Physicochemical properties and nuclease resistance of antisense-oligodeoxynucleotides entrapped in the core of polyion complex micelles composed of poly(ethylene glycol)-poly(L-Lysine) block copolymers

European Journal of Pharmaceutical Sciences

Volumn 13, Issue 1, 2001, Pages 35-42

  Harada, Atsushi ^a   Togawa, Hideyuki ^a   Kataoka, Kazunori ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Antisense oligodeoxynucleotides; Nuclease resistance; Poly(ethylene glycol) poly(L lysine) block copolymer; Polyion complex micelle; Targeting

Indexed keywords

BLOOD; CAPILLARITY; COPOLYMERS; DIFFUSION; ELECTROPHORESIS; GELS; LIGHT SCATTERING;

NUCLEASE;

ENZYMES;

ANTISENSE OLIGODEOXYNUCLEOTIDE; COPOLYMER; DEOXYRIBONUCLEASE I; MACROGOL; MACROGOL POLYLYSINE BLOCK COPOLYMER; NUCLEASE; POLYION; POLYLYSINE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG FORMULATION; DRUG TARGETING; GEL ELECTROPHORESIS; LIGHT SCATTERING; MICELLE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

DEOXYRIBONUCLEASE I; MICELLES; OLIGONUCLEOTIDES, ANTISENSE; POLYETHYLENE GLYCOLS; POLYLYSINE;

EID: 0035080570     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00205-0     Document Type: Article

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