Recent advances in the DABOs family as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Current Medicinal Chemistry

Volumn 18, Issue 16, 2011, Pages 2376-2385

  Yu, Mingyan ^a   Fan, Erkang ^b   Wu, Jingde ^a   Liu, Xinyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

AIDS; DABOs; HAART; HIV; NNRTIs; RT; SAR

Indexed keywords

2 SEC BUTYLOXY 5 METHYL 6 (3,5 DIMETHYLBENZYL) 3,4 DIHYDRO 4 OXOPYRIMIDINE; 2 SEC BUTYLTHIO 3,4 DIHYDRO 6 (3 METHYLBENZYL) 4 OXOPYRIMIDINE; 6 (4 METHOXYBENZYL) 2 BUTYLOXY 3,4 OXOPYRIMIDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DIHYDROOXYBENZYLOXOPYRIMIDINE DERIVATIVE; DIHYDROTHIOBENZYLOXOPYRIMIDINE DERIVATIVE; EFAVIRENZ; EMIVIRINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CYTOTOXICITY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SAFETY; GENE MUTATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS STRAIN; WILD TYPE;

ANTI-HIV AGENTS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79957943089     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711795843209     Document Type: Article

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