-
1
-
-
68849093989
-
Tumour suppression by p53: The importance of apoptosis and cellular senescence
-
Zuckerman V., Wolyniec K., Sionov R. V., Haupt S., Haupt Y., Tumour suppression by p53: the importance of apoptosis and cellular senescence Journal of Pathology 2009 219 1 3 15
-
(2009)
Journal of Pathology
, vol.219
, Issue.1
, pp. 3-15
-
-
Zuckerman, V.1
Wolyniec, K.2
Sionov, R.V.3
Haupt, S.4
Haupt, Y.5
-
3
-
-
34548842816
-
Inhibition of tumor angiogenesis by p53: A new role for the guardian of the genome
-
DOI 10.1007/s00109-007-0221-2
-
Teodoro J. G., Evans S. K., Green M. R., Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome Journal of Molecular Medicine 2007 85 11 1175 1186 (Pubitemid 47622219)
-
(2007)
Journal of Molecular Medicine
, vol.85
, Issue.11
, pp. 1175-1186
-
-
Teodoro, J.G.1
Evans, S.K.2
Green, M.R.3
-
5
-
-
19744363342
-
Modification of MDMX by sumoylation
-
DOI 10.1016/j.bbrc.2005.05.012, PII S0006291X05009897
-
Pan Y., Chen J., Modification of MDMX by sumoylation Biochemical and Biophysical Research Communications 2005 332 3 702 709 (Pubitemid 40745171)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.332
, Issue.3
, pp. 702-709
-
-
Pan, Y.1
Chen, J.2
-
6
-
-
22544438112
-
Regulation of p53-MDMX interaction by casein kinase 1 alpha
-
DOI 10.1128/MCB.25.15.6509-6520.2005
-
Chen L., Li C., Pan Y., Chen J., Regulation of p53-MDMX interaction by casein kinase 1 alpha Molecular and Cellular Biology 2005 25 15 6509 6520 (Pubitemid 41023226)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.15
, pp. 6509-6520
-
-
Chen, L.1
Li, C.2
Pan, Y.3
Chen, J.4
-
7
-
-
17844385110
-
p34 is required for nuclear export of Mdm2
-
DOI 10.1038/sj.onc.1208488
-
Elias B., Laine A., Ronai Z., Phosphorylation of MdmX by CDK2/Cdc2 is required for nuclear export of Mdm2 Oncogene 2005 24 15 2574 2579 (Pubitemid 40593048)
-
(2005)
Oncogene
, vol.24
, Issue.15
, pp. 2574-2579
-
-
Elias, B.1
Laine, A.2
Ronai, Z.3
-
8
-
-
70449724796
-
Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo
-
Wang Y. V., Wade M., Wahl G. M., Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo Cell Cycle 2009 8 21 3443 3444
-
(2009)
Cell Cycle
, vol.8
, Issue.21
, pp. 3443-3444
-
-
Wang, Y.V.1
Wade, M.2
Wahl, G.M.3
-
9
-
-
77952543499
-
The p53 orchestra: Mdm2 and Mdmx set the tone
-
Wade M., Wang Y. V., Wahl G. M., The p53 orchestra: Mdm2 and Mdmx set the tone Trends in Cell Biology 2010 20 5 299 309
-
(2010)
Trends in Cell Biology
, vol.20
, Issue.5
, pp. 299-309
-
-
Wade, M.1
Wang, Y.V.2
Wahl, G.M.3
-
10
-
-
77449101168
-
Mdm2-mediated ubiquitylation: P53 and beyond
-
Marine J. C., Lozano G., Mdm2-mediated ubiquitylation: p53 and beyond Cell Death and Differentiation 2010 17 1 93 102
-
(2010)
Cell Death and Differentiation
, vol.17
, Issue.1
, pp. 93-102
-
-
Marine, J.C.1
Lozano, G.2
-
11
-
-
0033531252
-
Comparative study of the p53-mdm2 and p53-MDMX interfaces
-
DOI 10.1038/sj.onc.1202281
-
Bttger V., Bttger A., Garcia-Echeverria C., Ramos Y. F. M., van der Eb A. J., Jochemsen A. G., Lane D. P., Comparative study of the p53-mdm2 and p53-MDMX interfaces Oncogene 1999 18 1 189 199 (Pubitemid 29060593)
-
(1999)
Oncogene
, vol.18
, Issue.1
, pp. 189-199
-
-
Bottger, V.1
Bottger, A.2
Garcia-Echeverria, C.3
Ramos, Y.F.M.4
Van Der Eb, A.J.5
Jochemsen, A.G.6
Lane, D.P.7
-
12
-
-
0033621415
-
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
-
DOI 10.1074/jbc.274.53.38189
-
Sharp D. A., Kratowicz S. A., Sank M. J., George D. L., Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein The Journal of Biological Chemistry 1999 274 53 38189 38196 (Pubitemid 30026893)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.53
, pp. 38189-38196
-
-
Sharp, D.A.1
Kratowicz, S.A.2
Sank, M.J.3
George, D.L.4
-
13
-
-
0038788827
-
Critical contribution of the MDM2 acidic domain to p53 ubiquitination
-
DOI 10.1128/MCB.23.14.4939-4947.2003
-
Kawai H., Wiederschain D., Yuan Z. M., Critical contribution of the MDM2 acidic domain to p53 ubiquitination Molecular and Cellular Biology 2003 23 14 4939 4947 (Pubitemid 36793339)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.14
, pp. 4939-4947
-
-
Kawai, H.1
Wiederschain, D.2
Yuan, Z.-M.3
-
14
-
-
0038451241
-
Critical role for a central part of Mdm2 in the ubiquitylation of p53
-
DOI 10.1128/MCB.23.14.4929-4938.2003
-
Meulmeester E., Frenk R., Stad R., de Graaf P., Marine J. C., Vousden K. H., Jochemsen A. G., Critical role for a central part of Mdm2 in the ubiquitylation of p53 Molecular and Cellular Biology 2003 23 14 4929 4938 (Pubitemid 36793338)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.14
, pp. 4929-4938
-
-
Meulmeester, E.1
Frenk, R.2
Stad, R.3
De Graaf, P.4
Marine, J.-C.5
Vousden, K.H.6
Jochemsen, A.G.7
-
15
-
-
33847276654
-
Monoubiquitylation promotes mitochondrial p53 translocation
-
Marchenko N. D., Wolff S., Erster S., Becker K., Moll U. M., Monoubiquitylation promotes mitochondrial p53 translocation The EMBO Journal 2007 26 4 923 934
-
(2007)
The EMBO Journal
, vol.26
, Issue.4
, pp. 923-934
-
-
Marchenko, N.D.1
Wolff, S.2
Erster, S.3
Becker, K.4
Moll, U.M.5
-
16
-
-
70349488818
-
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53
-
Shi D., Pop M. S., Kulikov R., Love I. M., Kung A., Grossman S. R., CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53 Proceedings of the National Academy of Sciences of the United States of America 2009 106 38 16275 16280
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, Issue.38
, pp. 16275-16280
-
-
Shi, D.1
Pop, M.S.2
Kulikov, R.3
Love, I.M.4
Kung, A.5
Grossman, S.R.6
-
17
-
-
77449155637
-
The multiple levels of regulation by p53 ubiquitination
-
Lee J. T., Gu W., The multiple levels of regulation by p53 ubiquitination Cell Death and Differentiation 2010 17 1 86 92
-
(2010)
Cell Death and Differentiation
, vol.17
, Issue.1
, pp. 86-92
-
-
Lee, J.T.1
Gu, W.2
-
18
-
-
10144259344
-
MDMX: A novel p53-binding protein with some functional properties of MDM2
-
Shvarts A., Steegenga W. T., Riteco N., van Laar T., Dekker P., Bazuine M., van Ham R. C. A., van der Houven van Oordt W., Hateboer G., van der Eb A. J., Jochemsen A. G., MDMX: a novel p53-binding protein with some functional properties of MDM2 The EMBO Journal 1996 15 19 5349 5357 (Pubitemid 26336217)
-
(1996)
EMBO Journal
, vol.15
, Issue.19
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
Van Laar, T.4
Dekker, P.5
Bazuine, M.6
Van Ham, R.C.A.7
Van Der Houven Van Oordt, W.8
Hateboer, G.9
Van Der Eb, A.J.10
Jochemsen, A.G.11
-
19
-
-
0036059108
-
MDMX inhibits the p300/CBP-mediated acetylation of p53
-
Sabbatini P., Mccormick F., MDMX inhibits the p300/CBP-mediated acetylation of p53 DNA and Cell Biology 2002 21 7 519 525
-
(2002)
DNA and Cell Biology
, vol.21
, Issue.7
, pp. 519-525
-
-
Sabbatini, P.1
McCormick, F.2
-
20
-
-
2942738959
-
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
-
DOI 10.1128/MCB.24.13.5835-5843.2004
-
Danovi D., Meulmeester E., Pasini D., Migliorini D., Capra M., Frenk R., de Graaf P., Francoz S., Gasparini P., Gobbi A., Helin K., Pelicci P. G., Jochemsen A. G., Marine J. C., Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity Molecular and Cellular Biology 2004 24 13 5835 5843 (Pubitemid 38787968)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.13
, pp. 5835-5843
-
-
Danovi, D.1
Meulmeester, E.2
Pasini, D.3
Migliorini, D.4
Capra, M.5
Frenk, R.6
De Graaf, P.7
Francoz, S.8
Gasparini, P.9
Gobbi, A.10
Helin, K.11
Pelicci, P.G.12
Jochemsen, A.G.13
Marine, J.-C.14
-
21
-
-
22544484456
-
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
-
DOI 10.1073/pnas.0503068102
-
Krummel K. A., Lee C. J., Toledo F., Wahl G. M., The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation Proceedings of the National Academy of Sciences of the United States of America 2005 102 29 10188 10193 (Pubitemid 41023347)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.29
, pp. 10188-10193
-
-
Krummel, K.A.1
Lee, C.J.2
Toledo, F.3
Wahl, G.M.4
-
22
-
-
0037205454
-
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
-
DOI 10.1074/jbc.C200150200
-
Gu J., Kawai H., Nie L., Kitao H., Wiederschain D., Jochemsen A. G., Parant J., Lozano G., Yuan Z. M., Mutual dependence of MDM2 and MDMX in their functional inactivation of p53 The Journal of Biological Chemistry 2002 277 22 19251 19254 (Pubitemid 34967428)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.22
, pp. 19251-19254
-
-
Gu, J.1
Kawai, H.2
Nie, L.3
Kitao, H.4
Wiederschain, D.5
Jochemsen, A.G.6
Parant, J.7
Lozano, G.8
Yuan, Z.-M.9
-
23
-
-
34447123808
-
RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity
-
DOI 10.1158/0008-5472.CAN-07-1313
-
Kawai H., Lopez-Pajares V., Kim M. M., Wiederschain D., Yuan Z. M., RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity Cancer Research 2007 67 13 6026 6030 (Pubitemid 47037481)
-
(2007)
Cancer Research
, vol.67
, Issue.13
, pp. 6026-6030
-
-
Kawai, H.1
Lopez-Pajares, V.2
Kim, M.M.3
Wiederschain, D.4
Yuan, Z.-M.5
-
24
-
-
42149105590
-
Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
-
DOI 10.1038/sj.cdd.4402309, PII 4402309
-
Linke K., Mace P. D., Smith C. A., Vaux D. L., Silke J., Day C. L., Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans Cell Death and Differentiation 2008 15 5 841 848 (Pubitemid 351524426)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.5
, pp. 841-848
-
-
Linke, K.1
Mace, P.D.2
Smith, C.A.3
Vaux, D.L.4
Silke, J.5
Day, C.L.6
-
25
-
-
33846239416
-
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
-
DOI 10.1038/sj.emboj.7601465, PII 7601465
-
Poyurovsky M. V., Priest C., Kentsis A., Borden K. L. B., Pan Z. Q., Pavletich N., Prives C., The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity The EMBO Journal 2007 26 1 90 101 (Pubitemid 46094702)
-
(2007)
EMBO Journal
, vol.26
, Issue.1
, pp. 90-101
-
-
Poyurovsky, M.V.1
Priest, C.2
Kentsis, A.3
Borden, K.L.B.4
Pan, Z.-Q.5
Pavletich, N.6
Prives, C.7
-
26
-
-
0032871092
-
Constitutive mdmx expression during cell growth, differentiation, and DNA damage
-
DOI 10.1089/104454999314971
-
Jackson M. W., Berberich S. J., Constitutive mdmx expression during cell growth, differentiation, and DNA damage DNA and Cell Biology 1999 18 9 693 700 (Pubitemid 29439221)
-
(1999)
DNA and Cell Biology
, vol.18
, Issue.9
, pp. 693-700
-
-
Jackson, M.W.1
Berberich, S.J.2
-
27
-
-
0036837868
-
DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms
-
Li C., Chen L., Chen J., DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms Molecular and Cellular Biology 2002 22 21 7562 7571
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.21
, pp. 7562-7571
-
-
Li, C.1
Chen, L.2
Chen, J.3
-
28
-
-
85047699938
-
MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts
-
DOI 10.1038/sj/onc/1205137
-
Gentiletti F., Mancini F., D'Angelo M., Sacchi A., Pontecorvi A., Jochemsen A. G., Moretti F., MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts Oncogene 2002 21 6 867 877 (Pubitemid 34146300)
-
(2002)
Oncogene
, vol.21
, Issue.6
, pp. 867-877
-
-
Gentiletti, F.1
Mancini, F.2
D'Angelo, M.3
Sacchi, A.4
Pontecorvi, A.5
Jochemsen, A.G.6
Moretti, F.7
-
29
-
-
0042592947
-
MDM2 promotes ubiquitination and degradation of MDMX
-
DOI 10.1128/MCB.23.15.5113-5121.2003
-
Pan Y., Chen J., MDM2 promotes ubiquitination and degradation of MDMX Molecular and Cellular Biology 2003 23 15 5113 5121 (Pubitemid 36950868)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.15
, pp. 5113-5121
-
-
Pan, Y.1
Chen, J.2
-
30
-
-
0141866880
-
Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2
-
DOI 10.1074/jbc.M213034200
-
de Graaf P., Little N. A., Ramos Y. F. M., Meulmeester E., Letteboer S. J. F., Jochemsen A. G., Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2 The Journal of Biological Chemistry 2003 278 40 38315 38324 (Pubitemid 37221723)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.40
, pp. 38315-38324
-
-
De Graaf, P.1
Little, N.A.2
Ramos, Y.F.M.3
Meulmeester, E.4
Letteboer, S.J.F.5
Jochemsen, A.G.6
-
31
-
-
0242580250
-
DNA Damage-induced MDMX Degradation Is Mediated by MDM2
-
DOI 10.1074/jbc.M308295200
-
Kawai H., Wiederschain D., Kitao H., Stuart J., Tsai K. K. C., Yuan Z. M., DNA damage-induced MDMX degradation is mediated by MDM2 The Journal of Biological Chemistry 2003 278 46 45946 45953 (Pubitemid 37432741)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.46
, pp. 45946-45953
-
-
Kawai, H.1
Wiederschain, D.2
Kitao, H.3
Stuart, J.4
Tsai, K.K.C.5
Yuan, Z.-M.6
-
32
-
-
27144444111
-
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
-
DOI 10.1038/sj.emboj.7600812, PII 7600812
-
Chen L., Gilkes D. M., Pan Y., Lane W. S., Chen J., ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage The EMBO Journal 2005 24 19 3411 3422 (Pubitemid 41486779)
-
(2005)
EMBO Journal
, vol.24
, Issue.19
, pp. 3411-3422
-
-
Chen, L.1
Gilkes, D.M.2
Pan, Y.3
Lane, W.S.4
Chen, J.5
-
33
-
-
20144387944
-
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
-
Pereg Y., Shkedy D., de Graaf P., Meulmeester E., Edelson-Averbukh M., Salek M., Biton S., Teunisse A. F. A. S., Lehmann W. D., Jochemsen A. G., Shiloh Y., Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage Proceedings of the National Academy of Sciences of the United States of America 2005 102 14 5056 5061
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.14
, pp. 5056-5061
-
-
Pereg, Y.1
Shkedy, D.2
De Graaf, P.3
Meulmeester, E.4
Edelson-Averbukh, M.5
Salek, M.6
Biton, S.7
Teunisse, A.F.A.S.8
Lehmann, W.D.9
Jochemsen, A.G.10
Shiloh, Y.11
-
34
-
-
27144541490
-
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation
-
DOI 10.1128/MCB.25.21.9608-9620.2005
-
Okamoto K., Kashima K., Pereg Y., Ishida M., Yamazaki S., Nota A., Teunisse A., Migliorini D., Kitabayashi I., Marine J. C., Prives C., Shiloh Y., Jochemsen A. G., Taya Y., DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation Molecular and Cellular Biology 2005 25 21 9608 9620 (Pubitemid 41507859)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.21
, pp. 9608-9620
-
-
Okamoto, K.1
Kashima, K.2
Pereg, Y.3
Ishida, M.4
Yamazaki, S.5
Nota, A.6
Teunisse, A.7
Migliorini, D.8
Kitabayashi, I.9
Marine, J.-C.10
Prives, C.11
Shiloh, Y.12
Jochemsen, A.G.13
Taya, Y.14
-
35
-
-
33748636939
-
Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage
-
DOI 10.1128/MCB.00562-06
-
Pereg Y., Lam S., Teunisse A., Biton S., Meulmeester E., Mittelman L., Buscemi G., Okamoto K., Taya Y., Shiloh Y., Jochemsen A. G., Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage Molecular and Cellular Biology 2006 26 18 6819 6831 (Pubitemid 44387632)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.18
, pp. 6819-6831
-
-
Pereg, Y.1
Lam, S.2
Teunisse, A.3
Biton, S.4
Meulmeester, E.5
Mittelman, L.6
Buscemi, G.7
Okamoto, K.8
Taya, Y.9
Shiloh, Y.10
Jochemsen, A.G.11
-
36
-
-
33645290219
-
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
-
LeBron C., Chen L., Gilkes D. M., Chen J., Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3 The EMBO Journal 2006 25 6 1196 1206
-
(2006)
The EMBO Journal
, vol.25
, Issue.6
, pp. 1196-1206
-
-
Lebron, C.1
Chen, L.2
Gilkes, D.M.3
Chen, J.4
-
37
-
-
19444367393
-
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
-
DOI 10.1016/j.molcel.2005.04.024, PII S1097276505012876
-
Meulmeester E., Maurice M. M., Boutell C., Teunisse A. F. A. S., Ovaa H., Abraham T. E., Dirks R. W., Jochemsen A. G., Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 Molecular Cell 2005 18 5 565 576 (Pubitemid 40726233)
-
(2005)
Molecular Cell
, vol.18
, Issue.5
, pp. 565-576
-
-
Meulmeester, E.1
Maurice, M.M.2
Boutell, C.3
Teunisse, A.F.A.S.4
Ovaa, H.5
Abraham, T.E.6
Dirks, R.W.7
Jochemsen, A.G.8
-
38
-
-
77957220495
-
Further insight into substrate recognition by USP7: Structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7
-
Sarkari F., La Delfa A., Arrowsmith C. H., Frappier L., Sheng Y., Saridakis V., Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7 Journal of Molecular Biology 2010 402 5 825 837
-
(2010)
Journal of Molecular Biology
, vol.402
, Issue.5
, pp. 825-837
-
-
Sarkari, F.1
La Delfa, A.2
Arrowsmith, C.H.3
Frappier, L.4
Sheng, Y.5
Saridakis, V.6
-
39
-
-
59849112565
-
14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2potential interplay with the PKB/Akt pathway and p14
-
Wood N. T., Meek D. W., MacKintosh C., 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2potential interplay with the PKB/Akt pathway and p14 FEBS Letters 2009 583 4 615 620
-
(2009)
FEBS Letters
, vol.583
, Issue.4
, pp. 615-620
-
-
Wood, N.T.1
Meek, D.W.2
MacKintosh, C.3
-
40
-
-
41849147869
-
CARPs enhance p53 turnover by degrading 14-3-3σ and stabilizing MDM2
-
Yang W., Dicker D. T., Chen J., El-Deiry W. S., CARPs enhance p53 turnover by degrading 14-3-3 and stabilizing MDM2 Cell Cycle 2008 7 5 670 682 (Pubitemid 351499007)
-
(2008)
Cell Cycle
, vol.7
, Issue.5
, pp. 670-682
-
-
Yang, W.1
Dicker, D.T.2
Chen, J.3
El-Deiry, W.S.4
-
41
-
-
2342567852
-
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
-
DOI 10.1038/sj.emboj.7600145
-
Stommel J. M., Wahl G. M., Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation The EMBO Journal 2004 23 7 1547 1556 (Pubitemid 38579515)
-
(2004)
EMBO Journal
, vol.23
, Issue.7
, pp. 1547-1556
-
-
Stommel, J.M.1
Wahl, G.M.2
-
42
-
-
33645293151
-
14-3-3 binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
-
Jin Y., Dai M. S., Lu S. Z., Xu Y., Luo Z., Zhao Y., Lu H., 14-3-3 binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation The EMBO Journal 2006 25 6 1207 1218
-
(2006)
The EMBO Journal
, vol.25
, Issue.6
, pp. 1207-1218
-
-
Jin, Y.1
Dai, M.S.2
Lu, S.Z.3
Xu, Y.4
Luo, Z.5
Zhao, Y.6
Lu, H.7
-
43
-
-
67649361514
-
Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases
-
Wang Y. V., Leblanc M., Wade M., Jochemsen A. G., Wahl G. M., Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases Cancer Cell 2009 16 1 33 43
-
(2009)
Cancer Cell
, vol.16
, Issue.1
, pp. 33-43
-
-
Wang, Y.V.1
Leblanc, M.2
Wade, M.3
Jochemsen, A.G.4
Wahl, G.M.5
-
44
-
-
63649142709
-
C-Abl phosphorylates Hdmx and regulates its interaction with p53
-
Zuckerman V., Lenos K., Popowicz G. M., Silberman I., Grossman T., Marine J. C., Holak T. A., Jochemsen A. G., Haupt Y., c-Abl phosphorylates Hdmx and regulates its interaction with p53 The Journal of Biological Chemistry 2009 284 6 4031 4039
-
(2009)
The Journal of Biological Chemistry
, vol.284
, Issue.6
, pp. 4031-4039
-
-
Zuckerman, V.1
Lenos, K.2
Popowicz, G.M.3
Silberman, I.4
Grossman, T.5
Marine, J.C.6
Holak, T.A.7
Jochemsen, A.G.8
Haupt, Y.9
-
45
-
-
0036655060
-
Alternative and aberrant splicing of MDM2 mRNA in human cancer
-
DOI 10.1016/S1535-6108(02)00091-0
-
Bartel F., Taubert H., Harris L. C., Alternative and aberrant splicing of MDM2 mRNA in human cancer Cancer Cell 2002 2 1 9 15 (Pubitemid 41043984)
-
(2002)
Cancer Cell
, vol.2
, Issue.1
, pp. 9-15
-
-
Bartel, F.1
Taubert, H.2
Harris, L.C.3
-
47
-
-
33750378188
-
Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4
-
DOI 10.1158/0008-5472.CAN-05-4271
-
Chandler D. S., Singh R. K., Caldwell L. C., Bitler J. L., Lozano G., Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4 Cancer Research 2006 66 19 9502 9508 (Pubitemid 44623648)
-
(2006)
Cancer Research
, vol.66
, Issue.19
, pp. 9502-9508
-
-
Chandler, D.S.1
Singh, R.K.2
Caldwell, L.C.3
Bitler, J.L.4
Lozano, G.5
-
48
-
-
0033583205
-
A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity
-
Rallapalli R., Strachan G., Cho B., Mercer W. E., Hall D. J., A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity The Journal of Biological Chemistry 1999 274 12 8299 8308
-
(1999)
The Journal of Biological Chemistry
, vol.274
, Issue.12
, pp. 8299-8308
-
-
Rallapalli, R.1
Strachan, G.2
Cho, B.3
Mercer, W.E.4
Hall, D.J.5
-
49
-
-
0038022602
-
Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells
-
DOI 10.1002/jcb.10535
-
Rallapalli R., Strachan G., Tuan R. S., Hall D. J., Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells Journal of Cellular Biochemistry 2003 89 3 563 575 (Pubitemid 36648778)
-
(2003)
Journal of Cellular Biochemistry
, vol.89
, Issue.3
, pp. 563-575
-
-
Rallapalli, R.1
Strachan, G.2
Tuan, R.S.3
Hall, D.J.4
-
50
-
-
0007570010
-
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation
-
DOI 10.1083/jcb.149.2.307
-
van der Houven van Oordt W., Diaz-Meco M. T., Lozano J., Krainer A. R., Moscat J., Cceres J. F., The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation Journal of Cell Biology 2000 149 2 307 316 (Pubitemid 30227149)
-
(2000)
Journal of Cell Biology
, vol.149
, Issue.2
, pp. 307-316
-
-
Van Oordt, W.V.D.H.1
Diaz-Meco, M.T.2
Lozano, J.3
Krainer, A.R.4
Moscat, J.5
Caceres, J.F.6
-
51
-
-
17244383094
-
Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing
-
DOI 10.1242/jcs.01720
-
Shomron N., Alberstein M., Reznik M., Ast G., Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing Journal of Cell Science 2005 118 6 1151 1159 (Pubitemid 40528686)
-
(2005)
Journal of Cell Science
, vol.118
, Issue.6
, pp. 1151-1159
-
-
Shomron, N.1
Alberstein, M.2
Reznik, M.3
Ast, G.4
-
52
-
-
65549147264
-
DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation
-
Muoz M. J., Santangelo M. S. P., Paronetto M. P., de la Mata M., Pelisch F., Boireau S., Glover-Cutter K., Ben-Dov C., Blaustein M., Lozano J. J., Bird G., Bentley D., Bertrand E., Kornblihtt A. R., DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation Cell 2009 137 4 708 720
-
(2009)
Cell
, vol.137
, Issue.4
, pp. 708-720
-
-
Muoz, M.J.1
Santangelo, M.S.P.2
Paronetto, M.P.3
De La Mata, M.4
Pelisch, F.5
Boireau, S.6
Glover-Cutter, K.7
Ben-Dov, C.8
Blaustein, M.9
Lozano, J.J.10
Bird, G.11
Bentley, D.12
Bertrand, E.13
Kornblihtt, A.R.14
-
53
-
-
67650501132
-
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
-
Mancini F., Di Conza G., Pellegrino M., Rinaldo C., Prodosmo A., Giglio S., D'Agnano I., Florenzano F., Felicioni L., Buttitta F., Marchetti A., Sacchi A., Pontecorvi A., Soddu S., Moretti F., MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway The EMBO Journal 2009 28 13 1926 1939
-
(2009)
The EMBO Journal
, vol.28
, Issue.13
, pp. 1926-1939
-
-
Mancini, F.1
Di Conza, G.2
Pellegrino, M.3
Rinaldo, C.4
Prodosmo, A.5
Giglio, S.6
D'Agnano, I.7
Florenzano, F.8
Felicioni, L.9
Buttitta, F.10
Marchetti, A.11
Sacchi, A.12
Pontecorvi, A.13
Soddu, S.14
Moretti, F.15
-
54
-
-
56149095484
-
Full-length hdmX transcripts decrease following genotoxic stress
-
Markey M., Berberich S. J., Full-length hdmX transcripts decrease following genotoxic stress Oncogene 2008 27 52 6657 6666
-
(2008)
Oncogene
, vol.27
, Issue.52
, pp. 6657-6666
-
-
Markey, M.1
Berberich, S.J.2
-
55
-
-
34249817549
-
Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis
-
DOI 10.1016/j.molcel.2007.05.010, PII S1097276507003103
-
Chang T. C., Wentzel E. A., Kent O. A., Ramachandran K., Mullendore M., Lee K., Feldmann G., Yamakuchi M., Ferlito M., Lowenstein C. J., Arking D., Beer M. A., Maitra A., Mendell J. T., Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis Molecular Cell 2007 26 5 745 752 (Pubitemid 46856245)
-
(2007)
Molecular Cell
, vol.26
, Issue.5
, pp. 745-752
-
-
Chang, T.-C.1
Wentzel, E.A.2
Kent, O.A.3
Ramachandran, K.4
Mullendore, M.5
Lee, K.6
Feldmann, G.7
Yamakuchi, M.8
Ferlito, M.9
Lowenstein, C.J.10
Arking, DanE.11
Beer, M.A.12
Maitra, A.13
Mendell, J.T.14
-
56
-
-
34249822779
-
Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis
-
DOI 10.1016/j.molcel.2007.05.017, PII S1097276507003188
-
Raver-Shapira N., Marciano E., Meiri E., Spector Y., Rosenfeld N., Moskovits N., Bentwich Z., Oren M., Transcriptional activation of miR-34a contributes to p53-mediated apoptosis Molecular Cell 2007 26 5 731 743 (Pubitemid 46856247)
-
(2007)
Molecular Cell
, vol.26
, Issue.5
, pp. 731-743
-
-
Raver-Shapira, N.1
Marciano, E.2
Meiri, E.3
Spector, Y.4
Rosenfeld, N.5
Moskovits, N.6
Bentwich, Z.7
Oren, M.8
-
57
-
-
10744230086
-
MDM4 (MDMX) Overexpression Enhances Stabilization of Stress-induced p53, and Promotes Apoptosis
-
DOI 10.1074/jbc.M311793200
-
Mancini F., Gentiletti F., D'Angelo M., Giglio S., Nanni S., D'Angelo C., Farsetti A., Citro G., Sacchi A., Pontecorvi A., Moretti F., MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis The Journal of Biological Chemistry 2004 279 9 8169 8180 (Pubitemid 38294708)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.9
, pp. 8169-8180
-
-
Mancini, F.1
Gentiletti, F.2
D'Angelo, M.3
Giglio, S.4
Nanni, S.5
D'Angelo, C.6
Farsetti, A.7
Citro, G.8
Sacchi, A.9
Pontecorvi, A.10
Moretti, F.11
-
58
-
-
0032701521
-
Disruption of p53 in human cancer cells alters the responses to therapeutic agents
-
Bunz F., Hwang P. M., Torrance C., Waldman T., Zhang Y., Dillehay L., Williams J., Lengauer C., Kinzler K. W., Vogelstein B., Disruption of p53 in human cancer cells alters the responses to therapeutic agents Journal of Clinical Investigation 1999 104 3 263 269
-
(1999)
Journal of Clinical Investigation
, vol.104
, Issue.3
, pp. 263-269
-
-
Bunz, F.1
Hwang, P.M.2
Torrance, C.3
Waldman, T.4
Zhang, Y.5
Dillehay, L.6
Williams, J.7
Lengauer, C.8
Kinzler, K.W.9
Vogelstein, B.10
-
59
-
-
0027143217
-
The mdm-2 gene is induced in response to UV light in a p53-dependent manner
-
DOI 10.1073/pnas.90.24.11623
-
Perry M. E., Piette J., Zawadzki J. A., Harvey D., Levine A. J., The mdm-2 gene is induced in response to UV light in a p53-dependent manner Proceedings of the National Academy of Sciences of the United States of America 1993 90 24 11623 11627 (Pubitemid 24008691)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.24
, pp. 11623-11627
-
-
Perry, M.E.1
Piette, J.2
Zawadzki, J.A.3
Harvey, D.4
Levine, A.J.5
-
60
-
-
0034003005
-
Stress signals utilize multiple pathways to stabilize p53
-
DOI 10.1128/MCB.20.9.3224-3233.2000
-
Ashcroft M., Taya Y., Vousden K. H., Stress signals utilize multiple pathways to stabilize p53 Molecular and Cellular Biology 2000 20 9 3224 3233 (Pubitemid 30215034)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.9
, pp. 3224-3233
-
-
Ashcroft, M.1
Taya, Y.2
Vousden, K.H.3
-
61
-
-
2542500783
-
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
-
Wang Y., Debatin K. M., Hug H., HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels BMC Molecular Biology 2001 2, article 8
-
(2001)
BMC Molecular Biology
, vol.28
-
-
Wang, Y.1
Debatin, K.M.2
Hug, H.3
-
62
-
-
3142682521
-
HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function
-
DOI 10.1038/sj.onc.1207656
-
Di Stefano V., Blandino G., Sacchi A., Soddu S., D'Orazi G., HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function Oncogene 2004 23 30 5185 5192 (Pubitemid 38980351)
-
(2004)
Oncogene
, vol.23
, Issue.30
, pp. 5185-5192
-
-
Di Stefano, V.1
Blandino, G.2
Sacchi, A.3
Soddu, S.4
D'Orazi, G.5
-
63
-
-
61349089240
-
P53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal
-
Batista L. F. Z., Roos W. P., Kaina B., Menck C. F. M., p53 mutant human glioma cells are sensitive to UV-C-induced apoptosis due to impaired cyclobutane pyrimidine dimer removal Molecular Cancer Research 2009 7 2 237 246
-
(2009)
Molecular Cancer Research
, vol.7
, Issue.2
, pp. 237-246
-
-
Batista, L.F.Z.1
Roos, W.P.2
Kaina, B.3
Menck, C.F.M.4
-
64
-
-
0031036695
-
P53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel
-
Debernardis D., Sir E. G., de Feudis P., Vikhanskaya F., Valenti M., Russo P., Parodi S., D'Incalci M., Broggini M., p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel Cancer Research 1997 57 5 870 874 (Pubitemid 27098011)
-
(1997)
Cancer Research
, vol.57
, Issue.5
, pp. 870-874
-
-
Debernardis, D.1
Sire, E.G.2
De Feudis, P.3
Vikhanskaya, F.4
Valenti, M.5
Russo, P.6
Parodi, S.7
D'Incalci, M.8
Broggini, M.9
-
65
-
-
77954170793
-
NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner
-
Shankar E., Basu C., Adkins B., Siede W., Basu A., NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner Journal of Molecular Signaling 2010 5, article 4
-
(2010)
Journal of Molecular Signaling
, vol.54
-
-
Shankar, E.1
Basu, C.2
Adkins, B.3
Siede, W.4
Basu, A.5
-
66
-
-
0344011603
-
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
-
DOI 10.1093/emboj/cdg579
-
Rubbi C. P., Milner J., Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses The EMBO Journal 2003 22 22 6068 6077 (Pubitemid 37463250)
-
(2003)
EMBO Journal
, vol.22
, Issue.22
, pp. 6068-6077
-
-
Rubbi, C.P.1
Milner, J.2
-
67
-
-
77955177254
-
Ribosome biogenesis surveillance: Probing the ribosomal protein-Mdm2-p53 pathway
-
Deisenroth C., Zhang Y., Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway Oncogene 2010 29 4253 4260
-
(2010)
Oncogene
, vol.29
, pp. 4253-4260
-
-
Deisenroth, C.1
Zhang, Y.2
-
68
-
-
70350497397
-
Signaling to p53: Ribosomal proteins find their way
-
Zhang Y., Lu H., Signaling to p53: ribosomal proteins find their way Cancer Cell 2009 16 5 369 377
-
(2009)
Cancer Cell
, vol.16
, Issue.5
, pp. 369-377
-
-
Zhang, Y.1
Lu, H.2
-
69
-
-
33751573462
-
MDMX regulation of p53 response to ribosomal stress
-
DOI 10.1038/sj.emboj.7601424, PII 7601424
-
Gilkes D. M., Chen L., Chen J., MDMX regulation of p53 response to ribosomal stress The EMBO Journal 2006 25 23 5614 5625 (Pubitemid 44847201)
-
(2006)
EMBO Journal
, vol.25
, Issue.23
, pp. 5614-5625
-
-
Gilkes, D.M.1
Chen, L.2
Chen, J.3
-
70
-
-
58149161997
-
Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells
-
Thant A. A., Wu Y., Lee J., Mishra D. K., Garcia H., Koeffler H. P., Vadgama J. V., Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells Anticancer Research 2008 28 6 A 3579 3592
-
(2008)
Anticancer Research
, vol.28
, Issue.6 A
, pp. 3579-3592
-
-
Thant, A.A.1
Wu, Y.2
Lee, J.3
Mishra, D.K.4
Garcia, H.5
Koeffler, H.P.6
Vadgama, J.V.7
-
71
-
-
77951622712
-
Role of Mdm4 in drug sensitivity of breast cancer cells
-
Lam S., Lodder K., Teunisse A. F. A. S., Rabelink M. J. W. E., Schutte M., Jochemsen A. G., Role of Mdm4 in drug sensitivity of breast cancer cells Oncogene 2010 29 16 2415 2426
-
(2010)
Oncogene
, vol.29
, Issue.16
, pp. 2415-2426
-
-
Lam, S.1
Lodder, K.2
Teunisse, A.F.A.S.3
Rabelink, M.J.W.E.4
Schutte, M.5
Jochemsen, A.G.6
-
72
-
-
70350440143
-
The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein
-
Derenzini M., Brighenti E., Donati G., Vici M., Ceccarelli C., Santini D., Taffurelli M., Montanaro L., Trer D., The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein Journal of Pathology 2009 219 3 373 382
-
(2009)
Journal of Pathology
, vol.219
, Issue.3
, pp. 373-382
-
-
Derenzini, M.1
Brighenti, E.2
Donati, G.3
Vici, M.4
Ceccarelli, C.5
Santini, D.6
Taffurelli, M.7
Montanaro, L.8
Trer, D.9
-
73
-
-
68349160548
-
Ribosomal protein S7 is both a regulator and a substrate of MDM2
-
Zhu Y., Poyurovsky M. V., Li Y., Biderman L., Stahl J., Jacq X., Prives C., Ribosomal protein S7 is both a regulator and a substrate of MDM2 Molecular Cell 2009 35 3 316 326
-
(2009)
Molecular Cell
, vol.35
, Issue.3
, pp. 316-326
-
-
Zhu, Y.1
Poyurovsky, M.V.2
Li, Y.3
Biderman, L.4
Stahl, J.5
Jacq, X.6
Prives, C.7
-
74
-
-
27544493522
-
Identification of an aberrantly spliced form of HDMX in human tumors: A new mechanism for HDM2 stabilization
-
DOI 10.1158/0008-5472.CAN-05-0450
-
Giglio S., Mancini F., Gentiletti F., Sparaco G., Felicioni L., Barassi F., Martella C., Prodosmo A., Iacovelli S., Buttitta F., Farsetti A., Soddu S., Marchetti A., Sacchi A., Pontecorvi A., Moretti F., Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization Cancer Research 2005 65 21 9687 9694 (Pubitemid 41541444)
-
(2005)
Cancer Research
, vol.65
, Issue.21
, pp. 9687-9694
-
-
Giglio, S.1
Mancini, F.2
Gentiletti, F.3
Sparaco, G.4
Felicioni, L.5
Barassi, F.6
Martella, C.7
Prodosmo, A.8
Iacovelli, S.9
Buttitta, F.10
Farsetti, A.11
Soddu, S.12
Marchetti, A.13
Sacchi, A.14
Pontecorvi, A.15
Moretti, F.16
-
75
-
-
0034623074
-
Hdmx stabilizes Mdm2 and p53
-
Stad R., Ramos Y. F. M., Little N., Grivell S., Attema J., van der Eb A. J., Jochemsen A. G., Hdmx stabilizes Mdm2 and p53 The Journal of Biological Chemistry 2000 275 36 28039 28044
-
(2000)
The Journal of Biological Chemistry
, vol.275
, Issue.36
, pp. 28039-28044
-
-
Stad, R.1
Ramos, Y.F.M.2
Little, N.3
Grivell, S.4
Attema, J.5
Van Der Eb, A.J.6
Jochemsen, A.G.7
-
76
-
-
0034458237
-
Effects of exogenous p53 transduction in thyroid tumor cells with different p53 status
-
DOI 10.1210/jc.85.1.302
-
Moretti F., Nanni S., Farsetti A., Narducci M., Crescenzi M., Giuliacci S., Sacchi A., Pontecorvi A., Effects of exogenous p53 transduction in thyroid tumor cells with different p53 status Journal of Clinical Endocrinology and Metabolism 2000 85 1 302 308 (Pubitemid 32268830)
-
(2000)
Journal of Clinical Endocrinology and Metabolism
, vol.85
, Issue.1
, pp. 302-308
-
-
Moretti, F.1
Nanni, S.2
Farsetti, A.3
Narducci, M.4
Crescenzi, M.5
Giuliacci, S.6
Sacchi, A.7
Pontecorvi, A.8
-
77
-
-
0343819885
-
Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification
-
Riemenschneider M. J., Bschges R., Wolter M., Reifenberger J., Bostrm J., Kraus J. A., Schlegel U., Reifenberger G., Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification Cancer Research 1999 59 24 6091 6096 (Pubitemid 30035626)
-
(1999)
Cancer Research
, vol.59
, Issue.24
, pp. 6091-6096
-
-
Riemenschneider, M.J.1
Buschges, R.2
Wolter, M.3
Reifenberger, J.4
Bostrom, J.5
Kraus, J.A.6
Schlegel, U.7
Reifenberger, G.8
-
78
-
-
26444599546
-
Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
-
DOI 10.1002/ijc.21206
-
Bartel F., Schulz J., Bhnke A., Blmke K., Kappler M., Bache M., Schmidt H., Wrl P., Taubert H., Hauptmann S., Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis International Journal of Cancer 2005 117 3 469 475 (Pubitemid 41429571)
-
(2005)
International Journal of Cancer
, vol.117
, Issue.3
, pp. 469-475
-
-
Bartel, F.1
Schulz, J.2
Bohnke, A.3
Blumke, K.4
Kappler, M.5
Bache, M.6
Schmidt, H.7
Wurl, P.8
Taubert, H.9
Hauptmann, S.10
-
79
-
-
43049150355
-
Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties
-
Prodosmo A., Giglio S., Moretti S., Mancini F., Barbi F., Avenia N., Di Conza G., Schnemann H. J., Pistola L., Ludovini V., Sacchi A., Pontecorvi A., Puxeddu E., Moretti F., Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties Journal of Molecular Medicine 2008 86 5 585 596
-
(2008)
Journal of Molecular Medicine
, vol.86
, Issue.5
, pp. 585-596
-
-
Prodosmo, A.1
Giglio, S.2
Moretti, S.3
Mancini, F.4
Barbi, F.5
Avenia, N.6
Di Conza, G.7
Schnemann, H.J.8
Pistola, L.9
Ludovini, V.10
Sacchi, A.11
Pontecorvi, A.12
Puxeddu, E.13
Moretti, F.14
-
80
-
-
78650140498
-
HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea
-
Jin G., Cook S., Cui B., Chen W. C., Keir S. T., Killela P., Di C., Payne C. A., Gregory S. G., McLendon R., Bigner D. D., Yan H., HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea Neuro-Oncology 2010 12 9 956 966
-
(2010)
Neuro-Oncology
, vol.12
, Issue.9
, pp. 956-966
-
-
Jin, G.1
Cook, S.2
Cui, B.3
Chen, W.C.4
Keir, S.T.5
Killela, P.6
Di, C.7
Payne, C.A.8
Gregory, S.G.9
McLendon, R.10
Bigner, D.D.11
Yan, H.12
-
81
-
-
77954325942
-
MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53 CLL with a poor cytotoxic response to Nutlin-3
-
Bo M. D., Secchiero P., Degan M., Marconi D., Bomben R., Pozzato G., Gaidano G., Del Poeta G., Forconi F., Zauli G., Gattei V., MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53 CLL with a poor cytotoxic response to Nutlin-3 British Journal of Haematology 2010 150 2 237 239
-
(2010)
British Journal of Haematology
, vol.150
, Issue.2
, pp. 237-239
-
-
Bo, M.D.1
Secchiero, P.2
Degan, M.3
Marconi, D.4
Bomben, R.5
Pozzato, G.6
Gaidano, G.7
Del Poeta, G.8
Forconi, F.9
Zauli, G.10
Gattei, V.11
-
82
-
-
34548692296
-
High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas
-
DOI 10.1016/j.humpath.2007.03.005, PII S0046817707001517
-
Valentin-Vega Y. A., Barboza J. A., Chau G. P., El-Naggar A. K., Lozano G., High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas Human Pathology 2007 38 10 1553 1562 (Pubitemid 47418967)
-
(2007)
Human Pathology
, vol.38
, Issue.10
, pp. 1553-1562
-
-
Valentin-Vega, Y.A.1
Barboza, J.A.2
Chau, G.P.3
El-Naggar, A.K.4
Lozano, G.5
-
83
-
-
33845695691
-
HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target
-
DOI 10.1038/modpathol.3800727, PII 3800727
-
Han X., Garcia-Manero G., McDonnell T. J., Lozano G., Medeiros L. J., Xiao L., Rosner G., Nguyen M., Fernandez M., Valentin-Vega Y. A., Barboza J., Jones D. M., Rassidakis G. Z., Kantarjian H. M., Bueso-Ramos C. E., HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target Modern Pathology 2007 20 1 54 62 (Pubitemid 44967950)
-
(2007)
Modern Pathology
, vol.20
, Issue.1
, pp. 54-62
-
-
Han, X.1
Garcia-Manero, G.2
McDonnell, T.J.3
Lozano, G.4
Medeiros, L.J.5
Xiao, L.6
Rosner, G.7
Nguyen, M.8
Fernandez, M.9
Valentin-Vega, Y.A.10
Barboza, J.11
Jones, D.M.12
Rassidakis, G.Z.13
Kantarjian, H.M.14
Bueso-Ramos, C.E.15
-
84
-
-
0942290415
-
Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth
-
DOI 10.1038/sj.onc.1206925
-
Steinman H. A., Sluss H. K., Sands A. T., Pihan G., Jones S. N., Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth Oncogene 2004 23 1 303 306 (Pubitemid 38142265)
-
(2004)
Oncogene
, vol.23
, Issue.1
, pp. 303-306
-
-
Steinman, H.A.1
Sluss, H.K.2
Sands, A.T.3
Pihan, G.4
Jones, S.N.5
-
85
-
-
38949124679
-
MDMX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice
-
DOI 10.1128/MCB.01108-07
-
Matijasevic Z., Steinman H. A., Hoover K., Jones S. N., MDMX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice Molecular and Cellular Biology 2008 28 4 1265 1273 (Pubitemid 351214129)
-
(2008)
Molecular and Cellular Biology
, vol.28
, Issue.4
, pp. 1265-1273
-
-
Matijasevic, Z.1
Steinman, H.A.2
Hoover, K.3
Jones, S.N.4
-
86
-
-
77956926019
-
Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4
-
Xiong S., Pant V., Suh Y.-A., van Pelt C. S., Wang Y., Valentin-Vega Y. A., Post S. M., Lozano G., Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4 Cancer Research 2010 70 18 7148 7154
-
(2010)
Cancer Research
, vol.70
, Issue.18
, pp. 7148-7154
-
-
Xiong, S.1
Pant, V.2
Suh, Y.-A.3
Van Pelt, C.S.4
Wang, Y.5
Valentin-Vega, Y.A.6
Post, S.M.7
Lozano, G.8
-
87
-
-
78649625045
-
Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo
-
de Clercq S., Gembarska A., Denecker G., Maetens M., Naessens M., Haigh K., Haigh J. J., Marine J.-C., Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo Molecular and Cellular Biology 2010 30 22 5394 5405
-
(2010)
Molecular and Cellular Biology
, vol.30
, Issue.22
, pp. 5394-5405
-
-
De Clercq, S.1
Gembarska, A.2
Denecker, G.3
Maetens, M.4
Naessens, M.5
Haigh, K.6
Haigh, J.J.7
Marine, J.-C.8
-
88
-
-
40349083970
-
Regulation of MDMX expression by mitogenic signaling
-
DOI 10.1128/MCB.01633-07
-
Gilkes D. M., Pan Y., Coppola D., Yeatman T., Reuther G. W., Chen J., Regulation of MDMX expression by mitogenic signaling Molecular and Cellular Biology 2008 28 6 1999 2010 (Pubitemid 351342630)
-
(2008)
Molecular and Cellular Biology
, vol.28
, Issue.6
, pp. 1999-2010
-
-
Gilkes, D.M.1
Pan, Y.2
Coppola, D.3
Yeatman, T.4
Reuther, G.W.5
Chen, J.6
-
89
-
-
0034644506
-
Opposing effects of RAS on p53: Transcriptional activation of mdm2 and induction of p19(ARF)
-
Ries S., Biederer C., Woods D., Shifman O., Shirasawa S., Sasazuki T., McMahon M., Oren M., McCormick F., Opposing effects of RAS on p53: transcriptional activation of mdm2 and induction of p19(ARF) Cell 2000 103 2 321 330
-
(2000)
Cell
, vol.103
, Issue.2
, pp. 321-330
-
-
Ries, S.1
Biederer, C.2
Woods, D.3
Shifman, O.4
Shirasawa, S.5
Sasazuki, T.6
McMahon, M.7
Oren, M.8
McCormick, F.9
-
90
-
-
30344478870
-
A global map of p53 transcription-factor binding sites in the human genome
-
DOI 10.1016/j.cell.2005.10.043, PII S0092867405013991
-
Wei C. L., Wu Q., Vega V. B., Chiu K. P., Ng P., Zhang T., Shahab A., Yong H. C., Fu Y., Weng Z., Liu J., Zhao X. D., Chew J. L., Lee Y. L., Kuznetsov V. A., Sung W. K., Miller L. D., Lim B., Liu E. T., Yu Q., Ng H. H., Ruan Y., A global map of p53 transcription-factor binding sites in the human genome Cell 2006 124 1 207 219 (Pubitemid 43069320)
-
(2006)
Cell
, vol.124
, Issue.1
, pp. 207-219
-
-
Wei, C.-L.1
Wu, Q.2
Vega, V.B.3
Chiu, K.P.4
Ng, P.5
Zhang, T.6
Shahab, A.7
Yong, H.C.8
Fu, Y.9
Weng, Z.10
Liu, J.11
Zhao, X.D.12
Chew, J.-L.13
Lee, Y.L.14
Kuznetsov, V.A.15
Sung, W.-K.16
Miller, L.D.17
Lim, B.18
Liu, E.T.19
Yu, Q.20
Ng, H.-H.21
Ruan, Y.22
more..
-
91
-
-
77953571903
-
P53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors
-
Li B., Cheng Q., Li Z., Chen J., p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors Cell Cycle 2010 9 7 1411 1420
-
(2010)
Cell Cycle
, vol.9
, Issue.7
, pp. 1411-1420
-
-
Li, B.1
Cheng, Q.2
Li, Z.3
Chen, J.4
-
92
-
-
77956518104
-
HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity
-
Phillips A., Teunisse A., Lam S., Lodder K., Darley M., Emaduddin M., Wolf A., Richter J., de Lange J., Vries M. V.-D., Lenos K., Bhnke A., Bartel F., Blaydes J. P., Jochemsen A. G., HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity The Journal of Biological Chemistry 2010 285 38 29111 29127
-
(2010)
The Journal of Biological Chemistry
, vol.285
, Issue.38
, pp. 29111-29127
-
-
Phillips, A.1
Teunisse, A.2
Lam, S.3
Lodder, K.4
Darley, M.5
Emaduddin, M.6
Wolf, A.7
Richter, J.8
De Lange, J.9
Vries, M.V.-D.10
Lenos, K.11
Bhnke, A.12
Bartel, F.13
Blaydes, J.P.14
Jochemsen, A.G.15
|