Expression of the genes of methyl-binding domain proteins in human gliomas

Oncology Reports

Volumn 9, Issue 2, 2002, Pages 393-395

  Schlegel, Jürgen ^a   Güneysu, Suzan ^b   Mennel, Hans Dieter ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

DNA methylation; Glioma; Transcriptional repression; Tumor suppressor genes

Indexed keywords

DEOXYRIBONUCLEASE; DNA BINDING PROTEIN; MBD1 PROTEIN, HUMAN; MBD2 PROTEIN, HUMAN; MBD3 PROTEIN, HUMAN; MBD4 PROTEIN, HUMAN; MESSENGER RNA; METHYL CPG BINDING PROTEIN 2; PRIMER DNA; REPRESSOR PROTEIN; RNA; TRANSCRIPTION FACTOR;

ARTICLE; BIOPSY; BRAIN TUMOR; CANCER STAGING; CELL CULTURE; CHEMISTRY; DNA METHYLATION; GENE EXPRESSION REGULATION; GENETICS; GLIOMA; HUMAN; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BIOPSY; BRAIN NEOPLASMS; DNA METHYLATION; DNA PRIMERS; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; NEOPLASM STAGING; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0036515642     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.9.2.393     Document Type: Article

References (20)

1. Ballestar E and Wolffe AP: Methyl-CpG-binding proteins. Targeting specific gene repression. Eur J Biochem 268: 1-6, 2001. (Pubitemid 32052241)
2. Wade PA: Methyl CpG binding proteins: coupling chromatin architecture to gene regulation. Oncogene 20: 3166-3173, 2001.
3. Gregory RI, Randall TE, Johnson CA, Khosla S, Hatada I, O'Neill LP, Turner BM and Feil R: DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1. Mol Cell Biol 21: 5426-5436, 2001. (Pubitemid 32702447)
4. Chandler SP, Guschin D, Landsberger N and Wolffe AP: The methyl-CpG binding transcriptional repressor MeCP2 stably associates with nucleosomal DNA. Biochemistry 38: 7008-7018, 1999.
5. Bellacosa A, Cicchillitti L, Schepis F, Riccio A, Yeung AT, Matsumoto Y, Golemis EA, Genuardi M and Neri G: MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1. Proc Natl Acad Sci USA 96: 3969-3974, 1999. (Pubitemid 29169020)
6. Ballestar E, Yusufzai TM and Wolffe AP: Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA. Biochemistry 39: 7100-7106, 2000. (Pubitemid 30413098)
7. Robertson KD and Jones PA: DNA methylation: past, present and future directions. Carcinogenesis 21: 461-467, 2000. (Pubitemid 30137931)
8. Bortolotto S, Chiado-Piat L, Cavalla P, Bosone I, Chio A, Mauro A and Schiffer D: CDKN2A/p16 inactivation in the prognosis of oligodendrogliomas. Int J Cancer 88: 554-557, 2000.
9. Kraus A, Gross MW, Knuechel R, Munkel K, Neff F and Schlegel J: Aberrant p21 regulation in radioresistant primary glioblastoma multiforme cells bearing wild-type p53. J Neurosurg 93: 863-872, 2000. (Pubitemid 32803412)
10. Schlegel J, Vogt T, Münkel K and Rüschoff J: DNA finger-printing of mammalian cell lines using noradioactive arbitrarily primed PCR (AP-PCR). Biotechniques 20: 178-179, 1996.
11. Weinstein JN: Pharmacogenomics - teaching old drugs new tricks. N Engl J Med 343: 1408-1409, 2000.
12. Nakamura M, Konishi N, Tsunoda S, Hiasa Y, Tsuzuki T, Aoki H, Kobitsu K, Nagai H and Sakaki T: Analyses of human gliomas by restriction landmark genomic scanning. J Neurooncol 35: 113-120, 1997. (Pubitemid 27361679)
13. Friedman HS, Johnson SP, Dong Q, Schold SC, Rasheed BK, Bigner SH, Ali-Osman F, Dolan E, Colvin OM, Houghton P, Germain G, Drummond JT, Keir S, Marcelli S, Bigner DD and Modrich P: Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. Cancer Res 57: 2933-2936, 1997. (Pubitemid 27315042)
14. Furnari FB, Huang HJS and Cavenee WK: Genetics and malignant progression of human brain tumours. In: Genetics and Cancer: A second look. Cancer Surveys, vol. 25. ICRF Press, London pp233-275, 1995.
15. Thiel G, Losanowa T, Kintzel D, Nisch G, Martin H, Vorpahl K and Witkowski R: Karyotypes in 90 human gliomas. Cancer Genet Cytogenet 58: 109-120, 1992.
16. Costello JF, Plass C and Cavenee WK: Aberrant methylation of genes in low-grade astrocytomas. Brain Tumor Pathol 17: 49-56, 2000.
17. Cross SH, Meehan RR, Nan X and Bird A: A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nat Genet 16: 256-259, 1997.
18. Esteller M, Garcia-Foncillas J, Andion E, Goodman SN, Hidalgo OF, Vanaclocha V, Baylin SB and Herman JG: Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med 343: 1350-1354, 2000.
19. Nakagawa T, Datta A and Kolodner RD: Multiple functions of MutS- and MutL-related heterocomplexes. Proc Natl Acad Sci USA 96: 14186-14188, 1999. (Pubitemid 30000618)
20. Bellacosa A: Role of MED1 (MBD4) gene in DNA repair and human cancer. J Cell Physiol 187: 137-144, 2001.