New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-Fused and hetero-fused systems

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 3, 2008, Pages 908-912

  Micheli, Fabrizio ^a   Bonanomi, Giorgio ^a   Braggio, Simone ^a   Capelli, Anna Maria ^b   Damiani, Federica ^d   Di Fabio, Romano ^a   Donati, Daniele ^a   Gentile, Gabriella ^a   Hamprecht, Dieter ^a   Perini, Ornella ^b   Petrone, Marcella ^a   Tedesco, Giovanna ^b   Terreni, Silvia ^a   Worby, Angela ^c   Heidbreder, Christian ^a  

^a GSK   (Italy)

^b Molecular Discovery Research   (Italy)

^c Harlow NFSP   (United Kingdom)

^d EUROPEAN PATENT OFFICE   (Germany)

Author keywords

D3 antagonists; Dopamine; Drug dependence; Rat; Selective

Indexed keywords

BENZAZEPINE DERIVATIVE; DOPAMINE 3 RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG SYNTHESIS; NONHUMAN; RAT;

ANIMALS; BENZAZEPINES; COMBINATORIAL CHEMISTRY TECHNIQUES; DOPAMINE ANTAGONISTS; DRUG DESIGN; MOLECULAR STRUCTURE; RATS; RECEPTORS, DOPAMINE D3; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 38749096639     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.042     Document Type: Article

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