5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3173-3176

  He, Yanping ^a   Chen, Fener ^a   Sun, Guangfu ^a   Wang, Yueping ^a   De Clercq, Erik ^b   Balzarini, Jan ^b   Pannecouque, Christophe ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL LINE; CONCENTRATION RESPONSE; DRUG POTENCY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; INHIBITION KINETICS; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; PYRIMIDINES; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 2442610540     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.008     Document Type: Article

References (23)

1. De Clercq E. Antiviral Res. 38:1998;153
2. De Clercq E. Curr. Med. Chem. 8:2001;1543
3. Bardsley Elliot A., Perry C.M. Pediatric Drugs. 2:2000;373
4. Scott L.J., Perry M. Drugs. 60:2000;1411
5. Tran J.Q., Gerber J.G., Kerr B.M. Clin. Phamacokinet. 40:2001;207
6. Adkins J.C., Nobel S. Drugs. 56:1998;1055
7. De Clercq E. Rev. Med. Virol. 10:2000;255
8. Kohlstaedt L.A., Wang J., Friedman J.M., Rice P.K., Tantillo C., Zhang W., Clark A.D.J., Jessen S., Lu X.A., Steitz T.A. Science. 256:1992;1783
9. Ding J., Das, Hsiou Y., Jacobo-Molina A., Andries K., Pauwels R., Moereels H., Koymans L., Janssen P.A.J., Smith R.H.J., Kroeger Koepke R., Michejda C.J., Hughes S.H., Arnold E. Structure. 3:1995;365
10. Esnouf R., Re J., Ross C., Jones Y., Stammers D., Stuart D. Struct. Biol. 2:1995;303
11. Buckheit R.W. Jr., Fliakas-Boltz V., Russell J., et al. Antimicrob. Agents Chemother. 45:2001;393
12. Baba M., Tanaka H., De Clercq E., Pauwels R., Balzarini J., Schols D., Nakashima H., Perno C.F., Walker R.T., Mitasaka T. Biochem. Biophys. Res. Commun. 165:1989;1375
13. Artico M., Massa S., Mai A., Marongiu M.E., Piras G., Tramontano E., La Colla P. Antiviral. Chem. Chemother. 4:1993;361
14. Vig R., Mao C., Venkatachalam T.K., Tuel-Ahlgren L., Sudbeck E.A., Uckun F.M. Bioorg. Med. Chem. Lett. 8:1998;1461
15. Mai A., Artico M., Sbardella G., Quartarone S., Massa S., Loi A.G., De Montis A., Scintu F., Putzolu M., La Colla P. J. Med. Chem. 40:1997;1447
16. Mai A., Sbardella G., Artico M., Ragno R., Massa S., Novellino E., Greco G., Lavecchia A., Musiu C., La Colla M., Murgioni C., La Colla P., Loddo R. J. Med. Chem. 44:2001;2544
17. Meng G., Chen F.E., Clercq D.E., Balzarini J., Pannecouque C. Chem. Pharm. Bull. 51:2003;779
18. Ren J., Esnouf R., Garman E. Nat. Struct. Biol. 2:1995;293
19. Artico M. Drugs of the Future. 27:2002;159
20. Hannick S.M., Kishi Y. J. Org. Chem. 48:1983;3833
21. 4), 163.0 (C-4), 191.5 (C=O)
22. Rey F., Barre-Sinoussi F., Schmidtmayerova H., Chemann J.C. J. Virol. Methods. 16:1987;239
23. Rey F., Donker G., Hirsch L., Chemann J.C. Virology. 181:1991;165