Reduced PBR/TSPO expression after minocycline treatment in a rat model of focal cerebral ischemia: A PET study using [18F]DPA-714

Molecular Imaging and Biology

Volumn 13, Issue 1, 2011, Pages 10-15

  Martín, Abraham ^a   Boisgard, Raphaël ^a   Kassiou, Michael ^b   Dollé, Frédéric ^c   Tavitian, Bertrand ^a  

^a DIF   (France)

^b UNIVERSITY OF SYDNEY   (Australia)

^c SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

Author keywords

Cerebral ischemia; DPA 714; Minocycline; Neuroinflammation; PBR; PET; TSPO

Indexed keywords

DPA 714 F 18; MINOCYCLINE; N,N DIETHYL 2 [2 [4 (2 FLUOROETHOXY)PHENYL] 5,7 DIMETHYLPYRAZOL[1,5 A]PYRIMIDIN 3 YL]ACETAMIDE F 18; PERIPHERAL BENZODIAZEPINE RECEPTOR; RADIOISOTOPE; RECEPTOR PROTEIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; STROKE;

ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; FLUORINE RADIOISOTOPES; MALE; MINOCYCLINE; PYRAZOLES; PYRIMIDINES; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A;

ANIMALIA; RATTUS;

EID: 79551604481     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-010-0324-y     Document Type: Article

References (33)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group 1995 Tissue plasminogen activation for acute ischemic stroke N Engl J Med 333 1581 1587 10.1056/NEJM199512143332401
2. J Montaner A Rovira CA Molina JF Arenillas M Ribo P Chacon J Monasterio Alvarez-Sabin 2003 Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke J Cereb Blood Flow Metab 23 1403 1407 1:CAS:528:DC%2BD3sXps1GqtLg%3D 10.1097/01.WCB. 0000100044.07481.97 14663335
3. HC Emsley PJ Tyrrell 2002 Inflammation and infection in clinical stroke J Cereb Blood Flow Metab 22 1399 419 1:CAS:528:DC%2BD38Xptleiu7g%3D 10.1097/00004647-200212000-00001 12468886
4. J Yrjänheikki R Keinänen M Pellikka T Hökfelt J Koistinaho 1998 Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia Proc Natl Acad Sci U S A 95 15769 15774 10.1073/pnas.95.26.15769 9861045
5. J Yrjänheikki T Tikka R Keinänen G Goldsteins PH Chan J Koistinaho 1999 A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window Proc Natl Acad Sci U S A 96 13496 13500 10.1073/pnas.96.23.13496 10557349
6. CX Wang T Yang A Shuaib 2003 Effects of minocycline alone and in combination with mild hypothermia in embolic stroke Brain Res 963 327 329 1:CAS:528:DC%2BD3sXmsV2nsw%3D%3D 10.1016/S0006-8993(02)04045-3 12560140
7. L Xu SC Fagan JL Waller D Edwards CV Borlongan J Zheng WD Hill G Feuerstein DC Hess 2004 Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats BMC Neurol 26 4 7
8. Y He S Appel W Le 2001 Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum Brain Res 909 187 193 1:CAS:528:DC%2BD3MXls1ejsLg%3D 10.1016/S0006-8993(01) 02681-6 11478935
9. DC Wu V Jackson-Lewis M Vila K Tieu P Teismann C Vadseth DK Choi H Ischiropoulos S Przedborski 2002 Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model of Parkinson disease J Neurosci 22 1763 1771 1:CAS:528: DC%2BD38XhvValtbo%3D 11880505
10. V Papadopoulos M Baraldi TR Guilarte TB Knudsen JJ Lacapère P Lindemann MD Norenberg D Nutt A Weizman MR Zhang M Gavish 2006 Trends Pharmacol Sci 27 402 409 1:CAS:528:DC%2BD28XntVylsr8%3D 10.1016/j.tips.2006.06.005 16822554
11. 11C]PK11195 by PET and induction of the peripheral-type benzodiazepine receptor after transient focal ischemia in rats J Cereb Blood Flow Metab 27 1975 1986 1:CAS:528:DC%2BD2sXhtlWqurrE 10.1038/sj.jcbfm.9600500 17457364
12. 18F]DPA-714 in a rat model of focal cerebral ischemia. J Cereb Blood Flow Metab 30(1):230-241
13. F Dollé C Luus A Reynolds M Kassiou 2009 Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography Curr Med Chem 16 2899 2923 10.2174/092986709788803150 19689272
14. 11C]PK11195 challengers Eur J Nucl Med Mol Imag 35 2304 2319 10.1007/s00259-008-0908-9
15. ML James RR Fulton J Vercoullie DJ Henderson L Garreau S Chalon F Dolle B Costa D Guilloteau M Kassiou 2008 DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization J Nucl Med 49 814 822 1:CAS:528:DC%2BD1cXmvVSju7s%3D 10.2967/jnumed.107.046151 18413395
16. 11C]-(R)-PK11195 in a rat model of herpes encephalitis Mol Imaging Biol 11 386 398 10.1007/s11307-009-0211-6 19330384
17. 11C]PK11195 in a rat model of acute neuroinflammation J Nucl Med 50 468 476 1:CAS:528:DC%2BD1MXktVyns7s%3D 10.2967/jnumed.108.058669 19223401
18. C Justicia A Martín S Rojas M Gironella A Cervera J Panés A Chamorro AM Planas 2006 Anti-VCAM-1 antibodies did not protect against ischemic damage either in rats or in mice J Cereb Blood Flow Metab 26 421 432 1:CAS:528:DC%2BD28XjslCksr8%3D 10.1038/sj.jcbfm.9600198 16079786
19. 18F]DPA-714, a selective radioligand for imaging the translocator protein (18 kDa) with PET J Labelled Comp Radiopharm 51 286 292 1:CAS:528:DC%2BD1cXhtVKntL3I 10.1002/jlcr.1523
20. P Schweinhardt P Fransson L Olson C Spenger JL Andersson 2003 A template for spatial normalisation of MR images of the rat brain J Neurosci Methods 129 105 113 10.1016/S0165-0270(03)00192-4 14511814
21. B Ji J Maeda M Sawada M Ono T Okauchi M Inaji MR Zhang K Suzuki K Ando M Staufenbiel JQ Trojanowski VM Lee M Higuchi T Suhara 2008 Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies J Neurosci 28 12255 12267 1:CAS:528:DC%2BD1cXhsVGmtLvF 10.1523/JNEUROSCI.2312-08.2008 19020019
22. M Koistinaho TM Malm MI Kettunen G Goldsteins S Starckx RA Kauppinen G Opdenakker J Koistinaho 2005 Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice J Cereb Blood Flow Metab 25 460 467 1:CAS:528:DC%2BD2MXjvVyqur8%3D 10.1038/sj.jcbfm. 9600040 15674236
23. DP Stirling K Khodarahmi J Liu LT McPhail CB McBride JD Steeves MS Ramer W Tetzlaff 2004 Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury J Neurosci 24 2182 2190 1:CAS:528:DC%2BD2cXitlCrtb8%3D 10.1523/JNEUROSCI.5275-03.2004 14999069
24. C Power S Henry MR Del Bigio PH Larsen D Corbett Y Imai VW Yong J Peeling 2003 Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases Ann Neurol 53 731 742 1:CAS:528:DC%2BD3sXkslGhs7g%3D 10.1002/ana.10553 12783419
25. Y Murata A Rosell RH Scannevin KJ Rhodes X Wang EH Lo 2008 Extension of the thrombolytic time window with minocycline in experimental stroke Stroke 39 3372 3377 1:CAS:528:DC%2BD1cXhtlylt7nE 10.1161/STROKEAHA.108.514026 18927459
26. M Chen VO Ona M Li RJ Ferrante KB Fink S Zhu J Bian L Guo LA Farrell SM Hersch W Hobbs JP Vonsattel JH Cha RM Friedlander 2000 Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease Nat Med 6 797 801 1:CAS:528:DC%2BD3cXltValtLs%3D 10.1038/80538 10888929
27. Y Du Z Ma S Lin RC Dodel F Gao KR Bales LC Triarhou E Chernet KW Perry DL Nelson S Luecke LA Phebus FP Bymaster SM Paul 2001 Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease Proc Natl Acad Sci U S A 98 14669 14674 1:CAS:528:DC%2BD3MXptFCksbo%3D 10.1073/pnas.251341998 11724929
28. TM Tikka NE Vartiainen G Goldsteins SS Oja PM Andersen SL Marklund J Koistinaho 2002 Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease Brain 125 722 731 10.1093/brain/awf068 11912107
29. S Jander M Schroeter O Peters OW Witte G Stoll 2003 Cortical spreading depression induces proinflammatory cytokine gene expression in the rat brain J Neurosci 23 11602 11610
30. SC Fagan DJ Edwards CV Borlongan L Xu A Arora G Feuerstein DC Hess 2004 Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection Exp Neurol 186 248 251 1:CAS:528:DC%2BD2cXitFKntrk%3D 10.1016/j.expneurol.2003.12.006 15026261
31. S Nessler R Dodel A Bittner, et al. 2002 Effect of minocycline in experimental autoimmune encephalomyelitis Ann Neurol 52 689 690 10.1002/ana.10353 12402274
32. A Rosell EH Lo 2008 Multiphasic roles for matrix metalloproteinases after stroke Curr Opin Pharmacol 8 82 89 1:CAS:528:DC%2BD1cXhsVOgu7s%3D 10.1016/j.coph.2007.12.001 18226583
33. VW Yong J Wells F Giuliani S Casha C Power LM Metz 2004 The promise of minocycline in neurology Lancet Neurol 3 744 751 10.1016/S1474-4422(04)00937-8 15556807