Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6- (arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Journal of Medicinal Chemistry

Volumn 50, Issue 8, 2007, Pages 1778-1786

  Ji, Lei ^a   Chen, Fen Er ^a   De Clercq, Erik ^b   Balzarini, Jan ^b   Pannecouque, Christophe ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 BENZOYLMETHYLTHIO 6 [ALPHA CYANO (1 NAPHTHYLMETHYL)] 3,4 DIHYDRO 5 METHYLPYRIMIDIN 4(3H) ONE; 6 [ALPHA CYANO (1 NAPHTHYLMETHYL)] 3,4 DIHYDRO 5 ETHYL 2 ISOPROPYLTHIOPYRIMIDIN 4(3H) ONE; ALKYL GROUP; CARBONYL DERIVATIVE; NEVIRAPINE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IC 50; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRILES; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247268630     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061167r     Document Type: Article

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