P53 gene repair with zinc finger nucleases optimised by yeast 1-hybrid and validated by solexa sequencing

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Herrmann, Frank ^a   Garriga Canut, Mireia ^a   Baumstark, Rebecca ^a   Fajardo Sanchez, Emmanuel ^a   Cotterell, James ^a   Minoche, André ^a,b   Himmelbauer, Heinz ^a   Isalan, Mark ^a  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE; DEOXYRIBONUCLEASE; ZINC FINGER PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENE REPAIR; GENE SEQUENCE; GENETIC ENGINEERING; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; HYBRID; IN VITRO STUDY; IN VIVO STUDY; PROTEIN CLEAVAGE; TUMOR SUPPRESSOR GENE; YEAST ONE HYBRID; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DNA REPAIR; EXON; GENE LOCUS; GENETICS; HUMAN CHROMOSOME; INTRON; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PLASMID; REPRODUCIBILITY; SEQUENCE ANALYSIS; TUMOR CELL LINE; TWO HYBRID SYSTEM;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; CHROMOSOMES, HUMAN; DEOXYRIBONUCLEASES; DNA REPAIR; EXONS; GENES, P53; GENETIC LOCI; HEK293 CELLS; HUMANS; INTRONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PLASMIDS; REPRODUCIBILITY OF RESULTS; SEQUENCE ANALYSIS; TWO-HYBRID SYSTEM TECHNIQUES; ZINC FINGERS;

EID: 79958247418     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020913     Document Type: Article

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