SCOPUS 정보 검색 플랫폼

Volumn 3, Issue 9, 2008, Pages 1412-1418

Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants

(8) Samuele, Alberta b Facchini, Marcella b Rotili, Dante a Mai, Antonello a Artico, Marino a Armand Ugön, Mercedes c Esté, José A c Maga, Giovanni b

a SAPIENZA UNIVERSITY OF ROME (Italy)

b CNR (Italy)

c HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL (Spain)

Author keywords

Antiviral agents; HIV 1; Medicinal chemistry; Reverse transcriptase

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; MC 1220; MC1838; MC1839; PYRIMIDINONE DERIVATIVE; RECOMBINANT PROTEIN; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL RESISTANCE; ARTICLE; BINDING COMPETITION; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME SPECIFICITY; GENE EXPRESSION PROFILING; GENETICS; KINETICS; MUTATION; POLYMERASE CHAIN REACTION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME;

ANTI-HIV AGENTS; BINDING SITES; BINDING, COMPETITIVE; CATALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, VIRAL; GENE EXPRESSION PROFILING; HIV REVERSE TRANSCRIPTASE; KINETICS; MOLECULAR STRUCTURE; MUTATION; POLYMERASE CHAIN REACTION; PYRIMIDINONES; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 54849438319 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200800051 Document Type: Article

Times cited : (9)

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