Synthesis and biological evaluation of 6-substituted 5-Alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs

ChemMedChem

Volumn 6, Issue 5, 2011, Pages 826-833

  Yu, Mingyan ^a   Li, Zhenyu ^a   Liu, Shuai ^a   Fan, Erkang ^b   Pannecouque, Christophe ^c   DeClercq, Erik ^c   Liu, Xinyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF WASHINGTON   (United States)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral agents; DABOs; HIV 1; Medicinal chemistry; NNRTIs

Indexed keywords

2 [(4 CYANOPHENYLAMINO)CARBONYLMETHYLTHIO] 6 (2 CHLORO 6 FLUOROBENZYL) 5 ETHYLPYRIMIDIN 4(3H) ONE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; PRIORITY JOURNAL; VIRUS STRAIN; WILD TYPE;

ANTI-HIV AGENTS; BINDING SITES; CELL LINE; COMPUTER SIMULATION; HIV REVERSE TRANSCRIPTASE; HUMANS; MODELS, MOLECULAR; MUTATION; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79954987862     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000555     Document Type: Article

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