메뉴 건너뛰기




Volumn 3, Issue 2, 2011, Pages 1798-1820

Apoptosis and DNA methylation

Author keywords

5 hydroxymethylation; Apoptosis; Demethylation; DNA repair; Dnmt1; Epigenetics; Mbd4; TDG

Indexed keywords

DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GUANINE; HISTONE H3; METHYL CPG BINDING PROTEIN; METHYL CPG BINDING PROTEIN 4; THYMINE; THYMINE DNA GLYCOSYLASE; UNCLASSIFIED DRUG;

EID: 79959734685     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3021798     Document Type: Review
Times cited : (14)

References (116)
  • 3
    • 3142782118 scopus 로고    scopus 로고
    • Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer
    • Beaujean, N.; Taylor, J.; Gardner, J.; Wilmut, I.; Meehan, R.; Young, L. Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer. Biol. Reprod. 2004, 71, 185-193.
    • (2004) Biol. Reprod , vol.71 , pp. 185-193
    • Beaujean, N.1    Taylor, J.2    Gardner, J.3    Wilmut, I.4    Meehan, R.5    Young, L.6
  • 4
    • 67349255210 scopus 로고    scopus 로고
    • CpG islands--'a rough guide'
    • Illingworth, R.S.; Bird, A.P. CpG islands--'a rough guide'. FEBS Lett. 2009, 583, 1713-1720.
    • (2009) FEBS Lett , vol.583 , pp. 1713-1720
    • Illingworth, R.S.1    Bird, A.P.2
  • 6
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis, S. and Heintz, N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 2009, 324, 929-930.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 9
    • 0034625064 scopus 로고    scopus 로고
    • Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
    • Ramsahoye, B.H.; Biniszkiewicz, D.; Lyko, F.; Clark, V.; Bird, A.P.; Jaenisch, R. Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc. Natl. Acad. Sci. USA 2000, 97, 5237-5242.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5237-5242
    • Ramsahoye, B.H.1    Biniszkiewicz, D.2    Lyko, F.3    Clark, V.4    Bird, A.P.5    Jaenisch, R.6
  • 10
    • 66749152204 scopus 로고    scopus 로고
    • Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids
    • Iyer, L.M.; Tahiliani, M.; Rao, A.; Aravind, L. Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. Cell Cycle 2009, 8, 1698-1710.
    • (2009) Cell Cycle , vol.8 , pp. 1698-1710
    • Iyer, L.M.1    Tahiliani, M.2    Rao, A.3    Aravind, L.4
  • 11
    • 0037106658 scopus 로고    scopus 로고
    • Synthesis of stable-isotope enriched 5-methylpyrimidines and their use as probes of base reactivity in DNA
    • Burdzy, A.; Noyes, K.T.; Valinluck, V.; Sowers, L.C. Synthesis of stable-isotope enriched 5-methylpyrimidines and their use as probes of base reactivity in DNA. Nucleic Acids Res. 2002, 30, 4068-4074.
    • (2002) Nucleic Acids Res , vol.30 , pp. 4068-4074
    • Burdzy, A.1    Noyes, K.T.2    Valinluck, V.3    Sowers, L.C.4
  • 13
    • 77954061853 scopus 로고    scopus 로고
    • Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA
    • Nestor, C.; Ruzov, A.; Meehan, R.; Dunican, D. Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA. Biotechniques 2010, 48, 317-319.
    • (2010) Biotechniques , vol.48 , pp. 317-319
    • Nestor, C.1    Ruzov, A.2    Meehan, R.3    Dunican, D.4
  • 15
    • 84855638505 scopus 로고    scopus 로고
    • Chemical discrimination between dC and 5MedC via their hydroxylamine adducts
    • Munzel, M.; Lercher, L.; Muller, M.; Carell, T. Chemical discrimination between dC and 5MedC via their hydroxylamine adducts. Nucleic Acids Res. 2010, 38, e192
    • (2010) Nucleic Acids Res , vol.38
    • Munzel, M.1    Lercher, L.2    Muller, M.3    Carell, T.4
  • 16
    • 77954362183 scopus 로고    scopus 로고
    • Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine
    • Jin, S.G.; Kadam, S.; Pfeifer, G.P. Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine. Nucleic Acids Res. 2010, 38, e125.
    • (2010) Nucleic Acids Res , vol.38
    • Jin, S.G.1    Kadam, S.2    Pfeifer, G.P.3
  • 18
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • Goll, M.G. and Bestor, T.H. Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 2005, 74, 481-514.
    • (2005) Annu. Rev. Biochem , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 19
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    • Okano, M.; Xie, S.; Li, E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat. Genet. 1998, 19, 219-220.
    • (1998) Nat. Genet , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 20
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano, M.; Bell, D.W.; Haber, D.A.; Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99, 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 22
    • 34249066239 scopus 로고    scopus 로고
    • Functional cooperation between HP1 and DNMT1 mediates gene silencing
    • Smallwood, A.; Esteve, P.O.; Pradhan, S.; Carey, M. Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev. 2007, 21, 1169-1178.
    • (2007) Genes Dev , vol.21 , pp. 1169-1178
    • Smallwood, A.1    Esteve, P.O.2    Pradhan, S.3    Carey, M.4
  • 23
    • 79952053850 scopus 로고    scopus 로고
    • Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation
    • Song, J.; Rechkoblit, O.; Bestor, T.H.; Patel, D.J. Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation. Science 2010, 331, 1036-1040.
    • (2010) Science , vol.331 , pp. 1036-1040
    • Song, J.1    Rechkoblit, O.2    Bestor, T.H.3    Patel, D.J.4
  • 25
    • 69249241855 scopus 로고    scopus 로고
    • SUMOylation enhances DNA methyltransferase 1 activity
    • Lee, B.; Muller, M.T. SUMOylation enhances DNA methyltransferase 1 activity. Biochem. J. 2009, 421, 449-461.
    • (2009) Biochem. J , vol.421 , pp. 449-461
    • Lee, B.1    Muller, M.T.2
  • 26
    • 77955238361 scopus 로고    scopus 로고
    • Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme
    • Patel, K.; Dickson, J.; Din, S.; Macleod, K.; Jodrell, D.; Ramsahoye, B. Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme. Nucleic Acids Res. 2010, 38, 4313-4324.
    • (2010) Nucleic Acids Res , vol.38 , pp. 4313-4324
    • Patel, K.1    Dickson, J.2    Din, S.3    Macleod, K.4    Jodrell, D.5    Ramsahoye, B.6
  • 32
    • 77950641592 scopus 로고    scopus 로고
    • Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation
    • Kaneda, M.; Hirasawa, R.; Chiba, H.; Okano, M.; Li, E.; Sasaki, H. Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation. Genes Cells 2010, 15, 169-179.
    • (2010) Genes Cells , vol.15 , pp. 169-179
    • Kaneda, M.1    Hirasawa, R.2    Chiba, H.3    Okano, M.4    Li, E.5    Sasaki, H.6
  • 33
    • 34548705374 scopus 로고    scopus 로고
    • Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse
    • Kato, Y.; Kaneda, M.; Hata, K.; Kumaki, K.; Hisano, M.; Kohara, Y.; Okano, M.; Li, E.; Nozaki, M.; Sasaki, H. Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum. Mol. Genet. 2007, 16, 2272-2280.
    • (2007) Hum. Mol. Genet , vol.16 , pp. 2272-2280
    • Kato, Y.1    Kaneda, M.2    Hata, K.3    Kumaki, K.4    Hisano, M.5    Kohara, Y.6    Okano, M.7    Li, E.8    Nozaki, M.9    Sasaki, H.10
  • 36
    • 0036176982 scopus 로고    scopus 로고
    • The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds
    • Qiu, C.; Sawada, K.; Zhang, X.; Cheng, X. The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat. Struct. Biol. 2002, 9, 217-224.
    • (2002) Nat. Struct. Biol , vol.9 , pp. 217-224
    • Qiu, C.1    Sawada, K.2    Zhang, X.3    Cheng, X.4
  • 37
    • 73449113904 scopus 로고    scopus 로고
    • Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation
    • Hervouet, E.; Vallette, F.M.; Cartron, P.F. Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation. Epigenetics. 2009, 4, 487-499.
    • (2009) Epigenetics , vol.4 , pp. 487-499
    • Hervouet, E.1    Vallette, F.M.2    Cartron, P.F.3
  • 39
    • 0019198357 scopus 로고
    • Mutagenic deamination of cytosine residues in DNA
    • Duncan, B.K.; Miller, J.H. Mutagenic deamination of cytosine residues in DNA. Nature 1980, 287, 560-561.
    • (1980) Nature , vol.287 , pp. 560-561
    • Duncan, B.K.1    Miller, J.H.2
  • 40
    • 0033575886 scopus 로고    scopus 로고
    • The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
    • Hendrich, B.; Hardeland, U.; Ng, H.H.; Jiricny, J.; Bird, A. The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature 1999, 401, 301-304.
    • (1999) Nature , vol.401 , pp. 301-304
    • Hendrich, B.1    Hardeland, U.2    Ng, H.H.3    Jiricny, J.4    Bird, A.5
  • 41
    • 43449097507 scopus 로고    scopus 로고
    • Characterization of Dnmt3b:Thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA
    • Boland, M.J.; Christman, J.K. Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA. J. Mol. Biol. 2008, 379, 492-504.
    • (2008) J. Mol. Biol , vol.379 , pp. 492-504
    • Boland, M.J.1    Christman, J.K.2
  • 42
    • 33846909036 scopus 로고    scopus 로고
    • Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair
    • Li, Y.Q.; Zhou, P.Z.; Zheng, X.D.; Walsh, C.P.; Xu, G.L. Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair. Nucleic Acids Res. 2007, 35, 390-400.
    • (2007) Nucleic Acids Res , vol.35 , pp. 390-400
    • Li, Y.Q.1    Zhou, P.Z.2    Zheng, X.D.3    Walsh, C.P.4    Xu, G.L.5
  • 43
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNA methylation and histone modification: Patterns and paradigms
    • Cedar, H. and Bergman, Y. Linking DNA methylation and histone modification: Patterns and paradigms. Nat. Rev. Genet. 2009, 10, 295-304.
    • (2009) Nat. Rev. Genet , vol.10 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 46
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D.P. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004, 116, 281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 47
    • 0035839105 scopus 로고    scopus 로고
    • RNA: Guiding gene silencing
    • Matzke, M.; Matzke, A.J.; Kooter, J.M. RNA: guiding gene silencing. Science 2001, 293, 1080-1083. 4
    • (2001) Science , vol.293 , Issue.4 , pp. 1080-1083
    • Matzke, M.1    Matzke, A.J.2    Kooter, J.M.3
  • 48
    • 4544242851 scopus 로고    scopus 로고
    • Induction of DNA methylation and gene silencing by short interfering RNAs in human cells
    • Kawasaki, H.; Taira, K. Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature 2004, 431, 211-217.
    • (2004) Nature , vol.431 , pp. 211-217
    • Kawasaki, H.1    Taira, K.2
  • 49
    • 78649540637 scopus 로고    scopus 로고
    • Induction of DNA methylation and gene silencing by short interfering RNAs in human cells
    • Taira, K. Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature 2006, 441, 1176.
    • (2006) Nature , vol.441 , pp. 1176
    • Taira, K.1
  • 50
    • 39849098733 scopus 로고    scopus 로고
    • Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro
    • Lim, H.G.; Suzuki, K.; Cooper, D.A.; Kelleher, A.D. Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro. Mol. Ther. 2008, 16, 565-570.
    • (2008) Mol. Ther , vol.16 , pp. 565-570
    • Lim, H.G.1    Suzuki, K.2    Cooper, D.A.3    Kelleher, A.D.4
  • 52
    • 78049265812 scopus 로고    scopus 로고
    • MicroRNA mediates DNA demethylation events triggered by retinoic acid during neuroblastoma cell differentiation
    • Das, S.; Foley, N.; Bryan, K.; Watters, K.M.; Bray, I.; Murphy, D.M.; Buckley, P.G.; Stallings, R.L. MicroRNA mediates DNA demethylation events triggered by retinoic acid during neuroblastoma cell differentiation. Cancer Res. 2010, 70, 7874-7881.
    • (2010) Cancer Res , vol.70 , pp. 7874-7881
    • Das, S.1    Foley, N.2    Bryan, K.3    Watters, K.M.4    Bray, I.5    Murphy, D.M.6    Buckley, P.G.7    Stallings, R.L.8
  • 53
    • 77953286321 scopus 로고    scopus 로고
    • Repression of transposable-elements-A microRNA anti-cancer defense mechanism?
    • Shalgi, R.; Pilpel, Y.; Oren, M. Repression of transposable-elements-A microRNA anti-cancer defense mechanism? Trends Genet. 2010, 26, 253-259.
    • (2010) Trends Genet , vol.26 , pp. 253-259
    • Shalgi, R.1    Pilpel, Y.2    Oren, M.3
  • 54
    • 77958576363 scopus 로고    scopus 로고
    • Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes
    • Schmitz, K.M.; Mayer, C.; Postepska, A.; Grummt, I. Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes. Genes Dev. 2010, 24, 2264-2269.
    • (2010) Genes Dev , vol.24 , pp. 2264-2269
    • Schmitz, K.M.1    Mayer, C.2    Postepska, A.3    Grummt, I.4
  • 55
    • 38649126918 scopus 로고    scopus 로고
    • Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation
    • Fouse, S.D.; Shen, Y.; Pellegrini, M.; Cole, S.; Meissner, A.; Van, Neste L.; Jaenisch, R.; Fan, G. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell 2008, 2, 160-169.
    • (2008) Cell Stem Cell , vol.2 , pp. 160-169
    • Fouse, S.D.1    Shen, Y.2    Pellegrini, M.3    Cole, S.4    Meissner, A.5    van Neste, L.6    Jaenisch, R.7    Fan, G.8
  • 57
    • 0842324785 scopus 로고    scopus 로고
    • The nucleosome: From genomic organization to genomic regulation
    • Khorasanizadeh, S. The nucleosome: from genomic organization to genomic regulation. Cell 2004, 116, 259-272.
    • (2004) Cell , vol.116 , pp. 259-272
    • Khorasanizadeh, S.1
  • 58
    • 77956153243 scopus 로고    scopus 로고
    • The language of histone crosstalk
    • Lee, J.S.; Smith, E.; Shilatifard, A. The language of histone crosstalk. Cell 2010, 142, 682-685.
    • (2010) Cell , vol.142 , pp. 682-685
    • Lee, J.S.1    Smith, E.2    Shilatifard, A.3
  • 59
    • 33746324216 scopus 로고    scopus 로고
    • Chromatin modifications by methylation and ubiquitination: Implications in the regulation of gene expression
    • Shilatifard, A. Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu. Rev. Biochem. 2006, 75, 243-269.
    • (2006) Annu. Rev. Biochem , vol.75 , pp. 243-269
    • Shilatifard, A.1
  • 60
    • 33845877732 scopus 로고    scopus 로고
    • Defining an epigenetic code
    • Turner, B.M. Defining an epigenetic code. Nat. Cell Biol. 2007, 9, 2-6.
    • (2007) Nat. Cell Biol , vol.9 , pp. 2-6
    • Turner, B.M.1
  • 62
    • 56149098200 scopus 로고    scopus 로고
    • Linking Heterochromatin Protein 1 (HP1) to cancer progression
    • Dialynas, G.K.; Vitalini, M.W.; Wallrath, L.L. Linking Heterochromatin Protein 1 (HP1) to cancer progression. Mutat. Res. 2008, 647, 13-20.
    • (2008) Mutat. Res , vol.647 , pp. 13-20
    • Dialynas, G.K.1    Vitalini, M.W.2    Wallrath, L.L.3
  • 64
    • 34047116826 scopus 로고    scopus 로고
    • Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    • Weber, M.; Hellmann, I.; Stadler, M.B.; Ramos, L.; Paabo, S.; Rebhan, M.; Schubeler, D. Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat. Genet. 2007, 39, 457-466.
    • (2007) Nat. Genet , vol.39 , pp. 457-466
    • Weber, M.1    Hellmann, I.2    Stadler, M.B.3    Ramos, L.4    Paabo, S.5    Rebhan, M.6    Schubeler, D.7
  • 65
    • 77954758157 scopus 로고    scopus 로고
    • Polycomb group protein-mediated repression of transcription
    • Morey, L. and Helin, K. Polycomb group protein-mediated repression of transcription. Trends Biochem. Sci. 2010, 35, 323-332.
    • (2010) Trends Biochem. Sci , vol.35 , pp. 323-332
    • Morey, L.1    Helin, K.2
  • 69
    • 77957369859 scopus 로고    scopus 로고
    • Epigenetic drivers of genetic alterations
    • Toyota, M. and Suzuki, H. Epigenetic drivers of genetic alterations. Adv. Genet. 2010, 70, 309-323.
    • (2010) Adv. Genet , vol.70 , pp. 309-323
    • Toyota, M.1    Suzuki, H.2
  • 70
    • 0036712913 scopus 로고    scopus 로고
    • Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells
    • Tao, Q.; Huang, H.; Geiman, T.M.; Lim, C.Y.; Fu, L.; Qiu, G.H.; Robertson, K.D. Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells. Hum. Mol. Genet. 2002, 11, 2091-2102.
    • (2002) Hum. Mol. Genet , vol.11 , pp. 2091-2102
    • Tao, Q.1    Huang, H.2    Geiman, T.M.3    Lim, C.Y.4    Fu, L.5    Qiu, G.H.6    Robertson, K.D.7
  • 71
    • 0029803192 scopus 로고    scopus 로고
    • De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
    • Lei, H.; Oh, S.P.; Okano, M.; Juttermann, R.; Goss, K.A.; Jaenisch, R.; Li, E. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development 1996, 122, 3195-3205.
    • (1996) Development , vol.122 , pp. 3195-3205
    • Lei, H.1    Oh, S.P.2    Okano, M.3    Juttermann, R.4    Goss, K.A.5    Jaenisch, R.6    Li, E.7
  • 72
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li, E.; Bestor, T.H.; Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992, 69, 915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 73
    • 0343485074 scopus 로고    scopus 로고
    • Transient depletion of xDnmt1 leads to premature gene activation in Xenopus embryos
    • Stancheva, I. and Meehan, R.R. Transient depletion of xDnmt1 leads to premature gene activation in Xenopus embryos. Genes Dev.2000, 14, 313-327.
    • (2000) Genes Dev , vol.14 , pp. 313-327
    • Stancheva, I.1    Meehan, R.R.2
  • 74
    • 0035901498 scopus 로고    scopus 로고
    • Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos
    • Stancheva, I.; Hensey, C.; Meehan, R.R. Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos. EMBO J. 2001, 20, 1963-1973.
    • (2001) EMBO J , vol.20 , pp. 1963-1973
    • Stancheva, I.1    Hensey, C.2    Meehan, R.R.3
  • 75
    • 33847293264 scopus 로고    scopus 로고
    • Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells
    • Chen, T.; Hevi, S.; Gay, F.; Tsujimoto, N.; He, T.; Zhang, B.; Ueda, Y.; Li, E. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat. Genet. 2007, 39, 391-396.
    • (2007) Nat. Genet , vol.39 , pp. 391-396
    • Chen, T.1    Hevi, S.2    Gay, F.3    Tsujimoto, N.4    He, T.5    Zhang, B.6    Ueda, Y.7    Li, E.8
  • 76
    • 43049108039 scopus 로고    scopus 로고
    • XDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function
    • Dunican, D.S.; Ruzov, A.; Hackett, J.A.; Meehan, R.R. xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function. Development 2008, 135, 1295-1302.
    • (2008) Development , vol.135 , pp. 1295-1302
    • Dunican, D.S.1    Ruzov, A.2    Hackett, J.A.3    Meehan, R.R.4
  • 77
    • 3042531072 scopus 로고    scopus 로고
    • Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells
    • Guo, G.; Wang, W.; Bradley, A. Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells. Nature 2004, 429, 891-895.
    • (2004) Nature , vol.429 , pp. 891-895
    • Guo, G.1    Wang, W.2    Bradley, A.3
  • 79
    • 37849026412 scopus 로고    scopus 로고
    • DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B
    • Palii, S.S.; Van Emburgh, B.O.; Sankpal, U.T.; Brown, K.D.; Robertson, K.D. DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol. Cell Biol.2008, 28, 752-771.
    • (2008) Mol. Cell Biol , vol.28 , pp. 752-771
    • Palii, S.S.1    van Emburgh, B.O.2    Sankpal, U.T.3    Brown, K.D.4    Robertson, K.D.5
  • 81
    • 0042790463 scopus 로고    scopus 로고
    • MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine
    • Sansom, O.J.; Zabkiewicz, J.; Bishop, S.M.; Guy, J.; Bird, A.; Clarke, A.R. MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine. Oncogene 2003, 22, 7130-7136.
    • (2003) Oncogene , vol.22 , pp. 7130-7136
    • Sansom, O.J.1    Zabkiewicz, J.2    Bishop, S.M.3    Guy, J.4    Bird, A.5    Clarke, A.R.6
  • 82
    • 3042791562 scopus 로고    scopus 로고
    • ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage
    • Luo, Y.; Lin, F.T.; Lin, W.C. ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage. Mol. Cell Biol. 2004, 24, 6430-6444.
    • (2004) Mol. Cell Biol , vol.24 , pp. 6430-6444
    • Luo, Y.1    Lin, F.T.2    Lin, W.C.3
  • 87
    • 0037099413 scopus 로고    scopus 로고
    • G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
    • Tachibana, M.; Sugimoto, K.; Nozaki, M.; Ueda, J.; Ohta, T.; Ohki, M.; Fukuda, M.; Takeda, N.; Niida, H.; Kato, H.; Shinkai, Y. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 2002, 16, 1779-1791.
    • (2002) Genes Dev , vol.16 , pp. 1779-1791
    • Tachibana, M.1    Sugimoto, K.2    Nozaki, M.3    Ueda, J.4    Ohta, T.5    Ohki, M.6    Fukuda, M.7    Takeda, N.8    Niida, H.9    Kato, H.10    Shinkai, Y.11
  • 88
    • 20144388930 scopus 로고    scopus 로고
    • Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9
    • Tachibana, M.; Ueda, J.; Fukuda, M.; Takeda, N.; Ohta, T.; Iwanari, H.; Sakihama, T.; Kodama, T.; Hamakubo, T.; Shinkai, Y. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 2005, 19, 815-826.
    • (2005) Genes Dev , vol.19 , pp. 815-826
    • Tachibana, M.1    Ueda, J.2    Fukuda, M.3    Takeda, N.4    Ohta, T.5    Iwanari, H.6    Sakihama, T.7    Kodama, T.8    Hamakubo, T.9    Shinkai, Y.10
  • 90
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan, J.; Yang, X.; Zhuang, L.; Jiang, X.; Chen, W.; Lee, P.L.; Karuturi, R.K.; Tan, P.B.; Liu, E.T.; Yu, Q. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007, 21, 1050-1063.
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6    Karuturi, R.K.7    Tan, P.B.8    Liu, E.T.9    Yu, Q.10
  • 91
    • 77950866779 scopus 로고    scopus 로고
    • Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression
    • Wu, Z.L.; Zheng, S.S.; Li, Z.M.; Qiao, Y.Y.; Aau, M.Y.; Yu, Q. Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression. Cell Death. Differ. 2010, 17, 801-810.
    • (2010) Cell Death. Differ , vol.17 , pp. 801-810
    • Wu, Z.L.1    Zheng, S.S.2    Li, Z.M.3    Qiao, Y.Y.4    Aau, M.Y.5    Yu, Q.6
  • 92
    • 70349329405 scopus 로고    scopus 로고
    • Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes
    • Sasai, N.; Defossez, P.A. Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes. Int. J. Dev. Biol. 2009, 53, 323-334.
    • (2009) Int. J. Dev. Biol , vol.53 , pp. 323-334
    • Sasai, N.1    Defossez, P.A.2
  • 95
    • 0037965916 scopus 로고    scopus 로고
    • Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis
    • Screaton, R.A.; Kiessling, S.; Sansom, O.J.; Millar, C.B.; Maddison, K.; Bird, A.; Clarke, A.R.; Frisch, S.M. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc. Natl. Acad. Sci. USA 2003, 100, 5211-5216.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 5211-5216
    • Screaton, R.A.1    Kiessling, S.2    Sansom, O.J.3    Millar, C.B.4    Maddison, K.5    Bird, A.6    Clarke, A.R.7    Frisch, S.M.8
  • 99
    • 57649210781 scopus 로고    scopus 로고
    • Evolution of DNA-methylation machinery: DNA methyltransferases and methyl-DNA binding proteins in the amphioxus Branchiostoma floridae
    • Albalat, R. Evolution of DNA-methylation machinery: DNA methyltransferases and methyl-DNA binding proteins in the amphioxus Branchiostoma floridae. Dev. Genes Evol. 2008, 218, 691-701.
    • (2008) Dev. Genes Evol , vol.218 , pp. 691-701
    • Albalat, R.1
  • 100
    • 0035169663 scopus 로고    scopus 로고
    • Methyl-CpG-binding proteins. Targeting specific gene repression
    • Ballestar, E.; Wolffe, A.P. Methyl-CpG-binding proteins. Targeting specific gene repression. Eur. J. Biochem. 2001, 268, 1-6.
    • (2001) Eur. J. Biochem , vol.268 , pp. 1-6
    • Ballestar, E.1    Wolffe, A.P.2
  • 101
    • 0031792779 scopus 로고    scopus 로고
    • Identification and characterization of a family of mammalian methyl-CpG binding proteins
    • Hendrich, B.; Bird, A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol. Cell Biol. 1998, 18, 6538-6547.
    • (1998) Mol. Cell Biol , vol.18 , pp. 6538-6547
    • Hendrich, B.1    Bird, A.2
  • 102
    • 35148887112 scopus 로고    scopus 로고
    • Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability
    • Miquel, C.; Jacob, S.; Grandjouan, S.; Aime, A.; Viguier, J.; Sabourin, J.C.; Sarasin, A.; Duval, A.; Praz, F. Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability. Oncogene 2007, 26, 5919-5926.
    • (2007) Oncogene , vol.26 , pp. 5919-5926
    • Miquel, C.1    Jacob, S.2    Grandjouan, S.3    Aime, A.4    Viguier, J.5    Sabourin, J.C.6    Sarasin, A.7    Duval, A.8    Praz, F.9
  • 103
    • 0035127794 scopus 로고    scopus 로고
    • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito, Y.; Kanai, Y.; Sakamoto, M.; Saito, H.; Ishii, H.; Hirohashi, S. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 2001, 33, 561-568.
    • (2001) Hepatology , vol.33 , pp. 561-568
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 104
    • 38749095527 scopus 로고    scopus 로고
    • Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer
    • Xi, Y.; Formentini, A.; Nakajima, G.; Kornmann, M.; Ju, J. Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer. Oncol. Rep. 2008, 19, 257-262.
    • (2008) Oncol. Rep , vol.19 , pp. 257-262
    • Xi, Y.1    Formentini, A.2    Nakajima, G.3    Kornmann, M.4    Ju, J.5
  • 105
    • 0036515642 scopus 로고    scopus 로고
    • Expression of the genes of methyl-binding domain proteins in human gliomas
    • Schlegel, J.; Guneysu, S.; Mennel, H.D. Expression of the genes of methyl-binding domain proteins in human gliomas. Oncol. Rep. 2002, 9, 393-395.
    • (2002) Oncol. Rep , vol.9 , pp. 393-395
    • Schlegel, J.1    Guneysu, S.2    Mennel, H.D.3
  • 106
    • 37549061057 scopus 로고    scopus 로고
    • Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells
    • Abdel-Rahman, W.M.; Knuutila, S.; Peltomaki, P.; Harrison, D.J.; Bader, S.A. Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. DNA Repair (Amst) 2008, 7, 321-328.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 321-328
    • Abdel-Rahman, W.M.1    Knuutila, S.2    Peltomaki, P.3    Harrison, D.J.4    Bader, S.A.5
  • 107
    • 0033599013 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency
    • Bader, S.; Walker, M.; Hendrich, B.; Bird, A.; Bird, C.; Hooper, M.; Wyllie, A. Somatic frameshift mutations in the MBD4 gene of sporadic colon cancers with mismatch repair deficiency. Oncogene 1999, 18, 8044-8047.
    • (1999) Oncogene , vol.18 , pp. 8044-8047
    • Bader, S.1    Walker, M.2    Hendrich, B.3    Bird, A.4    Bird, C.5    Hooper, M.6    Wyllie, A.7
  • 108
    • 0034543135 scopus 로고    scopus 로고
    • Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations
    • Bader, S.; Walker, M.; Harrison, D. Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations. Br. J. Cancer 2000, 83, 1646-1649.
    • (2000) Br. J. Cancer , vol.83 , pp. 1646-1649
    • Bader, S.1    Walker, M.2    Harrison, D.3
  • 109
    • 33847233256 scopus 로고    scopus 로고
    • A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells
    • Bader, S.A.; Walker, M.; Harrison, D.J. A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells. Br. J. Cancer 2007, 96, 660-666.
    • (2007) Br. J. Cancer , vol.96 , pp. 660-666
    • Bader, S.A.1    Walker, M.2    Harrison, D.J.3
  • 110
    • 68049122105 scopus 로고    scopus 로고
    • Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs
    • Aziz, M.A.; Schupp, J.E.; Kinsella, T.J. Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs. Cancer Biol. Ther. 2009, 8, 1156-1163.
    • (2009) Cancer Biol. Ther , vol.8 , pp. 1156-1163
    • Aziz, M.A.1    Schupp, J.E.2    Kinsella, T.J.3
  • 112
    • 77956095231 scopus 로고    scopus 로고
    • Active DNA demethylation: Many roads lead to Rome
    • Wu, S.C. and Zhang, Y. Active DNA demethylation: many roads lead to Rome. Nat. Rev. Mol. Cell Biol. 2010, 11, 607-620.
    • (2010) Nat. Rev. Mol. Cell Biol , vol.11 , pp. 607-620
    • Wu, S.C.1    Zhang, Y.2
  • 113
    • 57649196594 scopus 로고    scopus 로고
    • DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45
    • Rai, K.; Huggins, I.J.; James, S.R.; Karpf, A.R.; Jones, D.A.; Cairns, B.R. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 2008, 135, 1201-1212.
    • (2008) Cell , vol.135 , pp. 1201-1212
    • Rai, K.1    Huggins, I.J.2    James, S.R.3    Karpf, A.R.4    Jones, D.A.5    Cairns, B.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.