ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 5906-5919

  Gleeson, Paul ^a   Bravi, Gianpaolo ^a   Modi, Sandeep ^a   Lowe, Daniel ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

ADMET; hERG inhibition; Matched molecular pairs; P450 inhibition; SAR; Solubility

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; POTASSIUM CHANNEL HERG;

ARTICLE; ARTIFICIAL MEMBRANE; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MEMBRANE PERMEABILITY;

CELL MEMBRANE PERMEABILITY; COMBINATORIAL CHEMISTRY TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; DRUG INDUSTRY; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; PHARMACEUTICAL PREPARATIONS; PROTEIN ISOFORMS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 68149129503     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.002     Document Type: Article

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