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Volumn 6, Issue 2, 2011, Pages 123-132

The role of minocycline in ischemia-reperfusion injury: A comprehensive review of an old drug with new implications

Author keywords

Apoptosis; Ischemia reperfusion injury; Minocycline

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; METALLOPROTEINASE; MINOCYCLINE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PENICILLIN G; PROCASPASE 9; PROTEIN BCL 2; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 79959326926     PISSN: 15748901     EISSN: 15748901     Source Type: Journal    
DOI: 10.2174/157489011795933783     Document Type: Review
Times cited : (16)

References (116)
  • 1
    • 0017254428 scopus 로고
    • A new tetracycline minocycline compared with ampicillin in general practice
    • Gallagher DJ, Settle KL. A new tetracycline minocycline compared with ampicillin in general practice. N Z Med J. 1976; 83(558): 105-7.
    • (1976) N Z Med J , vol.83 , Issue.558 , pp. 105-107
    • Gallagher, D.J.1    Settle, K.L.2
  • 3
    • 0038359549 scopus 로고    scopus 로고
    • Liquid chromatographic determination of minocycline in brain-to-plasma distribution studies in the rat
    • Colovic M, Caccia S. Liquid chromatographic determination of minocycline in brain-to-plasma distribution studies in the rat. J Chromatogr B Analyt Technol Biomed Life Sci 2003; 791(1-2): 337-43.
    • (2003) J Chromatogr B Analyt Technol Biomed Life Sci , vol.791 , Issue.1-2 , pp. 337-343
    • Colovic, M.1    Caccia, S.2
  • 4
    • 0029066948 scopus 로고
    • Tetracyclines
    • NC, Cunha BA. Tetracyclines. Med Clin North Am. 1995;79(4): 789-801.
    • (1995) Med Clin North Am , vol.79 , Issue.4 , pp. 789-801
  • 5
    • 79959357444 scopus 로고    scopus 로고
    • AHFS Drug information: Tetracycline general statement
    • McEvoy G. AHFS Drug information: Tetracycline general statement. Amer Soc Health-Sys Pharma 2004; 433-49.
    • (2004) Amer Soc Health-Sys Pharma , pp. 433-449
    • McEvoy, G.1
  • 6
    • 79959356224 scopus 로고    scopus 로고
    • In: Laurence L Brunton JSL, Keith LP, Ed., Goodman and Gilman's the pharmacological basis of therapeutics 11. 11/e ed. New York: McGraw-Hill Company, Inc
    • Chambers HF. Tetracyclines. In: Laurence L Brunton JSL, Keith LP, Ed. Goodman and Gilman's the pharmacological basis of therapeutics 11. 11/e ed. New York: McGraw-Hill Company, Inc.2006.
    • (2006) Tetracyclines
    • Chambers, H.F.1
  • 7
    • 0019475136 scopus 로고
    • Evidence for metabolic inertness of doxycycline
    • Nelis HJ, De Leenheer AP. Evidence for metabolic inertness of doxycycline. J Pharm Sci 1981; 70(2): 226-8.
    • (1981) J Pharm Sci , vol.70 , Issue.2 , pp. 226-228
    • Nelis, H.J.1    de Leenheer, A.P.2
  • 8
    • 0025816816 scopus 로고
    • Identification and determination of the two principal metabolites of minocycline in humans
    • Bocker RH, Peter R, Machbert G, Bauer W. Identification and determination of the two principal metabolites of minocycline in humans. J Chromatogr. 1991; 568(2): 363-74.
    • (1991) J Chromatogr , vol.568 , Issue.2 , pp. 363-374
    • Bocker, R.H.1    Peter, R.2    Machbert, G.3    Bauer, W.4
  • 12
    • 77958018645 scopus 로고    scopus 로고
    • Minocycline to improve neurologic outcome in stroke (MINOS): A dose-finding study
    • Fagan SC, Waller JL, Nichols FT, Edwards DJ, Pettigrew LC, Clark WM, et al. Minocycline to improve neurologic outcome in stroke (MINOS): A dose-finding study. Stroke 2010; 41(10): 2283-7.
    • (2010) Stroke , vol.41 , Issue.10 , pp. 2283-2287
    • Fagan, S.C.1    Waller, J.L.2    Nichols, F.T.3    Edwards, D.J.4    Pettigrew, L.C.5    Clark, W.M.6
  • 13
    • 6444242134 scopus 로고    scopus 로고
    • Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity
    • Sanchez AR, Rogers RS, 3rd, Sheridan PJ. Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity. Int J Dermatol 2004; 43(10): 709-15.
    • (2004) Int J Dermatol , vol.43 , Issue.10 , pp. 709-715
    • Sanchez, A.R.1    Rogers 3rd, R.S.2    Sheridan, P.J.3
  • 14
    • 0036867440 scopus 로고    scopus 로고
    • An in vitro model of ciprofloxacin and minocycline transport by oral epithelial cells
    • Brayton JJ, Yang Q, Nakkula RJ, Walters JD. An in vitro model of ciprofloxacin and minocycline transport by oral epithelial cells. J Periodontol 2002; 73(11): 1267-72.
    • (2002) J Periodontol , vol.73 , Issue.11 , pp. 1267-1272
    • Brayton, J.J.1    Yang, Q.2    Nakkula, R.J.3    Walters, J.D.4
  • 15
    • 0025855089 scopus 로고
    • Fluxes and accumulation of tetracyclines by human blood cells
    • Gabler WL. Fluxes and accumulation of tetracyclines by human blood cells. Res Commun Chem Pathol Pharmacol. 1991; 72(1): 39-51.
    • (1991) Res Commun Chem Pathol Pharmacol , vol.72 , Issue.1 , pp. 39-51
    • Gabler, W.L.1
  • 16
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • Lipton P. Ischemic cell death in brain neurons. Physiol Rev 1999; 79(4): 1431-568.
    • (1999) Physiol Rev , vol.79 , Issue.4 , pp. 1431-1568
    • Lipton, P.1
  • 18
    • 0037464448 scopus 로고    scopus 로고
    • Mitochondria in apoptosis of ischemic heart
    • Borutaite V, Brown GC. Mitochondria in apoptosis of ischemic heart. FEBS Lett 2003; 541(1-3):1-5.
    • (2003) FEBS Lett , vol.541 , Issue.1-3 , pp. 1-5
    • Borutaite, V.1    Brown, G.C.2
  • 19
    • 1142273368 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection
    • Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc Res 2004; 61(3): 372-85.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 372-385
    • Halestrap, A.P.1    Clarke, S.J.2    Javadov, S.A.3
  • 20
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
    • Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004; 68(2): 320-44.
    • (2004) Microbiol Mol Biol Rev , vol.68 , Issue.2 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 21
    • 0025065449 scopus 로고
    • Luminol enhanced chemiluminescence of the perfused rat heart during ischemia and reperfusion
    • Kumar C, Okuda M, Ikai I, Chance B. Luminol enhanced chemiluminescence of the perfused rat heart during ischemia and reperfusion. FEBS Lett 1990; 272(1-2): 121-4.
    • (1990) FEBS Lett , vol.272 , Issue.1-2 , pp. 121-124
    • Kumar, C.1    Okuda, M.2    Ikai, I.3    Chance, B.4
  • 22
    • 67349222523 scopus 로고    scopus 로고
    • Controlling metabolism and cell death: At the heart of mitochondrial calcium signalling
    • Murgia M, Giorgi C, Pinton P, Rizzuto R. Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling. J Mol Cell Cardiol 2009; 46(6): 781-8.
    • (2009) J Mol Cell Cardiol , vol.46 , Issue.6 , pp. 781-788
    • Murgia, M.1    Giorgi, C.2    Pinton, P.3    Rizzuto, R.4
  • 23
    • 35848940084 scopus 로고    scopus 로고
    • Reperfusion injury as a therapeutic challenge in patients with acute myocardial infarction
    • Rodriguez-Sinovas A, Abdallah Y, Piper HM, Garcia-Dorado D. Reperfusion injury as a therapeutic challenge in patients with acute myocardial infarction. Heart Fail Rev 2007; 12(3-4): 207-16.
    • (2007) Heart Fail Rev , vol.12 , Issue.3-4 , pp. 207-216
    • Rodriguez-Sinovas, A.1    Abdallah, Y.2    Piper, H.M.3    Garcia-Dorado, D.4
  • 25
    • 0032777020 scopus 로고    scopus 로고
    • Apoptosis in myocardial ischemiareperfusion
    • Gottlieb RA, Engler RL. Apoptosis in myocardial ischemiareperfusion. Ann NY Acad Sci 1999; 874: 412-26.
    • (1999) Ann NY Acad Sci , vol.874 , pp. 412-426
    • Gottlieb, R.A.1    Engler, R.L.2
  • 26
    • 0032570292 scopus 로고    scopus 로고
    • Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor
    • Yaoita H, Ogawa K, Maehara K, Maruyama Y. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. Circulation 1998; 97(3): 276-81.
    • (1998) Circulation , vol.97 , Issue.3 , pp. 276-281
    • Yaoita, H.1    Ogawa, K.2    Maehara, K.3    Maruyama, Y.4
  • 27
    • 0031892704 scopus 로고    scopus 로고
    • Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family
    • Endres M, Namura S, Shimizu-Sasamata M, Waeber C, Zhang L, Gomez-Isla T, et al. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab 1998; 18(3): 238-47.
    • (1998) J Cereb Blood Flow Metab , vol.18 , Issue.3 , pp. 238-247
    • Endres, M.1    Namura, S.2    Shimizu-Sasamata, M.3    Waeber, C.4    Zhang, L.5    Gomez-Isla, T.6
  • 28
    • 35348890230 scopus 로고    scopus 로고
    • Characterization of the antinociceptive and anti-inflammatory activities of doxycycline and minocycline in different experimental models
    • Bastos LF, Merlo LA, Rocha LT, Coelho MM. Characterization of the antinociceptive and anti-inflammatory activities of doxycycline and minocycline in different experimental models. Eur J Pharmacol 2007; 576(1-3): 171-9.
    • (2007) Eur J Pharmacol , vol.576 , Issue.1-3 , pp. 171-179
    • Bastos, L.F.1    Merlo, L.A.2    Rocha, L.T.3    Coelho, M.M.4
  • 29
    • 10744226569 scopus 로고    scopus 로고
    • Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO
    • Scarabelli TM, Stephanou A, Pasini E, Gitti G, Townsend P, Lawrence K, et al. Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. J Am Coll Cardiol 2004; 43(5): 865-74.
    • (2004) J Am Coll Cardiol , vol.43 , Issue.5 , pp. 865-874
    • Scarabelli, T.M.1    Stephanou, A.2    Pasini, E.3    Gitti, G.4    Townsend, P.5    Lawrence, K.6
  • 31
    • 1042263796 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitor development and the remodeling of drug discovery
    • Peterson JT. Matrix metalloproteinase inhibitor development and the remodeling of drug discovery. Heart Fail Rev. 2004; 9(1): 63-79.
    • (2004) Heart Fail Rev , vol.9 , Issue.1 , pp. 63-79
    • Peterson, J.T.1
  • 32
    • 23244453399 scopus 로고    scopus 로고
    • Antioxidant properties of minocycline: Neuroprotection in an oxidative stress assay and direct radicalscavenging activity
    • Kraus RL, Pasieczny R, Lariosa-Willingham K, Turner MS, Jiang A, Trauger JW. Antioxidant properties of minocycline: Neuroprotection in an oxidative stress assay and direct radicalscavenging activity. J Neurochem. 2005; 94(3): 819-27.
    • (2005) J Neurochem , vol.94 , Issue.3 , pp. 819-827
    • Kraus, R.L.1    Pasieczny, R.2    Lariosa-Willingham, K.3    Turner, M.S.4    Jiang, A.5    Trauger, J.W.6
  • 33
    • 79959356472 scopus 로고    scopus 로고
    • Direct protection of cultured neurons from ischemia-like injury by minocycline
    • Huang WC, Qiao Y, Xu L, Kacimi R, Sun X, Giffard RG, et al. Direct protection of cultured neurons from ischemia-like injury by minocycline. Anat Cell Biol 2010;43(4): 325-31.
    • (2010) Anat Cell Biol , vol.43 , Issue.4 , pp. 325-331
    • Huang, W.C.1    Qiao, Y.2    Xu, L.3    Kacimi, R.4    Sun, X.5    Giffard, R.G.6
  • 34
    • 43449092856 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase appears and is co-expressed with the neuronal isoform in interneurons of the rat hippocampus after transient ischemia induced by middle cerebral artery occlusion
    • Corsani L, Bizzoco E, Pedata F, Gianfriddo M, Faussone-Pellegrini MS, Vannucchi MG. Inducible nitric oxide synthase appears and is co-expressed with the neuronal isoform in interneurons of the rat hippocampus after transient ischemia induced by middle cerebral artery occlusion. Exp Neurol 2008; 211(2): 433-40.
    • (2008) Exp Neurol , vol.211 , Issue.2 , pp. 433-440
    • Corsani, L.1    Bizzoco, E.2    Pedata, F.3    Gianfriddo, M.4    Faussone-Pellegrini, M.S.5    Vannucchi, M.G.6
  • 35
    • 0035876916 scopus 로고    scopus 로고
    • Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia
    • Tikka TM, Koistinaho JE. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 2001; 166(12): 7527-33.
    • (2001) J Immunol , vol.166 , Issue.12 , pp. 7527-7533
    • Tikka, T.M.1    Koistinaho, J.E.2
  • 36
    • 0036803602 scopus 로고    scopus 로고
    • In the cellular garden of forking paths: How p38 MAPKs signal for downstream assistance
    • Shi Y, Gaestel M. In the cellular garden of forking paths: How p38 MAPKs signal for downstream assistance. Biol Chem 2002; 383(10): 1519-36.
    • (2002) Biol Chem , vol.383 , Issue.10 , pp. 1519-1536
    • Shi, Y.1    Gaestel, M.2
  • 37
    • 0036847840 scopus 로고    scopus 로고
    • Role of p38 and p44/42 mitogenactivated protein kinases in microglia
    • Koistinaho M, Koistinaho J. Role of p38 and p44/42 mitogenactivated protein kinases in microglia. Glia 2002; 40(2): 175-83.
    • (2002) Glia , vol.40 , Issue.2 , pp. 175-183
    • Koistinaho, M.1    Koistinaho, J.2
  • 38
    • 0028278413 scopus 로고
    • Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment
    • discussion 6
    • Clark WM, Calcagno FA, Gabler WL, Smith JR, Coull BM. Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment. Stroke. 1994; 25(7): 1411-5; discussion 6.
    • (1994) Stroke , vol.25 , Issue.7 , pp. 1411-1415
    • Clark, W.M.1    Calcagno, F.A.2    Gabler, W.L.3    Smith, J.R.4    Coull, B.M.5
  • 39
    • 28744435045 scopus 로고    scopus 로고
    • Intrathecal minocycline attenuates peripheral inflammationinduced hyperalgesia by inhibiting p38 MAPK in spinal microglia
    • Hua XY, Svensson CI, Matsui T, Fitzsimmons B, Yaksh TL, Webb M. Intrathecal minocycline attenuates peripheral inflammationinduced hyperalgesia by inhibiting p38 MAPK in spinal microglia. Eur J Neurosci 2005; 22(10): 2431-40.
    • (2005) Eur J Neurosci , vol.22 , Issue.10 , pp. 2431-2440
    • Hua, X.Y.1    Svensson, C.I.2    Matsui, T.3    Fitzsimmons, B.4    Yaksh, T.L.5    Webb, M.6
  • 40
    • 33745457705 scopus 로고    scopus 로고
    • Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations
    • Alano CC, Kauppinen TM, Valls AV, Swanson RA. Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations. Proc Natl Acad Sci USA 2006; 103(25): 9685-90.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.25 , pp. 9685-9690
    • Alano, C.C.1    Kauppinen, T.M.2    Valls, A.V.3    Swanson, R.A.4
  • 41
    • 44949225039 scopus 로고    scopus 로고
    • Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia
    • Henry CJ, Huang Y, Wynne A, Hanke M, Himler J, Bailey MT, et al. Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia. J Neuroinflammation 2008; 5:15.
    • (2008) J Neuroinflammation , vol.5 , pp. 15
    • Henry, C.J.1    Huang, Y.2    Wynne, A.3    Hanke, M.4    Himler, J.5    Bailey, M.T.6
  • 42
    • 0033559511 scopus 로고    scopus 로고
    • Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide
    • Attur MG, Patel RN, Patel PD, Abramson SB, Amin AR. Tetracycline up-regulates COX-2 expression and prostaglandin E2 production independent of its effect on nitric oxide. J Immunol 1999;162(6): 3160-7.
    • (1999) J Immunol , vol.162 , Issue.6 , pp. 3160-3167
    • Attur, M.G.1    Patel, R.N.2    Patel, P.D.3    Abramson, S.B.4    Amin, A.R.5
  • 43
    • 33644876641 scopus 로고    scopus 로고
    • Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia
    • Nikodemova M, Duncan ID, Watters JJ. Minocycline exerts inhibitory effects on multiple mitogen-activated protein kinases and IkappaBalpha degradation in a stimulus-specific manner in microglia. J Neurochem 2006; 96(2): 314-23.
    • (2006) J Neurochem , vol.96 , Issue.2 , pp. 314-323
    • Nikodemova, M.1    Duncan, I.D.2    Watters, J.J.3
  • 45
    • 0021160015 scopus 로고
    • Neutrophil chemotaxis in patients with acne receiving oral tetracycline therapy
    • Esterly NB, Koransky JS, Furey NL, Trevisan M. Neutrophil chemotaxis in patients with acne receiving oral tetracycline therapy. Arch Dermatol 1984; 120(10): 1308-13.
    • (1984) Arch Dermatol , vol.120 , Issue.10 , pp. 1308-1313
    • Esterly, N.B.1    Koransky, J.S.2    Furey, N.L.3    Trevisan, M.4
  • 46
    • 0018741148 scopus 로고
    • Inhibition of mitogen-induced human lymphocyte proliferative responses by tetracycline analogues
    • Thong YH, Ferrante A. Inhibition of mitogen-induced human lymphocyte proliferative responses by tetracycline analogues. Clin Exp Immunol 1979; 35(3): 443-6.
    • (1979) Clin Exp Immunol , vol.35 , Issue.3 , pp. 443-446
    • Thong, Y.H.1    Ferrante, A.2
  • 47
    • 20444483258 scopus 로고    scopus 로고
    • Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions
    • Fernandez-Gomez FJ, Galindo MF, Gomez-Lazaro M, Gonzalez-Garcia C, Cena V, Aguirre N, et al. Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions. Neuroscience 2005; 133(4): 959-67.
    • (2005) Neuroscience , vol.133 , Issue.4 , pp. 959-967
    • Fernandez-Gomez, F.J.1    Galindo, M.F.2    Gomez-Lazaro, M.3    Gonzalez-Garcia, C.4    Cena, V.5    Aguirre, N.6
  • 48
    • 9744263921 scopus 로고    scopus 로고
    • Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways
    • Pi R, Li W, Lee NT, Chan HH, Pu Y, Chan LN, et al. Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways. J Neurochem 2004; 91(5): 1219-30.
    • (2004) J Neurochem , vol.91 , Issue.5 , pp. 1219-1230
    • Pi, R.1    Li, W.2    Lee, N.T.3    Chan, H.H.4    Pu, Y.5    Chan, L.N.6
  • 49
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    • Zhu S, Stavrovskaya IG, Drozda M, Kim BY, Ona V, Li M, et al. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 2002; 417(6884): 74-8.
    • (2002) Nature , vol.417 , Issue.6884 , pp. 74-78
    • Zhu, S.1    Stavrovskaya, I.G.2    Drozda, M.3    Kim, B.Y.4    Ona, V.5    Li, M.6
  • 52
    • 7244242682 scopus 로고    scopus 로고
    • Minocycline inhibits apoptotic cell death via attenuation of TNFalpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures
    • Lee SM, Yune TY, Kim SJ, Kim YC, Oh YJ, Markelonis GJ, et al. Minocycline inhibits apoptotic cell death via attenuation of TNFalpha expression following iNOS/NO induction by lipopolysaccharide in neuron/glia co-cultures. J Neurochem 2004; 91(3): 568-78.
    • (2004) J Neurochem , vol.91 , Issue.3 , pp. 568-578
    • Lee, S.M.1    Yune, T.Y.2    Kim, S.J.3    Kim, Y.C.4    Oh, Y.J.5    Markelonis, G.J.6
  • 53
    • 0033912716 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
    • Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 2000; 6(7): 797-801.
    • (2000) Nat Med , vol.6 , Issue.7 , pp. 797-801
    • Chen, M.1    Ona, V.O.2    Li, M.3    Ferrante, R.J.4    Fink, K.B.5    Zhu, S.6
  • 54
    • 2442454612 scopus 로고    scopus 로고
    • Minocycline up-regulates BCl-2 and protects against cell death in mitochondria
    • Wang J, Wei Q, Wang CY, Hill WD, HessDC, Dong Z. Minocycline up-regulates BCl-2 and protects against cell death in mitochondria. J Biol Chem. 2004; 279(19): 19948-54.
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 19948-19954
    • Wang, J.1    Wei, Q.2    Wang, C.Y.3    Hill, W.D.4    Hess, D.C.5    Dong, Z.6
  • 55
    • 0021984681 scopus 로고
    • Oxygen-derived free radicals in postischemic tissue injury
    • McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985; 312(3): 159-63.
    • (1985) N Engl J Med , vol.312 , Issue.3 , pp. 159-163
    • McCord, J.M.1
  • 57
    • 77953473424 scopus 로고    scopus 로고
    • Attenuation of diabetic retinopathy by enhanced inhibition of MMP-2 and MMP-9 using aspirin and minocycline in streptozotocin-diabetic rats
    • Bhatt LK, Addepalli V. Attenuation of diabetic retinopathy by enhanced inhibition of MMP-2 and MMP-9 using aspirin and minocycline in streptozotocin-diabetic rats. Am J Transl Res 2010; 2(2): 181-9.
    • (2010) Am J Transl Res , vol.2 , Issue.2 , pp. 181-189
    • Bhatt, L.K.1    Addepalli, V.2
  • 58
    • 38749096624 scopus 로고    scopus 로고
    • Multiphasic roles for matrix metalloproteinases after stroke
    • Rosell A, Lo EH. Multiphasic roles for matrix metalloproteinases after stroke. Curr Opin Pharmacol 2008; 8(1): 82-9.
    • (2008) Curr Opin Pharmacol , vol.8 , Issue.1 , pp. 82-89
    • Rosell, A.1    Lo, E.H.2
  • 59
    • 34948852291 scopus 로고    scopus 로고
    • Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature
    • Chow AK, Cena J, Schulz R. Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature. Br J Pharmacol 2007; 152(2): 189-205.
    • (2007) Br J Pharmacol , vol.152 , Issue.2 , pp. 189-205
    • Chow, A.K.1    Cena, J.2    Schulz, R.3
  • 60
    • 33746886986 scopus 로고    scopus 로고
    • The role of matrix metalloproteinase inhibitors in ischemia-reperfusion injury in the liver
    • Viappiani S, Sariahmetoglu M, Schulz R. The role of matrix metalloproteinase inhibitors in ischemia-reperfusion injury in the liver. Curr Pharm Des 2006; 12(23): 2923-34.
    • (2006) Curr Pharm Des , vol.12 , Issue.23 , pp. 2923-2934
    • Viappiani, S.1    Sariahmetoglu, M.2    Schulz, R.3
  • 61
    • 0742318927 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition decreases ischemiareperfusion injury after lung transplantation
    • Soccal PM, Gasche Y, Miniati DN, Hoyt G, Berry GJ, Doyle RL, et al. Matrix metalloproteinase inhibition decreases ischemiareperfusion injury after lung transplantation. Am J Transplant 2004; 4(1): 41-50.
    • (2004) Am J Transplant , vol.4 , Issue.1 , pp. 41-50
    • Soccal, P.M.1    Gasche, Y.2    Miniati, D.N.3    Hoyt, G.4    Berry, G.J.5    Doyle, R.L.6
  • 63
    • 0036518135 scopus 로고    scopus 로고
    • Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline
    • Roach DM, Fitridge RA, Laws PE, Millard SH, Varelias A, Cowled PA. Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline. Eur J Vasc Endovasc Surg 2002; 23(3): 260-9.
    • (2002) Eur J Vasc Endovasc Surg , vol.23 , Issue.3 , pp. 260-269
    • Roach, D.M.1    Fitridge, R.A.2    Laws, P.E.3    Millard, S.H.4    Varelias, A.5    Cowled, P.A.6
  • 64
  • 65
    • 0015838330 scopus 로고
    • Detection and localization of experimental myocardial infarction with 99m Tc-tetracycline
    • Holman BL, Idoine J, Fliegel CP, Davis MA, Treves S, Eldh P, et al. Detection and localization of experimental myocardial infarction with 99m Tc-tetracycline. J Nucl Med 1973; 14(8): 595-9.
    • (1973) J Nucl Med , vol.14 , Issue.8 , pp. 595-599
    • Holman, B.L.1    Idoine, J.2    Fliegel, C.P.3    Davis, M.A.4    Treves, S.5    Eldh, P.6
  • 66
    • 0032198174 scopus 로고    scopus 로고
    • Chemical and biological dynamics of tetracyclines
    • Nelson ML. Chemical and biological dynamics of tetracyclines. Adv Dent Res 1998; 12(2): 5-11.
    • (1998) Adv Dent Res , vol.12 , Issue.2 , pp. 5-11
    • Nelson, M.L.1
  • 67
    • 78751643428 scopus 로고    scopus 로고
    • Minocycline protects cardiac myocytes against simulated simulated ischemiareperfusion injury by inhibiting poly(ADP-ribose) polymerase-1
    • Tao R, Kim SH, Honbo N, Karliner JS, Alano CC. Minocycline protects cardiac myocytes against simulated simulated ischemiareperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. J Cardiovasc Pharmacol 2010.
    • (2010) J Cardiovasc Pharmacol
    • Tao, R.1    Kim, S.H.2    Honbo, N.3    Karliner, J.S.4    Alano, C.C.5
  • 68
    • 77953543903 scopus 로고    scopus 로고
    • Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats
    • Hu X, Zhou X, He B, Xu C, Wu L, Cui B, et al. Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Eur J Pharmacol 2010; 638(1-3): 84-9.
    • (2010) Eur J Pharmacol , vol.638 , Issue.1-3 , pp. 84-89
    • Hu, X.1    Zhou, X.2    He, B.3    Xu, C.4    Wu, L.5    Cui, B.6
  • 69
    • 79951681007 scopus 로고    scopus 로고
    • Minocycline attenuates ischemia-induced ventricular arrhythmias in rats
    • Hu X, Wu B, Wang X, Xu C, He B, Cui B, et al. Minocycline attenuates ischemia-induced ventricular arrhythmias in rats. Eur J Pharmacol 2011; 654(3): 274-9.
    • (2011) Eur J Pharmacol , vol.654 , Issue.3 , pp. 274-279
    • Hu, X.1    Wu, B.2    Wang, X.3    Xu, C.4    He, B.5    Cui, B.6
  • 71
    • 0032442475 scopus 로고    scopus 로고
    • Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
    • Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T, Koistinaho J. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci USA 1998; 95(26): 15769-74.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.26 , pp. 15769-15774
    • Yrjanheikki, J.1    Keinanen, R.2    Pellikka, M.3    Hokfelt, T.4    Koistinaho, J.5
  • 72
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, Koistinaho J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci USA 1999; 96(23): 13496-500.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.23 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 73
    • 79551604481 scopus 로고    scopus 로고
    • Reduced PBR/TSPO expression after minocycline treatment in a rat model of focal cerebral ischemia: A PET study using [(18)F]DPA-714
    • Martin A, Boisgard R, Kassiou M, Dolle F, Tavitian B. Reduced PBR/TSPO expression after minocycline treatment in a rat model of focal cerebral ischemia: A PET study using [(18)F]DPA-714. Mol Imaging Biol 2011; 13(1): 10-5.
    • (2011) Mol Imaging Biol , vol.13 , Issue.1 , pp. 10-15
    • Martin, A.1    Boisgard, R.2    Kassiou, M.3    Dolle, F.4    Tavitian, B.5
  • 74
    • 70350525386 scopus 로고    scopus 로고
    • Anxiety after cardiac arrest/cardiopulmonary resuscitation: Exacerbated by stress and prevented by minocycline
    • Neigh GN, Karelina K, Glasper ER, Bowers SL, Zhang N, Popovich PG, et al. Anxiety after cardiac arrest/cardiopulmonary resuscitation: Exacerbated by stress and prevented by minocycline. Stroke 2009; 40(11): 3601-7.
    • (2009) Stroke , vol.40 , Issue.11 , pp. 3601-3607
    • Neigh, G.N.1    Karelina, K.2    Glasper, E.R.3    Bowers, S.L.4    Zhang, N.5    Popovich, P.G.6
  • 75
    • 37349030729 scopus 로고    scopus 로고
    • Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: Effects on BBB breakdown and MMP expression in the acute and subacute phase
    • Nagel S, Su Y, Horstmann S, Heiland S, Gardner H, Koziol J, et al. Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: effects on BBB breakdown and MMP expression in the acute and subacute phase. Brain Res 2008; 1188: 198-206.
    • (2008) Brain Res , vol.1188 , pp. 198-206
    • Nagel, S.1    Su, Y.2    Horstmann, S.3    Heiland, S.4    Gardner, H.5    Koziol, J.6
  • 77
    • 70350005202 scopus 로고    scopus 로고
    • Minocycline treatment following hypoxic/ ischaemic injury attenuates white matter injury in a rodent model of periventricular leucomalacia
    • Lechpammer M, Manning SM, Samonte F, Nelligan J, Sabo E, Talos DM, et al. Minocycline treatment following hypoxic/ ischaemic injury attenuates white matter injury in a rodent model of periventricular leucomalacia. Neuropathol Appl Neurobiol 2008;34(4): 379-93.
    • (2008) Neuropathol Appl Neurobiol , vol.34 , Issue.4 , pp. 379-393
    • Lechpammer, M.1    Manning, S.M.2    Samonte, F.3    Nelligan, J.4    Sabo, E.5    Talos, D.M.6
  • 78
    • 74749100704 scopus 로고    scopus 로고
    • Minocycline inhibits 5-lipoxygenase expression and accelerates functional recovery in chronic phase of focal cerebral ischemia in rats
    • Chu LS, Fang SH, Zhou Y, Yin YJ, Chen WY, Li JH, et al. Minocycline inhibits 5-lipoxygenase expression and accelerates functional recovery in chronic phase of focal cerebral ischemia in rats. Life Sci 2010; 86(5-6): 170-7.
    • (2010) Life Sci , vol.86 , Issue.5-6 , pp. 170-177
    • Chu, L.S.1    Fang, S.H.2    Zhou, Y.3    Yin, Y.J.4    Chen, W.Y.5    Li, J.H.6
  • 79
    • 34848857092 scopus 로고    scopus 로고
    • Minocycline treatment in acute stroke: An open-label, evaluator-blinded study
    • Lampl Y, Boaz M, Gilad R, Lorberboym M, Dabby R, Rapoport A, et al. Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology 2007; 69(14): 1404-10.
    • (2007) Neurology , vol.69 , Issue.14 , pp. 1404-1410
    • Lampl, Y.1    Boaz, M.2    Gilad, R.3    Lorberboym, M.4    Dabby, R.5    Rapoport, A.6
  • 80
    • 53949090120 scopus 로고    scopus 로고
    • Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion
    • Cai ZY, Yan Y, Sun SQ, Zhang J, Huang LG, Yan N, et al. Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion. Neurosci Bull 2008; 24(5): 305-13.
    • (2008) Neurosci Bull , vol.24 , Issue.5 , pp. 305-313
    • Cai, Z.Y.1    Yan, Y.2    Sun, S.Q.3    Zhang, J.4    Huang, L.G.5    Yan, N.6
  • 81
    • 76649110556 scopus 로고    scopus 로고
    • Minocycline reduces astrocytic reactivation and neuroinflammation in the hippocampus of a vascular cognitive impairment rat model
    • Cai ZY, Yan Y, Chen R. Minocycline reduces astrocytic reactivation and neuroinflammation in the hippocampus of a vascular cognitive impairment rat model. Neurosci Bull 2010; 26(1): 28-36.
    • (2010) Neurosci Bull , vol.26 , Issue.1 , pp. 28-36
    • Cai, Z.Y.1    Yan, Y.2    Chen, R.3
  • 82
    • 33645799230 scopus 로고    scopus 로고
    • Microglia potentiate damage to blood-brain barrier constituents: Improvement by minocycline in vivo and in vitro
    • Yenari MA, Xu L, Tang XN, Qiao Y, Giffard RG. Microglia potentiate damage to blood-brain barrier constituents: Improvement by minocycline in vivo and in vitro. Stroke 2006; 37(4): 1087-93.
    • (2006) Stroke , vol.37 , Issue.4 , pp. 1087-1093
    • Yenari, M.A.1    Xu, L.2    Tang, X.N.3    Qiao, Y.4    Giffard, R.G.5
  • 83
    • 0036289498 scopus 로고    scopus 로고
    • Minocycline markedly protects the neonatal brain against hypoxicischemic injury
    • Arvin KL, Han BH, Du Y, Lin SZ, Paul SM, Holtzman DM. Minocycline markedly protects the neonatal brain against hypoxicischemic injury. Ann Neurol 2002; 52(1): 54-61.
    • (2002) Ann Neurol , vol.52 , Issue.1 , pp. 54-61
    • Arvin, K.L.1    Han, B.H.2    Du, Y.3    Lin, S.Z.4    Paul, S.M.5    Holtzman, D.M.6
  • 84
    • 34547640300 scopus 로고    scopus 로고
    • Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain
    • Kremlev SG, Roberts RL, Palmer C. Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain. J Neurosci Res 2007; 85(11): 2450-9.
    • (2007) J Neurosci Res , vol.85 , Issue.11 , pp. 2450-2459
    • Kremlev, S.G.1    Roberts, R.L.2    Palmer, C.3
  • 85
    • 3543073536 scopus 로고    scopus 로고
    • Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse model
    • Tsuji M, Wilson MA, Lange MS, Johnston MV. Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse model. Exp Neurol 2004; 189(1): 58-65.
    • (2004) Exp Neurol , vol.189 , Issue.1 , pp. 58-65
    • Tsuji, M.1    Wilson, M.A.2    Lange, M.S.3    Johnston, M.V.4
  • 86
    • 29744434032 scopus 로고    scopus 로고
    • Minocycline alleviates hypoxic-ischemic injury to developing oligodendrocytes in the neonatal rat brain
    • Cai Z, Lin S, Fan LW, Pang Y, Rhodes PG. Minocycline alleviates hypoxic-ischemic injury to developing oligodendrocytes in the neonatal rat brain. Neuroscience 2006; 137(2): 425-35.
    • (2006) Neuroscience , vol.137 , Issue.2 , pp. 425-435
    • Cai, Z.1    Lin, S.2    Fan, L.W.3    Pang, Y.4    Rhodes, P.G.5
  • 87
    • 33746254939 scopus 로고    scopus 로고
    • Minocycline attenuates hypoxia-ischemia-induced neurological dysfunction and brain injury in the juvenile rat
    • Fan LW, Lin S, Pang Y, Rhodes PG, Cai Z. Minocycline attenuates hypoxia-ischemia-induced neurological dysfunction and brain injury in the juvenile rat. Eur J Neurosci 2006; 24(2): 341-50.
    • (2006) Eur J Neurosci , vol.24 , Issue.2 , pp. 341-350
    • Fan, L.W.1    Lin, S.2    Pang, Y.3    Rhodes, P.G.4    Cai, Z.5
  • 88
    • 43049181767 scopus 로고    scopus 로고
    • Post-insult minocycline treatment attenuates hypoxia-ischemia-induced neuroinflammation and white matter injury in the neonatal rat: A comparison of two different dose regimens
    • Carty ML, Wixey JA, Colditz PB, Buller KM. Post-insult minocycline treatment attenuates hypoxia-ischemia-induced neuroinflammation and white matter injury in the neonatal rat: A comparison of two different dose regimens. Int J Dev Neurosci 2008; 26(5): 477-85.
    • (2008) Int J Dev Neurosci , vol.26 , Issue.5 , pp. 477-485
    • Carty, M.L.1    Wixey, J.A.2    Colditz, P.B.3    Buller, K.M.4
  • 89
    • 24944591312 scopus 로고    scopus 로고
    • Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion
    • Fox C, Dingman A, Derugin N, Wendland MF, Manabat C, Ji S, et al. Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 2005; 25(9): 1138-49.
    • (2005) J Cereb Blood Flow Metab , vol.25 , Issue.9 , pp. 1138-1149
    • Fox, C.1    Dingman, A.2    Derugin, N.3    Wendland, M.F.4    Manabat, C.5    Ji, S.6
  • 90
    • 33645123006 scopus 로고    scopus 로고
    • Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: Role of tumor necrosis factor-alpha
    • Sriram K, Miller DB, O'Callaghan JP. Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha. J Neurochem 2006; 96(3): 706-18.
    • (2006) J Neurochem , vol.96 , Issue.3 , pp. 706-718
    • Sriram, K.1    Miller, D.B.2    O'Callaghan, J.P.3
  • 91
    • 18844457358 scopus 로고    scopus 로고
    • Minocycline attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain
    • Fan LW, Pang Y, Lin S, Rhodes PG, Cai Z. Minocycline attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain. Neuroscience 2005; 133(1): 159-68.
    • (2005) Neuroscience , vol.133 , Issue.1 , pp. 159-168
    • Fan, L.W.1    Pang, Y.2    Lin, S.3    Rhodes, P.G.4    Cai, Z.5
  • 93
    • 38649116627 scopus 로고    scopus 로고
    • Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition
    • Theruvath TP, Zhong Z, Pediaditakis P, Ramshesh VK, Currin RT, Tikunov A, et al. Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology 2008; 47(1): 236-46.
    • (2008) Hepatology , vol.47 , Issue.1 , pp. 236-246
    • Theruvath, T.P.1    Zhong, Z.2    Pediaditakis, P.3    Ramshesh, V.K.4    Currin, R.T.5    Tikunov, A.6
  • 96
    • 79551583611 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases reduces ischemiareperfusion acute kidney injury
    • Kunugi S, Shimizu A, Kuwahara N, Du X, Takahashi M, Terasaki Y, et al. Inhibition of matrix metalloproteinases reduces ischemiareperfusion acute kidney injury. Lab Invest 2011; 91(2): 170-80.
    • (2011) Lab Invest , vol.91 , Issue.2 , pp. 170-180
    • Kunugi, S.1    Shimizu, A.2    Kuwahara, N.3    Du, X.4    Takahashi, M.5    Terasaki, Y.6
  • 98
    • 31344476048 scopus 로고    scopus 로고
    • Tetracyclines: Nonantibiotic properties and their clinical implications
    • Sapadin AN, Fleischmajer R. Tetracyclines: Nonantibiotic properties and their clinical implications. J Am Acad Dermatol 2006; 54(2): 258-65.
    • (2006) J Am Acad Dermatol , vol.54 , Issue.2 , pp. 258-265
    • Sapadin, A.N.1    Fleischmajer, R.2
  • 99
    • 39449123099 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyte
    • Leon H, Baczko I, Sawicki G, Light PE, Schulz R. Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyte. Br J Pharmacol 2008; 153(4): 676-83.
    • (2008) Br J Pharmacol , vol.153 , Issue.4 , pp. 676-683
    • Leon, H.1    Baczko, I.2    Sawicki, G.3    Light, P.E.4    Schulz, R.5
  • 100
    • 0028888687 scopus 로고
    • Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group
    • Tilley BC, Alarcon GS, Heyse SP, Trentham DE, Neuner R, Kaplan DA, et al. Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group. Ann Intern Med 1995; 122(2): 81-9.
    • (1995) Ann Intern Med , vol.122 , Issue.2 , pp. 81-89
    • Tilley, B.C.1    Alarcon, G.S.2    Heyse, S.P.3    Trentham, D.E.4    Neuner, R.5    Kaplan, D.A.6
  • 101
    • 0034998271 scopus 로고    scopus 로고
    • Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
    • discussion 9-401
    • Sanchez Mejia RO, Ona VO, Li M, Friedlander RM. Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery 2001; 48(6): 1393-9; discussion 9-401.
    • (2001) Neurosurgery , vol.48 , Issue.6 , pp. 1393-1399
    • Sanchez, M.R.O.1    Ona, V.O.2    Li, M.3    Friedlander, R.M.4
  • 102
    • 0035807904 scopus 로고    scopus 로고
    • Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    • Du Y, Ma Z, Lin S, Dodel RC, Gao F, Bales KR, Triarhou LC, et al. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 2001; 98(25): 14669-74.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.25 , pp. 14669-14674
    • Du, Y.1    Ma, Z.2    Lin, S.3    Dodel, R.C.4    Gao, F.5    Bales, K.R.6    Triarhou, L.C.7
  • 103
    • 1542376941 scopus 로고    scopus 로고
    • Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury
    • Stirling DP, Khodarahmi K, Liu J, McPhail LT, McBride CB, Steeves JD, et al. Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J Neurosci 2004; 24(9): 2182-90.
    • (2004) J Neurosci , vol.24 , Issue.9 , pp. 2182-2190
    • Stirling, D.P.1    Khodarahmi, K.2    Liu, J.3    McPhail, L.T.4    McBride, C.B.5    Steeves, J.D.6
  • 104
    • 12144290904 scopus 로고    scopus 로고
    • Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury
    • Teng YD, Choi H, Onario RC, Zhu S, Desilets FC, Lan S, et al. Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury. Proc Natl Acad Sci USA 2004; 101(9): 3071-6.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.9 , pp. 3071-3076
    • Teng, Y.D.1    Choi, H.2    Onario, R.C.3    Zhu, S.4    Desilets, F.C.5    Lan, S.6
  • 105
    • 0142025464 scopus 로고    scopus 로고
    • Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat
    • Lee SM, Yune TY, Kim SJ, Park DW, Lee YK, Kim YC, et al. Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. J Neurotrauma 2003; 20(10): 1017-27.
    • (2003) J Neurotrauma , vol.20 , Issue.10 , pp. 1017-1027
    • Lee, S.M.1    Yune, T.Y.2    Kim, S.J.3    Park, D.W.4    Lee, Y.K.5    Kim, Y.C.6
  • 107
    • 0030062668 scopus 로고    scopus 로고
    • Confluent and reticulated papillomatosis: Response to minocycline
    • Montemarano AD, Hengge M, Sau P, Welch M. Confluent and reticulated papillomatosis: Response to minocycline. J Am Acad Dermatol 1996; 34(2 Pt 1): 253-6.
    • (1996) J Am Acad Dermatol , vol.34 , Issue.2 PART 1 , pp. 253-256
    • Montemarano, A.D.1    Hengge, M.2    Sau, P.3    Welch, M.4
  • 108
    • 0019797533 scopus 로고
    • Pyoderma gangrenosum: Successful treatment with minocycline
    • Davies MG, Piper S. Pyoderma gangrenosum: Successful treatment with minocycline. Clin Exp Dermatol 1981; 6(2): 219-23.
    • (1981) Clin Exp Dermatol , vol.6 , Issue.2 , pp. 219-223
    • Davies, M.G.1    Piper, S.2
  • 109
    • 0024582372 scopus 로고
    • Minocycline in the treatment of patients with Reiter's syndrome
    • Panayi GS, Clark B. Minocycline in the treatment of patients with Reiter's syndrome. Clin Exp Rheumatol, 1989; 7(1): 100-1.
    • (1989) Clin Exp Rheumatol , vol.7 , Issue.1 , pp. 100-101
    • Panayi, G.S.1    Clark, B.2


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