-
1
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
-
S. Oddo, A. Caccamo, J.D. Shepherd, M.P. Murphy, T.E. Golde, R. Kayed, R. Metherate, M.P. Mattson, Y. Akbari, and F.M. LaFerla Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction Neuron 39 2003 409 421
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
Laferla, F.M.10
-
2
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
J. Lewis, D.W. Dickson, W.-L. Lin, L. Chisholm, A. Corral, G. Jones, S.-H. Yen, N. Sahara, L. Skipper, D. Yager, C. Eckman, J. Hardy, M. Hutton, and E. McGowan Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP Science 293 2001 1487 1491
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.-L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
Yen, S.-H.7
Sahara, N.8
Skipper, L.9
Yager, D.10
Eckman, C.11
Hardy, J.12
Hutton, M.13
McGowan, E.14
-
3
-
-
0035943436
-
Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils
-
J. Götz, F. Chen, R. van Dorpe, and R.M. Nitsch Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Aβ42 fibrils Science 293 2001 1491 1495
-
(2001)
Science
, vol.293
, pp. 1491-1495
-
-
Götz, J.1
Chen, F.2
Van Dorpe, R.3
Nitsch, R.M.4
-
4
-
-
0042334542
-
Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes
-
M.A. Kurt, D.C. Davies, M. Kidd, K. Duff, and D.R. Howlett Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes Neurobiol. Dis. 14 2003 89 97
-
(2003)
Neurobiol. Dis.
, vol.14
, pp. 89-97
-
-
Kurt, M.A.1
Davies, D.C.2
Kidd, M.3
Duff, K.4
Howlett, D.R.5
-
5
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
C. Sturchler-Pierrat, D. Abramowski, M. Duke, K.H. Wiederhold, C. Mistl, S. Rothacher, B. Ledermann, K. Burki, P. Frey, P.A. Paganetti, C. Waridel, M.E. Calhoun, M. Jucker, A. Probst, M. Staufenbiel, and B. Sommer Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology Proc. Natl. Acad. Sci. U. S. A. 94 1997 13287 13292
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Burki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
6
-
-
0037197836
-
Tau is essential to β-amyloid-induced neurotoxicity
-
M. Rapoport, H.N. Dawson, L.I. Binder, M.P. Vitek, and A. Ferreira Tau is essential to β-amyloid-induced neurotoxicity Proc. Natl. Acad. Sci. U. S. A. 99 2002 6364 6369
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 6364-6369
-
-
Rapoport, M.1
Dawson, H.N.2
Binder, L.I.3
Vitek, M.P.4
Ferreira, A.5
-
7
-
-
0942265972
-
Amyloid-β-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression
-
T. Liu, G. Perry, H.W. Chan, G. Verdile, R.N. Martins, M.A. Smith, and C.S. Atwood Amyloid-β-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression J. Neurochem. 88 2004 554 563
-
(2004)
J. Neurochem.
, vol.88
, pp. 554-563
-
-
Liu, T.1
Perry, G.2
Chan, H.W.3
Verdile, G.4
Martins, R.N.5
Smith, M.A.6
Atwood, C.S.7
-
8
-
-
0141960033
-
β-Amyloid induces PHF-like tau filaments in tissue culture
-
A. Ferrari, F. Hoerndli, T. Baechi, R.M. Nitsch, and J. Götz β-Amyloid induces PHF-like tau filaments in tissue culture J. Biol. Chem. 278 2003 40162 40168
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 40162-40168
-
-
Ferrari, A.1
Hoerndli, F.2
Baechi, T.3
Nitsch, R.M.4
Götz, J.5
-
9
-
-
0028986916
-
β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding
-
J. Busciglio, A. Lorenzo, J. Yeh, and B.A. Yankner β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding Neuron 14 1995 879 888
-
(1995)
Neuron
, vol.14
, pp. 879-888
-
-
Busciglio, J.1
Lorenzo, A.2
Yeh, J.3
Yankner, B.A.4
-
10
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
D.J. Selkoe Alzheimer's disease: genes, proteins, and therapy Physiol. Rev. 81 2001 741 766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
11
-
-
0030174981
-
The gene defects responsible for familial Alzheimer's disease
-
R.E. Tanzi, D.M. Kovacs, T.W. Kim, R.D. Moir, S.Y. Guenette, and W. Wasco The gene defects responsible for familial Alzheimer's disease Neurobiol. Dis. 3 1996 159 168
-
(1996)
Neurobiol. Dis.
, vol.3
, pp. 159-168
-
-
Tanzi, R.E.1
Kovacs, D.M.2
Kim, T.W.3
Moir, R.D.4
Guenette, S.Y.5
Wasco, W.6
-
13
-
-
0030879686
-
Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ
-
A. Ferreira, Q. Lu, L. Orecchio, and K.S. Kosik Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ Mol. Cell. Neurosci. 9 1997 220 234
-
(1997)
Mol. Cell. Neurosci.
, vol.9
, pp. 220-234
-
-
Ferreira, A.1
Lu, Q.2
Orecchio, L.3
Kosik, K.S.4
-
14
-
-
0028278593
-
Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family
-
L. Lannfelt, N. Bogdanovic, H. Appelgren, K. Axelman, L. Lilius, G. Hansson, D. Schenk, J. Hardy, and B. Winblad Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family Neurosci. Lett. 168 1994 254 256
-
(1994)
Neurosci. Lett.
, vol.168
, pp. 254-256
-
-
Lannfelt, L.1
Bogdanovic, N.2
Appelgren, H.3
Axelman, K.4
Lilius, L.5
Hansson, G.6
Schenk, D.7
Hardy, J.8
Winblad, B.9
-
15
-
-
0026907151
-
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
-
M. Mullan, F. Crawford, K. Axelman, H. Houlden, L. Lilius, B. Winblad, and L. Lannfelt A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid Nat. Genet. 1 1992 345 347
-
(1992)
Nat. Genet.
, vol.1
, pp. 345-347
-
-
Mullan, M.1
Crawford, F.2
Axelman, K.3
Houlden, H.4
Lilius, L.5
Winblad, B.6
Lannfelt, L.7
-
16
-
-
0029742199
-
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
-
K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang, and G. Cole Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice Science 274 1996 99 102
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
17
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
J. Lewis, E. McGowan, J. Rockwood, H. Melrose, P. Nacharaju, M. Van Slegtenhorst, K. Gwinn-Hardy, M.P. Murphy, M. Baker, X. Yu, K. Duff, J. Hardy, A. Corral, W.-L. Lin, S.-H. Yen, D.W. Dickson, P. Davies, and M. Hutton Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein Nat. Genet. 25 2000
-
(2000)
Nat. Genet.
, vol.25
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van Slegtenhorst, M.6
Gwinn-Hardy, K.7
Murphy, M.P.8
Baker, M.9
Yu, X.10
Duff, K.11
Hardy, J.12
Corral, A.13
Lin, W.-L.14
Yen, S.-H.15
Dickson, D.W.16
Davies, P.17
Hutton, M.18
-
18
-
-
0035808361
-
Tau filament formation in transgenic mice expressing P301L tau
-
J. Götz, F. Chen, R. Barmettler, and R.M. Nitsch Tau filament formation in transgenic mice expressing P301L tau J. Biol. Chem. 276 2001 529 534
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 529-534
-
-
Götz, J.1
Chen, F.2
Barmettler, R.3
Nitsch, R.M.4
-
19
-
-
0020608562
-
Association of microtubule-associated protein 2 (MAP 2) with microtubules and intermediate filaments in cultured brain cells
-
G.S. Bloom, and R.B. Vallee Association of microtubule-associated protein 2 (MAP 2) with microtubules and intermediate filaments in cultured brain cells J. Cell Biol. 96 1983 1523 1531
-
(1983)
J. Cell Biol.
, vol.96
, pp. 1523-1531
-
-
Bloom, G.S.1
Vallee, R.B.2
-
20
-
-
0026595567
-
Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs
-
D. Burdick, B. Soreghan, M. Kwon, J. Kosmoski, M. Knauer, A. Henschen, J. Yates, C. Cotman, and C. Glabe Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs J. Biol. Chem. 267 1992 546 554
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 546-554
-
-
Burdick, D.1
Soreghan, B.2
Kwon, M.3
Kosmoski, J.4
Knauer, M.5
Henschen, A.6
Yates, J.7
Cotman, C.8
Glabe, C.9
-
21
-
-
0029560256
-
Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps
-
P.A. Conrad, E.J. Smart, Y.-S. Ying, R.G.W. Anderson, and G.S. Bloom Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps J. Cell Biol. 131 1995 1421 1433
-
(1995)
J. Cell Biol.
, vol.131
, pp. 1421-1433
-
-
Conrad, P.A.1
Smart, E.J.2
Ying, Y.-S.3
Anderson, R.G.W.4
Bloom, G.S.5
-
22
-
-
0023505501
-
Phosphorylation determines two distinct species of tau in the central nervous system
-
S.C. Papasozomenos, and L.I. Binder Phosphorylation determines two distinct species of tau in the central nervous system Cell Motil. Cytoskelet. 8 1987 210 226
-
(1987)
Cell Motil. Cytoskelet.
, vol.8
, pp. 210-226
-
-
Papasozomenos, S.C.1
Binder, L.I.2
-
24
-
-
0028853922
-
Functional implications for the microtubule-associated protein tau: Localization in oligodendrocytes
-
P. LoPresti, S. Szuchet, S.C. Papasozomenos, R.P. Zinkowski, and L.I. Binder Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes Proc. Natl. Acad. Sci. U. S. A. 92 1995 10369 10373
-
(1995)
Proc. Natl. Acad. Sci. U. S. A.
, vol.92
, pp. 10369-10373
-
-
Lopresti, P.1
Szuchet, S.2
Papasozomenos, S.C.3
Zinkowski, R.P.4
Binder, L.I.5
-
25
-
-
0028593606
-
Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404
-
L.J. Otvos, L. Feiner, E. Lang, G.I. Szendrei, M. Goedert, and V.M.-Y. Lee Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404 J. Neurosci. Res. 39 1994 669 673
-
(1994)
J. Neurosci. Res.
, vol.39
, pp. 669-673
-
-
Otvos, L.J.1
Feiner, L.2
Lang, E.3
Szendrei, G.I.4
Goedert, M.5
Lee, V.M.-Y.6
-
26
-
-
0021352916
-
10-nm filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin
-
S.H. Blose, D.M. Meltzer, and J.R. Feramisco 10-nm filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin J. Cell Biol. 98 1984 847 858
-
(1984)
J. Cell Biol.
, vol.98
, pp. 847-858
-
-
Blose, S.H.1
Meltzer, D.M.2
Feramisco, J.R.3
-
27
-
-
0023053369
-
Carboxy-terminal regions on the surface of tubulin and microtubules. Epitope locations of YOL1/34, DM1A and DM1B
-
F. Breitling, and M. Little Carboxy-terminal regions on the surface of tubulin and microtubules. Epitope locations of YOL1/34, DM1A and DM1B J. Mol. Biol. 189 1986 367 370
-
(1986)
J. Mol. Biol.
, vol.189
, pp. 367-370
-
-
Breitling, F.1
Little, M.2
-
28
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
29
-
-
0032845739
-
The nonfibrillar amyloid β-peptide induces apoptotic neuronal cell death: Involvement of its C-terminal fusogenic domain
-
T. Pillot, B. Drouet, S. Queille, C. Labeur, J. Vandekerchkhove, M. Rosseneu, M. Pinçon-Raymond, and J. Chambaz The nonfibrillar amyloid β-peptide induces apoptotic neuronal cell death: involvement of its C-terminal fusogenic domain J. Neurochem. 73 1999 1626 1634
-
(1999)
J. Neurochem.
, vol.73
, pp. 1626-1634
-
-
Pillot, T.1
Drouet, B.2
Queille, S.3
Labeur, C.4
Vandekerchkhove, J.5
Rosseneu, M.6
Pinçon-Raymond, M.7
Chambaz, J.8
-
30
-
-
0021334794
-
Widespread distribution of the major polypeptide component of MAP1 (microtubule-associated protein 1) in the nervous system
-
G.S. Bloom, T.A. Schoenfeld, and R.B. Vallee Widespread distribution of the major polypeptide component of MAP1 (microtubule-associated protein 1) in the nervous system J. Cell Biol. 98 1984 320 330
-
(1984)
J. Cell Biol.
, vol.98
, pp. 320-330
-
-
Bloom, G.S.1
Schoenfeld, T.A.2
Vallee, R.B.3
-
31
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
R. Kayed, E. Head, J.L. Thompson, T.M. McIntire, S.C. Milton, C.W. Cotman, and C.G. Glabe Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis Science 300 2003 486 489
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
32
-
-
10944243437
-
Caveolin binds long chain unsaturated fatty acids with high affinity
-
B.L. Trigatti, R.G.W. Anderson, and G.E. Gerber Caveolin binds long chain unsaturated fatty acids with high affinity J. Biol. Chem. 1995 (submitted for publication)
-
(1995)
J. Biol. Chem.
-
-
Trigatti, B.L.1
Anderson, R.G.W.2
Gerber, G.E.3
-
33
-
-
0345405447
-
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
-
J.C. Cruz, H.C. Tseng, J.A. Goldman, H. Shih, and L.H. Tsai Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles Neuron 40 2003 471 483
-
(2003)
Neuron
, vol.40
, pp. 471-483
-
-
Cruz, J.C.1
Tseng, H.C.2
Goldman, J.A.3
Shih, H.4
Tsai, L.H.5
-
34
-
-
0038689162
-
Cdk5 is a key factor in tau aggregation and tangle formation in vivo
-
W. Noble, V. Olm, K. Takata, E. Casey, O. Mary, J. Meyerson, K. Gaynor, J. LaFrancois, L. Wang, T. Kondo, P. Davies, M. Burns, Veeranna, R. Nixon, D. Dickson, Y. Matsuoka, M. Ahlijanian, L.F. Lau, and K. Duff Cdk5 is a key factor in tau aggregation and tangle formation in vivo Neuron 38 2003 555 565
-
(2003)
Neuron
, vol.38
, pp. 555-565
-
-
Noble, W.1
Olm, V.2
Takata, K.3
Casey, E.4
Mary, O.5
Meyerson, J.6
Gaynor, K.7
Lafrancois, J.8
Wang, L.9
Kondo, T.10
Davies, P.11
Burns, M.12
Veeranna13
Nixon, R.14
Dickson, D.15
Matsuoka, Y.16
Ahlijanian, M.17
Lau, L.F.18
Duff, K.19
-
35
-
-
0041689948
-
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease
-
T.C. Gamblin, F. Chen, A. Zambrano, A. Abraha, S. Lagalwar, A.L. Guillozet, M. Lu, Y. Fu, F. Garcia-Sierra, N. LaPointe, R. Miller, R.W. Berry, L.I. Binder, and V.L. Cryns Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 100 2003 10032 10037
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 10032-10037
-
-
Gamblin, T.C.1
Chen, F.2
Zambrano, A.3
Abraha, A.4
Lagalwar, S.5
Guillozet, A.L.6
Lu, M.7
Fu, Y.8
Garcia-Sierra, F.9
Lapointe, N.10
Miller, R.11
Berry, R.W.12
Binder, L.I.13
Cryns, V.L.14
-
36
-
-
0037017399
-
Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons
-
Y. Zhang, R. McLaughlin, C. Goodyer, and A. LeBlanc Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons J. Cell Biol. 156 2002 519 529
-
(2002)
J. Cell Biol.
, vol.156
, pp. 519-529
-
-
Zhang, Y.1
McLaughlin, R.2
Goodyer, C.3
Leblanc, A.4
-
37
-
-
0037070606
-
Direct interaction of soluble human recombinant tau protein with Aβ 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II
-
K.B. Rank, A.M. Pauley, K. Bhattacharya, Z. Wang, D.B. Evans, T.J. Fleck, J.A. Johnston, and S.K. Sharma Direct interaction of soluble human recombinant tau protein with Aβ 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II FEBS Lett. 514 2002 263 268
-
(2002)
FEBS Lett.
, vol.514
, pp. 263-268
-
-
Rank, K.B.1
Pauley, A.M.2
Bhattacharya, K.3
Wang, Z.4
Evans, D.B.5
Fleck, T.J.6
Johnston, J.A.7
Sharma, S.K.8
-
38
-
-
0037118247
-
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
-
G.R. Jackson, M. Wiedau-Pazos, T.K. Sang, N. Wagle, C.A. Brown, S. Massachi, and D.H. Geschwind Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila Neuron 34 2002 509 519
-
(2002)
Neuron
, vol.34
, pp. 509-519
-
-
Jackson, G.R.1
Wiedau-Pazos, M.2
Sang, T.K.3
Wagle, N.4
Brown, C.A.5
Massachi, S.6
Geschwind, D.H.7
-
39
-
-
0028937631
-
mark)
-
mark) J. Biol. Chem. 270 1995 7679 7688
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7679-7688
-
-
Drewes, G.1
Trinczek, B.2
Illenberger, S.3
Biernat, J.4
Schmitt-Ulms, G.5
Meyer, H.E.6
Mandelkow, E.M.7
Mandelkow, E.8
|