Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 22, 2009, Pages 7749-7754

  Yu, Mingyan ^a   Liu, Xinyong ^a   Li, Zhenyu ^a   Liu, Shuai ^a   Pannecouque, Christophe ^b   Clercq, Erik De ^b  

^a SHANDONG UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

AIDS; Anti HIV 1 activity; HIV 1; NNRTIs; S DABOs

Indexed keywords

2 [(4 BROMOPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (2,6 DICHLOROBENZYL) 5 METHYLPYRIMIDIN 4(3H) ONE; PYRIMIDINONE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CELL LINE; DRUG EVALUATION, PRECLINICAL; HIV-1; HUMANS; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 71749121628     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.035     Document Type: Article

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