Anxiety after cardiac arrest/cardiopulmonary resuscitation: Exacerbated by stress and prevented by minocycline

Stroke

Volumn 40, Issue 11, 2009, Pages 3601-3607

  Neigh, Gretchen N ^a   Karelina, Kate ^a   Glasper, Erica R ^a   Bowers, Stephanie L K ^a   Zhang, Ning ^a   Popovich, Phillip G ^a   Devries, A Courtney ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Anxiety; Cardiac arrest; Inflammation; Microglia; Stress

Indexed keywords

MINOCYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN ISCHEMIA; BRAIN NERVE CELL; CHRONIC STRESS; CONTROLLED STUDY; DISEASE EXACERBATION; HEART ARREST; HIPPOCAMPUS; IMMOBILIZATION STRESS; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RESUSCITATION;

ANIMALS; ANXIETY; CARDIOPULMONARY RESUSCITATION; HEART ARREST; MALE; MICE; MICE, INBRED C57BL; MINOCYCLINE; STRESS, PSYCHOLOGICAL;

EID: 70350525386     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.109.564146     Document Type: Article

References (27)

1. Grippo AJ, Johnson AK. Stress, depression and cardiovascular dysregu-lation: a review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress. 2009;12:1-21.
2. Coumel P. The role of stress in sudden death: can it be prevented? In: Aliot E, Clementy J, Prystowsky EN, eds. Fighting Sudden Cardiac Death: A Worldwide Challenge. Armonk, NY: Futura; 2000:567-579.
3. Nair A, Bonneau RH. Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J Neuroimmunol. 2006;171:72-85.
4. Ramos-Remus C, Gonzalez-Castaneda RE, Gonzalez-Perez O, Luquin S, Garcia-Estrada J. Prednisone induces cognitive dysfunction, neuronal degeneration, and reactive gliosis in rats. J Investig Med. 2002;50: 458-464.
5. Stoll G, Jander S. The role of microglia and macrophages in the patho-physiology of the CNS. Prog Neurobiol. 1999;58:233-247.
6. Amantea D, Nappi G, Bernardi G, Bagetta G, Corasaniti MT. Post-ische-mic brain damage: pathophysiology and role of inflammatory mediators. FEBS J. 2009;276:13-26.
7. Clemens JA, Stephenson DT, Smalstig EB, Roberts EF, Johnstone EM, Sharp JD, Little SP, Kramer RM. Reactive glia express cytosolic phos-pholipase a2 after transient global forebrain ischemia in the rat. Stroke. 1996;27:527-535.
8. Sugawara T, Lewen A, Noshita N, Gasche Y, Chan PH. Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal ca1 subregion in rats. J Neurotrauma. 2002;19:85-98.
9. Gonzalez-Perez O, Ramos-Remus C, Garcia-Estrada J, Luquin S. Pred-nisone induces anxiety and glial cerebral changes in rats. J Rheumatol. 2001;28:2529-2534.
10. Parnia S, Spearpoint K, Fenwick PB. Near death experiences, cognitive function and psychological outcomes of surviving cardiac arrest. Resuscitation. 2007;74: 215-221.
11. Wachelder EM, Moulaert VR, van Heugten C, Verbunt JA, Bekkers SC, Wade DT. Life after survival: long-term daily functioning and quality of life after an out-of-hospital cardiac arrest. Resuscitation. 2009;80: 517-522.
12. Yan B, He J, Xu H, Zhang Y, Bi X, Thakur S, Gendron A, Kong J, Li XM. Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice. Behav Brain Res. 2007;182:36-41.
13. Dhooper A, Young C, Reid KH. Ischemia-induced anxiety following cardiac arrest in the rat. Behav Brain Res. 1997;84:57-62.
14. Neigh GN, Kofler J, Meyers JL, Bergdall V, La Perle KM, Traystman RJ, DeVries AC. Cardiac arrest/cardiopulmonary resuscitation increases anxiety-like behavior and decreases social interaction. J Cereb Blood Flow Metab. 2004;24:372-382.
15. Cai ZY, Yan Y, Sun SQ, Zhang J, Huang LG, Yan N, Wu F, Li JY. Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion. Neurosci Bull. 2008;24:305-313.
16. Peeling J, Yan H, Buist R, Sitar DS, Corbett D. Protective effect of minocycline treatment on striatal ischemia. J Stroke Cerebrovasc Dis. 2006;15:101-105.
17. Fan LW, Lin S, Pang Y, Rhodes PG, Cai Z. Minocycline attenuates hypoxia-ischemia-induced neurological dysfunction and brain injury in the juvenile rat. Eur J Neurosci. 2006;24:341-350.
18. Neigh GN, Bowers SL, Pyter LM, Gatien ML, Nelson RJ. Pyruvate prevents restraint-induced immunosuppression via alterations in glu-cocorticoid responses. Endocrinology. 2004;145:4309-4319.
19. Kofler J, Hattori K, Sawada M, DeVries AC, Martin LJ, Hurn PD, Traystman RJ. Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice. J Neurosci Methods. 2004;136:33-44.
20. Zemke D, Majid A. The potential of minocycline for neuroprotection in human neurologic disease. Clin Neuropharmacol. 2004;27:293-298.
21. Fowler H. Curiousity and Exploratory Behavior. New York: Macmillan; 1965.
22. Adams LM, Geyer MA. A proposed animal model for hallucinogens based on LSD's effects on patterns of exploration in rats. Behav Neurosci. 1985;99:881-900.
23. Sugo N, Hurn PD, Morahan MB, Hattori K, Traystman RJ, DeVries AC. Social stress exacerbates focal cerebral ischemia in mice. Stroke. 2002; 33:1660-1664.
24. Garden GA, Moller T. Microglia biology in health and disease. J Neu-roimmune Pharmacol. 2006;1:127-137.
25. Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T, Koistinaho J. Tetra-cyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci U S A. 1998;95:15769-15774.
26. Neigh GN, Glasper ER, Kofler J, Traystman RJ, Mervis RF, Bachstetter A, DeVries AC. Cardiac arrest with cardiopulmonary resuscitation reduces dendritic spine density in ca1 pyramidal cells and selectively alters acquisition of spatial memory. Eur J Neurosci. 2004;20:1865-1872.
27. Lampl Y, Boaz M, Gilad R, Lorberboym M, Dabby R, Rapoport A, Anca-Hershkowitz M, Sadeh M. Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology. 2007;69:1404-1410.