-
1
-
-
55349133352
-
Present and future drug treatments for chronic kidney diseases: Evolving targets in renoprotection
-
Perico, N., Benigni, A. & Remuzzi, G. Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection. Nat. Rev. Drug Discov. 7, 936-953 (2008).
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 936-953
-
-
Perico, N.1
Benigni, A.2
Remuzzi, G.3
-
2
-
-
1642413198
-
Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization
-
Keith, D. S., Nichols, G. A., Gullion, C. M., Brown, J. B. & Smith, D. H. Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch. Intern. Med. 164, 659-663 (2004).
-
(2004)
Arch. Intern. Med.
, vol.164
, pp. 659-663
-
-
Keith, D.S.1
Nichols, G.A.2
Gullion, C.M.3
Brown, J.B.4
Smith, D.H.5
-
3
-
-
0141468244
-
Kidney disease as a risk factor for development of cardiovascular disease: A statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
-
Sarnak, M. J. et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 108, 2154-2169 (2003).
-
(2003)
Circulation
, vol.108
, pp. 2154-2169
-
-
Sarnak, M.J.1
-
4
-
-
15844368318
-
Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency
-
The Angiotensin-Converting- Enzyme Inhibition in Progressive Renal Insufficiency Study Group
-
Maschio, G. et al. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting- Enzyme Inhibition in Progressive Renal Insufficiency Study Group. N. Engl. J. Med. 334, 939-945 (1996).
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 939-945
-
-
Maschio, G.1
-
5
-
-
0035922441
-
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
-
Brenner, B. M. et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N. Engl. J. Med. 345, 861-869 (2001).
-
(2001)
N. Engl. J. Med.
, vol.345
, pp. 861-869
-
-
Brenner, B.M.1
-
6
-
-
77950611468
-
siRNA-based therapy ameliorates glomerulonephritis
-
Shimizu, H. et al. siRNA-based therapy ameliorates glomerulonephritis. J. Am. Soc. Nephrol. 21, 622-633 (2010).
-
(2010)
J. Am. Soc. Nephrol.
, vol.21
, pp. 622-633
-
-
Shimizu, H.1
-
7
-
-
2342453844
-
Gene therapy in renal diseases
-
Imai, E., Takabatake, Y., Mizui, M. & Isaka, Y. Gene therapy in renal diseases. Kidney Int. 65, 1551-1555 (2004).
-
(2004)
Kidney Int.
, vol.65
, pp. 1551-1555
-
-
Imai, E.1
Takabatake, Y.2
Mizui, M.3
Isaka, Y.4
-
8
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
-
9
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
-
10
-
-
0035905766
-
Role for a bidentate ribonuclease in the initiation step of RNA interference
-
Bernstein, E., Caudy, A. A., Hammond, S. M. & Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366 (2001).
-
(2001)
Nature
, vol.409
, pp. 363-366
-
-
Bernstein, E.1
Caudy, A.A.2
Hammond, S.M.3
Hannon, G.J.4
-
11
-
-
5144225452
-
Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity
-
Rand, T. A., Ginalski, K., Grishin, N. V. & Wang, X. Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc. Natl Acad. Sci. USA 101, 14385-14389 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 14385-14389
-
-
Rand, T.A.1
Ginalski, K.2
Grishin, N.V.3
Wang, X.4
-
12
-
-
0037031576
-
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
-
Martinez, J., Patkaniowska, A., Urlaub, H., Lührmann, R. & Tuschl, T. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110, 563-574 (2002).
-
(2002)
Cell
, vol.110
, pp. 563-574
-
-
Martinez, J.1
Patkaniowska, A.2
Urlaub, H.3
Lührmann, R.4
Tuschl, T.5
-
13
-
-
27744590896
-
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
-
Matranga, C., Tomari, Y., Shin, C., Bartel, D. P. & Zamore, P. D. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 123, 607-620 (2005).
-
(2005)
Cell
, vol.123
, pp. 607-620
-
-
Matranga, C.1
Tomari, Y.2
Shin, C.3
Bartel, D.P.4
Zamore, P.D.5
-
14
-
-
34447102459
-
Molecular basis for target RNA recognition and cleavage by human RISC
-
Ameres, S. L., Martinez, J. & Schroeder, R. Molecular basis for target RNA recognition and cleavage by human RISC. Cell 130, 101-112 (2007).
-
(2007)
Cell
, vol.130
, pp. 101-112
-
-
Ameres, S.L.1
Martinez, J.2
Schroeder, R.3
-
15
-
-
0037144546
-
A microRNA in a multiple-turnover RNAi enzyme complex
-
Hutvágner, G. & Zamore, P. D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060 (2002).
-
(2002)
Science
, vol.297
, pp. 2056-2060
-
-
Hutvágner, G.1
Zamore, P.D.2
-
16
-
-
31544456413
-
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
-
Bartlett, D. W. & Davis, M. E. Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res. 34, 322-333 (2006).
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 322-333
-
-
Bartlett, D.W.1
Davis, M.E.2
-
17
-
-
0037019339
-
RNA interference in adult mice
-
McCaffrey, A. P. et al. RNA interference in adult mice. Nature 418, 38-39 (2002).
-
(2002)
Nature
, vol.418
, pp. 38-39
-
-
McCaffrey, A.P.1
-
18
-
-
16244377103
-
A crucial test
-
Check, E. A crucial test. Nat. Med. 11, 243-244 (2005).
-
(2005)
Nat. Med.
, vol.11
, pp. 243-244
-
-
Check, E.1
-
19
-
-
43749096100
-
Neovascular age- related macular degeneration: Potential therapies
-
Chappelow, A. V. & Kaiser, P. K. Neovascular age- related macular degeneration: potential therapies. Drugs 68, 1029-1036 (2008).
-
(2008)
Drugs
, vol.68
, pp. 1029-1036
-
-
Chappelow, A.V.1
Kaiser, P.K.2
-
20
-
-
36849044732
-
Nonviral delivery of synthetic siRNAs in vivo
-
Akhtar, S. & Benter, I. F. Nonviral delivery of synthetic siRNAs in vivo. J. Clin. Invest. 117, 3623-3632 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3623-3632
-
-
Akhtar, S.1
Benter, I.F.2
-
21
-
-
59349116903
-
Knocking down barriers: Advances in siRNA delivery
-
Whitehead, K. A., Langer, R. & Anderson, D. G. Knocking down barriers: advances in siRNA delivery. Nat. Rev. Drug Discov. 8, 129-138 (2009).
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 129-138
-
-
Whitehead, K.A.1
Langer, R.2
Anderson, D.G.3
-
22
-
-
58749104364
-
The promises and pitfalls of RNA-interference-based therapeutics
-
Castanotto, D. & Rossi, J. J. The promises and pitfalls of RNA-interference-based therapeutics. Nature 457, 426-433 (2009).
-
(2009)
Nature
, vol.457
, pp. 426-433
-
-
Castanotto, D.1
Rossi, J.J.2
-
23
-
-
70449089802
-
Strategies for targeted nonviral delivery of siRNAs in vivo
-
Kim, S. S., Garg, H., Joshi, A. & Manjunath, N. Strategies for targeted nonviral delivery of siRNAs in vivo. Trends Mol. Med. 15, 491-500 (2009).
-
(2009)
Trends Mol. Med.
, vol.15
, pp. 491-500
-
-
Kim, S.S.1
Garg, H.2
Joshi, A.3
Manjunath, N.4
-
24
-
-
69549119978
-
siRNAs: Their potential as therapeutic agents - Part II. Methods of delivery
-
Singh, S. K. & Hajeri, P. B. siRNAs: their potential as therapeutic agents - Part II. Methods of delivery. Drug Discov. Today 14, 859-865 (2009).
-
(2009)
Drug Discov. Today
, vol.14
, pp. 859-865
-
-
Singh, S.K.1
Hajeri, P.B.2
-
25
-
-
65749119809
-
Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy
-
Takahashi, Y., Nisikawa, M. & Takakura, Y. Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy. Adv. Drug Deliv. Rev. 61, 760-766 (2009).
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, pp. 760-766
-
-
Takahashi, Y.1
Nisikawa, M.2
Takakura, Y.3
-
26
-
-
44949122670
-
Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
-
Savaskan, N. E. et al. Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema. Nat. Med. 14, 629-632 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 629-632
-
-
Savaskan, N.E.1
-
27
-
-
30144434185
-
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
-
Palliser, D. et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 439, 89-94 (2006).
-
(2006)
Nature
, vol.439
, pp. 89-94
-
-
Palliser, D.1
-
28
-
-
43049176170
-
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
-
Akinc, A. et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat. Biotechnol. 26, 561-569 (2008).
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 561-569
-
-
Akinc, A.1
-
29
-
-
38749136602
-
Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
-
DeVincenzo, J. et al. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res. 77, 225-231 (2008).
-
(2008)
Antiviral Res.
, vol.77
, pp. 225-231
-
-
DeVincenzo, J.1
-
30
-
-
39149111247
-
Single-nucleotide-specific siRNA targeting in a dominant-negative skin model
-
Hickerson, R. P. et al. Single-nucleotide-specific siRNA targeting in a dominant-negative skin model. J. Invest. Dermatol. 128, 594-605 (2008).
-
(2008)
J. Invest. Dermatol.
, vol.128
, pp. 594-605
-
-
Hickerson, R.P.1
-
31
-
-
55549114663
-
5'-triphosphate-siRNA: Turning gene silencing and Rig-I activation against melanoma
-
Poeck, H. et al. 5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat. Med. 14, 1256-1263 (2008).
-
(2008)
Nat. Med.
, vol.14
, pp. 1256-1263
-
-
Poeck, H.1
-
32
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann, T. S. et al. RNAi-mediated gene silencing in non-human primates. Nature 441, 111-114 (2006).
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
-
33
-
-
51049092308
-
Factors affecting the clearance and biodistribution of polymeric nanoparticles
-
Alexis, F., Pridgen, E., Molnar, L. K. & Farokhzad, O. C. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 5, 505-515 (2008).
-
(2008)
Mol. Pharm.
, vol.5
, pp. 505-515
-
-
Alexis, F.1
Pridgen, E.2
Molnar, L.K.3
Farokhzad, O.C.4
-
34
-
-
33746070441
-
Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules
-
van de Water, F. M. et al. Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules. Drug Metab. Dispos. 34, 1393-1397 (2006).
-
(2006)
Drug Metab. Dispos.
, vol.34
, pp. 1393-1397
-
-
Van De Water, F.M.1
-
35
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
Morrissey, D. V. et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotechnol. 23, 1002-1007 (2005).
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1002-1007
-
-
Morrissey, D.V.1
-
36
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek, J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173-178 (2004).
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
-
37
-
-
4344618969
-
Extracellular matrix glycoproteins and diffusion barriers in human astrocytic tumors
-
Zámecník, J., Vargová, L., Homola, A., Kodet, R. & Syková, E. Extracellular matrix glycoproteins and diffusion barriers in human astrocytic tumors. Neuropathol. Appl. Neurobiol. 30, 338-350 (2004).
-
(2004)
Neuropathol. Appl. Neurobiol.
, vol.30
, pp. 338-350
-
-
Zámecník, J.1
Vargová, L.2
Homola, A.3
Kodet, R.4
Syková, E.5
-
38
-
-
59849125915
-
Phosphorothioate- stimulated cellular uptake of siRNA: A cell culture model for mechanistic studies
-
Detzer, A., Overhoff, M., Mescalchin, A., Rompf, M. & Sczakiel, G. Phosphorothioate- stimulated cellular uptake of siRNA: a cell culture model for mechanistic studies. Curr. Pharm. Des. 14, 3666-3673 (2008).
-
(2008)
Curr. Pharm. Des.
, vol.14
, pp. 3666-3673
-
-
Detzer, A.1
Overhoff, M.2
Mescalchin, A.3
Rompf, M.4
Sczakiel, G.5
-
39
-
-
33846813849
-
Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
-
Oliveira, S., van Rooy, I., Kranenburg, O., Storm, G. & Schiffelers, R. M. Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes. Int. J. Pharm. 331, 211-214 (2007).
-
(2007)
Int. J. Pharm.
, vol.331
, pp. 211-214
-
-
Oliveira, S.1
Van Rooy, I.2
Kranenburg, O.3
Storm, G.4
Schiffelers, R.M.5
-
40
-
-
33646685202
-
Delivery strategies for siRNA-mediated gene silencing
-
Gilmore, I. R., Fox, S. P., Hollins, A. J. & Akhtar, S. Delivery strategies for siRNA-mediated gene silencing. Curr. Drug Deliv. 3, 147-155 (2006).
-
(2006)
Curr. Drug Deliv.
, vol.3
, pp. 147-155
-
-
Gilmore, I.R.1
Fox, S.P.2
Hollins, A.J.3
Akhtar, S.4
-
41
-
-
34548532823
-
Targeted delivery systems of small interfering RNA by systemic administration
-
Kawakami, S. & Hashida, M. Targeted delivery systems of small interfering RNA by systemic administration. Drug Metab. Pharmacokinet. 22, 142-151 (2007).
-
(2007)
Drug Metab. Pharmacokinet.
, vol.22
, pp. 142-151
-
-
Kawakami, S.1
Hashida, M.2
-
42
-
-
34248672837
-
Toxicogenomics of non- viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene silencing activity and specificity
-
Akhtar, S. & Benter, I. Toxicogenomics of non- viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity. Adv. Drug Deliv. Rev. 59, 164-182 (2007).
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, pp. 164-182
-
-
Akhtar, S.1
Benter, I.2
-
43
-
-
0037468660
-
Gene silencing by adenovirus- delivered siRNAs
-
Shen, C. Buck, A. K., Liu, X., Winkler, M. & Reske, S. N. Gene silencing by adenovirus- delivered siRNAs. FEBS Lett. 539, 111-114 (2003).
-
(2003)
FEBS Lett.
, vol.539
, pp. 111-114
-
-
Shen, C.1
Buck, A.K.2
Liu, X.3
Winkler, M.4
Reske, S.N.5
-
44
-
-
44249085878
-
Safety and efficacy of gene transfer for Leber's congenital amaurosis
-
Maguire, A. M. et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N. Engl. J. Med. 358, 2240-2248 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2240-2248
-
-
Maguire, A.M.1
-
45
-
-
34248146697
-
High-capacity adenoviral vector-mediated reduction of Huntingtin aggregate load in vitro and in vivo
-
Huang, B. et al. High-capacity adenoviral vector-mediated reduction of Huntingtin aggregate load in vitro and in vivo. Hum. Gene Ther. 18, 303-311 (2007).
-
(2007)
Hum. Gene Ther.
, vol.18
, pp. 303-311
-
-
Huang, B.1
-
46
-
-
0037448352
-
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
-
Hacein-Bey-Abina, S. et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N. Engl. J. Med. 348, 255-256 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 255-256
-
-
Hacein-Bey-Abina, S.1
-
47
-
-
5444250395
-
Retroviral vectors: New applications for an old tool
-
Barquinero, J., Eixarch, H. & Pérez-Melgosa, M. Retroviral vectors: new applications for an old tool. Gene Ther. 11 (Suppl. 1), S3-S9 (2004).
-
(2004)
Gene Ther.
, vol.11
, Issue.SUPPL. 1
-
-
Barquinero, J.1
Eixarch, H.2
Pérez-Melgosa, M.3
-
48
-
-
57149115125
-
Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccine
-
Lambeth, L. S., Zhao, Y., Smith, L. P., Kgosana, L. & Nair, V. Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccine. Vaccine 27, 298-306 (2009).
-
(2009)
Vaccine
, vol.27
, pp. 298-306
-
-
Lambeth, L.S.1
Zhao, Y.2
Smith, L.P.3
Kgosana, L.4
Nair, V.5
-
49
-
-
49649114274
-
Suppression of hepatitis C virus replication by baculovirus vector-mediated short-hairpin RNA expression
-
Suzuki, H., Tamai, N., Habu, Y., Chang, M. O. & Takaku, H. Suppression of hepatitis C virus replication by baculovirus vector-mediated short-hairpin RNA expression. FEBS Lett. 582, 3085-3089 (2008).
-
(2008)
FEBS Lett.
, vol.582
, pp. 3085-3089
-
-
Suzuki, H.1
Tamai, N.2
Habu, Y.3
Chang, M.O.4
Takaku, H.5
-
50
-
-
36849026128
-
Applications of RNA interference in mammalian systems
-
Martin, S. E. & Caplen, N. J. Applications of RNA interference in mammalian systems. Annu. Rev. Genomics Hum. Genet. 8, 81-108 (2007).
-
(2007)
Annu. Rev. Genomics Hum. Genet.
, vol.8
, pp. 81-108
-
-
Martin, S.E.1
Caplen, N.J.2
-
51
-
-
34248637892
-
Systemic siRNA delivery via hydrodynamic intravascular injection
-
Lewis, D. L. & Wolff, J. A. Systemic siRNA delivery via hydrodynamic intravascular injection. Adv. Drug Deliv. Rev. 59, 115-123 (2007).
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, pp. 115-123
-
-
Lewis, D.L.1
Wolff, J.A.2
-
52
-
-
0346873025
-
Small interfering RNA inhibits hepatitis B virus replication in mice
-
Giladi, H. et al. Small interfering RNA inhibits hepatitis B virus replication in mice. Mol. Ther. 8, 769-776 (2003).
-
(2003)
Mol. Ther.
, vol.8
, pp. 769-776
-
-
Giladi, H.1
-
53
-
-
0038449221
-
Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA
-
Klein, C. et al. Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA. Gastroenterology 125, 9-18 (2003).
-
(2003)
Gastroenterology
, vol.125
, pp. 9-18
-
-
Klein, C.1
-
54
-
-
20044396377
-
Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication
-
Morrissey, D. V. et al. Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication. Hepatology 41, 1349-1356 (2005).
-
(2005)
Hepatology
, vol.41
, pp. 1349-1356
-
-
Morrissey, D.V.1
-
55
-
-
33746265976
-
Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules
-
Sebestyén, M. G. et al. Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J. Gene Med. 8, 852-873 (2006).
-
(2006)
J. Gene Med.
, vol.8
, pp. 852-873
-
-
Sebestyén, M.G.1
-
56
-
-
52449107112
-
Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes
-
Yuan, H. et al. Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes. Am. J. Physiol. Renal Physiol. 295, F605-F617 (2008).
-
(2008)
Am. J. Physiol. Renal Physiol.
, vol.295
-
-
Yuan, H.1
-
57
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
Judge, A. D. et al. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23, 457-462 (2005).
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
-
58
-
-
0030802140
-
Interaction of oligonucleotide- conjugates with the dipeptide transporter system in Caco-2 cells
-
Moore, V. A., Dunnion, D. J., Brown, T., Irwin, W. J. & Akhtar, S. Interaction of oligonucleotide- conjugates with the dipeptide transporter system in Caco-2 cells. Biochem. Pharmacol. 53, 1223-1228 (1997).
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 1223-1228
-
-
Moore, V.A.1
Dunnion, D.J.2
Brown, T.3
Irwin, W.J.4
Akhtar, S.5
-
59
-
-
43049176170
-
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
-
Akinc, A. et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat. Biotechnol. 26, 561-569 (2008).
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 561-569
-
-
Akinc, A.1
-
60
-
-
50149101511
-
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
-
Frank-Kamenetsky, M. et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc. Natl Acad. Sci. USA 105, 11915-11920 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 11915-11920
-
-
Frank-Kamenetsky, M.1
-
61
-
-
41849117310
-
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
-
Sato, Y. et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat. Biotechnol. 26, 431-442 (2008).
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 431-442
-
-
Sato, Y.1
-
62
-
-
33645720317
-
Postexposure protection of guinea pigs against a lethal Ebola virus challenge is conferred by RNA interference
-
Geisbert, T. W. et al. Postexposure protection of guinea pigs against a lethal Ebola virus challenge is conferred by RNA interference. J. Infect. Dis. 193, 1650-1657 (2006).
-
(2006)
J. Infect. Dis.
, vol.193
, pp. 1650-1657
-
-
Geisbert, T.W.1
-
63
-
-
16244362066
-
Cationic lipids enhance siRNA-mediated interferon response in mice
-
Ma, Z. et al. Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem. Biophys. Res. Commun. 330, 755-759 (2005).
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.330
, pp. 755-759
-
-
Ma, Z.1
-
64
-
-
34248213490
-
Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity
-
Hollins, A. J., Omidi, Y., Benter, I. F. & Akhtar, S. Toxicogenomics of drug delivery systems: exploiting delivery system-induced changes in target gene expression to enhance siRNA activity. J. Drug Target. 15, 83-88 (2007).
-
(2007)
J. Drug Target.
, vol.15
, pp. 83-88
-
-
Hollins, A.J.1
Omidi, Y.2
Benter, I.F.3
Akhtar, S.4
-
65
-
-
0031612974
-
The novel lipid delivery system of amphotericin B: Drug profile and relevance to clinical practice
-
Rust, D. M. & Jameson, G. The novel lipid delivery system of amphotericin B: drug profile and relevance to clinical practice. Oncol. Nurs. Forum 25, 35-48 (1998).
-
(1998)
Oncol. Nurs. Forum
, vol.25
, pp. 35-48
-
-
Rust, D.M.1
Jameson, G.2
-
66
-
-
0029160083
-
A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
-
Boussif, O. et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl Acad. Sci. USA 92, 7297-7301 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7297-7301
-
-
Boussif, O.1
-
67
-
-
33744805790
-
Polymers for gene delivery across length scales
-
Putnam, D. Polymers for gene delivery across length scales. Nat. Mater. 5, 439-451 (2006).
-
(2006)
Nat. Mater.
, vol.5
, pp. 439-451
-
-
Putnam, D.1
-
68
-
-
20444377785
-
Polyethylenimine-based non-viral gene delivery systems
-
Lungwitz, U., Breunig, M., Blunk, T. & Göpferich, A. Polyethylenimine-based non-viral gene delivery systems. Eur. J. Pharm. Biopharm. 60, 247-266 (2005).
-
(2005)
Eur. J. Pharm. Biopharm.
, vol.60
, pp. 247-266
-
-
Lungwitz, U.1
Breunig, M.2
Blunk, T.3
Göpferich, A.4
-
69
-
-
47749100430
-
Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity
-
Zintchenko, A., Philipp, A., Dehshahri, A. & Wagner, E. Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity. Bioconjug. Chem. 19, 1448-1455 (2008).
-
(2008)
Bioconjug. Chem.
, vol.19
, pp. 1448-1455
-
-
Zintchenko, A.1
Philipp, A.2
Dehshahri, A.3
Wagner, E.4
-
70
-
-
15444373116
-
RNAi-mediated gene- targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
-
Urban-Klein, B., Werth, S., Abuharbeid, S., Czubayko, F. & Aigner, A. RNAi-mediated gene- targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther. 12, 461-466 (2005).
-
(2005)
Gene Ther.
, vol.12
, pp. 461-466
-
-
Urban-Klein, B.1
Werth, S.2
Abuharbeid, S.3
Czubayko, F.4
Aigner, A.5
-
71
-
-
2942530436
-
Inhibition of influenza virus production in virus-infected mice by RNA interference
-
Ge, Q. et al. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl Acad. Sci. USA 101, 8676-8681 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 8676-8681
-
-
Ge, Q.1
-
72
-
-
3242807724
-
Gene transfer with modified polyethylenimines
-
Kichler, A. Gene transfer with modified polyethylenimines. J. Gene Med. 6 (Suppl. 1), S3-S10 (2004).
-
(2004)
J. Gene Med.
, vol.6
, Issue.SUPPL. 1
-
-
Kichler, A.1
-
73
-
-
0035980982
-
Design and gene delivery activity of modified polyethylenimines
-
Kircheis, R., Wightman, L. & Wagner, E. Design and gene delivery activity of modified polyethylenimines. Adv. Drug Deliv. Rev. 53, 341-358 (2001).
-
(2001)
Adv. Drug Deliv. Rev.
, vol.53
, pp. 341-358
-
-
Kircheis, R.1
Wightman, L.2
Wagner, E.3
-
74
-
-
34548644167
-
Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life
-
Sato, A. et al. Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life. J. Control. Release 122, 209-216 (2007).
-
(2007)
J. Control. Release
, vol.122
, pp. 209-216
-
-
Sato, A.1
-
75
-
-
46549085779
-
Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer
-
Kim, S. H., Jeong, J. H., Lee, S. H., Kim, S. W. & Park, T. G. Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J. Control. Release 129, 107-116 (2008).
-
(2008)
J. Control. Release
, vol.129
, pp. 107-116
-
-
Kim, S.H.1
Jeong, J.H.2
Lee, S.H.3
Kim, S.W.4
Park, T.G.5
-
76
-
-
67649229657
-
Intelligent polymeric micelles from functional poly(ethylene glycol)- poly(amino acid) block copolymers
-
Bae, Y. & Kataoka, K. Intelligent polymeric micelles from functional poly(ethylene glycol)- poly(amino acid) block copolymers. Adv. Drug Deliv. Rev. 61, 768-784 (2009).
-
(2009)
Adv. Drug Deliv. Rev.
, vol.61
, pp. 768-784
-
-
Bae, Y.1
Kataoka, K.2
-
77
-
-
33750136313
-
Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery
-
Nishiyama, N. & Kataoka, K. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol. Ther. 112, 630-648 (2006).
-
(2006)
Pharmacol. Ther.
, vol.112
, pp. 630-648
-
-
Nishiyama, N.1
Kataoka, K.2
-
78
-
-
85047695467
-
Polyion complex micelles as vectors in gene therapy-pharmacokinetics and in vivo gene transfer
-
Harada-Shiba, M. et al. Polyion complex micelles as vectors in gene therapy-pharmacokinetics and in vivo gene transfer. Gene Ther. 9, 407-414 (2002).
-
(2002)
Gene Ther.
, vol.9
, pp. 407-414
-
-
Harada-Shiba, M.1
-
79
-
-
0035080570
-
Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)- Poly(l-lysine) block copolymers
-
Harada, A., Togawa, H. & Kataoka, K. Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)- poly(l-lysine) block copolymers. Eur. J. Pharm. Sci. 13, 35-42 (2001).
-
(2001)
Eur. J. Pharm. Sci.
, vol.13
, pp. 35-42
-
-
Harada, A.1
Togawa, H.2
Kataoka, K.3
-
80
-
-
34250770499
-
Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation
-
Akagi, D. et al. Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation. Gene Ther. 14, 1029-1038 (2007).
-
(2007)
Gene Ther.
, vol.14
, pp. 1029-1038
-
-
Akagi, D.1
-
81
-
-
0022858683
-
A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
-
Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387-6392 (1986).
-
(1986)
Cancer Res.
, vol.46
, pp. 6387-6392
-
-
Matsumura, Y.1
Maeda, H.2
-
82
-
-
34447632643
-
Angiogenesis in brain tumors
-
Jain, R. K. et al. Angiogenesis in brain tumors. Nat. Rev. Neurosci. 8, 610-622 (2007).
-
(2007)
Nat. Rev. Neurosci.
, vol.8
, pp. 610-622
-
-
Jain, R.K.1
-
83
-
-
33644772618
-
Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
-
Dreher, M. R. et al. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J. Natl Cancer Inst. 98, 335-344 (2006).
-
(2006)
J. Natl Cancer Inst.
, vol.98
, pp. 335-344
-
-
Dreher, M.R.1
-
84
-
-
58549112795
-
Environment-responsive block copolymer micelles with a disulfide crosslinked core for enhanced siRNA delivery
-
Matsumoto, S. et al. Environment-responsive block copolymer micelles with a disulfide crosslinked core for enhanced siRNA delivery. Biomacromolecules 10, 119-127 (2009).
-
(2009)
Biomacromolecules
, vol.10
, pp. 119-127
-
-
Matsumoto, S.1
-
85
-
-
77953962853
-
Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown
-
Kim, H. J. et al. Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J. Control. Release 145, 141-148 (2010).
-
(2010)
J. Control. Release
, vol.145
, pp. 141-148
-
-
Kim, H.J.1
-
86
-
-
77956012879
-
Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system
-
Takemoto, H. et al. Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system. Biomaterials 31, 8097-8105 (2010).
-
(2010)
Biomaterials
, vol.31
, pp. 8097-8105
-
-
Takemoto, H.1
-
87
-
-
10844293438
-
Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle- encapsulated doxorubicin
-
Matsumura, Y. et al. Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle- encapsulated doxorubicin. Br. J. Cancer 91, 1775-1781 (2004).
-
(2004)
Br. J. Cancer
, vol.91
, pp. 1775-1781
-
-
Matsumura, Y.1
-
88
-
-
34447331464
-
A phase I and pharmacokinetic study of NK105, a paclitaxel- incorporating micellar nanoparticle formulation
-
Hamaguchi, T. et al. A phase I and pharmacokinetic study of NK105, a paclitaxel- incorporating micellar nanoparticle formulation. Br. J. Cancer 97, 170-176 (2007).
-
(2007)
Br. J. Cancer
, vol.97
, pp. 170-176
-
-
Hamaguchi, T.1
-
89
-
-
37849039288
-
Nanomedicine: Sizing up targets with nanoparticles
-
Minchin, R. Nanomedicine: sizing up targets with nanoparticles. Nat. Nanotechnol. 3, 12-13 (2008).
-
(2008)
Nat. Nanotechnol.
, vol.3
, pp. 12-13
-
-
Minchin, R.1
-
90
-
-
40449122796
-
Nanoparticle-mediated cellular response is size- dependent
-
Jiang, W., Kim, B. Y., Rutka, J. T. & Chan, W. C. Nanoparticle-mediated cellular response is size- dependent. Nat. Nanotechnol. 3, 145-150 (2008).
-
(2008)
Nat. Nanotechnol.
, vol.3
, pp. 145-150
-
-
Jiang, W.1
Kim, B.Y.2
Rutka, J.T.3
Chan, W.C.4
-
91
-
-
0025144965
-
Structure of the glomerular mesangium: A biomechanical interpretation
-
Kriz, W., Elger, M., Lemley, K. & Sakai, T. Structure of the glomerular mesangium: a biomechanical interpretation. Kidney Int. Suppl. 30, S2-S9 (1990).
-
(1990)
Kidney Int. Suppl.
, vol.30
-
-
Kriz, W.1
Elger, M.2
Lemley, K.3
Sakai, T.4
-
92
-
-
0027138877
-
Glomerulosclerosis induced by in vivo transfection of transforming growth factor-β or platelet-derived growth factor gene into the rat kidney
-
Isaka, Y. et al. Glomerulosclerosis induced by in vivo transfection of transforming growth factor-β or platelet-derived growth factor gene into the rat kidney. J. Clin. Invest. 92, 2597-2601 (1993).
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 2597-2601
-
-
Isaka, Y.1
-
93
-
-
0032103310
-
Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo
-
Maeshima, Y. et al. Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo. J. Clin. Invest. 101, 2589-2597 (1998).
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 2589-2597
-
-
Maeshima, Y.1
-
94
-
-
0034050031
-
In vivo administration of a nuclear transcription factor-.B decoy suppresses experimental crescentic glomerulonephritis
-
Tomita, N. et al. In vivo administration of a nuclear transcription factor-.B decoy suppresses experimental crescentic glomerulonephritis. J. Am. Soc. Nephrol. 11, 1244-1252 (2000).
-
(2000)
J. Am. Soc. Nephrol.
, vol.11
, pp. 1244-1252
-
-
Tomita, N.1
-
95
-
-
21344454891
-
Exploring RNA interference as a therapeutic strategy for renal disease
-
Takabatake, Y. et al. Exploring RNA interference as a therapeutic strategy for renal disease. Gene Ther. 12, 965-973 (2005).
-
(2005)
Gene Ther.
, vol.12
, pp. 965-973
-
-
Takabatake, Y.1
-
96
-
-
44749089187
-
Renal press-mediated transfection method for plasmid DNA and siRNA to the kidney
-
Mukai, H., Kawakami, S. & Hashida, M. Renal press-mediated transfection method for plasmid DNA and siRNA to the kidney. Biochem. Biophys. Res. Commun. 372, 383-387 (2008).
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.372
, pp. 383-387
-
-
Mukai, H.1
Kawakami, S.2
Hashida, M.3
-
97
-
-
33644873618
-
Immunoliposome targeting to mesangial cells: A promising strategy for specific drug delivery to the kidney
-
Tuffin, G., Waelti, E., Huwyler, J., Hammer, C. & Marti, H. P. Immunoliposome targeting to mesangial cells: a promising strategy for specific drug delivery to the kidney. J. Am. Soc. Nephrol. 16, 3295-3305 (2005).
-
(2005)
J. Am. Soc. Nephrol.
, vol.16
, pp. 3295-3305
-
-
Tuffin, G.1
Waelti, E.2
Huwyler, J.3
Hammer, C.4
Marti, H.P.5
-
98
-
-
41149118880
-
Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone- loaded AbEsel liposomes
-
Asgeirsdóttir, S. A. et al. Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone. loaded AbEsel liposomes. Am. J. Physiol. Renal Physiol. 294, F554-F561 (2008).
-
(2008)
Am. J. Physiol. Renal Physiol.
, vol.294
-
-
Asgeirsdóttir, S.A.1
-
99
-
-
54949095836
-
Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
-
Robbins, M. et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum. Gene Ther. 19, 991-999 (2008).
-
(2008)
Hum. Gene Ther.
, vol.19
, pp. 991-999
-
-
Robbins, M.1
-
100
-
-
41649115210
-
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
-
Kleinman, M. E. et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452, 591-597 (2008).
-
(2008)
Nature
, vol.452
, pp. 591-597
-
-
Kleinman, M.E.1
-
101
-
-
39449097277
-
Overcoming the innate immune response to small interfering RNA
-
Judge, A. & MacLachan, I. Overcoming the innate immune response to small interfering RNA. Hum. Gene Ther. 19, 111-124 (2008).
-
(2008)
Hum. Gene Ther.
, vol.19
, pp. 111-124
-
-
Judge, A.1
MacLachan, I.2
-
102
-
-
53449090205
-
Gene silencing of β-catenin in melanoma cells retards their growth but promotes the formulation of pulmonary metastasis in mice
-
Takahashi, Y., Nishikawa, M., Suehara, T., Takiguchi, N. & Takakura, Y. Gene silencing of β-catenin in melanoma cells retards their growth but promotes the formulation of pulmonary metastasis in mice. Int. J. Cancer 123, 2315-2320 (2008).
-
(2008)
Int. J. Cancer
, vol.123
, pp. 2315-2320
-
-
Takahashi, Y.1
Nishikawa, M.2
Suehara, T.3
Takiguchi, N.4
Takakura, Y.5
-
103
-
-
38649099969
-
Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity
-
Chen, P. Y. et al. Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA 14, 263-274 (2008).
-
(2008)
RNA
, vol.14
, pp. 263-274
-
-
Chen, P.Y.1
-
104
-
-
34648843428
-
5 integrins
-
5 integrins. Bioconjung. Chem. 18, 1415-1423 (2007).
-
(2007)
Bioconjung. Chem.
, vol.18
, pp. 1415-1423
-
-
Oba, M.1
-
105
-
-
56549091431
-
The complexity of mitogen-activated protein kinases (MAPKs) made simple
-
Krishna, M. & Narang, H. The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell. Mol. Life Sci. 65, 3525-3544 (2008).
-
(2008)
Cell. Mol. Life Sci.
, vol.65
, pp. 3525-3544
-
-
Krishna, M.1
Narang, H.2
-
106
-
-
77950620597
-
siRNA therapy for glomerulonephritis
-
Kreidberg, J. A. siRNA therapy for glomerulonephritis. J. Am. Soc. Nephrol. 21, 549-551 (2010).
-
(2010)
J. Am. Soc. Nephrol.
, vol.21
, pp. 549-551
-
-
Kreidberg, J.A.1
|