Synthesis and biological evaluation of novel 2-arylalkylthio-4-amino-6-benzyl pyrimidines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 9, 2010, Pages 3003-3005

  Qin, Hua ^a   Liu, Chang ^a   Zhang, Jianfang ^a   Guo, Ying ^b   Zhang, Siwei ^c   Zhang, Zhili ^b   Wang, Xiaowei ^b   Zhang, Liangren ^c   Liu, Junyi ^b,c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

2 Aryalkylthio 4 amino 6 benzylpyrimidines; Docking; Non nucleoside reverse transcriptase inhibitors (NNRTIs)

Indexed keywords

2 ARYALKYLTHIO 4 AMINO 6 BENZYLPYRIMIDINE DERIVATIVE; LYSINE; NEVIRAPINE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN;

ANTI-HIV AGENTS; BINDING SITES; COMPUTER SIMULATION; HIV REVERSE TRANSCRIPTASE; HUMANS; HYDROGEN BONDING; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77950861081     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.051     Document Type: Article

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