDNA for guanidinoacetate methyltransferase from rat liver
23. Biosynthesis and disposition of g-guanidinobutyric acid in mammalian tissues
24. Expression of the rat brain creatine transporter in situ and in transfected HeLa cells
25. The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues
26. Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: Diagnostic tools for a new inborn error of metabolism
27. The cloning and expression of a human creatine transporter
28. Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes
29. Identification of the cationic amino acid transporter (System y+) of the rat blood-brain barrier
30. Creatine replacement therapy in guanidinoacetate methyltransferase deficiency, a novel inborn error of metabolism
31. Creatine deficiency in the brain: A new, treatable inborn error of metabolism
32. Guanidinoacetate methyltransferase deficiency: The first inborn error of creatine metabolism in man
33. Guanidino compounds in guanidinoacetate methyltransferase deficiency, a new inborn error of creatine synthesis
34. Transaminidase activities, in vitro, of tissues from various mammals and from rats fed protein-free, creatine supplemented and normal diets
35. Distribution of creatine, guanidinoacetate and enzymes for their biosynthesis in the animal kingdom. Implications for phylogeny
36. Creatine kinase in non-muscle tissues and cells
37. Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1 H magnetic resonance spectroscopy
38. Arginine kinase expression and localization in growth cone migration
39. Creatine and nucleoside triphosphates in rat cerebral gray and white matter
40. Creatine and creatinine metabolism