Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1016-1023

  Wang, Yue Ping ^a   Chen, Fen Er ^a   De Clercq, Erik ^b   Balzarini, Jan ^b   Pannecouque, Christophe ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral activity; HIV 1; HIV 2; In vitro; NNRTIs; S DABOs; SAR

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; 2 (4 METHOXYBENZYLSULFANYL) 5 METHYL 6 (4 PHENYLBENZYL)PYRIMIDIN 4(3H) ONE; 2 (4 METHOXYBENZYLSULFANYL) 6 (1 NAPHTHYLMETHYL) 5 (ISOPROPYL)PYRIMIDIN 4(3H) ONE; 2 (BENZYLSULFANYL) 6 (3,5 DIMETHYLBENZYL) 5 ETHYLPYRIMIDIN 4(3H) ONE; 5 ETHYL 2 (4 METHOXYBENZYLSULFANYL) 6 (1 NAPHTHYLMETHYL)PYRIMIDIN 4(3H) ONE; 5 ETHYL 2 (4 METHOXYBENZYLSULFANYL) 6 (4 PHENYLBENZYL)PYRIMIDIN 4(3H) ONE; 6 (2 BROMOBENZYL) 2 (4 METHOXYBENZYLSULFANYL) 5 METHYLPYRIMIDIN 4(3H) ONE; 6 (2 BROMOBENZYL) 5 ETHYL 2 (4 METHOXYBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (2 BROMOBENZYL) 5 ETHYL 2 (4 NITROBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (2 BROMOBENZYL) 5 METHYL 2 (4 NITROBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (2,6 DICHLOROBENZYL) 5 ETHYL 2 (4 METHOXYBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (2,6 DICHLOROBENZYL) 5 ETHYL 2 (4 NITROBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (3 BROMOBENZYL) 2 (4 METHOXYBENZYLSULFANYL) 5 METHYLPYRIMIDIN 4(3H) ONE; 6 (3 BROMOBENZYL) 5 ETHYL 2 (4 METHOXYBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (3 BROMOBENZYL) 5 ETHYL 2 (4 NITROBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (3 BROMOBENZYL) 5 METHYL 2 (4 NITROBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (3,5 DIMETHYLBENZYL) 2 (4 METHOXYBENZYLSULFANYL) 5 METHYLPYRIMIDIN 4(3H) ONE; 6 (3,5 DIMETHYLBENZYL) 5 ETHYL 2 (4 NITROBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (3,5 DIMETHYLBENZYL) 5 METHYL 2 (4 NITROBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 (4 BROMOBENZYL) 2 (4 METHOXYBENZYLSULFANYL) 5 METHYLPYRIMIDIN 4(3H) ONE; 6 (4 BROMOBENZYL) 5 ETHYL 2 (4 METHOXYBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 2 (4 METHOXYBENZYLSULFANYL) 5 METHYLPYRIMIDIN 4(3H) ONE; 6 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 5 ETHYL 2 (4 METHOXYBENZYLSULFANYL)PYRAMIDIN 4(3H) ONE; 6 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 5 ETHYL 2 (4 NITROBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; 6 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 5 METHYL 2 (4 NITROBENZYLSULFANYL)PYRIMIDIN 4(3H) ONE; DIDANOSINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

CELL LINE; CRYSTALLOGRAPHY, X-RAY; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60549105209     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.06.028     Document Type: Article

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