Erratum: Telomere shortening reduces Alzheimer's disease amyloid pathology in mice (Brain (2011) 134 (2044-2056) DOI: 10.1093/brain/awr133);Telomere shortening reduces Alzheimer's disease amyloid pathology in mice

Brain

Volumn 134, Issue 7, 2011, Pages 2044-2056

  Rolyan, Harshvardhan ^a,b   Scheffold, Annika ^a   Heinrich, Annette ^c   Begus Nahrmann, Yvonne ^a   Langkopf, Britta Heike ^a   Hölter, Sabine M ^d   Vogt Weisenhorn, Daniela M ^d   Liss, Birgit ^a   Wurst, Wolfgang ^d   Lie, Dieter Chichung ^d   Thal, Dietmar Rudolf ^a   Biber, Knut ^c,e   Rudolph, Karl Lenhard ^a  

^a UNIVERSITY OF ULM   (Germany)

^b International PhD Program in Molecular Medicine   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

adult neurogenesis; ageing; Alzheimer's disease; amyloid plaques; DNA damage; microglia; telomeres

Indexed keywords

AGING; ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; COGNITIVE DEFECT; DENTATE GYRUS; DISEASE COURSE; FRONTAL CORTEX; HIPPOCAMPUS; LEARNING; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; SHORT TERM MEMORY; TELOMERE;

EID: 79959699254     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awz161     Document Type: Erratum

References (77)

1. Abrous DN, Koehl M, Le Moal M. Adult neurogenesis: from precursors to network and physiology. Physiol Rev 2005; 85: 523-69. (Pubitemid 40404636)
2. Aikata H, Takaishi H, Kawakami Y, Takahashi S, Kitamoto M, Nakanishi T, et al. Telomere reduction in human liver tissues with age and chronic inflammation. Exp Cell Res 2000; 256: 578-82. (Pubitemid 30244216)
3. Aimone JB, Wiles J, Gage FH. Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci 2006; 9: 723-7.
4. Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW, et al. Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res 1995; 220: 194-200.
5. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, et al. Telomere length predicts replicative capacity of human fibro-blasts. Proc Natl Acad Sci USA 1992; 89: 10114-8.
6. Alzheimer A, Stelzmann RA, Schnitzlein HN, Murtagh FR. An English translation of Alzheimer's 1907 paper, "Über eine eigenartige Erkankung der Hirnrinde". Clin Anat 1995; 8: 429-31.
7. Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, Lamb BT. Regulation of tau pathology by the microglial fractalkine receptor. Neuron 2010; 68: 19-31.
8. Blasco MA, Lee HW, Hande MP, Samper E, Landsorp PM, DePinho RA, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997; 91: 25-34. (Pubitemid 27431310)
9. Brasnjevic I, Hof PR, Steinbusch HW, Schmitz C. Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases. DNA Repair (Amst) 2008; 7: 1087-97.
10. Cardona AE, Huang D, Sasse ME, Ransohoff RM. Isolation of murine microglial cells for RNA analysis or flow cytometry. Nat Protoc 2006; 1: 1947-51. (Pubitemid 46773316)
11. Chen Q, Nakajima A, Choi SH, Xiong X, Sisodia SS, Tang YP. Adult neurogenesis is functionally associated with AD-like neurodegenera-tion. Neurobiol Dis 2008; 29: 316-26.
12. Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, et al. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 2007; 39: 99-105. (Pubitemid 46026508)
13. Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, et al. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell 2009; 139: 1157-69.
14. Colonnier M. Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study. Brain Res 1968; 9: 268-87.
15. Conde JR, Streit WJ. Microglia in the ageing brain. J Neuropathol Exp Neurol 2006; 65: 199-203.
16. Couillard-Despres S, Winner B, Schaubeck S, Aigner R, Vroemen M, Weidner N, et al. Doublecortin expression levels in adult brain reflect neurogenesis. Eur J Neurosci 2005; 21: 1-14. (Pubitemid 40193870)
17. Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurode-generation. J Neurosci 2005; 25: 9275-84. (Pubitemid 41500836)
18. d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003; 426: 194-198. (Pubitemid 37442589)
19. DeFelipe J, Marco P, Busturia I, Merchán-Pérez A. Estimation of the number of synapses in the cerebral cortex: methodological considerations. Cereb Cortex 1999; 9: 722-32.
20. de Souza-Pinto NC, Wilson DM 3rd, Stevnsner TV, Bohr VA. Mitochondrial DNA, base excision repair and neurodegeneration. DNA Repair (Amst) 2008; 7: 1098-109.
21. Dilger RN, Johnson RW. Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 2008; 84: 932-9.
22. El-Khoury AE, Basile A, Beaumier L, Wang SY, Al-Amiri HA, Selvaraj A, et al. Twenty-four-hour intravenous and oral tracer studies with L-(1-13C)-2-aminoadipic acid and L-(1-13C)lysine as tracers at generous nitrogen and lysine intakes in healthy adults. Am J Clin Nutr 1998; 68: 827-39. (Pubitemid 28471065)
23. Ferrón S, Mira H, Franco S, Cano-Jaimez M, Bellmunt E, Ramírez C, et al. Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells. Development 2004; 131: 4059-4070. (Pubitemid 39232164)
24. Forstl H. Alzheimer's disease: the size of the problem, clinical manifestation and heterogeneity. J Neural Transm Suppl 1998; 54: 1-8. (Pubitemid 28539338)
25. Frank S, Burbach GJ, Bonin M, Walter M, Streit W, Bechmann I, et al. TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice. Glia 2008; 56: 1438-47.
26. Freude S, Hettich MM, Schumann C, Stöhr O, Koch L, Köhler C, et al. Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. FASEB J 2009; 23: 3315-33.
27. Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 1999; 2: 260-5. (Pubitemid 30491297)
28. Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 2009; 12: 1361-3.
29. Imai Y, Ibata I, Ito D, Ohsawa K, Kohsaka S. A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem Biophys Res Commun 1996; 224: 855-62. (Pubitemid 26278674)
30. Imayoshi I, Sakamoto M, Ohtsuka T, Kageyama R. Continuous neurogenesis in the adult brain. Dev Growth Differ 2009; 51: 379-86.
31. Jessberger S, Clark RE, Broadbent NJ, Clemenson GD Jr, Consiglio A, Lie DC, et al. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem 2009; 16: 147-54.
32. Jin K, Peel AL, Mao XO, Xie L, Cottrell BA, Henshall DC, et al. Increased hippocampal neurogenesis in Alzheimer's disease. Proc Natl Acad Sci USA 2004; 101: 343-47. (Pubitemid 38084252)
33. Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C, et al. Telomere dysfunction induces environmental alterations limiting hem-atopoietic stem cell function and engraftment. Nat Med 2007; 13: 742-7. (Pubitemid 46889751)
34. Kempermann G, Gage FH. Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. Eur J Neurosci 2002; 16: 129-36. (Pubitemid 35463603)
35. Kidd M. Alzheimer's disease-an electron microscopical study. Brain 1964; 87: 307-20.
36. Killick R, Scales G, Leroy K, Causevic M, Hopper C, Irvine EE, et al. Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochem Biophys Res Commun 2009; 386: 257-62.
37. Koenigsknecht J, Landreth G. Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism. J Neurosci 2004; 24: 9838-46. (Pubitemid 39463564)
38. Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, et al. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. J Neurosci 2008; 28: 14156-64.
39. Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, et al. Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci 2007; 27: 12623-9. (Pubitemid 350127816)
40. Lee HW, Blasco MA, Gottlieb GJ, Horner JW, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature 1998; 392: 569-74. (Pubitemid 28207706)
41. Lee JS, Im DS, An YS, Hong JM, Gwag BJ, Joo IS. Chronic cerebral hypoperfusion in a mouse model of Alzheimer's disease: an additional contributing factor of cognitive impairment. Neurosci Lett 2011; 489: 84-8.
42. Malm TM, Koistinaho M, Pärepalo M, Vatanen T, Ooka A, Karlsson S, et al. Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. Neurobiol Dis 2005; 18: 134-42. (Pubitemid 40092904)
43. Ming GL, Song H. Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci 2005; 28: 223-50. (Pubitemid 41098905)
44. Miranda R, Sebrie C, Degrouard J, Gillet B, Jaillard D, Laroche S, et al. Reorganization of inhibitory synapses and increased PSD length of perforated excitatory synapses in hippocampal area CA1 of dystrophin-deficient mdx mice. Cerebral Cortex 2009; 19: 876-88.
45. Mirochnic S, Wolf S, Staufenbiel M, Kempermann G. Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease. Hippocampus 2009; 19: 1008-18.
46. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984; 11: 47-60. (Pubitemid 14088970)
47. Mullen RJ, Buck CR, Smith AM. NeuN, a neuronal specific nuclear protein in vertebrates. Development 1992; 116: 201-11.
48. Nalapareddy K, Jiang H, Guachalla Gutierrez LM, Rudolph KL. Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use? Exp Gerontol 2008; 43: 998-1004.
49. Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appaldoorn E, et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 2006; 444: 1038-43. (Pubitemid 46018517)
50. Ninkovic J, Mori T, Götz M. Distinct modes of neuron addition in adult mouse neurogenesis. J Neurosci 2007; 27: 10906-11.
51. Panossian LA, Porter VR, Valenzuela HF, Zhu X, Reback E, Mastermann D, et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging 2003; 24: 77-84. (Pubitemid 35454145)
52. Rass U, Ahel I, West SC. Defective DNA repair and neurodegenerative disease. Cell 2007; 130: 991-1004. (Pubitemid 47410275)
53. Rodier F, CoppéJP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009; 11: 973-9.
54. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273: 5858-68. (Pubitemid 28124064)
55. Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, et al. Longevity, stress response, and cancer in ageing telomerase-deficient mice. Cell 1999; 96: 701-12. (Pubitemid 29122812)
56. Satoh H, Hiyama K, Takeda M, Awaya Y, Watanabe K, Ihara Y, et al. Telomere shortening in peripheral blood cells was related with ageing but not with white blood cell count. Jpn J Hum Genet 1996; 41: 413-7. (Pubitemid 27066107)
57. Satyanarayana A, Wiemann SU, Buer J, Lauber J, Dittmar KE, Wüstefeld T, et al. Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. EMBO J 2003; 22: 4003-13. (Pubitemid 36975726)
58. Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepczynska A, Lilli DR, et al. Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell 2007; 130: 863-77. (Pubitemid 47332579)
59. Sedelnikova OA, Horikawa I, Zimonjic DB, Popescu NC, Bonner WM, Barrett JC. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol 2004; 6: 168-70. (Pubitemid 38425717)
60. Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, O'Banion MK. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 2007; 117: 1595-604. (Pubitemid 46871344)
61. Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. Microglia derived from ageing mice exhibit an altered inflammatory profile. Glia 2007; 55: 412-24.
62. Simard AR, Soulet D, Gowing G, Julien JP, Rivest S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 2006; 49: 489-502. (Pubitemid 43221886)
63. Sparkman NL, Johnson RW. Neuroinflammation associated with ageing sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation 2008; 15: 323-30.
64. Streit WJ. Microglial senescence: does the brain's immune system have an expiration date? Trends Neurosci 2006; 29: 506-10. (Pubitemid 44291814)
65. Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, et al. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 1997; 94: 13287-92.
66. Tashiro A, Makino H, Gage FH. Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J Neurosci 2007; 27: 3252-9. (Pubitemid 46474131)
67. Thal DR, Capetillo-Zarate E, Del Tredici K, Braak H. The development of amyloid beta protein deposits in the aged brain. Sci Aging Knowledge Environ 2006; 2006: re1.
68. Thal DR, Rüb U, Orantes M, Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 2002; 58: 1791-800. (Pubitemid 34663580)
69. Thomas P, O'Callaghan NJ, Fenech M. Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mech Ageing Dev 2008; 129: 183-90.
70. Tyas SL, Manfreda J, Strain LA, Montgomery PR. Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada. Int J Epidemiol 2001; 30: 590-7. (Pubitemid 32600256)
71. Van Dam D, D'Hooge R, Staufenbiel M, Van Ginneken C, Van Meir F, De Deyn PP. Age-dependent cognitive decline in the APP23 model precedes amyloid deposition. Eur J Neurosci 2003; 17: 388-96. (Pubitemid 36459519)
72. van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH. Functional neurogenesis in the adult hippocampus. Nature 2002; 415: 1030-4. (Pubitemid 34193451)
73. Venneti S, Wiley CA, Kofler J. Imageing microglial activation during neuroinflammation and Alzheimer's disease. J Neuroimmune Pharmacol 2009; 4: 227-43.
74. von Bernhardi R, Tichauer JE, Eugenín J. Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders. J Neurochem 2010; 112: 1099-114.
75. von Zglinicki T, Saretzki G, Docke W, Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995; 220: 186-93.
76. Yang L, Suwa T, Wright WE, Shay JW, Hornsby PJ. Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells. Mech Ageing Dev 2001; 122: 1685-94. (Pubitemid 32835216)
77. Zhang J, Kong Q, Zhang Z, Ge P, Ba D, He W. Telomere dysfunction of lymphocytes in patients with Alzheimer disease. Cogn Behav Neurol 2003; 16: 170-6. (Pubitemid 37243440)