The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats

Neuropsychopharmacology

Volumn 31, Issue 7, 2006, Pages 1393-1405

  Xi, Zheng Xiong ^a   Newman, Amy Hauck ^a   Gilbert, Jeremy G ^a   Pak, Arlene C ^a   Peng, Xiao Qing ^a   Ashby Jr , Charles R ^b   Gitajn, Leah ^a   Gardner, Eliot L ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b ST JOHN'S UNIVERSITY   (United States)

Author keywords

Brain reward; Cocaine; D3 receptor; NGB 2904; Relapse; Self administration

Indexed keywords

COCAINE; DOPAMINE 3 RECEPTOR BLOCKING AGENT; N [4 [4 (2,3 DICHLOROPHENYL) 1 PIPERAZINYL]BUTYL] 3 FLUORENYLCARBOXAMIDE; NGB 2904; PIPERAZINE DERIVATIVE; SUCROSE; UNCLASSIFIED DRUG; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE UPTAKE INHIBITOR; FLUORENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEPTH STIMULATION; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG SELF ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; REINFORCEMENT; REWARD; STATISTICAL SIGNIFICANCE; WITHDRAWAL SYNDROME; ADDICTION; ANIMAL; ANIMAL BEHAVIOR; BRAIN; COMPARATIVE STUDY; DOSE RESPONSE; DRUG INTERACTION; ELECTROSTIMULATION; INSTRUMENTAL CONDITIONING; LONG EVANS RAT; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; RADIATION EXPOSURE;

ANIMALS; BEHAVIOR, ADDICTIVE; BEHAVIOR, ANIMAL; BRAIN; COCAINE; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; DOPAMINE ANTAGONISTS; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; EXTINCTION, PSYCHOLOGICAL; FLUORENES; MALE; PIPERAZINES; RATS; RATS, LONG-EVANS; REINFORCEMENT SCHEDULE; REWARD; SELF ADMINISTRATION;

EID: 33745193915     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300912     Document Type: Article

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