Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part one: Lead identification

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4799-4801

  Holmes, Ian P ^a   Micheli, Fabrizio ^b   Gaines, Simon ^c   Lorthioir, Olivier ^c   Watson, Steve P ^c   Fabio, Romano Di ^b   Gentile, Gabriella ^b   Heidbreder, Christian ^d   Savoia, Chiara ^b   Worby, Angela ^c  

^a Cancer Therapeutics   (Australia)

^b GSK   (Italy)

^c GLAXOSMITHKLINE   (United Kingdom)

^d Altria Client Services   (United States)

Author keywords

Antagonists; Dopamine D3; Ligand; PET

Indexed keywords

DOPAMINE 3 RECEPTOR BLOCKING AGENT; LIGAND; POTASSIUM CHANNEL HERG; DOPAMINE 3 RECEPTOR; IMIDAZOLIDINE DERIVATIVE; KCNH1 PROTEIN, HUMAN;

ARTICLE; DRUG CLEARANCE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; CAT; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; SYNTHESIS;

ANIMALS; CATS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; IMIDAZOLIDINES; LIGANDS; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, DOPAMINE D3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67651108948     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.043     Document Type: Article

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