Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3887-3894

  Wang, Yue Ping ^a   Chen, Fen Er ^a   De Clercq, Erik ^b   Balzarini, Jan ^b   Pannecouque, Christophe ^b  

^a FUDAN UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

HIV; NNRTIs; S DABOs; SAR

Indexed keywords

5 ETHYL 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO) 6 (ALPHA PHENYLBENZYL)PYRIMIDIN 4(3H)ONE; 5 METHYL 6 (1 NAPHTHYLMETHYL) 2 (PHENYLCARBONYLMETHYLTHIO) 4(3H)ONE; 6 (2 BROMOBENZYL) 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO) 5 METHYLPYRIMIDIN 4(3H)ONE; 6 (2 BROMOBENZYL) 5 ETHYL 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO)PYRIMIDIN 4(3H)ONE; 6 (2,6 DICHLORORBENZYL) 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO) 5 METHYLPYRIMIDIN 4(3H)ONE; 6 (3 BROMOBENZYL) 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO)5 METHYLPYRIMIDIN 4(3H)ONE; 6 (3 BROMOBENZYL) 5 ETHYL 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO)PYRIMIDIN 4(3H)ONE; 6 (3 HYDROXYBENZYL) 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO) 5 METHYLPYRIMIDIN 4(3H)ONE; 6 (3,5 DIMETHYLBENZYL) 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO) 5 METHYLPYRIMIDIN 4(3H)ONE; 6 (3,5 DIMETHYLBENZYL) 5 ETHYL 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO)PYRIMIDIN 4(3H)ONE; 6 (3,5 DIMETHYLBENZYL) 5 ETHYL 2 (PHENYLCARBONYLMETHYLTHIO)PYRIMIDIN 4(3H)ONE; 6 (4 BROMOBENZYL) 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO) 5 METHYLPYRIMIDIN 4(3H)ONE; 6 (4 BROMOBENZYL) 5 ETHYL 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO)PYRIMIDIN 4(3H)ONE; 6 (4 PHENYLBENZYL) 5 ETHYL 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO)PYRIMIDIN 4(3H)ONE; 6 (ALPHA PHENYLBENZYL) 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO) 5 METHYLPYRIMIDIN 4(3H)ONE; 6 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO) 5 METHYLPYRIMIDIN 4(3H)ONE; 6 [3,5 BIS(TRIFLUOROMETHYL)BENZYL] 5 ETHYL 2 (4 METHOXYPHENYLCARBONYLMETHYLTHIO)PYRIMIDIN 4(3H)ONE; ANTIVIRUS AGENT; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOPATHOGENIC EFFECT; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; VIRUS STRAIN; WILD TYPE;

ALKYLATION; CELL LINE; HIV-1; HUMANS; METHYLATION; MOLECULAR STRUCTURE; NUCLEOSIDES; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 41649106236     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.039     Document Type: Article

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