HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity

Journal of Biological Chemistry

Volumn 285, Issue 38, 2010, Pages 29111-29127

  Phillips, Anna ^a   Teunisse, Amina ^b   Lam, Suzanne ^b   Lodder, Kirsten ^b   Darley, Matthew ^a   Emaduddin, Muhammad ^a   Wolf, Anja ^c   Richter, Julia ^c   De Lange, Job ^b   Vries, Matty Verlaan De ^b   Lenos, Kristiaan ^b   Böhnke, Anja ^c   Bartel, Frank ^c   Blaydes, Jeremy P ^a   Jochemsen, Aart G ^b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; DEGRADATION; FEEDBACK;

ACTIVATING AGENTS; APOPTOSIS; CELLULAR SENESCENCE; DNA DAMAGES; FEED-BACK LOOP; IN-CELL; LOW LEVEL; NEGATIVE REGULATORS; POSITIVE FEEDBACK LOOP; POST-TRANSLATIONAL MODIFICATIONS; REGULATORY NETWORK; STRESS-INDUCED; UBIQUITINATION;

TRANSCRIPTION;

MESSENGER RNA; PROTEIN; PROTEIN HDMX L; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG; DOXYCYCLINE; ETOPOSIDE; IMIDAZOLE DERIVATIVE; MDM2 PROTEIN, HUMAN; MDM4 PROTEIN, HUMAN; NUCLEAR PROTEIN; NUTLIN 3; ONCOPROTEIN; PIPERAZINE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOREGULATION; CELL AGING; CELL CYCLE ARREST; CELL STRESS; CONTROLLED STUDY; DNA DAMAGE; FEEDBACK SYSTEM; GENE; GENE ACTIVATION; GENETIC TRANSCRIPTION; HDMX GENE; HUMAN; HUMAN CELL; INTRON; NONHUMAN; ONCOGENE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN TARGETING; UBIQUITINATION; UPREGULATION; ANIMAL; BINDING SITE; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DRUG EFFECTS; GENETICS; METABOLISM; MOLECULAR EVOLUTION; MOUSE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DOXYCYCLINE; ETOPOSIDE; EVOLUTION, MOLECULAR; HUMANS; IMIDAZOLES; INTRONS; MICE; NUCLEAR PROTEINS; PIPERAZINES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 77956518104     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.129726     Document Type: Article

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