메뉴 건너뛰기




Volumn 2011, Issue , 2011, Pages

Functions of MDMX in the modulation of the p53-response

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DOXORUBICIN; ETOPOSIDE; LEPTOMYCIN B; MESSENGER RNA; PROTEIN MDMX; PROTEIN P53; TRANSCRIPTION ELONGATION FACTOR; UBIQUITIN; PROTEIN MDM2;

EID: 79959336105     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/876173     Document Type: Review
Times cited : (34)

References (92)
  • 1
    • 68849093989 scopus 로고    scopus 로고
    • Tumour suppression by p53: The importance of apoptosis and cellular senescence
    • Zuckerman V., Wolyniec K., Sionov R. V., Haupt S., Haupt Y., Tumour suppression by p53: the importance of apoptosis and cellular senescence Journal of Pathology 2009 219 1 3 15
    • (2009) Journal of Pathology , vol.219 , Issue.1 , pp. 3-15
    • Zuckerman, V.1    Wolyniec, K.2    Sionov, R.V.3    Haupt, S.4    Haupt, Y.5
  • 2
    • 33847083565 scopus 로고    scopus 로고
    • P53 modulation of the DNA damage response
    • Helton E. S., Chen X., p53 modulation of the DNA damage response Journal of Cellular Biochemistry 2007 100 4 883 896
    • (2007) Journal of Cellular Biochemistry , vol.100 , Issue.4 , pp. 883-896
    • Helton, E.S.1    Chen, X.2
  • 3
    • 34548842816 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis by p53: A new role for the guardian of the genome
    • DOI 10.1007/s00109-007-0221-2
    • Teodoro J. G., Evans S. K., Green M. R., Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome Journal of Molecular Medicine 2007 85 11 1175 1186 (Pubitemid 47622219)
    • (2007) Journal of Molecular Medicine , vol.85 , Issue.11 , pp. 1175-1186
    • Teodoro, J.G.1    Evans, S.K.2    Green, M.R.3
  • 5
    • 19744363342 scopus 로고    scopus 로고
    • Modification of MDMX by sumoylation
    • DOI 10.1016/j.bbrc.2005.05.012, PII S0006291X05009897
    • Pan Y., Chen J., Modification of MDMX by sumoylation Biochemical and Biophysical Research Communications 2005 332 3 702 709 (Pubitemid 40745171)
    • (2005) Biochemical and Biophysical Research Communications , vol.332 , Issue.3 , pp. 702-709
    • Pan, Y.1    Chen, J.2
  • 6
    • 22544438112 scopus 로고    scopus 로고
    • Regulation of p53-MDMX interaction by casein kinase 1 alpha
    • DOI 10.1128/MCB.25.15.6509-6520.2005
    • Chen L., Li C., Pan Y., Chen J., Regulation of p53-MDMX interaction by casein kinase 1 alpha Molecular and Cellular Biology 2005 25 15 6509 6520 (Pubitemid 41023226)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.15 , pp. 6509-6520
    • Chen, L.1    Li, C.2    Pan, Y.3    Chen, J.4
  • 7
    • 17844385110 scopus 로고    scopus 로고
    • p34 is required for nuclear export of Mdm2
    • DOI 10.1038/sj.onc.1208488
    • Elias B., Laine A., Ronai Z., Phosphorylation of MdmX by CDK2/Cdc2 is required for nuclear export of Mdm2 Oncogene 2005 24 15 2574 2579 (Pubitemid 40593048)
    • (2005) Oncogene , vol.24 , Issue.15 , pp. 2574-2579
    • Elias, B.1    Laine, A.2    Ronai, Z.3
  • 8
    • 70449724796 scopus 로고    scopus 로고
    • Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo
    • Wang Y. V., Wade M., Wahl G. M., Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo Cell Cycle 2009 8 21 3443 3444
    • (2009) Cell Cycle , vol.8 , Issue.21 , pp. 3443-3444
    • Wang, Y.V.1    Wade, M.2    Wahl, G.M.3
  • 9
    • 77952543499 scopus 로고    scopus 로고
    • The p53 orchestra: Mdm2 and Mdmx set the tone
    • Wade M., Wang Y. V., Wahl G. M., The p53 orchestra: Mdm2 and Mdmx set the tone Trends in Cell Biology 2010 20 5 299 309
    • (2010) Trends in Cell Biology , vol.20 , Issue.5 , pp. 299-309
    • Wade, M.1    Wang, Y.V.2    Wahl, G.M.3
  • 10
    • 77449101168 scopus 로고    scopus 로고
    • Mdm2-mediated ubiquitylation: P53 and beyond
    • Marine J. C., Lozano G., Mdm2-mediated ubiquitylation: p53 and beyond Cell Death and Differentiation 2010 17 1 93 102
    • (2010) Cell Death and Differentiation , vol.17 , Issue.1 , pp. 93-102
    • Marine, J.C.1    Lozano, G.2
  • 12
    • 0033621415 scopus 로고    scopus 로고
    • Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
    • DOI 10.1074/jbc.274.53.38189
    • Sharp D. A., Kratowicz S. A., Sank M. J., George D. L., Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein The Journal of Biological Chemistry 1999 274 53 38189 38196 (Pubitemid 30026893)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.53 , pp. 38189-38196
    • Sharp, D.A.1    Kratowicz, S.A.2    Sank, M.J.3    George, D.L.4
  • 13
    • 0038788827 scopus 로고    scopus 로고
    • Critical contribution of the MDM2 acidic domain to p53 ubiquitination
    • DOI 10.1128/MCB.23.14.4939-4947.2003
    • Kawai H., Wiederschain D., Yuan Z. M., Critical contribution of the MDM2 acidic domain to p53 ubiquitination Molecular and Cellular Biology 2003 23 14 4939 4947 (Pubitemid 36793339)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.14 , pp. 4939-4947
    • Kawai, H.1    Wiederschain, D.2    Yuan, Z.-M.3
  • 17
    • 77449155637 scopus 로고    scopus 로고
    • The multiple levels of regulation by p53 ubiquitination
    • Lee J. T., Gu W., The multiple levels of regulation by p53 ubiquitination Cell Death and Differentiation 2010 17 1 86 92
    • (2010) Cell Death and Differentiation , vol.17 , Issue.1 , pp. 86-92
    • Lee, J.T.1    Gu, W.2
  • 19
    • 0036059108 scopus 로고    scopus 로고
    • MDMX inhibits the p300/CBP-mediated acetylation of p53
    • Sabbatini P., Mccormick F., MDMX inhibits the p300/CBP-mediated acetylation of p53 DNA and Cell Biology 2002 21 7 519 525
    • (2002) DNA and Cell Biology , vol.21 , Issue.7 , pp. 519-525
    • Sabbatini, P.1    McCormick, F.2
  • 21
    • 22544484456 scopus 로고    scopus 로고
    • The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
    • DOI 10.1073/pnas.0503068102
    • Krummel K. A., Lee C. J., Toledo F., Wahl G. M., The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation Proceedings of the National Academy of Sciences of the United States of America 2005 102 29 10188 10193 (Pubitemid 41023347)
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.29 , pp. 10188-10193
    • Krummel, K.A.1    Lee, C.J.2    Toledo, F.3    Wahl, G.M.4
  • 23
    • 34447123808 scopus 로고    scopus 로고
    • RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity
    • DOI 10.1158/0008-5472.CAN-07-1313
    • Kawai H., Lopez-Pajares V., Kim M. M., Wiederschain D., Yuan Z. M., RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity Cancer Research 2007 67 13 6026 6030 (Pubitemid 47037481)
    • (2007) Cancer Research , vol.67 , Issue.13 , pp. 6026-6030
    • Kawai, H.1    Lopez-Pajares, V.2    Kim, M.M.3    Wiederschain, D.4    Yuan, Z.-M.5
  • 24
    • 42149105590 scopus 로고    scopus 로고
    • Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
    • DOI 10.1038/sj.cdd.4402309, PII 4402309
    • Linke K., Mace P. D., Smith C. A., Vaux D. L., Silke J., Day C. L., Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans Cell Death and Differentiation 2008 15 5 841 848 (Pubitemid 351524426)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.5 , pp. 841-848
    • Linke, K.1    Mace, P.D.2    Smith, C.A.3    Vaux, D.L.4    Silke, J.5    Day, C.L.6
  • 25
    • 33846239416 scopus 로고    scopus 로고
    • The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
    • DOI 10.1038/sj.emboj.7601465, PII 7601465
    • Poyurovsky M. V., Priest C., Kentsis A., Borden K. L. B., Pan Z. Q., Pavletich N., Prives C., The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity The EMBO Journal 2007 26 1 90 101 (Pubitemid 46094702)
    • (2007) EMBO Journal , vol.26 , Issue.1 , pp. 90-101
    • Poyurovsky, M.V.1    Priest, C.2    Kentsis, A.3    Borden, K.L.B.4    Pan, Z.-Q.5    Pavletich, N.6    Prives, C.7
  • 26
    • 0032871092 scopus 로고    scopus 로고
    • Constitutive mdmx expression during cell growth, differentiation, and DNA damage
    • DOI 10.1089/104454999314971
    • Jackson M. W., Berberich S. J., Constitutive mdmx expression during cell growth, differentiation, and DNA damage DNA and Cell Biology 1999 18 9 693 700 (Pubitemid 29439221)
    • (1999) DNA and Cell Biology , vol.18 , Issue.9 , pp. 693-700
    • Jackson, M.W.1    Berberich, S.J.2
  • 27
    • 0036837868 scopus 로고    scopus 로고
    • DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms
    • Li C., Chen L., Chen J., DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms Molecular and Cellular Biology 2002 22 21 7562 7571
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.21 , pp. 7562-7571
    • Li, C.1    Chen, L.2    Chen, J.3
  • 28
    • 85047699938 scopus 로고    scopus 로고
    • MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts
    • DOI 10.1038/sj/onc/1205137
    • Gentiletti F., Mancini F., D'Angelo M., Sacchi A., Pontecorvi A., Jochemsen A. G., Moretti F., MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts Oncogene 2002 21 6 867 877 (Pubitemid 34146300)
    • (2002) Oncogene , vol.21 , Issue.6 , pp. 867-877
    • Gentiletti, F.1    Mancini, F.2    D'Angelo, M.3    Sacchi, A.4    Pontecorvi, A.5    Jochemsen, A.G.6    Moretti, F.7
  • 29
    • 0042592947 scopus 로고    scopus 로고
    • MDM2 promotes ubiquitination and degradation of MDMX
    • DOI 10.1128/MCB.23.15.5113-5121.2003
    • Pan Y., Chen J., MDM2 promotes ubiquitination and degradation of MDMX Molecular and Cellular Biology 2003 23 15 5113 5121 (Pubitemid 36950868)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.15 , pp. 5113-5121
    • Pan, Y.1    Chen, J.2
  • 32
    • 27144444111 scopus 로고    scopus 로고
    • ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
    • DOI 10.1038/sj.emboj.7600812, PII 7600812
    • Chen L., Gilkes D. M., Pan Y., Lane W. S., Chen J., ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage The EMBO Journal 2005 24 19 3411 3422 (Pubitemid 41486779)
    • (2005) EMBO Journal , vol.24 , Issue.19 , pp. 3411-3422
    • Chen, L.1    Gilkes, D.M.2    Pan, Y.3    Lane, W.S.4    Chen, J.5
  • 36
    • 33645290219 scopus 로고    scopus 로고
    • Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
    • LeBron C., Chen L., Gilkes D. M., Chen J., Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3 The EMBO Journal 2006 25 6 1196 1206
    • (2006) The EMBO Journal , vol.25 , Issue.6 , pp. 1196-1206
    • Lebron, C.1    Chen, L.2    Gilkes, D.M.3    Chen, J.4
  • 37
    • 19444367393 scopus 로고    scopus 로고
    • Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
    • DOI 10.1016/j.molcel.2005.04.024, PII S1097276505012876
    • Meulmeester E., Maurice M. M., Boutell C., Teunisse A. F. A. S., Ovaa H., Abraham T. E., Dirks R. W., Jochemsen A. G., Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 Molecular Cell 2005 18 5 565 576 (Pubitemid 40726233)
    • (2005) Molecular Cell , vol.18 , Issue.5 , pp. 565-576
    • Meulmeester, E.1    Maurice, M.M.2    Boutell, C.3    Teunisse, A.F.A.S.4    Ovaa, H.5    Abraham, T.E.6    Dirks, R.W.7    Jochemsen, A.G.8
  • 38
    • 77957220495 scopus 로고    scopus 로고
    • Further insight into substrate recognition by USP7: Structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7
    • Sarkari F., La Delfa A., Arrowsmith C. H., Frappier L., Sheng Y., Saridakis V., Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7 Journal of Molecular Biology 2010 402 5 825 837
    • (2010) Journal of Molecular Biology , vol.402 , Issue.5 , pp. 825-837
    • Sarkari, F.1    La Delfa, A.2    Arrowsmith, C.H.3    Frappier, L.4    Sheng, Y.5    Saridakis, V.6
  • 39
    • 59849112565 scopus 로고    scopus 로고
    • 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2potential interplay with the PKB/Akt pathway and p14
    • Wood N. T., Meek D. W., MacKintosh C., 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2potential interplay with the PKB/Akt pathway and p14 FEBS Letters 2009 583 4 615 620
    • (2009) FEBS Letters , vol.583 , Issue.4 , pp. 615-620
    • Wood, N.T.1    Meek, D.W.2    MacKintosh, C.3
  • 40
    • 41849147869 scopus 로고    scopus 로고
    • CARPs enhance p53 turnover by degrading 14-3-3σ and stabilizing MDM2
    • Yang W., Dicker D. T., Chen J., El-Deiry W. S., CARPs enhance p53 turnover by degrading 14-3-3 and stabilizing MDM2 Cell Cycle 2008 7 5 670 682 (Pubitemid 351499007)
    • (2008) Cell Cycle , vol.7 , Issue.5 , pp. 670-682
    • Yang, W.1    Dicker, D.T.2    Chen, J.3    El-Deiry, W.S.4
  • 41
    • 2342567852 scopus 로고    scopus 로고
    • Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
    • DOI 10.1038/sj.emboj.7600145
    • Stommel J. M., Wahl G. M., Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation The EMBO Journal 2004 23 7 1547 1556 (Pubitemid 38579515)
    • (2004) EMBO Journal , vol.23 , Issue.7 , pp. 1547-1556
    • Stommel, J.M.1    Wahl, G.M.2
  • 42
    • 33645293151 scopus 로고    scopus 로고
    • 14-3-3 binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
    • Jin Y., Dai M. S., Lu S. Z., Xu Y., Luo Z., Zhao Y., Lu H., 14-3-3 binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation The EMBO Journal 2006 25 6 1207 1218
    • (2006) The EMBO Journal , vol.25 , Issue.6 , pp. 1207-1218
    • Jin, Y.1    Dai, M.S.2    Lu, S.Z.3    Xu, Y.4    Luo, Z.5    Zhao, Y.6    Lu, H.7
  • 43
    • 67649361514 scopus 로고    scopus 로고
    • Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases
    • Wang Y. V., Leblanc M., Wade M., Jochemsen A. G., Wahl G. M., Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases Cancer Cell 2009 16 1 33 43
    • (2009) Cancer Cell , vol.16 , Issue.1 , pp. 33-43
    • Wang, Y.V.1    Leblanc, M.2    Wade, M.3    Jochemsen, A.G.4    Wahl, G.M.5
  • 45
    • 0036655060 scopus 로고    scopus 로고
    • Alternative and aberrant splicing of MDM2 mRNA in human cancer
    • DOI 10.1016/S1535-6108(02)00091-0
    • Bartel F., Taubert H., Harris L. C., Alternative and aberrant splicing of MDM2 mRNA in human cancer Cancer Cell 2002 2 1 9 15 (Pubitemid 41043984)
    • (2002) Cancer Cell , vol.2 , Issue.1 , pp. 9-15
    • Bartel, F.1    Taubert, H.2    Harris, L.C.3
  • 46
  • 47
    • 33750378188 scopus 로고    scopus 로고
    • Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4
    • DOI 10.1158/0008-5472.CAN-05-4271
    • Chandler D. S., Singh R. K., Caldwell L. C., Bitler J. L., Lozano G., Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4 Cancer Research 2006 66 19 9502 9508 (Pubitemid 44623648)
    • (2006) Cancer Research , vol.66 , Issue.19 , pp. 9502-9508
    • Chandler, D.S.1    Singh, R.K.2    Caldwell, L.C.3    Bitler, J.L.4    Lozano, G.5
  • 48
    • 0033583205 scopus 로고    scopus 로고
    • A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity
    • Rallapalli R., Strachan G., Cho B., Mercer W. E., Hall D. J., A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity The Journal of Biological Chemistry 1999 274 12 8299 8308
    • (1999) The Journal of Biological Chemistry , vol.274 , Issue.12 , pp. 8299-8308
    • Rallapalli, R.1    Strachan, G.2    Cho, B.3    Mercer, W.E.4    Hall, D.J.5
  • 49
    • 0038022602 scopus 로고    scopus 로고
    • Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells
    • DOI 10.1002/jcb.10535
    • Rallapalli R., Strachan G., Tuan R. S., Hall D. J., Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells Journal of Cellular Biochemistry 2003 89 3 563 575 (Pubitemid 36648778)
    • (2003) Journal of Cellular Biochemistry , vol.89 , Issue.3 , pp. 563-575
    • Rallapalli, R.1    Strachan, G.2    Tuan, R.S.3    Hall, D.J.4
  • 50
    • 0007570010 scopus 로고    scopus 로고
    • The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation
    • DOI 10.1083/jcb.149.2.307
    • van der Houven van Oordt W., Diaz-Meco M. T., Lozano J., Krainer A. R., Moscat J., Cceres J. F., The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation Journal of Cell Biology 2000 149 2 307 316 (Pubitemid 30227149)
    • (2000) Journal of Cell Biology , vol.149 , Issue.2 , pp. 307-316
    • Van Oordt, W.V.D.H.1    Diaz-Meco, M.T.2    Lozano, J.3    Krainer, A.R.4    Moscat, J.5    Caceres, J.F.6
  • 51
    • 17244383094 scopus 로고    scopus 로고
    • Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing
    • DOI 10.1242/jcs.01720
    • Shomron N., Alberstein M., Reznik M., Ast G., Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing Journal of Cell Science 2005 118 6 1151 1159 (Pubitemid 40528686)
    • (2005) Journal of Cell Science , vol.118 , Issue.6 , pp. 1151-1159
    • Shomron, N.1    Alberstein, M.2    Reznik, M.3    Ast, G.4
  • 54
    • 56149095484 scopus 로고    scopus 로고
    • Full-length hdmX transcripts decrease following genotoxic stress
    • Markey M., Berberich S. J., Full-length hdmX transcripts decrease following genotoxic stress Oncogene 2008 27 52 6657 6666
    • (2008) Oncogene , vol.27 , Issue.52 , pp. 6657-6666
    • Markey, M.1    Berberich, S.J.2
  • 60
    • 0034003005 scopus 로고    scopus 로고
    • Stress signals utilize multiple pathways to stabilize p53
    • DOI 10.1128/MCB.20.9.3224-3233.2000
    • Ashcroft M., Taya Y., Vousden K. H., Stress signals utilize multiple pathways to stabilize p53 Molecular and Cellular Biology 2000 20 9 3224 3233 (Pubitemid 30215034)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.9 , pp. 3224-3233
    • Ashcroft, M.1    Taya, Y.2    Vousden, K.H.3
  • 61
    • 2542500783 scopus 로고    scopus 로고
    • HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
    • Wang Y., Debatin K. M., Hug H., HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels BMC Molecular Biology 2001 2, article 8
    • (2001) BMC Molecular Biology , vol.28
    • Wang, Y.1    Debatin, K.M.2    Hug, H.3
  • 62
    • 3142682521 scopus 로고    scopus 로고
    • HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function
    • DOI 10.1038/sj.onc.1207656
    • Di Stefano V., Blandino G., Sacchi A., Soddu S., D'Orazi G., HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function Oncogene 2004 23 30 5185 5192 (Pubitemid 38980351)
    • (2004) Oncogene , vol.23 , Issue.30 , pp. 5185-5192
    • Di Stefano, V.1    Blandino, G.2    Sacchi, A.3    Soddu, S.4    D'Orazi, G.5
  • 63
    • 61349089240 scopus 로고    scopus 로고
    • P53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal
    • Batista L. F. Z., Roos W. P., Kaina B., Menck C. F. M., p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal Molecular Cancer Research 2009 7 2 237 246
    • (2009) Molecular Cancer Research , vol.7 , Issue.2 , pp. 237-246
    • Batista, L.F.Z.1    Roos, W.P.2    Kaina, B.3    Menck, C.F.M.4
  • 66
    • 0344011603 scopus 로고    scopus 로고
    • Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
    • DOI 10.1093/emboj/cdg579
    • Rubbi C. P., Milner J., Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses The EMBO Journal 2003 22 22 6068 6077 (Pubitemid 37463250)
    • (2003) EMBO Journal , vol.22 , Issue.22 , pp. 6068-6077
    • Rubbi, C.P.1    Milner, J.2
  • 67
    • 77955177254 scopus 로고    scopus 로고
    • Ribosome biogenesis surveillance: Probing the ribosomal protein-Mdm2-p53 pathway
    • Deisenroth C., Zhang Y., Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway Oncogene 2010 29 4253 4260
    • (2010) Oncogene , vol.29 , pp. 4253-4260
    • Deisenroth, C.1    Zhang, Y.2
  • 68
    • 70350497397 scopus 로고    scopus 로고
    • Signaling to p53: Ribosomal proteins find their way
    • Zhang Y., Lu H., Signaling to p53: ribosomal proteins find their way Cancer Cell 2009 16 5 369 377
    • (2009) Cancer Cell , vol.16 , Issue.5 , pp. 369-377
    • Zhang, Y.1    Lu, H.2
  • 69
    • 33751573462 scopus 로고    scopus 로고
    • MDMX regulation of p53 response to ribosomal stress
    • DOI 10.1038/sj.emboj.7601424, PII 7601424
    • Gilkes D. M., Chen L., Chen J., MDMX regulation of p53 response to ribosomal stress The EMBO Journal 2006 25 23 5614 5625 (Pubitemid 44847201)
    • (2006) EMBO Journal , vol.25 , Issue.23 , pp. 5614-5625
    • Gilkes, D.M.1    Chen, L.2    Chen, J.3
  • 70
    • 58149161997 scopus 로고    scopus 로고
    • Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells
    • Thant A. A., Wu Y., Lee J., Mishra D. K., Garcia H., Koeffler H. P., Vadgama J. V., Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells Anticancer Research 2008 28 6 A 3579 3592
    • (2008) Anticancer Research , vol.28 , Issue.6 A , pp. 3579-3592
    • Thant, A.A.1    Wu, Y.2    Lee, J.3    Mishra, D.K.4    Garcia, H.5    Koeffler, H.P.6    Vadgama, J.V.7
  • 77
    • 0343819885 scopus 로고    scopus 로고
    • Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification
    • Riemenschneider M. J., Bschges R., Wolter M., Reifenberger J., Bostrm J., Kraus J. A., Schlegel U., Reifenberger G., Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification Cancer Research 1999 59 24 6091 6096 (Pubitemid 30035626)
    • (1999) Cancer Research , vol.59 , Issue.24 , pp. 6091-6096
    • Riemenschneider, M.J.1    Buschges, R.2    Wolter, M.3    Reifenberger, J.4    Bostrom, J.5    Kraus, J.A.6    Schlegel, U.7    Reifenberger, G.8
  • 78
    • 26444599546 scopus 로고    scopus 로고
    • Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
    • DOI 10.1002/ijc.21206
    • Bartel F., Schulz J., Bhnke A., Blmke K., Kappler M., Bache M., Schmidt H., Wrl P., Taubert H., Hauptmann S., Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis International Journal of Cancer 2005 117 3 469 475 (Pubitemid 41429571)
    • (2005) International Journal of Cancer , vol.117 , Issue.3 , pp. 469-475
    • Bartel, F.1    Schulz, J.2    Bohnke, A.3    Blumke, K.4    Kappler, M.5    Bache, M.6    Schmidt, H.7    Wurl, P.8    Taubert, H.9    Hauptmann, S.10
  • 82
    • 34548692296 scopus 로고    scopus 로고
    • High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas
    • DOI 10.1016/j.humpath.2007.03.005, PII S0046817707001517
    • Valentin-Vega Y. A., Barboza J. A., Chau G. P., El-Naggar A. K., Lozano G., High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas Human Pathology 2007 38 10 1553 1562 (Pubitemid 47418967)
    • (2007) Human Pathology , vol.38 , Issue.10 , pp. 1553-1562
    • Valentin-Vega, Y.A.1    Barboza, J.A.2    Chau, G.P.3    El-Naggar, A.K.4    Lozano, G.5
  • 84
    • 0942290415 scopus 로고    scopus 로고
    • Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth
    • DOI 10.1038/sj.onc.1206925
    • Steinman H. A., Sluss H. K., Sands A. T., Pihan G., Jones S. N., Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth Oncogene 2004 23 1 303 306 (Pubitemid 38142265)
    • (2004) Oncogene , vol.23 , Issue.1 , pp. 303-306
    • Steinman, H.A.1    Sluss, H.K.2    Sands, A.T.3    Pihan, G.4    Jones, S.N.5
  • 85
    • 38949124679 scopus 로고    scopus 로고
    • MDMX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice
    • DOI 10.1128/MCB.01108-07
    • Matijasevic Z., Steinman H. A., Hoover K., Jones S. N., MDMX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice Molecular and Cellular Biology 2008 28 4 1265 1273 (Pubitemid 351214129)
    • (2008) Molecular and Cellular Biology , vol.28 , Issue.4 , pp. 1265-1273
    • Matijasevic, Z.1    Steinman, H.A.2    Hoover, K.3    Jones, S.N.4
  • 91
    • 77953571903 scopus 로고    scopus 로고
    • P53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors
    • Li B., Cheng Q., Li Z., Chen J., p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors Cell Cycle 2010 9 7 1411 1420
    • (2010) Cell Cycle , vol.9 , Issue.7 , pp. 1411-1420
    • Li, B.1    Cheng, Q.2    Li, Z.3    Chen, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.