Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity

Journal of Medicinal Chemistry

Volumn 48, Issue 25, 2005, Pages 8000-8008

  Manetti, Fabrizio ^a   Esté, José A ^b   Clotet Codina, Imma ^b   Armand Ugón, Mercedes ^b   Maga, Giovanni ^c   Crespan, Emmanuele ^c   Cancio, Reynel ^c   Mugnaini, Claudia ^a   Bernardini, Cesare ^a   Togninelli, Andrea ^a   Carmi, Caterina ^d   Alongi, Maddalena ^a   Petricci, Elena ^a   Massa, Silvio ^a   Corelli, Federico ^a   Botta, Maurizio ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^c CNR   (Italy)

^d UNIVERSITY OF PARMA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 (2,6 DICHLOROBENZYL) 2 [2 (4 METHOXYPHENYL)ETHYLTHIO] 5 METHYLPYRIMIDIN 4(3H) ONE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BENZYLATION; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME PURIFICATION; HUMAN IMMUNODEFICIENCY VIRUS 1; METHODOLOGY; MICROWAVE RADIATION; MOLECULAR MODEL; NONHUMAN; PARALLEL SOLUTION PHASE; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; VIRUS STRAIN; WILD TYPE;

ANTI-HIV AGENTS; CELL LINE; DRUG RESISTANCE, MULTIPLE, VIRAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MICROWAVES; MODELS, MOLECULAR; MUTATION; PYRIMIDINES; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 29144440875     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050744t     Document Type: Article

References (39)

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