Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4011-4013

  Micheli, Fabrizio ^a   Holmes, Ian ^b   Arista, Luca ^c   Bonanomi, Giorgio ^a   Braggio, Simone ^a   Cardullo, Francesca ^a   Fabio, Romano Di ^a   Donati, Daniele ^d   Gentile, Gabriella ^a   Hamprecht, Dieter ^e   Terreni, Silvia ^a   Heidbreder, Christian ^f   Savoia, Chiara ^a   Griffante, Cristiana ^a   Worby, Angela ^g  

^a GSK   (Italy)

^b Cancer Therapeutics   (Australia)

^c NOVARTIS PHARMA AG   (Switzerland)

^d NERVIANO MEDICAL SCIENCES   (Italy)

^e Boehringer Ingelheim   (Italy)

^f Altria Client Services   (United States)

^g GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antagonist; Dopamine D3; Ligand; PET

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR BLOCKING AGENT; LIGAND;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN TISSUE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIVER MICROSOME; NONHUMAN; RAT;

ANIMALS; BRAIN; CHEMISTRY, ORGANIC; CHEMISTRY, PHARMACEUTICAL; HUMANS; IMIDAZOLIDINES; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, CHEMICAL; POSITRON-EMISSION TOMOGRAPHY; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 67650102585     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.028     Document Type: Article

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11. The research complied with national legislation and with company policy on the Care and Use of Animals and with related codes of practice.