Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 9, 2010, Pages 3231-3237

  Qin, Hua ^a   Liu, Chang ^b   Guo, Ying ^c   Wang, Ruiping ^b   Zhang, Jianfang ^b   Ma, Liying ^d   Zhang, Zhili ^c   Wang, Xiaowei ^c   Cui, Yuxin ^a   Liu, Junyi ^a,c  

^a PEKING UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^d CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Docking; HIV 1 RT; NNRTIs; S DABO analogues

Indexed keywords

2 (ALLYLTHIO) 6 BENZYL 5 METHYLPYRIMIDIN 4(3H) ONE; 2 (ALLYLTHIO) 6 BENZYLPYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (1 PHENYLETHYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (2 METHYL BENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (3 METHOXYBENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (3 METHYL BENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (3 PHENYLPROPYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (4 TERT BUTYLBENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (BENZYLOXYMETHYLTHIO) 5 METHYL PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (BENZYLOXYMETHYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (BENZYLTHIO) 5 IODOPYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (BENZYLTHIO) 5 METHYLPYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (BENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (ETHOXYMETHYLTHIO) 5 METHYL PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (ETHOXYMETHYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (NAPHTHALEN 2 YLMETHYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 2 (PHENETHYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 5 METHYL 2 (1 PHENYLETHYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 5 METHYL 2 (2 METHYLBENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 5 METHYL 2 (3 METHOXYBENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 5 METHYL 2 (3 METHYLBENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 5 METHYL 2 (3 PHENYLPROPYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 5 METHYL 2 (4 TERT BUTYLBENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 5 METHYL 2 (BENZYLTHIO)PYRIMIDIN 4(3H) ONE; 6 BENZYL 5 METHYL 2 (NAPHTHALEN 2 YLMETHYLTHIO)PYRIMIDIN 4(3H) ONE; DIHYDRO ALKOXY BENZYL OXOPYRIMIDINE DERIVATIVE; EMIVIRINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; MOLECULAR DOCKING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; HALOGENS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NEVIRAPINE; PYRIMIDINONES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REVERSE TRANSCRIPTASE INHIBITORS; SULFUR;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77951206884     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.03.025     Document Type: Article

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