메뉴 건너뛰기




Volumn 7, Issue 7, 2011, Pages 407-415

New short interfering RNA-based therapies for glomerulonephritis

Author keywords

[No Author keywords available]

Indexed keywords

DRUG VEHICLE; LIPOSOME; NANOPARTICLE; POLYMER; SMALL INTERFERING RNA; VIRUS VECTOR;

EID: 79959761258     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2011.61     Document Type: Review
Times cited : (9)

References (106)
  • 1
    • 55349133352 scopus 로고    scopus 로고
    • Present and future drug treatments for chronic kidney diseases: Evolving targets in renoprotection
    • Perico, N., Benigni, A. & Remuzzi, G. Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection. Nat. Rev. Drug Discov. 7, 936-953 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 936-953
    • Perico, N.1    Benigni, A.2    Remuzzi, G.3
  • 2
    • 1642413198 scopus 로고    scopus 로고
    • Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization
    • Keith, D. S., Nichols, G. A., Gullion, C. M., Brown, J. B. & Smith, D. H. Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch. Intern. Med. 164, 659-663 (2004).
    • (2004) Arch. Intern. Med. , vol.164 , pp. 659-663
    • Keith, D.S.1    Nichols, G.A.2    Gullion, C.M.3    Brown, J.B.4    Smith, D.H.5
  • 3
    • 0141468244 scopus 로고    scopus 로고
    • Kidney disease as a risk factor for development of cardiovascular disease: A statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention
    • Sarnak, M. J. et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation 108, 2154-2169 (2003).
    • (2003) Circulation , vol.108 , pp. 2154-2169
    • Sarnak, M.J.1
  • 4
    • 15844368318 scopus 로고    scopus 로고
    • Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency
    • The Angiotensin-Converting- Enzyme Inhibition in Progressive Renal Insufficiency Study Group
    • Maschio, G. et al. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting- Enzyme Inhibition in Progressive Renal Insufficiency Study Group. N. Engl. J. Med. 334, 939-945 (1996).
    • (1996) N. Engl. J. Med. , vol.334 , pp. 939-945
    • Maschio, G.1
  • 5
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner, B. M. et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N. Engl. J. Med. 345, 861-869 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 861-869
    • Brenner, B.M.1
  • 6
    • 77950611468 scopus 로고    scopus 로고
    • siRNA-based therapy ameliorates glomerulonephritis
    • Shimizu, H. et al. siRNA-based therapy ameliorates glomerulonephritis. J. Am. Soc. Nephrol. 21, 622-633 (2010).
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 622-633
    • Shimizu, H.1
  • 8
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1
  • 9
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1
  • 10
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein, E., Caudy, A. A., Hammond, S. M. & Hannon, G. J. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363-366 (2001).
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 11
    • 5144225452 scopus 로고    scopus 로고
    • Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity
    • Rand, T. A., Ginalski, K., Grishin, N. V. & Wang, X. Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc. Natl Acad. Sci. USA 101, 14385-14389 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 14385-14389
    • Rand, T.A.1    Ginalski, K.2    Grishin, N.V.3    Wang, X.4
  • 12
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez, J., Patkaniowska, A., Urlaub, H., Lührmann, R. & Tuschl, T. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110, 563-574 (2002).
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Lührmann, R.4    Tuschl, T.5
  • 13
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    • Matranga, C., Tomari, Y., Shin, C., Bartel, D. P. & Zamore, P. D. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 123, 607-620 (2005).
    • (2005) Cell , vol.123 , pp. 607-620
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.P.4    Zamore, P.D.5
  • 14
    • 34447102459 scopus 로고    scopus 로고
    • Molecular basis for target RNA recognition and cleavage by human RISC
    • Ameres, S. L., Martinez, J. & Schroeder, R. Molecular basis for target RNA recognition and cleavage by human RISC. Cell 130, 101-112 (2007).
    • (2007) Cell , vol.130 , pp. 101-112
    • Ameres, S.L.1    Martinez, J.2    Schroeder, R.3
  • 15
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvágner, G. & Zamore, P. D. A microRNA in a multiple-turnover RNAi enzyme complex. Science 297, 2056-2060 (2002).
    • (2002) Science , vol.297 , pp. 2056-2060
    • Hutvágner, G.1    Zamore, P.D.2
  • 16
    • 31544456413 scopus 로고    scopus 로고
    • Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
    • Bartlett, D. W. & Davis, M. E. Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res. 34, 322-333 (2006).
    • (2006) Nucleic Acids Res. , vol.34 , pp. 322-333
    • Bartlett, D.W.1    Davis, M.E.2
  • 17
    • 0037019339 scopus 로고    scopus 로고
    • RNA interference in adult mice
    • McCaffrey, A. P. et al. RNA interference in adult mice. Nature 418, 38-39 (2002).
    • (2002) Nature , vol.418 , pp. 38-39
    • McCaffrey, A.P.1
  • 18
    • 16244377103 scopus 로고    scopus 로고
    • A crucial test
    • Check, E. A crucial test. Nat. Med. 11, 243-244 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 243-244
    • Check, E.1
  • 19
    • 43749096100 scopus 로고    scopus 로고
    • Neovascular age- related macular degeneration: Potential therapies
    • Chappelow, A. V. & Kaiser, P. K. Neovascular age- related macular degeneration: potential therapies. Drugs 68, 1029-1036 (2008).
    • (2008) Drugs , vol.68 , pp. 1029-1036
    • Chappelow, A.V.1    Kaiser, P.K.2
  • 20
    • 36849044732 scopus 로고    scopus 로고
    • Nonviral delivery of synthetic siRNAs in vivo
    • Akhtar, S. & Benter, I. F. Nonviral delivery of synthetic siRNAs in vivo. J. Clin. Invest. 117, 3623-3632 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 3623-3632
    • Akhtar, S.1    Benter, I.F.2
  • 22
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto, D. & Rossi, J. J. The promises and pitfalls of RNA-interference-based therapeutics. Nature 457, 426-433 (2009).
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 23
    • 70449089802 scopus 로고    scopus 로고
    • Strategies for targeted nonviral delivery of siRNAs in vivo
    • Kim, S. S., Garg, H., Joshi, A. & Manjunath, N. Strategies for targeted nonviral delivery of siRNAs in vivo. Trends Mol. Med. 15, 491-500 (2009).
    • (2009) Trends Mol. Med. , vol.15 , pp. 491-500
    • Kim, S.S.1    Garg, H.2    Joshi, A.3    Manjunath, N.4
  • 24
    • 69549119978 scopus 로고    scopus 로고
    • siRNAs: Their potential as therapeutic agents - Part II. Methods of delivery
    • Singh, S. K. & Hajeri, P. B. siRNAs: their potential as therapeutic agents - Part II. Methods of delivery. Drug Discov. Today 14, 859-865 (2009).
    • (2009) Drug Discov. Today , vol.14 , pp. 859-865
    • Singh, S.K.1    Hajeri, P.B.2
  • 25
    • 65749119809 scopus 로고    scopus 로고
    • Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy
    • Takahashi, Y., Nisikawa, M. & Takakura, Y. Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy. Adv. Drug Deliv. Rev. 61, 760-766 (2009).
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 760-766
    • Takahashi, Y.1    Nisikawa, M.2    Takakura, Y.3
  • 26
    • 44949122670 scopus 로고    scopus 로고
    • Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
    • Savaskan, N. E. et al. Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema. Nat. Med. 14, 629-632 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 629-632
    • Savaskan, N.E.1
  • 27
    • 30144434185 scopus 로고    scopus 로고
    • An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
    • Palliser, D. et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 439, 89-94 (2006).
    • (2006) Nature , vol.439 , pp. 89-94
    • Palliser, D.1
  • 28
    • 43049176170 scopus 로고    scopus 로고
    • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
    • Akinc, A. et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat. Biotechnol. 26, 561-569 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , pp. 561-569
    • Akinc, A.1
  • 29
    • 38749136602 scopus 로고    scopus 로고
    • Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
    • DeVincenzo, J. et al. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). Antiviral Res. 77, 225-231 (2008).
    • (2008) Antiviral Res. , vol.77 , pp. 225-231
    • DeVincenzo, J.1
  • 30
    • 39149111247 scopus 로고    scopus 로고
    • Single-nucleotide-specific siRNA targeting in a dominant-negative skin model
    • Hickerson, R. P. et al. Single-nucleotide-specific siRNA targeting in a dominant-negative skin model. J. Invest. Dermatol. 128, 594-605 (2008).
    • (2008) J. Invest. Dermatol. , vol.128 , pp. 594-605
    • Hickerson, R.P.1
  • 31
    • 55549114663 scopus 로고    scopus 로고
    • 5'-triphosphate-siRNA: Turning gene silencing and Rig-I activation against melanoma
    • Poeck, H. et al. 5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat. Med. 14, 1256-1263 (2008).
    • (2008) Nat. Med. , vol.14 , pp. 1256-1263
    • Poeck, H.1
  • 32
    • 33646185371 scopus 로고    scopus 로고
    • RNAi-mediated gene silencing in non-human primates
    • Zimmermann, T. S. et al. RNAi-mediated gene silencing in non-human primates. Nature 441, 111-114 (2006).
    • (2006) Nature , vol.441 , pp. 111-114
    • Zimmermann, T.S.1
  • 33
    • 51049092308 scopus 로고    scopus 로고
    • Factors affecting the clearance and biodistribution of polymeric nanoparticles
    • Alexis, F., Pridgen, E., Molnar, L. K. & Farokhzad, O. C. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm. 5, 505-515 (2008).
    • (2008) Mol. Pharm. , vol.5 , pp. 505-515
    • Alexis, F.1    Pridgen, E.2    Molnar, L.K.3    Farokhzad, O.C.4
  • 34
    • 33746070441 scopus 로고    scopus 로고
    • Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules
    • van de Water, F. M. et al. Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules. Drug Metab. Dispos. 34, 1393-1397 (2006).
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 1393-1397
    • Van De Water, F.M.1
  • 35
    • 23444445660 scopus 로고    scopus 로고
    • Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
    • Morrissey, D. V. et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotechnol. 23, 1002-1007 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1002-1007
    • Morrissey, D.V.1
  • 36
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek, J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173-178 (2004).
    • (2004) Nature , vol.432 , pp. 173-178
    • Soutschek, J.1
  • 38
    • 59849125915 scopus 로고    scopus 로고
    • Phosphorothioate- stimulated cellular uptake of siRNA: A cell culture model for mechanistic studies
    • Detzer, A., Overhoff, M., Mescalchin, A., Rompf, M. & Sczakiel, G. Phosphorothioate- stimulated cellular uptake of siRNA: a cell culture model for mechanistic studies. Curr. Pharm. Des. 14, 3666-3673 (2008).
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 3666-3673
    • Detzer, A.1    Overhoff, M.2    Mescalchin, A.3    Rompf, M.4    Sczakiel, G.5
  • 39
    • 33846813849 scopus 로고    scopus 로고
    • Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
    • Oliveira, S., van Rooy, I., Kranenburg, O., Storm, G. & Schiffelers, R. M. Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes. Int. J. Pharm. 331, 211-214 (2007).
    • (2007) Int. J. Pharm. , vol.331 , pp. 211-214
    • Oliveira, S.1    Van Rooy, I.2    Kranenburg, O.3    Storm, G.4    Schiffelers, R.M.5
  • 41
    • 34548532823 scopus 로고    scopus 로고
    • Targeted delivery systems of small interfering RNA by systemic administration
    • Kawakami, S. & Hashida, M. Targeted delivery systems of small interfering RNA by systemic administration. Drug Metab. Pharmacokinet. 22, 142-151 (2007).
    • (2007) Drug Metab. Pharmacokinet. , vol.22 , pp. 142-151
    • Kawakami, S.1    Hashida, M.2
  • 42
    • 34248672837 scopus 로고    scopus 로고
    • Toxicogenomics of non- viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene silencing activity and specificity
    • Akhtar, S. & Benter, I. Toxicogenomics of non- viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity. Adv. Drug Deliv. Rev. 59, 164-182 (2007).
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 164-182
    • Akhtar, S.1    Benter, I.2
  • 43
    • 0037468660 scopus 로고    scopus 로고
    • Gene silencing by adenovirus- delivered siRNAs
    • Shen, C. Buck, A. K., Liu, X., Winkler, M. & Reske, S. N. Gene silencing by adenovirus- delivered siRNAs. FEBS Lett. 539, 111-114 (2003).
    • (2003) FEBS Lett. , vol.539 , pp. 111-114
    • Shen, C.1    Buck, A.K.2    Liu, X.3    Winkler, M.4    Reske, S.N.5
  • 44
    • 44249085878 scopus 로고    scopus 로고
    • Safety and efficacy of gene transfer for Leber's congenital amaurosis
    • Maguire, A. M. et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N. Engl. J. Med. 358, 2240-2248 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2240-2248
    • Maguire, A.M.1
  • 45
    • 34248146697 scopus 로고    scopus 로고
    • High-capacity adenoviral vector-mediated reduction of Huntingtin aggregate load in vitro and in vivo
    • Huang, B. et al. High-capacity adenoviral vector-mediated reduction of Huntingtin aggregate load in vitro and in vivo. Hum. Gene Ther. 18, 303-311 (2007).
    • (2007) Hum. Gene Ther. , vol.18 , pp. 303-311
    • Huang, B.1
  • 46
    • 0037448352 scopus 로고    scopus 로고
    • A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
    • Hacein-Bey-Abina, S. et al. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N. Engl. J. Med. 348, 255-256 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 255-256
    • Hacein-Bey-Abina, S.1
  • 47
    • 5444250395 scopus 로고    scopus 로고
    • Retroviral vectors: New applications for an old tool
    • Barquinero, J., Eixarch, H. & Pérez-Melgosa, M. Retroviral vectors: new applications for an old tool. Gene Ther. 11 (Suppl. 1), S3-S9 (2004).
    • (2004) Gene Ther. , vol.11 , Issue.SUPPL. 1
    • Barquinero, J.1    Eixarch, H.2    Pérez-Melgosa, M.3
  • 48
    • 57149115125 scopus 로고    scopus 로고
    • Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccine
    • Lambeth, L. S., Zhao, Y., Smith, L. P., Kgosana, L. & Nair, V. Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccine. Vaccine 27, 298-306 (2009).
    • (2009) Vaccine , vol.27 , pp. 298-306
    • Lambeth, L.S.1    Zhao, Y.2    Smith, L.P.3    Kgosana, L.4    Nair, V.5
  • 49
    • 49649114274 scopus 로고    scopus 로고
    • Suppression of hepatitis C virus replication by baculovirus vector-mediated short-hairpin RNA expression
    • Suzuki, H., Tamai, N., Habu, Y., Chang, M. O. & Takaku, H. Suppression of hepatitis C virus replication by baculovirus vector-mediated short-hairpin RNA expression. FEBS Lett. 582, 3085-3089 (2008).
    • (2008) FEBS Lett. , vol.582 , pp. 3085-3089
    • Suzuki, H.1    Tamai, N.2    Habu, Y.3    Chang, M.O.4    Takaku, H.5
  • 50
    • 36849026128 scopus 로고    scopus 로고
    • Applications of RNA interference in mammalian systems
    • Martin, S. E. & Caplen, N. J. Applications of RNA interference in mammalian systems. Annu. Rev. Genomics Hum. Genet. 8, 81-108 (2007).
    • (2007) Annu. Rev. Genomics Hum. Genet. , vol.8 , pp. 81-108
    • Martin, S.E.1    Caplen, N.J.2
  • 51
    • 34248637892 scopus 로고    scopus 로고
    • Systemic siRNA delivery via hydrodynamic intravascular injection
    • Lewis, D. L. & Wolff, J. A. Systemic siRNA delivery via hydrodynamic intravascular injection. Adv. Drug Deliv. Rev. 59, 115-123 (2007).
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 115-123
    • Lewis, D.L.1    Wolff, J.A.2
  • 52
    • 0346873025 scopus 로고    scopus 로고
    • Small interfering RNA inhibits hepatitis B virus replication in mice
    • Giladi, H. et al. Small interfering RNA inhibits hepatitis B virus replication in mice. Mol. Ther. 8, 769-776 (2003).
    • (2003) Mol. Ther. , vol.8 , pp. 769-776
    • Giladi, H.1
  • 53
    • 0038449221 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA
    • Klein, C. et al. Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA. Gastroenterology 125, 9-18 (2003).
    • (2003) Gastroenterology , vol.125 , pp. 9-18
    • Klein, C.1
  • 54
    • 20044396377 scopus 로고    scopus 로고
    • Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication
    • Morrissey, D. V. et al. Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication. Hepatology 41, 1349-1356 (2005).
    • (2005) Hepatology , vol.41 , pp. 1349-1356
    • Morrissey, D.V.1
  • 55
    • 33746265976 scopus 로고    scopus 로고
    • Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules
    • Sebestyén, M. G. et al. Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J. Gene Med. 8, 852-873 (2006).
    • (2006) J. Gene Med. , vol.8 , pp. 852-873
    • Sebestyén, M.G.1
  • 56
    • 52449107112 scopus 로고    scopus 로고
    • Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes
    • Yuan, H. et al. Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes. Am. J. Physiol. Renal Physiol. 295, F605-F617 (2008).
    • (2008) Am. J. Physiol. Renal Physiol. , vol.295
    • Yuan, H.1
  • 57
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge, A. D. et al. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 23, 457-462 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-462
    • Judge, A.D.1
  • 58
    • 0030802140 scopus 로고    scopus 로고
    • Interaction of oligonucleotide- conjugates with the dipeptide transporter system in Caco-2 cells
    • Moore, V. A., Dunnion, D. J., Brown, T., Irwin, W. J. & Akhtar, S. Interaction of oligonucleotide- conjugates with the dipeptide transporter system in Caco-2 cells. Biochem. Pharmacol. 53, 1223-1228 (1997).
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 1223-1228
    • Moore, V.A.1    Dunnion, D.J.2    Brown, T.3    Irwin, W.J.4    Akhtar, S.5
  • 59
    • 43049176170 scopus 로고    scopus 로고
    • A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
    • Akinc, A. et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat. Biotechnol. 26, 561-569 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , pp. 561-569
    • Akinc, A.1
  • 60
    • 50149101511 scopus 로고    scopus 로고
    • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
    • Frank-Kamenetsky, M. et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc. Natl Acad. Sci. USA 105, 11915-11920 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 11915-11920
    • Frank-Kamenetsky, M.1
  • 61
    • 41849117310 scopus 로고    scopus 로고
    • Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
    • Sato, Y. et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat. Biotechnol. 26, 431-442 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , pp. 431-442
    • Sato, Y.1
  • 62
    • 33645720317 scopus 로고    scopus 로고
    • Postexposure protection of guinea pigs against a lethal Ebola virus challenge is conferred by RNA interference
    • Geisbert, T. W. et al. Postexposure protection of guinea pigs against a lethal Ebola virus challenge is conferred by RNA interference. J. Infect. Dis. 193, 1650-1657 (2006).
    • (2006) J. Infect. Dis. , vol.193 , pp. 1650-1657
    • Geisbert, T.W.1
  • 63
    • 16244362066 scopus 로고    scopus 로고
    • Cationic lipids enhance siRNA-mediated interferon response in mice
    • Ma, Z. et al. Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem. Biophys. Res. Commun. 330, 755-759 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.330 , pp. 755-759
    • Ma, Z.1
  • 64
    • 34248213490 scopus 로고    scopus 로고
    • Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity
    • Hollins, A. J., Omidi, Y., Benter, I. F. & Akhtar, S. Toxicogenomics of drug delivery systems: exploiting delivery system-induced changes in target gene expression to enhance siRNA activity. J. Drug Target. 15, 83-88 (2007).
    • (2007) J. Drug Target. , vol.15 , pp. 83-88
    • Hollins, A.J.1    Omidi, Y.2    Benter, I.F.3    Akhtar, S.4
  • 65
    • 0031612974 scopus 로고    scopus 로고
    • The novel lipid delivery system of amphotericin B: Drug profile and relevance to clinical practice
    • Rust, D. M. & Jameson, G. The novel lipid delivery system of amphotericin B: drug profile and relevance to clinical practice. Oncol. Nurs. Forum 25, 35-48 (1998).
    • (1998) Oncol. Nurs. Forum , vol.25 , pp. 35-48
    • Rust, D.M.1    Jameson, G.2
  • 66
    • 0029160083 scopus 로고
    • A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine
    • Boussif, O. et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl Acad. Sci. USA 92, 7297-7301 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 7297-7301
    • Boussif, O.1
  • 67
    • 33744805790 scopus 로고    scopus 로고
    • Polymers for gene delivery across length scales
    • Putnam, D. Polymers for gene delivery across length scales. Nat. Mater. 5, 439-451 (2006).
    • (2006) Nat. Mater. , vol.5 , pp. 439-451
    • Putnam, D.1
  • 69
    • 47749100430 scopus 로고    scopus 로고
    • Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity
    • Zintchenko, A., Philipp, A., Dehshahri, A. & Wagner, E. Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity. Bioconjug. Chem. 19, 1448-1455 (2008).
    • (2008) Bioconjug. Chem. , vol.19 , pp. 1448-1455
    • Zintchenko, A.1    Philipp, A.2    Dehshahri, A.3    Wagner, E.4
  • 70
    • 15444373116 scopus 로고    scopus 로고
    • RNAi-mediated gene- targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo
    • Urban-Klein, B., Werth, S., Abuharbeid, S., Czubayko, F. & Aigner, A. RNAi-mediated gene- targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther. 12, 461-466 (2005).
    • (2005) Gene Ther. , vol.12 , pp. 461-466
    • Urban-Klein, B.1    Werth, S.2    Abuharbeid, S.3    Czubayko, F.4    Aigner, A.5
  • 71
    • 2942530436 scopus 로고    scopus 로고
    • Inhibition of influenza virus production in virus-infected mice by RNA interference
    • Ge, Q. et al. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl Acad. Sci. USA 101, 8676-8681 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 8676-8681
    • Ge, Q.1
  • 72
    • 3242807724 scopus 로고    scopus 로고
    • Gene transfer with modified polyethylenimines
    • Kichler, A. Gene transfer with modified polyethylenimines. J. Gene Med. 6 (Suppl. 1), S3-S10 (2004).
    • (2004) J. Gene Med. , vol.6 , Issue.SUPPL. 1
    • Kichler, A.1
  • 73
    • 0035980982 scopus 로고    scopus 로고
    • Design and gene delivery activity of modified polyethylenimines
    • Kircheis, R., Wightman, L. & Wagner, E. Design and gene delivery activity of modified polyethylenimines. Adv. Drug Deliv. Rev. 53, 341-358 (2001).
    • (2001) Adv. Drug Deliv. Rev. , vol.53 , pp. 341-358
    • Kircheis, R.1    Wightman, L.2    Wagner, E.3
  • 74
    • 34548644167 scopus 로고    scopus 로고
    • Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life
    • Sato, A. et al. Polymer brush-stabilized polyplex for a siRNA carrier with long circulatory half-life. J. Control. Release 122, 209-216 (2007).
    • (2007) J. Control. Release , vol.122 , pp. 209-216
    • Sato, A.1
  • 75
    • 46549085779 scopus 로고    scopus 로고
    • Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer
    • Kim, S. H., Jeong, J. H., Lee, S. H., Kim, S. W. & Park, T. G. Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J. Control. Release 129, 107-116 (2008).
    • (2008) J. Control. Release , vol.129 , pp. 107-116
    • Kim, S.H.1    Jeong, J.H.2    Lee, S.H.3    Kim, S.W.4    Park, T.G.5
  • 76
    • 67649229657 scopus 로고    scopus 로고
    • Intelligent polymeric micelles from functional poly(ethylene glycol)- poly(amino acid) block copolymers
    • Bae, Y. & Kataoka, K. Intelligent polymeric micelles from functional poly(ethylene glycol)- poly(amino acid) block copolymers. Adv. Drug Deliv. Rev. 61, 768-784 (2009).
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 768-784
    • Bae, Y.1    Kataoka, K.2
  • 77
    • 33750136313 scopus 로고    scopus 로고
    • Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery
    • Nishiyama, N. & Kataoka, K. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol. Ther. 112, 630-648 (2006).
    • (2006) Pharmacol. Ther. , vol.112 , pp. 630-648
    • Nishiyama, N.1    Kataoka, K.2
  • 78
    • 85047695467 scopus 로고    scopus 로고
    • Polyion complex micelles as vectors in gene therapy-pharmacokinetics and in vivo gene transfer
    • Harada-Shiba, M. et al. Polyion complex micelles as vectors in gene therapy-pharmacokinetics and in vivo gene transfer. Gene Ther. 9, 407-414 (2002).
    • (2002) Gene Ther. , vol.9 , pp. 407-414
    • Harada-Shiba, M.1
  • 79
    • 0035080570 scopus 로고    scopus 로고
    • Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)- Poly(l-lysine) block copolymers
    • Harada, A., Togawa, H. & Kataoka, K. Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)- poly(l-lysine) block copolymers. Eur. J. Pharm. Sci. 13, 35-42 (2001).
    • (2001) Eur. J. Pharm. Sci. , vol.13 , pp. 35-42
    • Harada, A.1    Togawa, H.2    Kataoka, K.3
  • 80
    • 34250770499 scopus 로고    scopus 로고
    • Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation
    • Akagi, D. et al. Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation. Gene Ther. 14, 1029-1038 (2007).
    • (2007) Gene Ther. , vol.14 , pp. 1029-1038
    • Akagi, D.1
  • 81
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura, Y. & Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46, 6387-6392 (1986).
    • (1986) Cancer Res. , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 82
    • 34447632643 scopus 로고    scopus 로고
    • Angiogenesis in brain tumors
    • Jain, R. K. et al. Angiogenesis in brain tumors. Nat. Rev. Neurosci. 8, 610-622 (2007).
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 610-622
    • Jain, R.K.1
  • 83
    • 33644772618 scopus 로고    scopus 로고
    • Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
    • Dreher, M. R. et al. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J. Natl Cancer Inst. 98, 335-344 (2006).
    • (2006) J. Natl Cancer Inst. , vol.98 , pp. 335-344
    • Dreher, M.R.1
  • 84
    • 58549112795 scopus 로고    scopus 로고
    • Environment-responsive block copolymer micelles with a disulfide crosslinked core for enhanced siRNA delivery
    • Matsumoto, S. et al. Environment-responsive block copolymer micelles with a disulfide crosslinked core for enhanced siRNA delivery. Biomacromolecules 10, 119-127 (2009).
    • (2009) Biomacromolecules , vol.10 , pp. 119-127
    • Matsumoto, S.1
  • 85
    • 77953962853 scopus 로고    scopus 로고
    • Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown
    • Kim, H. J. et al. Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown. J. Control. Release 145, 141-148 (2010).
    • (2010) J. Control. Release , vol.145 , pp. 141-148
    • Kim, H.J.1
  • 86
    • 77956012879 scopus 로고    scopus 로고
    • Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system
    • Takemoto, H. et al. Polyion complex stability and gene silencing efficiency with a siRNA-grafted polymer delivery system. Biomaterials 31, 8097-8105 (2010).
    • (2010) Biomaterials , vol.31 , pp. 8097-8105
    • Takemoto, H.1
  • 87
    • 10844293438 scopus 로고    scopus 로고
    • Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle- encapsulated doxorubicin
    • Matsumura, Y. et al. Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle- encapsulated doxorubicin. Br. J. Cancer 91, 1775-1781 (2004).
    • (2004) Br. J. Cancer , vol.91 , pp. 1775-1781
    • Matsumura, Y.1
  • 88
    • 34447331464 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of NK105, a paclitaxel- incorporating micellar nanoparticle formulation
    • Hamaguchi, T. et al. A phase I and pharmacokinetic study of NK105, a paclitaxel- incorporating micellar nanoparticle formulation. Br. J. Cancer 97, 170-176 (2007).
    • (2007) Br. J. Cancer , vol.97 , pp. 170-176
    • Hamaguchi, T.1
  • 89
    • 37849039288 scopus 로고    scopus 로고
    • Nanomedicine: Sizing up targets with nanoparticles
    • Minchin, R. Nanomedicine: sizing up targets with nanoparticles. Nat. Nanotechnol. 3, 12-13 (2008).
    • (2008) Nat. Nanotechnol. , vol.3 , pp. 12-13
    • Minchin, R.1
  • 90
    • 40449122796 scopus 로고    scopus 로고
    • Nanoparticle-mediated cellular response is size- dependent
    • Jiang, W., Kim, B. Y., Rutka, J. T. & Chan, W. C. Nanoparticle-mediated cellular response is size- dependent. Nat. Nanotechnol. 3, 145-150 (2008).
    • (2008) Nat. Nanotechnol. , vol.3 , pp. 145-150
    • Jiang, W.1    Kim, B.Y.2    Rutka, J.T.3    Chan, W.C.4
  • 91
    • 0025144965 scopus 로고
    • Structure of the glomerular mesangium: A biomechanical interpretation
    • Kriz, W., Elger, M., Lemley, K. & Sakai, T. Structure of the glomerular mesangium: a biomechanical interpretation. Kidney Int. Suppl. 30, S2-S9 (1990).
    • (1990) Kidney Int. Suppl. , vol.30
    • Kriz, W.1    Elger, M.2    Lemley, K.3    Sakai, T.4
  • 92
    • 0027138877 scopus 로고
    • Glomerulosclerosis induced by in vivo transfection of transforming growth factor-β or platelet-derived growth factor gene into the rat kidney
    • Isaka, Y. et al. Glomerulosclerosis induced by in vivo transfection of transforming growth factor-β or platelet-derived growth factor gene into the rat kidney. J. Clin. Invest. 92, 2597-2601 (1993).
    • (1993) J. Clin. Invest. , vol.92 , pp. 2597-2601
    • Isaka, Y.1
  • 93
    • 0032103310 scopus 로고    scopus 로고
    • Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo
    • Maeshima, Y. et al. Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo. J. Clin. Invest. 101, 2589-2597 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 2589-2597
    • Maeshima, Y.1
  • 94
    • 0034050031 scopus 로고    scopus 로고
    • In vivo administration of a nuclear transcription factor-.B decoy suppresses experimental crescentic glomerulonephritis
    • Tomita, N. et al. In vivo administration of a nuclear transcription factor-.B decoy suppresses experimental crescentic glomerulonephritis. J. Am. Soc. Nephrol. 11, 1244-1252 (2000).
    • (2000) J. Am. Soc. Nephrol. , vol.11 , pp. 1244-1252
    • Tomita, N.1
  • 95
    • 21344454891 scopus 로고    scopus 로고
    • Exploring RNA interference as a therapeutic strategy for renal disease
    • Takabatake, Y. et al. Exploring RNA interference as a therapeutic strategy for renal disease. Gene Ther. 12, 965-973 (2005).
    • (2005) Gene Ther. , vol.12 , pp. 965-973
    • Takabatake, Y.1
  • 96
    • 44749089187 scopus 로고    scopus 로고
    • Renal press-mediated transfection method for plasmid DNA and siRNA to the kidney
    • Mukai, H., Kawakami, S. & Hashida, M. Renal press-mediated transfection method for plasmid DNA and siRNA to the kidney. Biochem. Biophys. Res. Commun. 372, 383-387 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.372 , pp. 383-387
    • Mukai, H.1    Kawakami, S.2    Hashida, M.3
  • 97
    • 33644873618 scopus 로고    scopus 로고
    • Immunoliposome targeting to mesangial cells: A promising strategy for specific drug delivery to the kidney
    • Tuffin, G., Waelti, E., Huwyler, J., Hammer, C. & Marti, H. P. Immunoliposome targeting to mesangial cells: a promising strategy for specific drug delivery to the kidney. J. Am. Soc. Nephrol. 16, 3295-3305 (2005).
    • (2005) J. Am. Soc. Nephrol. , vol.16 , pp. 3295-3305
    • Tuffin, G.1    Waelti, E.2    Huwyler, J.3    Hammer, C.4    Marti, H.P.5
  • 98
    • 41149118880 scopus 로고    scopus 로고
    • Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone- loaded AbEsel liposomes
    • Asgeirsdóttir, S. A. et al. Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone. loaded AbEsel liposomes. Am. J. Physiol. Renal Physiol. 294, F554-F561 (2008).
    • (2008) Am. J. Physiol. Renal Physiol. , vol.294
    • Asgeirsdóttir, S.A.1
  • 99
    • 54949095836 scopus 로고    scopus 로고
    • Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
    • Robbins, M. et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum. Gene Ther. 19, 991-999 (2008).
    • (2008) Hum. Gene Ther. , vol.19 , pp. 991-999
    • Robbins, M.1
  • 100
    • 41649115210 scopus 로고    scopus 로고
    • Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
    • Kleinman, M. E. et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452, 591-597 (2008).
    • (2008) Nature , vol.452 , pp. 591-597
    • Kleinman, M.E.1
  • 101
    • 39449097277 scopus 로고    scopus 로고
    • Overcoming the innate immune response to small interfering RNA
    • Judge, A. & MacLachan, I. Overcoming the innate immune response to small interfering RNA. Hum. Gene Ther. 19, 111-124 (2008).
    • (2008) Hum. Gene Ther. , vol.19 , pp. 111-124
    • Judge, A.1    MacLachan, I.2
  • 102
    • 53449090205 scopus 로고    scopus 로고
    • Gene silencing of β-catenin in melanoma cells retards their growth but promotes the formulation of pulmonary metastasis in mice
    • Takahashi, Y., Nishikawa, M., Suehara, T., Takiguchi, N. & Takakura, Y. Gene silencing of β-catenin in melanoma cells retards their growth but promotes the formulation of pulmonary metastasis in mice. Int. J. Cancer 123, 2315-2320 (2008).
    • (2008) Int. J. Cancer , vol.123 , pp. 2315-2320
    • Takahashi, Y.1    Nishikawa, M.2    Suehara, T.3    Takiguchi, N.4    Takakura, Y.5
  • 103
    • 38649099969 scopus 로고    scopus 로고
    • Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity
    • Chen, P. Y. et al. Strand-specific 5′-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA 14, 263-274 (2008).
    • (2008) RNA , vol.14 , pp. 263-274
    • Chen, P.Y.1
  • 104
    • 34648843428 scopus 로고    scopus 로고
    • 5 integrins
    • 5 integrins. Bioconjung. Chem. 18, 1415-1423 (2007).
    • (2007) Bioconjung. Chem. , vol.18 , pp. 1415-1423
    • Oba, M.1
  • 105
    • 56549091431 scopus 로고    scopus 로고
    • The complexity of mitogen-activated protein kinases (MAPKs) made simple
    • Krishna, M. & Narang, H. The complexity of mitogen-activated protein kinases (MAPKs) made simple. Cell. Mol. Life Sci. 65, 3525-3544 (2008).
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 3525-3544
    • Krishna, M.1    Narang, H.2
  • 106
    • 77950620597 scopus 로고    scopus 로고
    • siRNA therapy for glomerulonephritis
    • Kreidberg, J. A. siRNA therapy for glomerulonephritis. J. Am. Soc. Nephrol. 21, 549-551 (2010).
    • (2010) J. Am. Soc. Nephrol. , vol.21 , pp. 549-551
    • Kreidberg, J.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.